UA61991C2 - Azapolycyclic compounds condensed with aryl, intermediate compounds (variants), pharmaceutical composition (variants), a method for lowering the nicotine dependence and help to stop or lower the tobacco use by a mammal, and a method for treatment - Google Patents
Azapolycyclic compounds condensed with aryl, intermediate compounds (variants), pharmaceutical composition (variants), a method for lowering the nicotine dependence and help to stop or lower the tobacco use by a mammal, and a method for treatment Download PDFInfo
- Publication number
- UA61991C2 UA61991C2 UA2000095418A UA2000095418A UA61991C2 UA 61991 C2 UA61991 C2 UA 61991C2 UA 2000095418 A UA2000095418 A UA 2000095418A UA 2000095418 A UA2000095418 A UA 2000095418A UA 61991 C2 UA61991 C2 UA 61991C2
- Authority
- UA
- Ukraine
- Prior art keywords
- azatricyclo
- alkyl
- triene
- formula
- tetraene
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 275
- 238000000034 method Methods 0.000 title claims abstract description 77
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
- 125000003118 aryl group Chemical class 0.000 title claims description 16
- 241000124008 Mammalia Species 0.000 title claims description 11
- 241000208125 Nicotiana Species 0.000 title claims description 9
- 235000002637 Nicotiana tabacum Nutrition 0.000 title claims description 9
- 206010057852 Nicotine dependence Diseases 0.000 title claims description 9
- 208000025569 Tobacco Use disease Diseases 0.000 title claims description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- -1 nitro- Chemical class 0.000 claims description 82
- 125000000217 alkyl group Chemical group 0.000 claims description 72
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 51
- 239000001257 hydrogen Substances 0.000 claims description 47
- 229910052739 hydrogen Inorganic materials 0.000 claims description 47
- 229920006395 saturated elastomer Polymers 0.000 claims description 38
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 150000002431 hydrogen Chemical class 0.000 claims description 21
- 125000001424 substituent group Chemical group 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 16
- 208000010877 cognitive disease Diseases 0.000 claims description 14
- 229910052731 fluorine Inorganic materials 0.000 claims description 14
- 230000009467 reduction Effects 0.000 claims description 14
- 125000001153 fluoro group Chemical group F* 0.000 claims description 13
- 229910052740 iodine Inorganic materials 0.000 claims description 13
- 125000003277 amino group Chemical group 0.000 claims description 12
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 12
- 125000002619 bicyclic group Chemical group 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 239000001301 oxygen Substances 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 12
- 125000003282 alkyl amino group Chemical group 0.000 claims description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
- 239000011737 fluorine Substances 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 11
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 10
- 206010012335 Dependence Diseases 0.000 claims description 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 10
- 208000002193 Pain Diseases 0.000 claims description 10
- 208000018737 Parkinson disease Diseases 0.000 claims description 10
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 10
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 10
- 229910052794 bromium Inorganic materials 0.000 claims description 10
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 10
- 239000011593 sulfur Chemical group 0.000 claims description 10
- 229910052717 sulfur Chemical group 0.000 claims description 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 9
- 208000035475 disorder Diseases 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 8
- 125000004429 atom Chemical group 0.000 claims description 8
- 125000005843 halogen group Chemical group 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000002950 monocyclic group Chemical group 0.000 claims description 8
- 229960002715 nicotine Drugs 0.000 claims description 8
- 230000009529 traumatic brain injury Effects 0.000 claims description 8
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 7
- 208000028698 Cognitive impairment Diseases 0.000 claims description 7
- 208000023105 Huntington disease Diseases 0.000 claims description 7
- 125000005605 benzo group Chemical group 0.000 claims description 7
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- 239000000460 chlorine Substances 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 7
- 206010015037 epilepsy Diseases 0.000 claims description 7
- 125000005842 heteroatom Chemical group 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 230000006999 cognitive decline Effects 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
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- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 5
- 206010003805 Autism Diseases 0.000 claims description 5
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- 208000020925 Bipolar disease Diseases 0.000 claims description 5
- 208000032841 Bulimia Diseases 0.000 claims description 5
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- 208000000094 Chronic Pain Diseases 0.000 claims description 5
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims description 5
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- 230000036506 anxiety Effects 0.000 claims description 5
- 206010003119 arrhythmia Diseases 0.000 claims description 5
- 229940125717 barbiturate Drugs 0.000 claims description 5
- 229940049706 benzodiazepine Drugs 0.000 claims description 5
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims description 5
- 229960003920 cocaine Drugs 0.000 claims description 5
- 206010061428 decreased appetite Diseases 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 206010013663 drug dependence Diseases 0.000 claims description 5
- 206010013932 dyslexia Diseases 0.000 claims description 5
- 208000010118 dystonia Diseases 0.000 claims description 5
- 231100000869 headache Toxicity 0.000 claims description 5
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 5
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims description 5
- 235000020824 obesity Nutrition 0.000 claims description 5
- 229940005483 opioid analgesics Drugs 0.000 claims description 5
- 208000019906 panic disease Diseases 0.000 claims description 5
- 208000028591 pheochromocytoma Diseases 0.000 claims description 5
- 201000000980 schizophrenia Diseases 0.000 claims description 5
- 208000019116 sleep disease Diseases 0.000 claims description 5
- 230000001148 spastic effect Effects 0.000 claims description 5
- 208000011117 substance-related disease Diseases 0.000 claims description 5
- 235000019505 tobacco product Nutrition 0.000 claims description 5
- 231100000397 ulcer Toxicity 0.000 claims description 5
- 230000025033 vasoconstriction Effects 0.000 claims description 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
- 208000007542 Paresis Diseases 0.000 claims description 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
- 208000006011 Stroke Diseases 0.000 claims description 4
- 230000003187 abdominal effect Effects 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical group C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 4
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 208000012661 Dyskinesia Diseases 0.000 claims description 3
- 208000003554 absence epilepsy Diseases 0.000 claims description 3
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- 210000004211 gastric acid Anatomy 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- 150000004702 methyl esters Chemical class 0.000 claims description 3
- 125000001624 naphthyl group Chemical group 0.000 claims description 3
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- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims description 3
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 2
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- 150000007513 acids Chemical class 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 150000001721 carbon Chemical group 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
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- 150000003457 sulfones Chemical group 0.000 claims description 2
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000006530 (C4-C6) alkyl group Chemical group 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 229920000297 Rayon Polymers 0.000 claims 1
- 241001582326 Renia Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
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- 238000012876 topography Methods 0.000 claims 1
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- 239000000543 intermediate Substances 0.000 abstract description 10
- 238000003786 synthesis reaction Methods 0.000 abstract description 8
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 118
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 53
- 238000004809 thin layer chromatography Methods 0.000 description 53
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 52
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 49
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- 239000000243 solution Substances 0.000 description 44
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- 238000010992 reflux Methods 0.000 description 25
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- 239000012267 brine Substances 0.000 description 23
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- FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 description 5
- JGQFVRIQXUFPAH-UHFFFAOYSA-N α-citronellol Chemical compound OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 4
- 102100033891 Arylsulfatase I Human genes 0.000 description 4
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- AVBGNFCMKJOFIN-UHFFFAOYSA-N triethylammonium acetate Chemical compound CC(O)=O.CCN(CC)CC AVBGNFCMKJOFIN-UHFFFAOYSA-N 0.000 description 1
- NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8355698P | 1998-04-29 | 1998-04-29 | |
| PCT/IB1999/000617 WO1999055680A1 (en) | 1998-04-29 | 1999-04-08 | Aryl fused azapolycyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA61991C2 true UA61991C2 (en) | 2003-12-15 |
Family
ID=22179102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2000095418A UA61991C2 (en) | 1998-04-29 | 1999-08-04 | Azapolycyclic compounds condensed with aryl, intermediate compounds (variants), pharmaceutical composition (variants), a method for lowering the nicotine dependence and help to stop or lower the tobacco use by a mammal, and a method for treatment |
Country Status (42)
| Country | Link |
|---|---|
| US (3) | US6462035B1 (ru) |
| EP (1) | EP1076650B1 (ru) |
| JP (1) | JP2002513007A (ru) |
| KR (1) | KR100420423B1 (ru) |
| CN (1) | CN1144787C (ru) |
| AP (1) | AP1154A (ru) |
| AR (1) | AR018596A1 (ru) |
| AT (1) | ATE258921T1 (ru) |
| AU (1) | AU749831B2 (ru) |
| BG (1) | BG64556B1 (ru) |
| BR (1) | BR9910058A (ru) |
| CA (1) | CA2330576A1 (ru) |
| CO (1) | CO5021124A1 (ru) |
| DE (1) | DE69914594T2 (ru) |
| DK (1) | DK1076650T3 (ru) |
| DZ (1) | DZ2778A1 (ru) |
| EA (1) | EA003669B1 (ru) |
| ES (1) | ES2213354T3 (ru) |
| GT (1) | GT199900059A (ru) |
| HK (1) | HK1036453A1 (ru) |
| HR (1) | HRP20000731A2 (ru) |
| HU (1) | HUP0103340A3 (ru) |
| ID (1) | ID26700A (ru) |
| IL (1) | IL138917A0 (ru) |
| IS (1) | IS5649A (ru) |
| MA (1) | MA26623A1 (ru) |
| MY (1) | MY133474A (ru) |
| NO (1) | NO317300B1 (ru) |
| NZ (1) | NZ507035A (ru) |
| OA (1) | OA11506A (ru) |
| PA (1) | PA8471301A1 (ru) |
| PE (1) | PE20000435A1 (ru) |
| PL (1) | PL344010A1 (ru) |
| PT (1) | PT1076650E (ru) |
| SK (1) | SK15952000A3 (ru) |
| TN (1) | TNSN99080A1 (ru) |
| TR (1) | TR200003122T2 (ru) |
| UA (1) | UA61991C2 (ru) |
| UY (1) | UY25636A1 (ru) |
| WO (1) | WO1999055680A1 (ru) |
| YU (1) | YU64400A (ru) |
| ZA (1) | ZA992971B (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1044189T2 (sl) | 1997-12-31 | 2015-05-29 | Pfizer Products Inc. | Z arilom kondenzirane azapoliciklične spojine |
| US6605610B1 (en) | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| US20010036943A1 (en) * | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| DE60225433T2 (de) * | 2001-04-20 | 2008-06-12 | Pfizer Products Inc., Groton | Verfahren zur herstellung von 1,3-substituierte indene und aryl-annellierte azapolycyclische verbindungen |
| HUP0401967A2 (hu) * | 2001-10-31 | 2005-01-28 | Pfizer Products Inc. | Nikotinsav-acetilkolin-receptor-agonisták alkalmazása nyugtalan láb szindróma kezelésére alkalmas gyógyszerkészítmények előállítására |
| DE60228478D1 (de) | 2001-11-30 | 2008-10-02 | Pfizer Prod Inc | Aryl-annellierte azapolyzyklische verbindungen |
| US20060089400A1 (en) * | 2002-05-03 | 2006-04-27 | The Vernalis Group Of Companies | Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolylcis/trans-isomerases |
| US20040224963A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| CA2533100A1 (en) * | 2003-07-21 | 2005-01-27 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
| WO2005007655A1 (en) | 2003-07-21 | 2005-01-27 | Pfizer Products Inc. | Nicotine addiction reducing heteroaryl fused azapolycyclic compounds |
| US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| WO2006061711A1 (en) * | 2004-12-07 | 2006-06-15 | Pfizer Products Inc. | 1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta [a] inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulating cholinergic function and in the treatment of addictive disorders |
| US20060210498A1 (en) * | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives for skin |
| US20060210497A1 (en) * | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives |
| DE102005061426A1 (de) * | 2005-12-22 | 2007-07-05 | Grünenthal GmbH | Substituierte tricyclische Piperidon-Derivate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687937A (en) * | 1970-06-23 | 1972-08-29 | Us Of America The | 1,5-methano-3-benzazocine derivatives |
| JPS4914473A (ru) * | 1972-06-09 | 1974-02-07 | ||
| JPS4924968A (ru) * | 1972-07-01 | 1974-03-05 |
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1999
- 1999-04-08 ID IDW20002185A patent/ID26700A/id unknown
- 1999-04-08 EA EA200000996A patent/EA003669B1/ru not_active IP Right Cessation
- 1999-04-08 TR TR2000/03122T patent/TR200003122T2/xx unknown
- 1999-04-08 JP JP2000545840A patent/JP2002513007A/ja not_active Withdrawn
- 1999-04-08 YU YU64400A patent/YU64400A/sh unknown
- 1999-04-08 KR KR10-2000-7012039A patent/KR100420423B1/ko not_active IP Right Cessation
- 1999-04-08 AU AU29516/99A patent/AU749831B2/en not_active Ceased
- 1999-04-08 AT AT99910600T patent/ATE258921T1/de not_active IP Right Cessation
- 1999-04-08 PL PL99344010A patent/PL344010A1/xx unknown
- 1999-04-08 CA CA002330576A patent/CA2330576A1/en not_active Abandoned
- 1999-04-08 PT PT99910600T patent/PT1076650E/pt unknown
- 1999-04-08 HU HU0103340A patent/HUP0103340A3/hu unknown
- 1999-04-08 WO PCT/IB1999/000617 patent/WO1999055680A1/en not_active Application Discontinuation
- 1999-04-08 DK DK99910600T patent/DK1076650T3/da active
- 1999-04-08 DE DE69914594T patent/DE69914594T2/de not_active Expired - Fee Related
- 1999-04-08 SK SK1595-2000A patent/SK15952000A3/sk unknown
- 1999-04-08 BR BR9910058-4A patent/BR9910058A/pt not_active Application Discontinuation
- 1999-04-08 ES ES99910600T patent/ES2213354T3/es not_active Expired - Lifetime
- 1999-04-08 EP EP99910600A patent/EP1076650B1/en not_active Expired - Lifetime
- 1999-04-08 US US09/582,513 patent/US6462035B1/en not_active Expired - Fee Related
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- 1999-04-08 IL IL13891799A patent/IL138917A0/xx unknown
- 1999-04-08 NZ NZ507035A patent/NZ507035A/en unknown
- 1999-04-20 GT GT199900059A patent/GT199900059A/es unknown
- 1999-04-23 PE PE1999000340A patent/PE20000435A1/es not_active Application Discontinuation
- 1999-04-27 MY MYPI99001648A patent/MY133474A/en unknown
- 1999-04-27 AR ARP990101941A patent/AR018596A1/es unknown
- 1999-04-28 MA MA25556A patent/MA26623A1/fr unknown
- 1999-04-28 TN TNTNSN99080A patent/TNSN99080A1/fr unknown
- 1999-04-28 DZ DZ990078A patent/DZ2778A1/xx active
- 1999-04-28 ZA ZA9902971A patent/ZA992971B/xx unknown
- 1999-04-29 PA PA19998471301A patent/PA8471301A1/es unknown
- 1999-04-29 AP APAP/P/1999/001524A patent/AP1154A/en active
- 1999-04-29 CO CO99026005A patent/CO5021124A1/es unknown
- 1999-08-03 UY UY25636A patent/UY25636A1/es not_active Application Discontinuation
- 1999-08-04 UA UA2000095418A patent/UA61991C2/uk unknown
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2000
- 2000-09-29 IS IS5649A patent/IS5649A/is unknown
- 2000-10-25 OA OA1200000295A patent/OA11506A/en unknown
- 2000-10-26 NO NO20005397A patent/NO317300B1/no unknown
- 2000-10-27 HR HR20000731A patent/HRP20000731A2/hr not_active Application Discontinuation
- 2000-11-24 BG BG104983A patent/BG64556B1/bg unknown
-
2001
- 2001-10-18 HK HK01107303A patent/HK1036453A1/xx not_active IP Right Cessation
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2002
- 2002-08-13 US US10/217,771 patent/US6706702B2/en not_active Expired - Fee Related
-
2004
- 2004-01-23 US US10/764,167 patent/US7122534B2/en not_active Expired - Fee Related
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