PE20000435A1 - Compuestos azapoliciclicos condensados con arilo - Google Patents
Compuestos azapoliciclicos condensados con ariloInfo
- Publication number
- PE20000435A1 PE20000435A1 PE1999000340A PE00034099A PE20000435A1 PE 20000435 A1 PE20000435 A1 PE 20000435A1 PE 1999000340 A PE1999000340 A PE 1999000340A PE 00034099 A PE00034099 A PE 00034099A PE 20000435 A1 PE20000435 A1 PE 20000435A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- azapolicyclic
- fluor
- piperazine
- bound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
SE REFIERE A COMPUESTOS AZAPOLICICLICOS CONDENSADOS CON ARILO DE FORMULA I, DONDE Z ES CH2, C=O, CF2; R1 ES H, ALQUILO C1-C6, ALQUENILO C3-C6, BENCILO, XC(=O)R13, -CH2CH2-O-(ALQUILO C1-C4); R2 Y R3 SON H, ALQUENILO C2-C6, ALQUINILO C2-C6, OH, -SOq-(ALQUILO C1-C6), ENTRE OTROS; q ES 0-2, CO2R4, CONR5R6, SO2NR7R8, C(=O)R13, X(C=O)R13; O R2 Y R3 FORMAN UN ANILLO CARBOCICLICO MONOCICLICO DE 4-7 MIEMBROS O BICICLICO DE 10-14 MIEMBROS DE PREFERENCIA DE FORMULA a, b, ENTRE OTROS; R10 Y R17 SON H Y ALQUILO C1-C6; R4, R5, R6, R7, R8, R13 SON H, ALQUILO C1-C6; O R5 Y R6 O R7 Y R8 JUNTO CON N FORMAN PIRROLIDINA, PIPERIDINA, MORFOLINA, AZETIDINA, PIPERAZINA, -N-(ALQUIL C1-C6)PIPERAZINA, TIOMORFOLINA; X ES ALQUILENO C1-C6; a)UNO DE R1, R2 Y R3 NO ES H; b)CUANDO R2 Y R3 SON H; R1 NO ES METILO o H; c)NINGUN FLUOR DE ALQUILO O ALCOXI SUSTITUIDO CON FLUOR DE R2 Y R3 ESTA UNIDO AL CARBONO QUE ESTA UNIDO A UN HETEROATOMO. EL COMPUESTO I SE UNE A SITIOS ESPECIFICOS DE RECEPTORES NICOTINICOS DE ACETILCOLINA PRESENTES EN LAS NEURONAS Y SON UTILES PARA MODULAR LA FUNCION COLINERGICA Y PUEDE SER UTIL PARA LA REDUCCION DE LA ADICCION A LA NICOTINA, REDUCIR EL USO DE TABACO, TRATAMIENTO DE LA ENFERMEDAD INFLAMATORIA DEL INTESTINO, SINDROME DEL INTESTINO IRRITABLE, DISTONIA ESPASTICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8355698P | 1998-04-29 | 1998-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000435A1 true PE20000435A1 (es) | 2000-05-26 |
Family
ID=22179102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000340A PE20000435A1 (es) | 1998-04-29 | 1999-04-23 | Compuestos azapoliciclicos condensados con arilo |
Country Status (42)
| Country | Link |
|---|---|
| US (3) | US6462035B1 (es) |
| EP (1) | EP1076650B1 (es) |
| JP (1) | JP2002513007A (es) |
| KR (1) | KR100420423B1 (es) |
| CN (1) | CN1144787C (es) |
| AP (1) | AP1154A (es) |
| AR (1) | AR018596A1 (es) |
| AT (1) | ATE258921T1 (es) |
| AU (1) | AU749831B2 (es) |
| BG (1) | BG64556B1 (es) |
| BR (1) | BR9910058A (es) |
| CA (1) | CA2330576A1 (es) |
| CO (1) | CO5021124A1 (es) |
| DE (1) | DE69914594T2 (es) |
| DK (1) | DK1076650T3 (es) |
| DZ (1) | DZ2778A1 (es) |
| EA (1) | EA003669B1 (es) |
| ES (1) | ES2213354T3 (es) |
| GT (1) | GT199900059A (es) |
| HK (1) | HK1036453A1 (es) |
| HR (1) | HRP20000731A2 (es) |
| HU (1) | HUP0103340A3 (es) |
| ID (1) | ID26700A (es) |
| IL (1) | IL138917A0 (es) |
| IS (1) | IS5649A (es) |
| MA (1) | MA26623A1 (es) |
| MY (1) | MY133474A (es) |
| NO (1) | NO317300B1 (es) |
| NZ (1) | NZ507035A (es) |
| OA (1) | OA11506A (es) |
| PA (1) | PA8471301A1 (es) |
| PE (1) | PE20000435A1 (es) |
| PL (1) | PL344010A1 (es) |
| PT (1) | PT1076650E (es) |
| SK (1) | SK15952000A3 (es) |
| TN (1) | TNSN99080A1 (es) |
| TR (1) | TR200003122T2 (es) |
| UA (1) | UA61991C2 (es) |
| UY (1) | UY25636A1 (es) |
| WO (1) | WO1999055680A1 (es) |
| YU (1) | YU64400A (es) |
| ZA (1) | ZA992971B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1044189T2 (sl) | 1997-12-31 | 2015-05-29 | Pfizer Products Inc. | Z arilom kondenzirane azapoliciklične spojine |
| US6605610B1 (en) | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| US20010036943A1 (en) * | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| DE60225433T2 (de) * | 2001-04-20 | 2008-06-12 | Pfizer Products Inc., Groton | Verfahren zur herstellung von 1,3-substituierte indene und aryl-annellierte azapolycyclische verbindungen |
| HUP0401967A2 (hu) * | 2001-10-31 | 2005-01-28 | Pfizer Products Inc. | Nikotinsav-acetilkolin-receptor-agonisták alkalmazása nyugtalan láb szindróma kezelésére alkalmas gyógyszerkészítmények előállítására |
| DE60228478D1 (de) | 2001-11-30 | 2008-10-02 | Pfizer Prod Inc | Aryl-annellierte azapolyzyklische verbindungen |
| US20060089400A1 (en) * | 2002-05-03 | 2006-04-27 | The Vernalis Group Of Companies | Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolylcis/trans-isomerases |
| US20040224963A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| CA2533100A1 (en) * | 2003-07-21 | 2005-01-27 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
| WO2005007655A1 (en) | 2003-07-21 | 2005-01-27 | Pfizer Products Inc. | Nicotine addiction reducing heteroaryl fused azapolycyclic compounds |
| US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| WO2006061711A1 (en) * | 2004-12-07 | 2006-06-15 | Pfizer Products Inc. | 1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta [a] inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulating cholinergic function and in the treatment of addictive disorders |
| US20060210498A1 (en) * | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives for skin |
| US20060210497A1 (en) * | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives |
| DE102005061426A1 (de) * | 2005-12-22 | 2007-07-05 | Grünenthal GmbH | Substituierte tricyclische Piperidon-Derivate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687937A (en) * | 1970-06-23 | 1972-08-29 | Us Of America The | 1,5-methano-3-benzazocine derivatives |
| JPS4914473A (es) * | 1972-06-09 | 1974-02-07 | ||
| JPS4924968A (es) * | 1972-07-01 | 1974-03-05 |
-
1999
- 1999-04-08 ID IDW20002185A patent/ID26700A/id unknown
- 1999-04-08 EA EA200000996A patent/EA003669B1/ru not_active IP Right Cessation
- 1999-04-08 TR TR2000/03122T patent/TR200003122T2/xx unknown
- 1999-04-08 JP JP2000545840A patent/JP2002513007A/ja not_active Withdrawn
- 1999-04-08 YU YU64400A patent/YU64400A/sh unknown
- 1999-04-08 KR KR10-2000-7012039A patent/KR100420423B1/ko not_active IP Right Cessation
- 1999-04-08 AU AU29516/99A patent/AU749831B2/en not_active Ceased
- 1999-04-08 AT AT99910600T patent/ATE258921T1/de not_active IP Right Cessation
- 1999-04-08 PL PL99344010A patent/PL344010A1/xx unknown
- 1999-04-08 CA CA002330576A patent/CA2330576A1/en not_active Abandoned
- 1999-04-08 PT PT99910600T patent/PT1076650E/pt unknown
- 1999-04-08 HU HU0103340A patent/HUP0103340A3/hu unknown
- 1999-04-08 WO PCT/IB1999/000617 patent/WO1999055680A1/en not_active Application Discontinuation
- 1999-04-08 DK DK99910600T patent/DK1076650T3/da active
- 1999-04-08 DE DE69914594T patent/DE69914594T2/de not_active Expired - Fee Related
- 1999-04-08 SK SK1595-2000A patent/SK15952000A3/sk unknown
- 1999-04-08 BR BR9910058-4A patent/BR9910058A/pt not_active Application Discontinuation
- 1999-04-08 ES ES99910600T patent/ES2213354T3/es not_active Expired - Lifetime
- 1999-04-08 EP EP99910600A patent/EP1076650B1/en not_active Expired - Lifetime
- 1999-04-08 US US09/582,513 patent/US6462035B1/en not_active Expired - Fee Related
- 1999-04-08 CN CNB998054542A patent/CN1144787C/zh not_active Expired - Fee Related
- 1999-04-08 IL IL13891799A patent/IL138917A0/xx unknown
- 1999-04-08 NZ NZ507035A patent/NZ507035A/en unknown
- 1999-04-20 GT GT199900059A patent/GT199900059A/es unknown
- 1999-04-23 PE PE1999000340A patent/PE20000435A1/es not_active Application Discontinuation
- 1999-04-27 MY MYPI99001648A patent/MY133474A/en unknown
- 1999-04-27 AR ARP990101941A patent/AR018596A1/es unknown
- 1999-04-28 MA MA25556A patent/MA26623A1/fr unknown
- 1999-04-28 TN TNTNSN99080A patent/TNSN99080A1/fr unknown
- 1999-04-28 DZ DZ990078A patent/DZ2778A1/xx active
- 1999-04-28 ZA ZA9902971A patent/ZA992971B/xx unknown
- 1999-04-29 PA PA19998471301A patent/PA8471301A1/es unknown
- 1999-04-29 AP APAP/P/1999/001524A patent/AP1154A/en active
- 1999-04-29 CO CO99026005A patent/CO5021124A1/es unknown
- 1999-08-03 UY UY25636A patent/UY25636A1/es not_active Application Discontinuation
- 1999-08-04 UA UA2000095418A patent/UA61991C2/uk unknown
-
2000
- 2000-09-29 IS IS5649A patent/IS5649A/is unknown
- 2000-10-25 OA OA1200000295A patent/OA11506A/en unknown
- 2000-10-26 NO NO20005397A patent/NO317300B1/no unknown
- 2000-10-27 HR HR20000731A patent/HRP20000731A2/hr not_active Application Discontinuation
- 2000-11-24 BG BG104983A patent/BG64556B1/bg unknown
-
2001
- 2001-10-18 HK HK01107303A patent/HK1036453A1/xx not_active IP Right Cessation
-
2002
- 2002-08-13 US US10/217,771 patent/US6706702B2/en not_active Expired - Fee Related
-
2004
- 2004-01-23 US US10/764,167 patent/US7122534B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |