BR9814055A - Composto, composição farmacêutica, processo para o tratamento de uma doença alérgica, uso do composto, e, processos para preparar e para produzir um composto - Google Patents

Composto, composição farmacêutica, processo para o tratamento de uma doença alérgica, uso do composto, e, processos para preparar e para produzir um composto

Info

Publication number
BR9814055A
BR9814055A BR9814055-8A BR9814055A BR9814055A BR 9814055 A BR9814055 A BR 9814055A BR 9814055 A BR9814055 A BR 9814055A BR 9814055 A BR9814055 A BR 9814055A
Authority
BR
Brazil
Prior art keywords
compound
processes
pharmaceutical composition
allergic disease
alkyl
Prior art date
Application number
BR9814055-8A
Other languages
English (en)
Other versions
BR9814055B1 (pt
Inventor
Yasuo Ohtsuka
Toshio Nishizuka
Sohjiro Shiokawa
Seiji Tsutsumi
Mami Kawaguchi
Hideo Kitagawa
Hiromi Takata
Takashi Shishikura
Toyoaki Ishikura
Kenichi Fushihara
Yumiko Okada
Sachiko Miyamoto
Maki Shiobara
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of BR9814055A publication Critical patent/BR9814055A/pt
Publication of BR9814055B1 publication Critical patent/BR9814055B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA O TRATAMENTO DE UMA DOENçA ALéRGICA, USO DO COMPOSTO, E, PROCESSOS PARA PREPARAR E PARA PRODUZIR UM COMPOSTO" Derivados de triazolbenzazepina tricíclicos sob a forma de uma pró-droga são providos. Os compostos de acordo com a presente invenção são aqueles representados pela fórmula (I) e solvatos e sais farmacologicamente aceitáveis dos mesmos. Os compostos são úteis como agentes antialérgicos e exibem excelente biodisponibilidade. em que R^ 1^ representa hidrogênio, OH, alquila ou fenil alquila, R^ 2^, R^ 3^, R^ 4^ e R^ 5^ representam hidrogênio, halogênio, hidroxila opcionalmente protegida, formila, alquila opcionalmente protegida, alquenila, alcoxi ou os similares, e Q representa um grupo selecionado a partir dos seguintes grupos (i) a (iv), halogênio ou alcoxi:
BRPI9814055-8A 1997-09-29 1998-09-29 composto, composição farmacêutica, uso do composto, e, processos para preparar e para produzir um composto. BR9814055B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26461197 1997-09-29
JP5206398 1998-03-04
PCT/JP1998/004363 WO1999016770A1 (fr) 1997-09-29 1998-09-29 Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique

Publications (2)

Publication Number Publication Date
BR9814055A true BR9814055A (pt) 2000-09-26
BR9814055B1 BR9814055B1 (pt) 2009-05-05

Family

ID=26392670

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9814055-8A BR9814055B1 (pt) 1997-09-29 1998-09-29 composto, composição farmacêutica, uso do composto, e, processos para preparar e para produzir um composto.

Country Status (25)

Country Link
US (3) US6372735B1 (pt)
EP (1) EP1026167B1 (pt)
JP (1) JP3188482B2 (pt)
KR (1) KR100389140B1 (pt)
CN (2) CN1155599C (pt)
AT (1) ATE233764T1 (pt)
AU (1) AU744636B2 (pt)
BR (1) BR9814055B1 (pt)
CA (1) CA2305307C (pt)
DE (1) DE69811930T2 (pt)
DK (1) DK1026167T3 (pt)
ES (1) ES2191963T3 (pt)
HK (1) HK1032782A1 (pt)
HU (1) HUP0004020A3 (pt)
ID (1) ID24101A (pt)
IL (1) IL135303A0 (pt)
NO (2) NO319542B1 (pt)
NZ (1) NZ503601A (pt)
PL (1) PL339544A1 (pt)
PT (1) PT1026167E (pt)
RU (1) RU2198885C2 (pt)
SK (1) SK283869B6 (pt)
TR (1) TR200000808T2 (pt)
TW (1) TW510902B (pt)
WO (1) WO1999016770A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1275968C (zh) * 2001-12-26 2006-09-20 明治制果株式会社 三环型三唑并苯并氮杂䓬衍生物的非晶态物质
ES2283781T3 (es) 2002-02-01 2007-11-01 Meiji Seika Kaisha, Ltd. Procedimiento para producir un compuesto de 1,2,3-triazol.
WO2004004665A2 (en) 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
AU2003248861B2 (en) 2002-07-09 2009-01-22 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004113343A1 (ja) * 2003-06-19 2004-12-29 Meiji Seika Kaisha, Ltd. 三環性トリアゾロベンゾアゼピン誘導体の新規結晶性物質
WO2004113451A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難溶性物質と水溶性高分子との共沈物およびその製造方法
JP4467616B2 (ja) 2004-05-14 2010-05-26 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法
WO2007100079A1 (ja) 2006-03-02 2007-09-07 Meiji Seika Kaisha, Ltd. 三環性トリアゾロベンゾアゼピン誘導体を含有する、アレルギー性眼疾患またはアレルギー性鼻疾患の予防または治療剤
EP2094711B8 (de) * 2006-09-25 2018-03-28 Forschungsverbund Berlin e.V. Strukturmimetika prolinreicher peptide und ihre pharmazeutische verwendung
CL2007003244A1 (es) * 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
JP4343268B2 (ja) * 2007-12-18 2009-10-14 明治製菓株式会社 炎症性腸疾患の予防または治療剤
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
AU2010339691B2 (en) * 2010-01-07 2015-04-02 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
JP2013520424A (ja) 2010-02-19 2013-06-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド ナトリウム４−｛［９−クロロ−７−（２−フルオロ−６−メトキシフェニル）−５Ｈ−ピリミド［５，４−ｄ］［２］ベンゾアゼピン−２−イル］アミノ｝−２−メトキシベンゾエートの結晶形
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN105209042B (zh) 2013-03-22 2019-03-08 米伦纽姆医药公司 催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018130A1 (fr) * 1993-12-28 1995-07-06 Meiji Seika Kabushiki Kaisha Derives tricycliques de benzazepine et benzothiazepine
JP3537446B2 (ja) * 1995-06-15 2004-06-14 明治製菓株式会社 三環性ベンゾアゼピン化合物
CN1084747C (zh) * 1996-03-08 2002-05-15 曾尼卡有限公司 作为神经活性剂的吡咯并苯并氮杂䓬衍生物
US20070059533A1 (en) * 2005-09-12 2007-03-15 Burdette Steven R Thermal reflow of glass and fused silica body

Also Published As

Publication number Publication date
RU2198885C2 (ru) 2003-02-20
AU9186998A (en) 1999-04-23
US20060074074A1 (en) 2006-04-06
JP3188482B2 (ja) 2001-07-16
NO20043765L (no) 2000-05-18
AU744636B2 (en) 2002-02-28
NO319542B1 (no) 2005-08-29
CN1312135C (zh) 2007-04-25
US6372735B1 (en) 2002-04-16
ES2191963T3 (es) 2003-09-16
EP1026167B1 (en) 2003-03-05
DE69811930D1 (de) 2003-04-10
EP1026167A1 (en) 2000-08-09
US7022860B2 (en) 2006-04-04
NO20001500D0 (no) 2000-03-23
HUP0004020A3 (en) 2002-12-28
HUP0004020A2 (hu) 2001-09-28
DE69811930T2 (de) 2003-12-18
ATE233764T1 (de) 2003-03-15
NO20001500L (no) 2000-05-18
TW510902B (en) 2002-11-21
CN1278262A (zh) 2000-12-27
ID24101A (id) 2000-07-06
KR20010030784A (ko) 2001-04-16
CN1523019A (zh) 2004-08-25
TR200000808T2 (tr) 2000-08-21
NZ503601A (en) 2002-02-01
CN1155599C (zh) 2004-06-30
SK4252000A3 (en) 2000-10-09
CA2305307C (en) 2004-11-30
US20020137739A1 (en) 2002-09-26
EP1026167A4 (en) 2001-07-11
KR100389140B1 (ko) 2003-06-25
HK1032782A1 (en) 2002-08-30
BR9814055B1 (pt) 2009-05-05
PT1026167E (pt) 2003-07-31
PL339544A1 (en) 2000-12-18
SK283869B6 (sk) 2004-03-02
DK1026167T3 (da) 2003-05-26
US7238812B2 (en) 2007-07-03
CA2305307A1 (en) 1999-04-08
IL135303A0 (en) 2001-05-20
WO1999016770A1 (fr) 1999-04-08

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.8: C07D 487/04, C07F 9/6561, A61K 31/55, C07D 249/04, C07C 69/738, C07C 59/76, A61P 37/08

Ipc: C07D 487/04 (2007.01), C07F 9/6561 (2007.01), A61K

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/07/2009, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: MEIJI SEIKA PHARMA CO., LTD. (JP)

Free format text: NOME ALTERADO DE: MEIJI SEIKA KAISHA, LTD.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2325 DE 28-07-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.