CO4920225A1 - 2-amino-6-(4-fenoxi-2-sustituido)-piridinas sustituidas - Google Patents
2-amino-6-(4-fenoxi-2-sustituido)-piridinas sustituidasInfo
- Publication number
- CO4920225A1 CO4920225A1 CO98006875A CO98006875A CO4920225A1 CO 4920225 A1 CO4920225 A1 CO 4920225A1 CO 98006875 A CO98006875 A CO 98006875A CO 98006875 A CO98006875 A CO 98006875A CO 4920225 A1 CO4920225 A1 CO 4920225A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- substituents
- substituted
- amino
- independently selected
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la fórmula (I) en la queR1 y R2 se seleccionan, independientemente entre hidrógeno, alquilo (C1 -C6 ), alquenilo (C2 -C6 ), alcoxi (C1 -C6 )-alquilo (C1 -C3 ), halo hidroxi, alcoxi(C1 -C6 ), alquilo (C1 -C7 ) y alcoxialquilo (C2 -C10 ); y G se selecciona entre hidrógeno, aminocarbonil-alquilo (C1 -C3 ) alquil (C1 -C3 )- aminocarbonil-alquilo (C1 -C3 ) di-[alquil(C1 -C3 )] aminocarbonil-alquilo (C1 -C3 ) y N(R3 ) (R4 ) alquilo (C0 -C4 ), donde R3 y R4 se seleccionan, independientemente entre hidrógeno, alquilo (C1 -C7 ), tetrahidronaftaleno y aralquilo, donde el radical arilo de dicho aralquilo es fenilo o naftilo y el radical alquilo es lineal o ramificado y contiene de 1 a 6 átomos de carbono, y donde dicho alquilo (C1 -C7 ) y dicho tetrahidronaftaleno y el radical arilo de dicho aralquilo, opcionalmente pueden estar sustituidos con uno a tres sustituyentes, preferiblemente de cero a dos sustituyentes, que se seleccionan, independientemente, entre halo, nitro, hidroxi, ciano, amino, alcoxi (C1 -C4 ) y alquilamino (C1 -C4 ); o R3 y R4 forman, junto con el nitrógeno al que están unidos, un anillo de piperazina, piperidina, azetidina o pirrolidina o un sistema de anillo azabicíclico saturado o insaturado que contiene de 6 a 14 miembros en el anillo, de los cuales de 1 a 3 son nitrógenos, de cero a dos son oxígenos y el resto son carbonos; y donde dicho anillo de piperazina, piperidina, azetidina y pirrolidina y dichos sistemas de anillo azabicíclicos pueden estar sustituidos opcionalmente con uno o más sustituyentes, preferiblemente con cero a dos sustituyentes, que se seleccionan, independientemente, entre alquilo (C1 -C6 ), amino, alquilamino (C1 -C6 ), [di-alquil (C1 -C6 )] amino, anillos heterocíclicos de 5 ó 6 miembros sustituidos con fenilo, que contienen de 1 a 4 átomos de nitrógeno en el anillo, benzoílo, benzoilmetilo, bencilcarbonilo, fenilaminocarbonilo, feniletilo y fenoxicarbonilo, y donde los radicales fenilo de cualquiera de los sustituyentes anteriores pueden estar sustituidos opcionalmente con uno o más sustituyentes, preferiblemente con cero a dos sustituyentes, que se seleccionan, independientemente, entre halo, alquilo (C1 -C3 ), alcoxi (C1 -C3 ), nitro, amino, ciano, CF3 y OCF3 ; y donde dichos anillos de piperazina, piperidina,...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3753397P | 1997-02-10 | 1997-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4920225A1 true CO4920225A1 (es) | 2000-05-29 |
Family
ID=21894849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98006875A CO4920225A1 (es) | 1997-02-10 | 1998-02-10 | 2-amino-6-(4-fenoxi-2-sustituido)-piridinas sustituidas |
Country Status (44)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| YU73200A (sh) * | 1998-06-03 | 2003-02-28 | Pfizer Products Inc. | 2-aminopiridini koji sadrže spojene ciklične supstituente kao inhibitori nitro oksid sintaze |
| NZ509298A (en) * | 1998-08-11 | 2005-02-25 | Pfizer Prod Inc | New pharmaceutical uses for NOS inhibitors |
| US7115557B2 (en) | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
| SE9803710L (sv) | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
| PT1155000E (pt) * | 1999-02-25 | 2003-10-31 | Pfizer Prod Inc | 2-aminopiridinas contendo aneis fundidos substituintes |
| FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| GB0019006D0 (en) * | 2000-08-04 | 2000-09-20 | Astrazeneca Ab | Novel compounds |
| US20030232739A1 (en) * | 2001-08-15 | 2003-12-18 | Pfizer Inc. | Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| US6803470B2 (en) | 2001-10-10 | 2004-10-12 | Pfizer Inc | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines |
| DOP2002000467A (es) * | 2001-10-10 | 2003-04-15 | Pfizer Prod Inc | 2-amino-6 (fenilo sustituido en las posiciones 2,4,5)-piridinas |
| US7045652B2 (en) | 2002-07-03 | 2006-05-16 | Pfizer Inc | Processes for preparing substituted aryl boronic acids |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| WO2005007627A1 (ja) * | 2003-07-18 | 2005-01-27 | Nihon Nohyaku Co., Ltd. | フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤 |
| EP1850838A2 (en) * | 2005-02-21 | 2007-11-07 | Proximagen Ltd. | Inhibition or treatment of dyskinesia |
| GB0607196D0 (en) * | 2006-04-11 | 2006-05-17 | Prosidion Ltd | G-protein coupled receptor agonists |
| WO2008080938A1 (en) * | 2006-12-28 | 2008-07-10 | Basf Se | Use 2-substituted pyridines for cancer treatment |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| JP6387023B2 (ja) | 2013-02-28 | 2018-09-05 | ティウムバイオ カンパニー、リミテッドＴｉｕｍＢｉｏ Ｃｏ．， Ｌｔｄ． | 三環式化合物およびその使用 |
| US10689344B2 (en) * | 2013-11-07 | 2020-06-23 | University Of Kansas | Biphenylamide derivative Hsp90 inhibitors |
| CA2957880A1 (en) * | 2014-08-13 | 2016-02-18 | Meiji Seika Pharma Co., Ltd. | Crystalline anti-trichophyton agents and preparation process thereof |
| CN106265640B (zh) * | 2016-08-11 | 2019-05-14 | 吉林大学 | Appa在制备治疗糖尿病肾病药物中的应用 |
| CN108069831B (zh) * | 2018-01-25 | 2020-11-24 | 上海恩氟佳科技有限公司 | 一种合成2,3-二甲基-4-氟苯酚的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08504798A (ja) * | 1992-12-18 | 1996-05-21 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬としての，ピリミジン，ピリジン，プテリジノンおよびインダゾール誘導体 |
| EP0724570B1 (en) * | 1993-10-21 | 1999-03-03 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| AU4515696A (en) * | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| UA49006C2 (uk) * | 1996-03-29 | 2002-09-16 | Файзер Інк. | Похідні 6-фенілпіридил-2-аміну, фармацевтична композиція, спосіб інгібування синтази оксиду нітрогену у ссавців та спосіб лікування |
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1998
- 1998-01-29 CN CN98802392A patent/CN1246848A/zh active Pending
- 1998-01-29 PT PT98900635T patent/PT958282E/pt unknown
- 1998-01-29 YU YU35699A patent/YU35699A/sh unknown
- 1998-01-29 CN CNA2004100073282A patent/CN1523015A/zh active Pending
- 1998-01-29 IL IL13089898A patent/IL130898A0/xx unknown
- 1998-01-29 KR KR10-1999-7007065A patent/KR100460399B1/ko not_active IP Right Cessation
- 1998-01-29 DK DK98900635T patent/DK0958282T3/da active
- 1998-01-29 CZ CZ19992769A patent/CZ292135B6/cs not_active IP Right Cessation
- 1998-01-29 NZ NZ518345A patent/NZ518345A/en unknown
- 1998-01-29 WO PCT/IB1998/000112 patent/WO1998034919A1/en active IP Right Grant
- 1998-01-29 SK SK1011-99A patent/SK101199A3/sk unknown
- 1998-01-29 CN CNA031086047A patent/CN1515554A/zh active Pending
- 1998-01-29 EA EA199900632A patent/EA003834B1/ru not_active IP Right Cessation
- 1998-01-29 SI SI9830699T patent/SI0958282T1/xx unknown
- 1998-01-29 AT AT98900635T patent/ATE271544T1/de not_active IP Right Cessation
- 1998-01-29 AU AU55727/98A patent/AU744313B2/en not_active Ceased
- 1998-01-29 CA CA002277990A patent/CA2277990C/en not_active Expired - Fee Related
- 1998-01-29 TR TR1999/01917T patent/TR199901917T2/xx unknown
- 1998-01-29 UA UA99084543A patent/UA64740C2/uk unknown
- 1998-01-29 NZ NZ336623A patent/NZ336623A/xx unknown
- 1998-01-29 BR BR9811093-4A patent/BR9811093A/pt not_active Application Discontinuation
- 1998-01-29 JP JP53404898A patent/JP3505189B2/ja not_active Expired - Fee Related
- 1998-01-29 ES ES98900635T patent/ES2224354T3/es not_active Expired - Lifetime
- 1998-01-29 DE DE69825147T patent/DE69825147T2/de not_active Expired - Fee Related
- 1998-01-29 PL PL98335161A patent/PL335161A1/xx unknown
- 1998-01-29 EP EP98900635A patent/EP0958282B1/en not_active Expired - Lifetime
- 1998-01-29 HU HU0000762A patent/HUP0000762A3/hu unknown
- 1998-02-03 TW TW087101311A patent/TW458969B/zh not_active IP Right Cessation
- 1998-02-05 AP APAP/P/1998/001178A patent/AP833A/en active
- 1998-02-05 PE PE1998000082A patent/PE58599A1/es not_active Application Discontinuation
- 1998-02-06 MY MYPI98000488A patent/MY120976A/en unknown
- 1998-02-06 UY UY24881A patent/UY24881A1/es not_active Application Discontinuation
- 1998-02-09 MA MA24958A patent/MA27676A1/fr unknown
- 1998-02-09 HN HN1998000030A patent/HN1998000030A/es unknown
- 1998-02-09 TN TNTNSN98024A patent/TNSN98024A1/fr unknown
- 1998-02-09 ZA ZA9801017A patent/ZA981017B/xx unknown
- 1998-02-09 DZ DZ980024A patent/DZ2414A1/xx active
- 1998-02-09 AR ARP980100551A patent/AR011117A1/es not_active Application Discontinuation
- 1998-02-10 PA PA19988446301A patent/PA8446301A1/es unknown
- 1998-02-10 CO CO98006875A patent/CO4920225A1/es unknown
- 1998-02-10 HR HR60/037,533A patent/HRP980069A2/hr not_active Application Discontinuation
- 1998-02-11 GT GT199800032A patent/GT199800032A/es unknown
- 1998-07-31 US US09/127,158 patent/US20010007873A1/en not_active Abandoned
-
1999
- 1999-07-16 IS IS5118A patent/IS5118A/is unknown
- 1999-08-03 BG BG103633A patent/BG103633A/bg unknown
- 1999-08-06 OA OA9900173A patent/OA11084A/en unknown
- 1999-08-09 NO NO19993823A patent/NO314803B1/no unknown
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2003
- 2003-02-20 US US10/371,357 patent/US20030162765A1/en not_active Abandoned
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