BRPI0411285A - composto, processo para preparar um composto formulação farmacêutica, uso de um composto, e, método de prevenção ou tratamento de distúrbios - Google Patents

composto, processo para preparar um composto formulação farmacêutica, uso de um composto, e, método de prevenção ou tratamento de distúrbios

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Publication number
BRPI0411285A
BRPI0411285A BRPI0411285-7A BRPI0411285A BRPI0411285A BR PI0411285 A BRPI0411285 A BR PI0411285A BR PI0411285 A BRPI0411285 A BR PI0411285A BR PI0411285 A BRPI0411285 A BR PI0411285A
Authority
BR
Brazil
Prior art keywords
compound
thiophen
benzo
alkynyl
cycloalkyl
Prior art date
Application number
BRPI0411285-7A
Other languages
English (en)
Inventor
Anders Johansson
Joachim Persson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0301744A external-priority patent/SE0301744D0/xx
Priority claimed from SE0303493A external-priority patent/SE0303493D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0411285A publication Critical patent/BRPI0411285A/pt

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    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARAR UM COMPOSTO FORMULAçãO FARMACêUTICA, USO DE UM COMPOSTO, E, MéTODO DE PREVENçãO OU TRATAMENTO DE DISTúRBIOS". A presente invenção refere-se a um composto da fórmula geral em que Het é um anel heterocíclico com 4, 5, 6, ou 7 membros, opcionalmente substituído, tendo pelo menos um átomo de nitrogênio; R1 é hidrogênio, hidróxi, alquila C~ 1-4~, cicloalquila C~ 3-4~, alquenila C~ 2-4~, ou alquinila C~ 2-4~; R2 e R3 são cada qual independentemente selecionados a partir de hidrogênio, alquila C~ 1-4~, cicloalquila C~ 3-4~, alquenila C~ 2-4~, alquinila C~ 2-4~, alcóxi C~ 1-4~, halogênio e ciano contanto que R2 e R3 não sejam ambos o hidrogênio; R4 é alquila C~ 1-4~, cicloalquila C~ 3-4~, alquenila C~ 2-4~, alquinila C~ 2-4~, Ar é um sistema de anel aromático opcionalmente substituído selecionado a partir de piridinila; 1-naftila; 5,6,7, 8-tetraidro-1-naftila; quinolina; 2,3-diidro-1,4-benzodioxinila; 1,3-benzodioxolila; 5,6,7,8-tetraidroquinolinila; 5,6,7,8-tetraidroisoquinolinila; 5,6,7,8-tetraidroquinazolin1-ila; 1-benzo¢b!tiofen-7ila; 1-benzo ¢b! tiofen-4-ila; 1-benzo ¢b! tiofen-3-ila; isoquinolinila; quinazolinila e indan-4-ila; ou Ar é fenila substituído; ou um enanciómero dos mesmos ou qualquer sal dos mesmos; a composições farmacêuticas contendo os referidos compostos e ao uso dos referidos compostos em terapia. A presente invenção refere-se ainda a processos para a preparação de compostos da fórmula I e a novos intermediários usados na preparação dos mesmos.
BRPI0411285-7A 2003-06-13 2004-06-09 composto, processo para preparar um composto formulação farmacêutica, uso de um composto, e, método de prevenção ou tratamento de distúrbios BRPI0411285A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0301744A SE0301744D0 (sv) 2003-06-13 2003-06-13 New compounds
SE0303493A SE0303493D0 (sv) 2003-12-19 2003-12-19 New compounds
PCT/SE2004/000901 WO2004110344A2 (en) 2003-06-13 2004-06-09 New azetidine compounds

Publications (1)

Publication Number Publication Date
BRPI0411285A true BRPI0411285A (pt) 2006-08-01

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Application Number Title Priority Date Filing Date
BRPI0411285-7A BRPI0411285A (pt) 2003-06-13 2004-06-09 composto, processo para preparar um composto formulação farmacêutica, uso de um composto, e, método de prevenção ou tratamento de distúrbios

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US (1) US7402581B2 (pt)
EP (1) EP1636221B1 (pt)
JP (1) JP4982886B2 (pt)
KR (1) KR20060021373A (pt)
AR (1) AR044662A1 (pt)
AT (1) ATE439358T1 (pt)
AU (1) AU2004246983B2 (pt)
BR (1) BRPI0411285A (pt)
CA (1) CA2529126C (pt)
CO (1) CO5640122A2 (pt)
DE (1) DE602004022546D1 (pt)
DK (1) DK1636221T3 (pt)
ES (1) ES2330522T3 (pt)
HK (1) HK1088004A1 (pt)
IL (1) IL171894A (pt)
IS (1) IS8228A (pt)
MX (1) MXPA05013276A (pt)
MY (1) MY146599A (pt)
NO (1) NO332109B1 (pt)
PL (1) PL1636221T3 (pt)
PT (1) PT1636221E (pt)
RU (1) RU2356888C2 (pt)
TW (1) TW200508221A (pt)
WO (1) WO2004110344A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0403005D0 (sv) * 2004-12-09 2004-12-09 Astrazeneca Ab New use
CN101208327A (zh) * 2005-06-23 2008-06-25 阿斯利康(瑞典)有限公司 作为神经激肽受体拮抗剂用于治疗胃肠疾病的新氮杂环丁烷衍生物
WO2006137790A1 (en) * 2005-06-23 2006-12-28 Astrazeneca Ab New azetidine derivatives as neurokinin receptor antagonists for the treatment of gastrointestinal diseases
AR057828A1 (es) * 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
AR056087A1 (es) * 2005-09-29 2007-09-19 Astrazeneca Ab Derivados de azetidina como antagonistas de receptores de neuroquina nk
WO2007043938A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab NOVEL CRYSTALLINE FORM OF 3,5-DIBROMO-N- [ (2S) -2- (-4- FLUOROPHENYL) -4- (3-MORPHOLIN-4-YLAZTIDIN-l-YL) BUTYL] -N METHYLBENZAMIDE, MODIFICATION B
WO2007043939A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a
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