EA199800794A1 - Новые производные арилглициламида, способ их получения и фармацевтическая композиция, содержащая эти соединения - Google Patents

Новые производные арилглициламида, способ их получения и фармацевтическая композиция, содержащая эти соединения

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Publication number
EA199800794A1
EA199800794A1 EA199800794A EA199800794A EA199800794A1 EA 199800794 A1 EA199800794 A1 EA 199800794A1 EA 199800794 A EA199800794 A EA 199800794A EA 199800794 A EA199800794 A EA 199800794A EA 199800794 A1 EA199800794 A1 EA 199800794A1
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Eurasian Patent Office
Prior art keywords
glyclilamide
aryl
connections
production
pharmaceutical composition
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EA199800794A
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English (en)
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EA002201B1 (ru
Inventor
Франц Эссер
Герд Шнорренберг
Курт Шромм
Хорст Доллингер
Биргит Инг
Георг Шпек
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Берингер Ингельхайм Интернациональ Гмбх
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Publication of EA199800794A1 publication Critical patent/EA199800794A1/ru
Publication of EA002201B1 publication Critical patent/EA002201B1/ru

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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Изобретение касается новых производных арилглицинамида общей формулы (I) и их фармацевтически приемлемых солей, где Rи Rвместе с атомом азота, с которым они связаны, образуют кольцо формулы ( а), (b), (с) или (d), где R, R, R, Ar, R, R, R, R, R, R, r, s и t имеют значения, приведенные в описании, а также их получения и применения. Новые соединения являются нейрокинин (тахикинин)-антагонистами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800794A 1996-03-06 1997-03-03 Новые производные арилглицинамида, способ их получения и фармацевтическая композиция, содержащая эти соединения EA002201B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608665A DE19608665A1 (de) 1996-03-06 1996-03-06 Neue Arylglycinamidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
PCT/EP1997/001038 WO1997032865A1 (de) 1996-03-06 1997-03-03 Neue arylglycinamidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen

Publications (2)

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EA199800794A1 true EA199800794A1 (ru) 1999-04-29
EA002201B1 EA002201B1 (ru) 2002-02-28

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US (2) US6498162B1 (ru)
EP (1) EP0885204B1 (ru)
JP (1) JP3465795B2 (ru)
KR (1) KR19990087636A (ru)
CN (1) CN1072664C (ru)
AR (1) AR009938A1 (ru)
AT (1) ATE219069T1 (ru)
AU (1) AU718584B2 (ru)
BG (1) BG102715A (ru)
BR (1) BR9708014A (ru)
CA (1) CA2247257C (ru)
CZ (1) CZ281498A3 (ru)
DE (2) DE19608665A1 (ru)
DK (1) DK0885204T3 (ru)
EA (1) EA002201B1 (ru)
EE (1) EE03767B1 (ru)
ES (1) ES2177940T3 (ru)
HK (1) HK1019327A1 (ru)
HR (1) HRP970130A2 (ru)
HU (1) HUP9901823A3 (ru)
ID (1) ID16128A (ru)
IL (1) IL125710A (ru)
NO (1) NO311518B1 (ru)
NZ (1) NZ332201A (ru)
PL (1) PL328779A1 (ru)
PT (1) PT885204E (ru)
SK (1) SK283052B6 (ru)
TR (1) TR199801734T2 (ru)
TW (1) TW375614B (ru)
UA (1) UA50762C2 (ru)
WO (1) WO1997032865A1 (ru)
YU (1) YU8197A (ru)
ZA (1) ZA971850B (ru)

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GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
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US7776315B2 (en) 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
DE10111058A1 (de) * 2001-03-08 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und NK¶1¶-Rezeptor-Antagonisten
GB0108594D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
EP1295599A1 (en) * 2001-09-21 2003-03-26 Boehringer Ingelheim International GmbH Method for the treatment of prevention of atopic dermatitis
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
AU2003244455A1 (en) 2002-02-08 2003-09-02 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
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HUP9901823A2 (hu) 1999-09-28
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JP3465795B2 (ja) 2003-11-10
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PL328779A1 (en) 1999-02-15
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ID16128A (id) 1997-09-04
CN1072664C (zh) 2001-10-10
CA2247257A1 (en) 1997-09-12
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