PT1058683E - Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao - Google Patents

Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao

Info

Publication number
PT1058683E
PT1058683E PT99901979T PT99901979T PT1058683E PT 1058683 E PT1058683 E PT 1058683E PT 99901979 T PT99901979 T PT 99901979T PT 99901979 T PT99901979 T PT 99901979T PT 1058683 E PT1058683 E PT 1058683E
Authority
PT
Portugal
Prior art keywords
formula
farnesil
preparation process
transferase inhibitors
compound
Prior art date
Application number
PT99901979T
Other languages
English (en)
Inventor
Jong Sung Koh
You Seung Shin
Hyun Il Lee
Jin Ho Lee
Jong Hyun Kim
Hyun Ho Chung
Kwi Hwa Kim
Tae Hwan Kwak
Seong Gu Ro
In Ae Ahn
Tae Saeng Choi
Young Hoon Oh
Chung Mi Kim
Sun Hwa Lee
Hyun Sung Kim
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019980002777A external-priority patent/KR100388789B1/ko
Priority claimed from KR1019980028340A external-priority patent/KR100388792B1/ko
Priority claimed from KR10-1998-0032150A external-priority patent/KR100388794B1/ko
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of PT1058683E publication Critical patent/PT1058683E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PT99901979T 1998-02-02 1999-02-01 Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao PT1058683E (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1019980002777A KR100388789B1 (ko) 1998-02-02 1998-02-02 피롤구조를갖는파네실전이효소억제제및그의제조방법
KR19980002776 1998-02-02
KR1019980028340A KR100388792B1 (ko) 1998-02-02 1998-07-14 피페리딘구조를갖는파네실전이효소억제제및그의제조방법
KR10-1998-0032150A KR100388794B1 (ko) 1998-08-07 1998-08-07 피페리딘구조를갖는파네실전이효소억제제및그의제조방법

Publications (1)

Publication Number Publication Date
PT1058683E true PT1058683E (pt) 2003-04-30

Family

ID=27483262

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99901979T PT1058683E (pt) 1998-02-02 1999-02-01 Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao

Country Status (12)

Country Link
US (1) US6436960B1 (pt)
EP (1) EP1058683B1 (pt)
JP (1) JP3283032B2 (pt)
CN (1) CN1158277C (pt)
AT (1) ATE229017T1 (pt)
AU (1) AU745855B2 (pt)
BR (1) BR9908545A (pt)
CA (1) CA2320233C (pt)
DE (1) DE69904302T2 (pt)
ES (1) ES2185307T3 (pt)
PT (1) PT1058683E (pt)
WO (1) WO1999038862A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100388794B1 (ko) * 1998-08-07 2003-10-10 주식회사 엘지생명과학 피페리딘구조를갖는파네실전이효소억제제및그의제조방법
KR100388792B1 (ko) * 1998-02-02 2003-09-22 주식회사 엘지생명과학 피페리딘구조를갖는파네실전이효소억제제및그의제조방법
WO2000064891A1 (en) * 1999-04-13 2000-11-02 Lg Chem Investment Ltd. Farnesyl transferase inhibitors having a pyrrole structure and process for preparation thereof
KR20010063274A (ko) * 1999-12-22 2001-07-09 성재갑 〔1-｛〔1-（1,3-벤조디옥솔-5-일메틸-1ｈ-이미다졸-5-일〕메틸｝-4-(1-나프틸)-1ｈ-피롤-3-일〕（4-메틸-1-피페라지닐）메타논의 약학적 조성물
US7035932B1 (en) * 2000-10-27 2006-04-25 Eric Morgan Dowling Federated multiprotocol communication
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
MXPA05006567A (es) 2002-12-20 2005-08-16 Glaxo Group Ltd Derivados de benzazepina para el tratamiento de trastornos neurologicos.
EP2316487B1 (en) 2003-04-11 2014-06-11 MedImmune, LLC Recombinant IL-9 antibodies & uses thereof
WO2005042743A2 (en) 2003-08-18 2005-05-12 Medimmune, Inc. Humanization of antibodies
JP4956191B2 (ja) * 2003-10-17 2012-06-20 インサイト コーポレーション マトリックスメタロプロテイナーゼの阻害剤としての置換環状ヒドロキサメート
US20060121042A1 (en) 2004-10-27 2006-06-08 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
AU2006227377B2 (en) 2005-03-18 2013-01-31 Medimmune, Llc Framework-shuffling of antibodies
WO2007002543A2 (en) 2005-06-23 2007-01-04 Medimmune, Inc. Antibody formulations having optimized aggregation and fragmentation profiles
NZ575163A (en) 2006-08-28 2011-12-22 Jolla Inst Allergy Immunolog Antagonistic human light-specific human monoclonal antibodies
MX2009010389A (es) 2007-03-30 2010-01-20 Medimmune Llc Formulacion de anticuerpos.
EP2668210B1 (en) 2011-01-26 2020-06-17 Celldex Therapeutics, Inc. Anti-kit antibodies and uses thereof
GB201107985D0 (en) 2011-05-13 2011-06-29 Astrazeneca Ab Process
SG11201500489YA (en) 2012-07-25 2015-02-27 Kolltan Pharmaceuticals Inc Anti-kit antibodies and uses thereof
AU2013329311A1 (en) 2012-10-09 2015-04-30 Igenica Biotherapeutics, Inc. Anti-C16orf54 antibodies and methods of use thereof
ES2891755T3 (es) 2013-06-06 2022-01-31 Pf Medicament Anticuerpos anti-C10orf54 y utilizaciones de los mismos
KR102553717B1 (ko) 2013-08-26 2023-07-11 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 시알릴-루이스 ａ에 대한 사람 항체 코드화 핵산
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
JP6626461B2 (ja) 2014-06-04 2019-12-25 バイオエヌテック リサーチ アンド デベロップメント， インコーポレイテッド ガングリオシドｇｄ２に対するヒトモノクローナル抗体
WO2016094837A2 (en) 2014-12-11 2016-06-16 Igenica Biotherapeutics, Inc. Anti-c10orf54 antibodies and uses thereof
BR112017015880A2 (pt) 2015-03-03 2018-07-31 Kymab Ltd anticorpos, usos e métodos
WO2017096051A1 (en) 2015-12-02 2017-06-08 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
KR20180100122A (ko) 2015-12-02 2018-09-07 주식회사 에스티사이언스 당화된 btla(b- 및 t-림프구 약화인자)에 특이적인 항체
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
AU2018277838A1 (en) 2017-05-31 2019-12-19 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof
AU2018277545A1 (en) 2017-05-31 2019-12-19 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1
JP2020522562A (ja) 2017-06-06 2020-07-30 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１又はｂｔｎ１ａ１リガンドに結合する抗体及び分子を用いて癌を治療する方法
EP3694889A1 (en) 2017-10-13 2020-08-19 Boehringer Ingelheim International GmbH Human antibodies to thomsen-nouvelle (tn) antigen
CA3106418A1 (en) 2018-07-20 2020-01-23 Pierre Fabre Medicament Receptor for vista

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
WO1993019059A1 (en) * 1992-03-25 1993-09-30 Pfizer Limited Antiviral peptides
GB9312806D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
AU716153B2 (en) * 1996-04-03 2000-02-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0891360A4 (en) * 1996-04-03 2002-05-15 Merck & Co Inc FARNESYL PROTEIN TRANSFERASE INHIBITORS
CA2249601A1 (en) * 1996-04-03 1997-10-23 Thorsten E. Fisher Inhibitors of farnesyl-protein transferase
CA2250232A1 (en) * 1996-04-03 1997-10-09 Allen I. Oliff A method of treating cancer
WO1997036890A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
HUP0004238A3 (en) * 1997-11-28 2001-07-30 Lg Chemical Ltd Imidazole derivatives having an inhibitory activity for farnesyl transferase, process for preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69904302D1 (de) 2003-01-16
CA2320233A1 (en) 1999-08-05
BR9908545A (pt) 2001-10-02
CN1158277C (zh) 2004-07-21
WO1999038862A1 (en) 1999-08-05
EP1058683B1 (en) 2002-12-04
ES2185307T3 (es) 2003-04-16
AU745855B2 (en) 2002-04-11
JP3283032B2 (ja) 2002-05-20
JP2002501918A (ja) 2002-01-22
US6436960B1 (en) 2002-08-20
EP1058683A1 (en) 2000-12-13
AU2188699A (en) 1999-08-16
CN1289331A (zh) 2001-03-28
ATE229017T1 (de) 2002-12-15
DE69904302T2 (de) 2003-08-14
CA2320233C (en) 2004-07-27

Similar Documents

Publication Publication Date Title
PT1058683E (pt) Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao
BR9815423A (pt) Composto derivado de imidazol, processo para preparar um derivado de imidazol, e, composição farmacêutica.
KR950017957A (ko) 3, 4, 4-삼치환-피페리디닐-n-알킬카르복실레이트의 제법 및 중간체
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
BR0108893A (pt) Composição farmacêutica, composto e processo de preparação de compostos
BR9913592A (pt) Compostos, processo de preparação dos compostos, e, composições farmacêuticas
DK0650476T3 (da) Perifert, vasodilaterende middel, der indeholder N-acylerede 4-aminopiperidinderivater som aktive bestanddele
BR9803883A (pt) Derivado de amida.
BRPI0208811B8 (pt) derivados de pirazol, seu uso e processo de preparação, bem como composição farmacêutica compreendendo os mesmos
ATE273305T1 (de) Thrombin-inhibitoren
BR0210874A (pt) Derivados de tiazol-benzamida e composições farmacêuticas para a inibição da proliferação celular e métodos para o seu uso
BR9909620A (pt) Inibidores de metaloproteases de hidroxamato de pirrolidina substituìdo
DE69635996D1 (de) Pharmazeutische zusammensetzungen mit hydroximsäurederivaten
PT842923E (pt) Derivados do pirrolo e composicoes medicinais
NO20001169L (no) 6,9-bro erythromycinderivater
NO20002099L (no) 6,11-bro-erytromycinderivater
SE9903894D0 (sv) Novel compounds
BR0008778A (pt) Análogos de prostaglandinas seletivos para fpc16 insaturados
TR200000153T2 (tr) İl-5 inhibite eden 6-azaurasil türevleri.
NO20023001L (no) Substituerte piperazinderivater som MTP inhibitorer
BR0115454A (pt) Composto de 1-metilcarbapenem ou um sal ou derivado de éster deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal ou derivado de éster deste farmaceuticamente aceitável
BR0014759A (pt) Inibidores de metaloprotease beta dissubstituìdos
EA200000374A2 (ru) Новые соединения 2,3-метаноаминокислоты, способ их получения и содержащие их фармацевтические композиции
EP0414903A4 (en) New thioproline derivative
MXPA05008190A (es) Derivado de oligosacarido.