BR9911182A - Composto, uso do mesmo, processo para o tratamento de um mamìfero, incluindo homem, de condições suscetìveis de melhora por um agonista de beta-adrenorreceptor atìpico, composição farmacêutica, e, processo para a preparação de um composto. - Google Patents
Composto, uso do mesmo, processo para o tratamento de um mamìfero, incluindo homem, de condições suscetìveis de melhora por um agonista de beta-adrenorreceptor atìpico, composição farmacêutica, e, processo para a preparação de um composto.Info
- Publication number
- BR9911182A BR9911182A BR9911182-9A BR9911182A BR9911182A BR 9911182 A BR9911182 A BR 9911182A BR 9911182 A BR9911182 A BR 9911182A BR 9911182 A BR9911182 A BR 9911182A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- compound
- preparation
- treatment
- improvement
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO, USO DO MESMO, PROCESSO PARA O TRATAMENTO DE UM MAMìFERO, INCLUINDO HOMEM, DE CONDIçõES SUSCETìVEIS DE MELHORA POR UM AGONISTA DE BETA-ADRENORRECEPTOR ATìPICO, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO" A presente invenção refere-se a derivados de biarila terapêuticos de fórmula (I): e derivados farmaceuticamente aceitáveis dos mesmos, em que R¹ é um grupo fenila, naftila, piridila, tiazolila, fenoximetila ou pirimidila, opcionalmente substituído por um ou mais substituintes selecionados dentre o grupo consistindo de halogênio, hidróxi, alcóxi C~ 1-6~, nitro, ciano, hidroximetila, trifluorometila, - NR^ 6^R^ 6^ e - NHSO~ 2~R^ 6^, onde cada R^ 6^ é independentemente hidrogênio ou alquila C~ 1-4~; R² é hidrogênio ou alquila C~ 1-6~; X é oxigênio, enxofre, - NH ou N - alquila C~ 1-4~; R³ é ciano, tetrazol - 5 - ila ou - CO~ 2~R^ 7^ onde R^ 7^ é hidrogênio ou alquila C~ 1-6~; R^ 4^ e R^ 5^ são independentemente hidrogênio, alquila C~ 1-6~, - CO~ 2~H, - alquila CO~ 2~C~ 1-6~, ciano, tetrazol - 5 - ila, halogênio, trifluorometila ou alcóxi C~ 1-6~, ou, quando R^ 4^ e R^ 5^ são ligados a átomos de carbono adjacentes, R^ 4^ e R^ 5^ podem, juntos com os átomos de carbono aos quais estão ligados, formar um anel de 5 ou 6 membros fundido contendo opcionalmente um ou dois átomos de nitrogênio, oxigênio ou enxofre; e Y é N ou CH, a processos para sua preparação e seu uso no tratamento de doenças suscetíveis de melhora por tratamento com um agonista de beta-3-adrenorreceptor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9812709.5A GB9812709D0 (en) | 1998-06-13 | 1998-06-13 | Chemical compounds |
PCT/EP1999/003958 WO1999065877A1 (en) | 1998-06-13 | 1999-06-09 | Therapeutic biaryl derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9911182A true BR9911182A (pt) | 2001-03-13 |
BR9911182B1 BR9911182B1 (pt) | 2010-09-08 |
Family
ID=10833658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9911182-9A BR9911182B1 (pt) | 1998-06-13 | 1999-06-09 | compostos derivados de biarila com propriedades agonistas de adrenorreceptores beta-3, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto. |
Country Status (38)
Country | Link |
---|---|
US (1) | US6251925B1 (pt) |
EP (1) | EP1087943B1 (pt) |
JP (1) | JP3471754B2 (pt) |
KR (1) | KR100415877B1 (pt) |
CN (1) | CN1214008C (pt) |
AP (1) | AP1687A (pt) |
AR (1) | AR029301A1 (pt) |
AT (1) | ATE302189T1 (pt) |
AU (1) | AU753004B2 (pt) |
BR (1) | BR9911182B1 (pt) |
CA (1) | CA2334713C (pt) |
CO (1) | CO5060482A1 (pt) |
CZ (1) | CZ299172B6 (pt) |
DE (1) | DE69926752T2 (pt) |
DK (1) | DK1087943T3 (pt) |
EA (1) | EA003641B1 (pt) |
EE (1) | EE04435B1 (pt) |
EG (1) | EG23856A (pt) |
ES (1) | ES2245107T3 (pt) |
GB (1) | GB9812709D0 (pt) |
HK (1) | HK1034253A1 (pt) |
HR (1) | HRP20000854B1 (pt) |
HU (1) | HUP0102668A3 (pt) |
ID (1) | ID27841A (pt) |
IL (2) | IL140219A0 (pt) |
IS (1) | IS2277B (pt) |
MY (1) | MY119542A (pt) |
NO (1) | NO318782B1 (pt) |
NZ (1) | NZ508805A (pt) |
PE (1) | PE20000726A1 (pt) |
PL (1) | PL196943B1 (pt) |
RS (1) | RS49921B (pt) |
SI (1) | SI1087943T1 (pt) |
SK (1) | SK286256B6 (pt) |
TR (1) | TR200100299T2 (pt) |
TW (1) | TWI244471B (pt) |
WO (1) | WO1999065877A1 (pt) |
ZA (1) | ZA200007417B (pt) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9929118D0 (en) * | 1999-12-10 | 2000-02-02 | Glaxo Group Ltd | Chemical compounds |
GB9929297D0 (en) * | 1999-12-11 | 2000-02-02 | Glaxo Group Ltd | Process |
DE10005150A1 (de) * | 2000-02-07 | 2001-08-09 | Merck Patent Gmbh | Verfahren zur Herstellung von 5-Arylnicotinaldehyden |
SK4612003A3 (en) | 2000-10-20 | 2004-06-08 | Pfizer Prod Inc | Alpha-aryl ethanolamines and their use as beta-3 adrenergic receptor agonists |
AR035605A1 (es) | 2000-12-11 | 2004-06-16 | Bayer Corp | Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores |
US7034053B2 (en) | 2001-01-31 | 2006-04-25 | Smithkline Beecham Corporation | Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors |
GB0102407D0 (en) * | 2001-01-31 | 2001-03-14 | Glaxo Group Ltd | Process |
US7709677B2 (en) | 2001-01-31 | 2010-05-04 | Glaxosmithkline Llc | Process of preparing arylethanoldiamines |
GB0102408D0 (en) * | 2001-01-31 | 2001-03-14 | Glaxo Group Ltd | Chemical compounds |
EP1236723A1 (en) | 2001-03-01 | 2002-09-04 | Pfizer Products Inc. | Sulfamide derivatives useful as beta3 agonists and pharmaceutical uses thereof |
AR035858A1 (es) | 2001-04-23 | 2004-07-21 | Bayer Corp | Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3 |
MXPA04001785A (es) | 2001-09-14 | 2004-07-08 | Bayer Ag | Benzofurano y derivados de dihidrobenzofurano utiles como agonistas de beta-3 adrenoreceptores. |
US6864268B2 (en) | 2002-02-27 | 2005-03-08 | Pfizer Inc. | β3 adrenergic receptor agonists |
AU2003248355A1 (en) * | 2002-02-27 | 2003-09-09 | Pfizer Products Inc. | Salt of a pyridyl ethanolamine derivative and its use as a beta-3-adrenergic receptor agonist |
AU2003209527A1 (en) * | 2002-02-27 | 2003-09-09 | Pfizer Products Inc. | Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol |
BR0307996A (pt) | 2002-02-27 | 2004-12-07 | Pfizer Prod Inc | Processos e intermediários úteis na preparação de receptores de agonistas beta3-adrenérgicos |
DOP2003000587A (es) * | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
WO2004007456A1 (en) * | 2002-07-17 | 2004-01-22 | Lek Pharmaceuticals D.D. | Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them |
GB0220730D0 (en) * | 2002-09-06 | 2002-10-16 | Glaxo Group Ltd | Medicinal compounds |
SI1569907T1 (sl) * | 2002-12-13 | 2016-06-30 | Ym Biosciences Australia Pty Ltd | Na nikotinamidu osnovani kinazni inhibitorji |
ES2308142T3 (es) * | 2003-02-14 | 2008-12-01 | Kissei Pharmaceutical Co., Ltd. | Derivados aminoalcohol, composiciones farmaceuticas que los contienen, y sus usos. |
CN100418944C (zh) * | 2003-02-14 | 2008-09-17 | 橘生药品工业株式会社 | 氨基醇衍生物、含有所述氨基醇衍生物的药物组合物及其应用 |
WO2005040093A1 (ja) * | 2003-10-24 | 2005-05-06 | Kissei Pharmaceutical Co., Ltd. | アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途 |
WO2005061433A2 (en) * | 2003-12-23 | 2005-07-07 | Astellas Pharma Inc. | Aminoalcohol derivatives |
US7915309B2 (en) * | 2007-06-20 | 2011-03-29 | Protia, Llc | Deuterium-enriched oseltamivir |
TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
WO2010118291A2 (en) | 2009-04-10 | 2010-10-14 | Auspex Pharmaceuticals, Inc. | Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor |
CN103269692B (zh) | 2010-08-03 | 2018-02-23 | 韦利塞普特治疗有限公司 | 用于治疗膀胱过度活动症的β‑3肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂的药物组合 |
US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
AU2013216864A1 (en) | 2012-02-09 | 2014-09-11 | Altherx, Inc. | Combination of muscarinic receptor antagonists and beta- 3 adrenoceptor agonists for treating overactive bladder |
US9784726B2 (en) | 2013-01-08 | 2017-10-10 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatment |
CN107205964A (zh) | 2014-12-03 | 2017-09-26 | 威力塞帕特治疗股份有限公司 | 使用调节释放索拉贝隆用于下尿路症状的组合物和方法 |
US10065922B2 (en) * | 2015-10-23 | 2018-09-04 | Velicept Therapeutics, Inc. | Solabegron zwitterion and uses thereof |
GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2965655D1 (en) * | 1978-06-28 | 1983-07-21 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
GB8519154D0 (en) * | 1985-07-30 | 1985-09-04 | Ici Plc | Aromatic ethers |
DE3934436A1 (de) * | 1989-06-01 | 1991-04-18 | Thomae Gmbh Dr K | 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5061727A (en) * | 1990-05-04 | 1991-10-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
AU2737295A (en) * | 1994-06-09 | 1996-01-04 | Glaxo Group Limited | Phenethanolamine derivatives and their use as atypical beta-adrenoceptor agonists |
-
1998
- 1998-06-13 GB GBGB9812709.5A patent/GB9812709D0/en not_active Ceased
-
1999
- 1999-06-09 CO CO99036228A patent/CO5060482A1/es unknown
- 1999-06-09 CA CA002334713A patent/CA2334713C/en not_active Expired - Lifetime
- 1999-06-09 EE EEP200000744A patent/EE04435B1/xx not_active IP Right Cessation
- 1999-06-09 ES ES99927923T patent/ES2245107T3/es not_active Expired - Lifetime
- 1999-06-09 AR ARP990102733A patent/AR029301A1/es active IP Right Grant
- 1999-06-09 AU AU45103/99A patent/AU753004B2/en not_active Expired
- 1999-06-09 NZ NZ508805A patent/NZ508805A/en not_active IP Right Cessation
- 1999-06-09 TR TR2001/00299T patent/TR200100299T2/xx unknown
- 1999-06-09 PL PL344865A patent/PL196943B1/pl unknown
- 1999-06-09 BR BRPI9911182-9A patent/BR9911182B1/pt not_active IP Right Cessation
- 1999-06-09 DK DK99927923T patent/DK1087943T3/da active
- 1999-06-09 EP EP99927923A patent/EP1087943B1/en not_active Expired - Lifetime
- 1999-06-09 AT AT99927923T patent/ATE302189T1/de active
- 1999-06-09 US US09/719,595 patent/US6251925B1/en not_active Expired - Lifetime
- 1999-06-09 IL IL14021999A patent/IL140219A0/xx active IP Right Grant
- 1999-06-09 CN CNB99809630XA patent/CN1214008C/zh not_active Expired - Lifetime
- 1999-06-09 JP JP2000554704A patent/JP3471754B2/ja not_active Expired - Lifetime
- 1999-06-09 DE DE69926752T patent/DE69926752T2/de not_active Expired - Lifetime
- 1999-06-09 WO PCT/EP1999/003958 patent/WO1999065877A1/en active IP Right Grant
- 1999-06-09 SK SK1908-2000A patent/SK286256B6/sk not_active IP Right Cessation
- 1999-06-09 AP APAP/P/2001/002028A patent/AP1687A/en active
- 1999-06-09 CZ CZ20004648A patent/CZ299172B6/cs not_active IP Right Cessation
- 1999-06-09 HU HU0102668A patent/HUP0102668A3/hu unknown
- 1999-06-09 ID IDW20010101A patent/ID27841A/id unknown
- 1999-06-09 SI SI9930827T patent/SI1087943T1/sl unknown
- 1999-06-09 EA EA200001172A patent/EA003641B1/ru not_active IP Right Cessation
- 1999-06-09 RS YUP-792/00A patent/RS49921B/sr unknown
- 1999-06-09 KR KR10-2000-7014098A patent/KR100415877B1/ko not_active IP Right Cessation
- 1999-06-10 EG EG70199A patent/EG23856A/xx active
- 1999-06-10 MY MYPI99002368A patent/MY119542A/en unknown
- 1999-06-10 PE PE1999000517A patent/PE20000726A1/es not_active Application Discontinuation
- 1999-06-16 TW TW088110054A patent/TWI244471B/zh not_active IP Right Cessation
-
2000
- 2000-12-08 IS IS5760A patent/IS2277B/is unknown
- 2000-12-11 IL IL140219A patent/IL140219A/en not_active IP Right Cessation
- 2000-12-12 ZA ZA200007417A patent/ZA200007417B/en unknown
- 2000-12-12 NO NO20006319A patent/NO318782B1/no not_active IP Right Cessation
- 2000-12-13 HR HR20000854A patent/HRP20000854B1/xx not_active IP Right Cessation
-
2001
- 2001-07-11 HK HK01104848A patent/HK1034253A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9911182A (pt) | Composto, uso do mesmo, processo para o tratamento de um mamìfero, incluindo homem, de condições suscetìveis de melhora por um agonista de beta-adrenorreceptor atìpico, composição farmacêutica, e, processo para a preparação de um composto. | |
NO155243C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive kinazolinderivater. | |
BR9914451A (pt) | Composto de oxazol, processo para sua preparação, composição farmacêutica compreendendo dito composto, uso da composição e métodos de tratamento | |
EA200000155A2 (ru) | 4-фенилпиридиновые производные | |
BR0111754A (pt) | Uso de um composto, método para inibir aurora 2 quinase em um animal de sangue quente, composto, e, composição farmacêutica | |
DE69524641D1 (de) | Benzamidanaloga zur Verwendung als PARP- (ADP-Ribosyltransferase, ADPRT) DNS-Reparaturenzym Inhibitoren | |
DK60887D0 (da) | Piperazinderivater og deres anvendelse til fremstilling af laegemidler med antiarrythmisk virkning | |
AR032453A1 (es) | Derivados alquinil fenil heteroaromaticos activadores de glucoquinasa, un proceso para su preparacion, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de medicamentos | |
EA200300354A1 (ru) | Хинолиноновые производные в качестве ингибиторов тирозинкиназы | |
BR0014133A (pt) | Uso de um composto, composto, métodos de preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica | |
BR0009297A (pt) | Composto, processo para produzir o mesmo,composição farmacêutica, método paraantagonizar hormÈnio de liberação degonadotropina em um mamìfero, e, uso de umcomposto | |
ATE37179T1 (de) | Dihydropyridazinone. | |
BR0009044A (pt) | Composto, composição farmacêutica, método para tratar uma doença em um animal, uso de um composto, e, processo para fabricar um composto | |
BR0112856A (pt) | Método para o tratamento dos distúrbios, composto ou um sal ou solvato deste, processo para a preparação dos mesmos, composição farmacêutico, método de tratamento e/ou profilaxia de um ou mais dos distúrbios, uso de um composto, e, método para o tratamento de diabetes, grande depressão, depressão manìaca, ansiedade, esquizofrenia e distúrbios do sono, em mamìferos humanos e não humanos | |
BRPI0510078A (pt) | composto, composição farmacêutica, uso de um composto, e, métodos de tratamento de uma condição, distúrbios ou doença tratável com androgênios, de tratamento de uma condição, distúrbio ou doença relacionada com receptor de androgênio e de contracepção masculina | |
HUP0203184A2 (hu) | Izoxazolkarboxamid-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
NO163855C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive arylcyklobutylalkylaminer. | |
BRPI0411285A (pt) | composto, processo para preparar um composto formulação farmacêutica, uso de um composto, e, método de prevenção ou tratamento de distúrbios | |
BR0311315A (pt) | Sulfonas aromáticas e sua utilização médica | |
DK43683D0 (da) | Aromatiske forbindelser med antihistamin-aktivitet, fremgangsmade til deres fremstilling samt deres anvendelse | |
BR9909326A (pt) | Derivados de piridina inibidores de pde iv | |
BR0004548A (pt) | Derivados i de quinolin-4-ila | |
BR0016187A (pt) | Processo para a preparação de derivados de aril etanol amina tendo propriedades anti-obesidade e anti-diabéticas | |
BR0016115A (pt) | Derivados peptìdicos de acriloìla, processo para sua preparação e seu uso como agentes inibidores de tumor | |
ES2065992T3 (es) | Uso de derivados de imidazopirazol como analgesicos y agentes anti-inflamatorios. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/09/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
B25A | Requested transfer of rights approved |
Owner name: ALTHERX, INC. (US) |
|
B25A | Requested transfer of rights approved |
Owner name: VELICEPT THERAPEUTICS INC. (US) |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 08.09.2020 |