EA200000996A1 - Конденсированные с арилом азаполициклические соединения - Google Patents

Конденсированные с арилом азаполициклические соединения

Info

Publication number
EA200000996A1
EA200000996A1 EA200000996A EA200000996A EA200000996A1 EA 200000996 A1 EA200000996 A1 EA 200000996A1 EA 200000996 A EA200000996 A EA 200000996A EA 200000996 A EA200000996 A EA 200000996A EA 200000996 A1 EA200000996 A1 EA 200000996A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
azapolycyclic
condensed
aryl
connections
Prior art date
Application number
EA200000996A
Other languages
English (en)
Other versions
EA003669B1 (ru
Inventor
Джоутам Уодзуэрт Коу
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200000996A1 publication Critical patent/EA200000996A1/ru
Publication of EA003669B1 publication Critical patent/EA003669B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Заявлены соединения формулы (I) и их фармацевтически приемлемые соли, где R, R, Rи Z являются такими, как в описании изобретения, промежуточные соединения в синтезе таких соединений, фармацевтические композиции, содержащие такие соединения, и способы применения таких соединений при лечении неврологических и психологических расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000996A 1998-04-29 1999-04-08 Конденсированные с арилом азаполициклические соединения EA003669B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8355698P 1998-04-29 1998-04-29
PCT/IB1999/000617 WO1999055680A1 (en) 1998-04-29 1999-04-08 Aryl fused azapolycyclic compounds

Publications (2)

Publication Number Publication Date
EA200000996A1 true EA200000996A1 (ru) 2001-06-25
EA003669B1 EA003669B1 (ru) 2003-08-28

Family

ID=22179102

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000996A EA003669B1 (ru) 1998-04-29 1999-04-08 Конденсированные с арилом азаполициклические соединения

Country Status (42)

Country Link
US (3) US6462035B1 (ru)
EP (1) EP1076650B1 (ru)
JP (1) JP2002513007A (ru)
KR (1) KR100420423B1 (ru)
CN (1) CN1144787C (ru)
AP (1) AP1154A (ru)
AR (1) AR018596A1 (ru)
AT (1) ATE258921T1 (ru)
AU (1) AU749831B2 (ru)
BG (1) BG64556B1 (ru)
BR (1) BR9910058A (ru)
CA (1) CA2330576A1 (ru)
CO (1) CO5021124A1 (ru)
DE (1) DE69914594T2 (ru)
DK (1) DK1076650T3 (ru)
DZ (1) DZ2778A1 (ru)
EA (1) EA003669B1 (ru)
ES (1) ES2213354T3 (ru)
GT (1) GT199900059A (ru)
HK (1) HK1036453A1 (ru)
HR (1) HRP20000731A2 (ru)
HU (1) HUP0103340A3 (ru)
ID (1) ID26700A (ru)
IL (1) IL138917A0 (ru)
IS (1) IS5649A (ru)
MA (1) MA26623A1 (ru)
MY (1) MY133474A (ru)
NO (1) NO317300B1 (ru)
NZ (1) NZ507035A (ru)
OA (1) OA11506A (ru)
PA (1) PA8471301A1 (ru)
PE (1) PE20000435A1 (ru)
PL (1) PL344010A1 (ru)
PT (1) PT1076650E (ru)
SK (1) SK15952000A3 (ru)
TN (1) TNSN99080A1 (ru)
TR (1) TR200003122T2 (ru)
UA (1) UA61991C2 (ru)
UY (1) UY25636A1 (ru)
WO (1) WO1999055680A1 (ru)
YU (1) YU64400A (ru)
ZA (1) ZA992971B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA66825C2 (ru) * 1997-12-31 2004-06-15 Пфайзер Продактс Інк. Азаполициклические соединения, конденсированные с арилом
US6605610B1 (en) 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
US20010036943A1 (en) * 2000-04-07 2001-11-01 Coe Jotham W. Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
ES2300430T3 (es) * 2001-04-20 2008-06-16 Pfizer Products Inc. Procedimiento para la preparacion de indenos 1,3-sustituidos y compuestos azapoliciclicos condensados con arilo.
KR20050038583A (ko) * 2001-10-31 2005-04-27 화이자 프로덕츠 인크. 하지 불안 증후군 치료에서의 니코틴성 아세틸콜린 수용체아고니스트
AU2002365314A1 (en) 2001-11-30 2003-06-10 Pfizer Products Inc. Aryl fused azapolycyclic compounds
WO2003093258A2 (en) * 2002-05-03 2003-11-13 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolyl-cis/trans-isomerases
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US20040224963A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
MXPA06000785A (es) * 2003-07-21 2006-04-18 Pfizer Prod Inc Compuestos azapoliciclicos condensados con heteroarilo que reducen la adiccion a la nicotina.
EP1648872A2 (en) * 2003-07-21 2006-04-26 Pfizer Products Inc. Aryl fused azapolycyclic compounds
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
WO2006061711A1 (en) * 2004-12-07 2006-06-15 Pfizer Products Inc. 1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta [a] inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulating cholinergic function and in the treatment of addictive disorders
US20060210498A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives for skin
US20060210497A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives
DE102005061426A1 (de) * 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte tricyclische Piperidon-Derivate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687937A (en) * 1970-06-23 1972-08-29 Us Of America The 1,5-methano-3-benzazocine derivatives
JPS4914473A (ru) * 1972-06-09 1974-02-07
JPS4924968A (ru) * 1972-07-01 1974-03-05

Also Published As

Publication number Publication date
ZA992971B (en) 2000-10-30
HK1036453A1 (en) 2002-01-04
YU64400A (sh) 2003-01-31
AR018596A1 (es) 2001-11-28
JP2002513007A (ja) 2002-05-08
PT1076650E (pt) 2004-05-31
NO20005397D0 (no) 2000-10-26
ATE258921T1 (de) 2004-02-15
EA003669B1 (ru) 2003-08-28
IL138917A0 (en) 2001-11-25
ID26700A (id) 2001-02-01
US6462035B1 (en) 2002-10-08
EP1076650B1 (en) 2004-02-04
DE69914594T2 (de) 2004-12-09
TR200003122T2 (tr) 2001-03-21
HUP0103340A3 (en) 2002-10-28
OA11506A (en) 2004-05-14
AP1154A (en) 2003-03-27
TNSN99080A1 (fr) 2005-11-10
GT199900059A (es) 2000-10-11
DE69914594D1 (de) 2004-03-11
CA2330576A1 (en) 1999-11-04
US6706702B2 (en) 2004-03-16
MA26623A1 (fr) 2004-12-20
US20030008890A1 (en) 2003-01-09
HUP0103340A2 (hu) 2002-02-28
DK1076650T3 (da) 2004-05-24
AP9901524A0 (en) 1999-06-30
WO1999055680A1 (en) 1999-11-04
EP1076650A1 (en) 2001-02-21
BG104983A (en) 2001-09-28
KR20010043143A (ko) 2001-05-25
UY25636A1 (es) 2000-02-23
DZ2778A1 (fr) 2005-04-23
PE20000435A1 (es) 2000-05-26
SK15952000A3 (sk) 2002-06-04
KR100420423B1 (ko) 2004-03-04
IS5649A (is) 2000-09-29
CO5021124A1 (es) 2001-03-27
ES2213354T3 (es) 2004-08-16
NO20005397L (no) 2000-10-26
CN1298394A (zh) 2001-06-06
AU749831B2 (en) 2002-07-04
US20040167149A1 (en) 2004-08-26
BR9910058A (pt) 2000-12-26
HRP20000731A2 (en) 2001-06-30
NZ507035A (en) 2003-05-30
BG64556B1 (bg) 2005-07-29
NO317300B1 (no) 2004-10-04
PL344010A1 (en) 2001-09-24
US7122534B2 (en) 2006-10-17
MY133474A (en) 2007-11-30
UA61991C2 (en) 2003-12-15
CN1144787C (zh) 2004-04-07
AU2951699A (en) 1999-11-16
PA8471301A1 (es) 2000-09-29

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU