PE51294A1 - Derivado de benzofurano, proceso para su preparacion y composicion farmaceutica que lo contiene - Google Patents

Derivado de benzofurano, proceso para su preparacion y composicion farmaceutica que lo contiene

Info

Publication number
PE51294A1
PE51294A1 PE1994240029A PE24002994A PE51294A1 PE 51294 A1 PE51294 A1 PE 51294A1 PE 1994240029 A PE1994240029 A PE 1994240029A PE 24002994 A PE24002994 A PE 24002994A PE 51294 A1 PE51294 A1 PE 51294A1
Authority
PE
Peru
Prior art keywords
benzofurano
derived
preparation
pharmaceutical composition
alkyl
Prior art date
Application number
PE1994240029A
Other languages
English (en)
Inventor
Sjoerd Nicolaas Wadman
Peter Charles North
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE51294A1 publication Critical patent/PE51294A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE 1) R1 ES -CH2-CO-NR3R4, 2) R2 ES -CH2-CH2-NR5R6, 3) R3 Y R4 FORMAN JUNTO CON EL ATOMO DE NITROGENO UN ANILLO SATURADO DE 4 A 7 MIEMBROS TAL COMO AZETIDINA, PIRROLIDINA, PIPERIDINA, HEXAMETILENIMINA, PIPERAZINA, MORFOLINA, EL CUAL PUEDE ESTAR SUSTITUIDO POR -CR7R8-, -O-, -NR9, 4) R5 Y R6 PUEDEN SER HIDROGENO, ALQUILO C1-C3, 5) R7 Y R8 SON HIDROGENO, HIDROXI, ALCOXI C1-C3, 6) R9 ES -SO2R10, -COR10, -COOR10, 7) R10 ES ALQUILO C1-C3; EL CUAL POR SER AGONISTA DE LOS RECEPTORES 5HT1 (SEROTONINA) PUEDE TENER ACTIVIDAD VASOCONSTRICTORA SELECTIVA SIENDO UTIL EN EL TRATAMIENTO DE LA MIGRANA, HEMICRANIA PAROXISMAL CRONICA Y DOLOR DE CABEZA ASOCIADO CON TRANSTORNOS VASCULARES
PE1994240029A 1992-10-16 1994-04-13 Derivado de benzofurano, proceso para su preparacion y composicion farmaceutica que lo contiene PE51294A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929221761A GB9221761D0 (en) 1992-10-16 1992-10-16 Chemical compounds

Publications (1)

Publication Number Publication Date
PE51294A1 true PE51294A1 (es) 1995-01-06

Family

ID=10723562

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994240029A PE51294A1 (es) 1992-10-16 1994-04-13 Derivado de benzofurano, proceso para su preparacion y composicion farmaceutica que lo contiene

Country Status (24)

Country Link
US (1) US5494910A (es)
EP (1) EP0664804A1 (es)
JP (1) JPH06211842A (es)
KR (1) KR940009179A (es)
CN (1) CN1092420A (es)
AP (1) AP425A (es)
AU (1) AU5333794A (es)
CA (1) CA2146569A1 (es)
CZ (1) CZ96895A3 (es)
EC (1) ECSP941050A (es)
FI (1) FI951798A (es)
GB (1) GB9221761D0 (es)
HU (1) HUT72752A (es)
IL (1) IL107302A0 (es)
IS (1) IS4081A (es)
MX (1) MX9306394A (es)
NO (1) NO951433D0 (es)
PE (1) PE51294A1 (es)
PL (1) PL308357A1 (es)
RU (1) RU95110110A (es)
SI (1) SI9300542A (es)
TW (1) TW262473B (es)
WO (1) WO1994008993A1 (es)
ZA (1) ZA937633B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407447D0 (en) * 1994-04-14 1994-06-08 Glaxo Group Ltd Chemical compounds
EP0759918A1 (en) * 1994-05-19 1997-03-05 MERCK SHARP & DOHME LTD. Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
GB9610979D0 (en) * 1996-05-24 1996-07-31 Merck Sharp & Dohme Therapeutic agents
AU4652697A (en) * 1996-10-08 1998-05-05 Eli Lilly And Company New serotonin 5-ht1f agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
PL2734634T3 (pl) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 do zastosowania do leczenia migreny
KR101443041B1 (ko) * 2013-05-06 2014-09-23 (주)하이레벤 태양광 발전설비의 효율향상설비
KR20240058859A (ko) 2021-08-12 2024-05-03 쿨레온 엘엘씨 환각성 및 비환각성 세로토닌 수용체 작용제 및 이의 제조 및 사용 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670105A1 (de) * 1966-07-08 1970-12-10 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung von Benzofuryl (3)-alkylaminen und deren Salzen
EP0398413A1 (en) * 1989-05-16 1990-11-22 Duphar International Research B.V "3,4-dehydropiperidine derivatives having psychotropic activity

Also Published As

Publication number Publication date
AP9300581A0 (en) 1993-10-31
NO951433L (no) 1995-04-12
US5494910A (en) 1996-02-27
MX9306394A (es) 1994-05-31
HU9501073D0 (en) 1995-06-28
RU95110110A (ru) 1996-12-27
CA2146569A1 (en) 1994-04-28
HUT72752A (en) 1996-05-28
KR940009179A (ko) 1994-05-20
WO1994008993A1 (en) 1994-04-28
SI9300542A (en) 1994-06-30
TW262473B (es) 1995-11-11
IS4081A (is) 1994-04-17
FI951798A0 (fi) 1995-04-13
PL308357A1 (en) 1995-07-24
AU5333794A (en) 1994-05-09
ZA937633B (en) 1994-08-01
JPH06211842A (ja) 1994-08-02
IL107302A0 (en) 1994-01-25
FI951798A (fi) 1995-04-13
GB9221761D0 (en) 1992-12-02
EP0664804A1 (en) 1995-08-02
CN1092420A (zh) 1994-09-21
CZ96895A3 (en) 1995-12-13
NO951433D0 (no) 1995-04-12
ECSP941050A (es) 1994-11-16
AP425A (en) 1995-11-08

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Legal Events

Date Code Title Description
FX Voluntary withdrawal