EA200300400A1 - 17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ - Google Patents

17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ

Info

Publication number
EA200300400A1
EA200300400A1 EA200300400A EA200300400A EA200300400A1 EA 200300400 A1 EA200300400 A1 EA 200300400A1 EA 200300400 A EA200300400 A EA 200300400A EA 200300400 A EA200300400 A EA 200300400A EA 200300400 A1 EA200300400 A1 EA 200300400A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
fluoralkylsteroids
production
compounds
compounds pharmaceutical
Prior art date
Application number
EA200300400A
Other languages
English (en)
Other versions
EA005772B1 (ru
Inventor
Свен Ринг
Гюнтер Кауфманн
Ральф Вирва
Вальтер Эльгер
Original Assignee
Шеринг Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шеринг Акциенгезельшафт filed Critical Шеринг Акциенгезельшафт
Publication of EA200300400A1 publication Critical patent/EA200300400A1/ru
Publication of EA005772B1 publication Critical patent/EA005772B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0078—Sulfur-containing hetero ring containing only sulfur
    • C07J71/0084—Episulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

В заявке описываются 17α-фторалкилстероиды общей формулы (I)в которой Rпредставляет собой остаток формулы CF, где n обозначает 1, 2, 3, 4, 5 или 6, и способ их получения, а также фармацевтические композиции, содержащие в своем составе эти соединения. Предлагаемые в изобретении соединения общей формулы (I) обладают андрогенной активностью.Отчет о международном поиске был опубликован 2002.06.20.
EA200300400A 2000-09-29 2001-09-28 17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ EA005772B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10049736A DE10049736A1 (de) 2000-09-29 2000-09-29 17alpha-Fluoralkylsteroide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
PCT/DE2001/003732 WO2002026759A2 (de) 2000-09-29 2001-09-28 17α-FLUORALKYLSTEROIDE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN

Publications (2)

Publication Number Publication Date
EA200300400A1 true EA200300400A1 (ru) 2003-10-30
EA005772B1 EA005772B1 (ru) 2005-06-30

Family

ID=7659018

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300400A EA005772B1 (ru) 2000-09-29 2001-09-28 17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ

Country Status (29)

Country Link
US (1) US20040024231A1 (ru)
EP (1) EP1322660B1 (ru)
JP (1) JP2004509971A (ru)
KR (1) KR20030061815A (ru)
CN (1) CN1305890C (ru)
AT (1) ATE338054T1 (ru)
AU (1) AU1382202A (ru)
BG (1) BG107763A (ru)
BR (1) BR0114258A (ru)
CA (1) CA2422056A1 (ru)
DE (2) DE10049736A1 (ru)
DK (1) DK1322660T3 (ru)
EA (1) EA005772B1 (ru)
EE (1) EE200300124A (ru)
ES (1) ES2272550T3 (ru)
HK (1) HK1061860A1 (ru)
HR (1) HRP20030334A2 (ru)
HU (1) HUP0301198A2 (ru)
IL (2) IL154828A0 (ru)
MX (1) MXPA03002606A (ru)
NO (1) NO325058B1 (ru)
NZ (1) NZ524781A (ru)
PL (1) PL361666A1 (ru)
PT (1) PT1322660E (ru)
SK (1) SK5192003A3 (ru)
UA (1) UA76125C2 (ru)
WO (1) WO2002026759A2 (ru)
YU (1) YU22903A (ru)
ZA (1) ZA200303216B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US20050182322A1 (en) * 2004-02-17 2005-08-18 Liebel-Flarsheim Company Injector auto purge
EP1854465A1 (en) * 2006-05-12 2007-11-14 Alexander Tobias Teichmann Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
KR101044794B1 (ko) * 2011-01-05 2011-06-27 연규백 복합판넬에 브이 홈을 컷팅하는 장치
CN102964411B (zh) * 2012-12-03 2015-04-22 华中药业股份有限公司 一种雄甾-4,6-二烯-17α-甲基-17β-醇-3-酮的合成方法
CN114409717B (zh) * 2021-12-17 2023-03-17 湖南科益新生物医药有限公司 替勃龙中间体醚化物和替勃龙的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3029261A (en) * 1959-11-30 1962-04-10 Syntex Sa Steroidal fluoro compounds and process for the production thereof
US3046273A (en) * 1961-01-18 1962-07-24 Merck & Co Inc Novel 17alpha-trifluoro-propynyl androstenes and processes
US3255182A (en) * 1961-02-13 1966-06-07 Merck & Co Inc 17alpha-haloethynyl-[3, 2-c]pyrazolo androstenes and intermediates therefor
CH431508A (de) * 1961-06-16 1967-03-15 Ciba Geigy Verfahren zur Ketalisierung der 3-Oxogruppe in 5(10)-3-Oxo-19-nor-steroiden
US3098851A (en) * 1961-11-20 1963-07-23 Searle & Co 17alpha-alkynyl-2beta-halo-5alpha-androstane-3alpha, 17beta-diols, esters thereof, and intermediates thereto
US3092623A (en) * 1961-12-01 1963-06-04 Merck & Co Inc [3, 2-c] pyrazolo-4, 9-androstadienes
US3076825A (en) * 1962-02-14 1963-02-05 Syntex Corp 17alpha-(1'-fluoroethyl) and 17alpha-(1', 1'-difluoroethyl) androstane derivatives and process therefor
US3340251A (en) * 1965-10-18 1967-09-05 Merck & Co Inc 17beta-hydroxy-17alpha-halohydrocarbon-19-nor-androst-4-ene-3-ones and the delta5(10)-isomers thereof
AU3257993A (en) * 1991-12-22 1993-07-28 Schering Aktiengesellschaft 3-methylsulphonylhydrazono and 3-oxyimino steroids, a method of preparing them, pharmaceutical preparations containing them and their use in the preparation of drugs
CN1072678C (zh) * 1994-05-30 2001-10-10 中国科学院上海有机化学研究所 三氟甲基甾体化合物、制备及其用途
DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
DE19860719A1 (de) * 1998-12-23 2000-06-29 Schering Ag Neue Testosteronderivate und ihre Verwendung zur Langzeittherapie von Androgen-abhängigen Erkrankungen
DE10221034A1 (de) * 2002-05-03 2003-11-20 Schering Ag 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln

Also Published As

Publication number Publication date
EE200300124A (et) 2005-04-15
ATE338054T1 (de) 2006-09-15
NO20031444L (no) 2003-05-28
BR0114258A (pt) 2003-12-30
NZ524781A (en) 2004-09-24
JP2004509971A (ja) 2004-04-02
AU1382202A (en) 2002-04-08
EP1322660B1 (de) 2006-08-30
SK5192003A3 (en) 2003-09-11
BG107763A (bg) 2004-03-31
DE50110892D1 (de) 2006-10-12
YU22903A (sh) 2006-03-03
US20040024231A1 (en) 2004-02-05
DE10049736A1 (de) 2002-04-18
MXPA03002606A (es) 2003-06-30
CN1466592A (zh) 2004-01-07
HUP0301198A2 (hu) 2003-09-29
NO20031444D0 (no) 2003-03-28
UA76125C2 (en) 2006-07-17
DK1322660T3 (da) 2007-01-08
PL361666A1 (en) 2004-10-04
PT1322660E (pt) 2007-01-31
IL154828A (en) 2007-07-24
EP1322660A2 (de) 2003-07-02
WO2002026759A2 (de) 2002-04-04
CA2422056A1 (en) 2003-03-11
EA005772B1 (ru) 2005-06-30
ES2272550T3 (es) 2007-05-01
ZA200303216B (en) 2005-02-03
IL154828A0 (en) 2003-10-31
WO2002026759A3 (de) 2002-06-20
CN1305890C (zh) 2007-03-21
HRP20030334A2 (en) 2005-06-30
NO325058B1 (no) 2008-01-21
HK1061860A1 (en) 2004-10-08
KR20030061815A (ko) 2003-07-22

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU