KR100415877B1 - 치료용 비아릴 유도체 - Google Patents
치료용 비아릴 유도체 Download PDFInfo
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- KR100415877B1 KR100415877B1 KR10-2000-7014098A KR20007014098A KR100415877B1 KR 100415877 B1 KR100415877 B1 KR 100415877B1 KR 20007014098 A KR20007014098 A KR 20007014098A KR 100415877 B1 KR100415877 B1 KR 100415877B1
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Abstract
Description
Claims (18)
- 하기 화학식 I의 화합물 또는 그의 약학적으로 허용가능한 유도체.<화학식 I>상기 식에서, R1은 페닐, 나프틸, 피리딜, 티아졸릴, 페녹시메틸, 또는 피리미딜기(이들은 할로겐, 히드록시, C1-6알콕시, C1-6알킬, 니트로, 시아노, 히드록시메틸, 트리플루오로메틸, -NR6R6및 -NHSO2R6(여기서 각 R6은 독립적으로 수소 또는 C1-4알킬임)로 이루어진 군으로부터 선택된 1종 이상의 치환기로 임의 치환됨)이고;R2는 수소 또는 C1-6알킬이고;X는 산소, 황, -NH 또는 -NC1-4알킬이고;R3는 시아노, 테트라졸-5-일 또는 -CO2R7(여기서 R7은 수소 또는 C1-6알킬임)이고;R4및 R5는 독립적으로 수소, C1-6알킬, -CO2H, -CO2C1-6알킬, 시아노, 테트라졸-5-일, 할로겐, 트리플루오로메틸 또는 C1-6알콕시이거나, R4및 R5가 인접 탄소원자에 결합되는 경우에는, R4및 R5는 결합된 탄소원자와 함께, 경우에 따라 1 또는 2개의 질소, 산소 또는 황 원자를 함유하는, 융합 5 또는 6원 고리를 형성하고;Y는 N 또는 CH이다.
- 제1항에 있어서, R1이, 할로겐, 히드록시, C1-6알콕시, C1-6알킬, 니트로, 시아노, 히드록시메틸 및 트리플루오로메틸로부터 선택된 1, 2 또는 3개의 치환기로 임의 치환된, 페녹시메틸 또는 페닐인 화합물.
- 제1 또는 2항에 있어서, R1이, 염소, 불소, 브롬, 메틸 또는 트리플루오로메틸로 치환된, 페녹시메틸 또는 페닐인 화합물.
- 제1 또는 2항에 있어서, R2가 수소 또는 메틸인 화합물.
- 제1 또는 2항에 있어서, R2가 수소인 화합물.
- 제1 또는 2항에 있어서, X가 NH인 화합물.
- 제1 또는 2항에 있어서, R3가 CO2H인 화합물.
- 제1 또는 2항에 있어서, 1 이상의 R4및 R5가 수소인 화합물.
- 제1 또는 2항에 있어서, R4및 R5가 둘 다 수소인 화합물.
- 제1 또는 2항에 있어서, Y가 CH인 화합물.
- 제1항에 있어서, R1이 염소, 불소, 브롬, 메틸, 또는 트리플루오로메틸로 치환된, 페녹시메틸 또는 페닐이고; R2가 수소 또는 메틸이고; X가 NH 또는 NCH3이고; R3가 CO2H이고; Y가 CH인 화합물.
- (R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-카르복실산 메틸 에스테르;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-2,4-디카르복실산 디메틸 에스테르;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-2-메틸-5-카르복실산 메틸 에스테르;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3,4-디카르복실산 디메틸 에스테르;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-클로로-4-카르복실산 메틸 에스테르;(R)-3'-[[2-[[2-(3,5-디클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-카르복실산 메틸 에스테르;(R)-3'-[[2-[[2-(3,5-디클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-카르복실산;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-카르복실산;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-2,4-디카르복실산 2-메틸 에스테르;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-2,4-디카르복실산;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-2-메틸-5-카르복실산;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-클로로-4-카르복실산;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3,4-디카르복실산;(R)-3'-[[2-[(2-히드록시-3-페녹시프로필)아미노]에틸]아미노]-[1.1'-비페닐]-3-카르복실산;(R)-3'-[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에톡시]-[1.1'-비페닐]-3-카르복실산;3'-[[2R-[[2-(3-클로로페닐)-2R-히드록시에틸]아미노]프로필]아미노]-[1.1'-비페닐]-4-카르복실산;3'-[[2R-[[2-(3-클로로페닐)-2R-히드록시에틸]아미노]프로필]아미노]-[1.1'-비페닐]-2-카르복실산;3'-[[2R-[[2-(3-클로로페닐)-2R-히드록시에틸]아미노]프로필]아미노]-[1.1'-비페닐]-2,4-디카르복실산;5-[3-[[2R-[[2-(3-클로로페닐)-2R-히드록시에틸]아미노]프로필]아미노]페닐]3-피리딘카르복실산;2-[3-[[2R-[[2-(3-클로로페닐)-2R-히드록시에틸]아미노]프로필]아미노]페닐]-3-피리딘카르복실산;(R)-5-[3-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]페닐]-2,3-디히드로-7-벤조푸란카르복실산;(R)-5-[3-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]페닐]-3-피리딘카르복실산;(R)-2-[3-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]페닐]-4-피리딘카르복실산;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-(1H-5-테트라졸);(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-카르보니트릴; 및(R)-2-[3-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]페닐]-2-피리딘카르복실산으로 이루어진 군으로부터 선택된 화합물 또는 그의 약학적으로 허용가능한 유도체.
- (R)-5-[3-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]페닐]-3-피리딘카르복실산;3'-[[2R-[[2-(3-클로로페닐)-2R-히드록시에틸]아미노]프로필]아미노]-[1.1'-비페닐]-2,4-디카르복실산;(R)-3'-[[2-[(2-히드록시-3-페녹시프로필)아미노]에틸]아미노]-[1.1'-비페닐]-3-카르복실산;(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-2-메틸-5-카르복실산; 및(R)-3'-[[2-[[2-(3-클로로페닐)-2-히드록시에틸]아미노]에틸]아미노]-[1.1'-비페닐]-3-카르복실산으로 이루어진 군으로부터 선택된 화합물 또는 그의 약학적으로 허용가능한 유도체.
- 삭제
- 삭제
- 삭제
- 삭제
- (A) 하기 화학식 II의 화합물을 탈보호시키거나<화학식 II>;(B) 화학식 I의 또다른 화합물로 상호전환시키거나;(C) 하기 화학식 III의 화합물을 하기 화학식 IV의 화합물과 반응시킨 후, 이어서 중간 생성물을 정제하지 않고 상기 단계 (A)를 행하거나; 또는<화학식 III><화학식 IV>(D) 하기 화학식 VIII의 화합물을 하기 화학식 IX의 화합물과 반응시키는 것을 포함하는, 제1항의 화학식 I의 화합물의 제조 방법.<화학식 VIII><화학식 IX>
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1998
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2000
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4772631A (en) * | 1985-07-30 | 1988-09-20 | Imperial Chemical Industries Plc | Phenyl ethers |
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