AR008826A1 - Derivados de xanteno y acridina, procedimiento para su preparacion y medicamentos que los contienen - Google Patents

Derivados de xanteno y acridina, procedimiento para su preparacion y medicamentos que los contienen

Info

Publication number
AR008826A1
AR008826A1 ARP970103554A ARP970103554A AR008826A1 AR 008826 A1 AR008826 A1 AR 008826A1 AR P970103554 A ARP970103554 A AR P970103554A AR P970103554 A ARP970103554 A AR P970103554A AR 008826 A1 AR008826 A1 AR 008826A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
het
halogen
substituents
alkyl
Prior art date
Application number
ARP970103554A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9616565.9A external-priority patent/GB9616565D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR008826A1 publication Critical patent/AR008826A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Se refiere a derivados de xanteno y acridina, de formula general (I) y sus sales, en donde W es hidrogeno o alquilo inferior; X es alquilo inferior;Y es un átomo de oxígeno o NR1; R1 es hidrogeno, alquilo inferior, alcoxicarboniloi nferior o alcoxicarbonilo inferior-alquilo; Z es arilo oo heteroarilo opcionalmente sustituido con uno o más substituyentes halogeno, ciano, nitro, alquilo inferior, halogeno-alquilo inferior, alcoxilo inferiorhalogeno-alcoxilo inferior, COR2,OCOR 2, CO2R2, OR2, S(O)nR2, NR2R3, N(R4)COR5, AR, Ar-alquilo inferior, Het o Het-alquilo inferior, y/o en átomos de carbonoadyacentes con alquilendioxilo inferior; R2, R3, R4 y R5 son cada uno individualmente substituyentes hidrogeno,alquilo i nferior, Ar, Ar-alquiloinferior, Het o Het-alquilo inferior, o R2 y R3 juntos son el grupo -CH=CH-CH=CH- o -CH=N-CH=CH-; Ar es arilo opcionalmente substituido conuno o más substituyentes halogeno, alquilo inferior, alcoxiloinferior o o nitro; Het es heteroarilo opcionalmente substituido con uno o mássustituyentes halogeno, alquilo inferior, alcoxilo inferior o nitro; y n es 0, 1 o 2, que son inhibidores de la timidina quinasa del virus del herpessimplex ypueden emplea rse en el tratamiento y profilaxis de infecciones causadas por el virus del herpes simplex. Se refiere además a un procedimientopara la preparacion de dichos derivados y a medicamentos que los contienen.
ARP970103554A 1996-08-07 1997-08-05 Derivados de xanteno y acridina, procedimiento para su preparacion y medicamentos que los contienen AR008826A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9616565.9A GB9616565D0 (en) 1996-08-07 1996-08-07 Tricyclic dione derivatives
GBGB9707695.4A GB9707695D0 (en) 1996-08-07 1997-04-18 Tricyclic dione derivatives

Publications (1)

Publication Number Publication Date
AR008826A1 true AR008826A1 (es) 2000-02-23

Family

ID=26309831

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103554A AR008826A1 (es) 1996-08-07 1997-08-05 Derivados de xanteno y acridina, procedimiento para su preparacion y medicamentos que los contienen

Country Status (10)

Country Link
US (2) US5969139A (es)
EP (1) EP0823426A1 (es)
JP (1) JPH1067749A (es)
CN (1) CN1100759C (es)
AR (1) AR008826A1 (es)
BR (1) BR9704271A (es)
CA (1) CA2210415A1 (es)
GB (1) GB9707695D0 (es)
MX (1) MX9706014A (es)
TR (1) TR199700761A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055517A1 (en) * 2000-09-15 2002-05-09 3M Innovative Properties Company Methods for delaying recurrence of herpes virus symptoms
EP2283871A1 (en) * 2004-06-18 2011-02-16 The Johns Hopkins University Imaging infection with compounds that bind to thymidine kinase
FR2962436B1 (fr) * 2010-07-09 2012-12-14 Fabre Pierre Dermo Cosmetique Derives de xanthedediones pour le traitement des troubles de la pigmentation et du vieillissement cutane
TW201444827A (zh) 2013-03-12 2014-12-01 Daiichi Sankyo Co Ltd 苯基□衍生物
CN103396362B (zh) * 2013-08-21 2015-11-04 郑州西格玛化工有限公司 一种制备吖啶酮乙酸的方法
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
CN110612300B (zh) * 2017-03-13 2023-10-20 组装生物科学股份有限公司 制备乙型肝炎核心蛋白调节剂的方法
US11976041B1 (en) 2023-10-23 2024-05-07 King Faisal University 9-(5-bromo-2-hydroxyphenyl)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione as an antimicrobial compound
US11952385B1 (en) 2023-10-31 2024-04-09 King Faisal University 12-bromo-2,16-dioxa-9,9,18,18-tetramethylpentacyclo[7.7.5.0 1, 21.0 3,8.0 10,15]henicosa3(8),10,12,14-tetraene-7,20-dione as an antimicrobial compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3454577A (en) * 1965-11-09 1969-07-08 Hoffmann La Roche 4-(1,2,3,4,5,6,7,8 - octahydro - 1,8 - dioxo-9-acridanyl) - benzenesulfonamide and derivatives
US3414587A (en) * 1965-11-09 1968-12-03 Hoffmann La Roche 4-(1, 2, 3, 4, 5, 6, 7, 8-octahydro-1, 8-dioxo-9-xanthenyl)-benzene-sulfonamide and derivatives
US3539590A (en) * 1968-05-20 1970-11-10 Monsanto Co Substituted 3,3,6,6 - tetramethyl-1,8 - diketo - 9 - (2 - hydroxyphenyl) octahydroxanthenes
DE2003148A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
GB9113624D0 (en) * 1991-06-25 1991-08-14 Wellcome Found Pesticides
GB9220570D0 (en) * 1991-10-21 1992-11-11 Ici Plc Therapeutic agent
US5340819A (en) * 1991-10-21 1994-08-23 Imperial Chemical Industries Plc Method for treating urinary incontinence using 9-(3-nitrophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H) acridinedione
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
CA2119315A1 (en) * 1993-03-18 1994-09-19 Tsujiaki Hata Nucleoside derivatives and anti-herpes composition

Also Published As

Publication number Publication date
BR9704271A (pt) 1998-11-03
GB9707695D0 (en) 1997-06-04
CA2210415A1 (en) 1998-02-07
EP0823426A1 (en) 1998-02-11
JPH1067749A (ja) 1998-03-10
MX9706014A (es) 1998-02-28
TR199700761A2 (xx) 1998-02-21
CN1178789A (zh) 1998-04-15
US6162918A (en) 2000-12-19
CN1100759C (zh) 2003-02-05
US5969139A (en) 1999-10-19

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