EA200300044A1 - Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции - Google Patents

Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции

Info

Publication number
EA200300044A1
EA200300044A1 EA200300044A EA200300044A EA200300044A1 EA 200300044 A1 EA200300044 A1 EA 200300044A1 EA 200300044 A EA200300044 A EA 200300044A EA 200300044 A EA200300044 A EA 200300044A EA 200300044 A1 EA200300044 A1 EA 200300044A1
Authority
EA
Eurasian Patent Office
Prior art keywords
production
pharmaceutical compositions
new substituted
substituted phthalides
group
Prior art date
Application number
EA200300044A
Other languages
English (en)
Inventor
Джунжу Го
Фэнмин Чу
Цзюньтянь Чжан
Гуанчжун Ян
Байлин Сюй
Синьи Ню
Чжухун Жэнь
Пьер Лестаж
Пьер Ренар
Original Assignee
Инститьют Оф Материа Медика
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инститьют Оф Материа Медика, Ле Лаборатуар Сервье filed Critical Инститьют Оф Материа Медика
Publication of EA200300044A1 publication Critical patent/EA200300044A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Изобретение относится к соединениям формулы (I)в которойRпредставляет собой алкильную или уреидогруппу,Rпредставляет собой алкильную группу или атом водорода илиRи Rсовместно образуют 5- или 6-членное кольцо,Rпредставляет собой группу CN, NO, NRR', NRSOR', NRCZRили CZNRR',Rпредставляет собой атом водорода или группу R.Лекарственные препараты.Отчет о международном поиске был опубликован 2002.05.23.
EA200300044A 2000-06-28 2001-06-27 Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции EA200300044A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB001193295A CN1182127C (zh) 2000-06-28 2000-06-28 新的取代的2-苯并[c]呋喃酮化合物,其制备方法以及包含它们的药物组合物
PCT/IB2001/001535 WO2002000638A2 (en) 2000-06-28 2001-06-27 Substituted phthalides as anti-convulsive drugs

Publications (1)

Publication Number Publication Date
EA200300044A1 true EA200300044A1 (ru) 2003-06-26

Family

ID=4587601

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300044A EA200300044A1 (ru) 2000-06-28 2001-06-27 Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции

Country Status (19)

Country Link
US (1) US6689808B2 (ru)
EP (1) EP1320528A2 (ru)
JP (1) JP2004501909A (ru)
KR (1) KR20030024710A (ru)
CN (2) CN1182127C (ru)
AR (1) AR030239A1 (ru)
AU (1) AU2001280004A1 (ru)
BR (1) BR0112043A (ru)
CA (1) CA2413752A1 (ru)
CZ (1) CZ2003245A3 (ru)
EA (1) EA200300044A1 (ru)
HU (1) HUP0301567A3 (ru)
MX (1) MXPA02012569A (ru)
NO (1) NO20026154L (ru)
NZ (1) NZ523174A (ru)
PL (1) PL359373A1 (ru)
SK (1) SK1062003A3 (ru)
WO (1) WO2002000638A2 (ru)
ZA (1) ZA200210004B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004022035D1 (de) 2003-05-14 2009-08-27 Dsm Ip Assets Bv Verwendung von pthalide derivativen zur behandlung
CN100518733C (zh) 2003-09-23 2009-07-29 帝斯曼知识产权资产管理有限公司 用于治疗和预防糖尿病的组合物
CN1605336A (zh) * 2003-10-10 2005-04-13 中国医学科学院药物研究所 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用
JP2008502607A (ja) * 2004-06-18 2008-01-31 石薬集団中奇制薬技術（石家庄）有限公司 痴呆の予防および治療におけるＬ−ｎ−ブチルフタリドの適用
CN106074497A (zh) * 2010-01-13 2016-11-09 石药集团恩必普药业有限公司 丁苯酞及其衍生物在制备治疗帕金森病的药物中的应用
CN102260233A (zh) * 2011-05-04 2011-11-30 武汉科技大学 3-丁基-1(3h)-异苯并呋喃酮衍生物及其制备方法
CN105367526B (zh) * 2015-10-14 2017-07-28 济南诚汇双达化工有限公司 一种高纯度正丁基苯酞的制备方法
CN108727352B (zh) * 2017-04-14 2021-04-23 四川大学 一类哌啶烷氨甲酰基苯酞类化合物、其制备方法和用途
PL3845524T3 (pl) * 2018-03-19 2022-10-24 Henan Genuine Biotech Co., Ltd. Związki kwasu benzoesowego i sposób ich wytwarzania oraz ich zastosowania
CN108752300B (zh) * 2018-05-16 2022-03-25 中国科学院昆明植物研究所 苄烯叉苯肽类化合物及其药物组合物和其应用
CN109111415B (zh) * 2018-10-25 2022-08-23 安徽中医药大学 一类石斛生物碱衍生物、制备方法和医药用途
CN112010827A (zh) * 2019-05-28 2020-12-01 四川大学 一类苄胺基苯酞类化合物、其制备方法和用途
CN112010837B (zh) * 2019-05-28 2021-12-17 四川大学 一类吡啶甲胺基苯酞类化合物、其制备方法和用途
CN110452203B (zh) * 2019-08-29 2021-04-13 忻州师范学院 一种1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的制备方法
CN112794831B (zh) * 2021-04-06 2021-07-27 北京理工大学 3-(3′-羟基丁基)异苯并呋喃-1(3h)-酮衍生物及其组合物、制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1183053B (it) * 1984-02-02 1987-10-05 Farmaceutico Ct Lab Derivati dell'alfa-amino-gamma-butirrolatton e, metodo per prepararli e composizioni farmaceutiche che li contengono
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
CA1330613C (en) * 1988-05-06 1994-07-05 Masanori Kawamura Amino acid derivatives
TW270133B (ru) * 1993-09-17 1996-02-11 Ciba Geigy
DE19618854A1 (de) * 1996-05-10 1997-11-13 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden

Also Published As

Publication number Publication date
CN1182127C (zh) 2004-12-29
MXPA02012569A (es) 2004-05-17
CA2413752A1 (en) 2002-01-03
AU2001280004A1 (en) 2002-01-08
CZ2003245A3 (cs) 2003-05-14
WO2002000638A2 (en) 2002-01-03
WO2002000638A3 (en) 2002-05-23
AR030239A1 (es) 2003-08-13
WO2002000638A8 (en) 2003-08-28
NZ523174A (en) 2004-06-25
KR20030024710A (ko) 2003-03-26
HUP0301567A3 (en) 2005-08-29
NO20026154D0 (no) 2002-12-20
PL359373A1 (en) 2004-08-23
NO20026154L (no) 2003-02-20
CN1440398A (zh) 2003-09-03
SK1062003A3 (en) 2003-05-02
US6689808B2 (en) 2004-02-10
HUP0301567A2 (hu) 2003-09-29
CN1330069A (zh) 2002-01-09
US20030220393A1 (en) 2003-11-27
EP1320528A2 (en) 2003-06-25
JP2004501909A (ja) 2004-01-22
CN100402515C (zh) 2008-07-16
BR0112043A (pt) 2003-10-28
ZA200210004B (en) 2003-12-10

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