HUP0004020A2 - Triciklusos triazolo-benzazepin-származékok, eljárás a vegyületek előállítására és alkalmazásuk antiallergiás szerként - Google Patents

Triciklusos triazolo-benzazepin-származékok, eljárás a vegyületek előállítására és alkalmazásuk antiallergiás szerként

Info

Publication number
HUP0004020A2
HUP0004020A2 HU0004020A HUP0004020A HUP0004020A2 HU P0004020 A2 HUP0004020 A2 HU P0004020A2 HU 0004020 A HU0004020 A HU 0004020A HU P0004020 A HUP0004020 A HU P0004020A HU P0004020 A2 HUP0004020 A2 HU P0004020A2
Authority
HU
Hungary
Prior art keywords
producing
same
hydrogen
group
antiallergic agent
Prior art date
Application number
HU0004020A
Other languages
English (en)
Inventor
Kenichi Fushihara
Toyoaki Ishikura
Mami Kawaguchi
Hideo Kitagawa
Sachiko Miyamoto
Toshio Nishizuka
Yasuo Ohtsuka
Yumiko Okada
Maki Shiobara
Sohjiro Shiokawa
Takashi Shishikura
Hiromi Takata
Seiji Tsutsumi
Original Assignee
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Ltd. filed Critical Meiji Seika Kaisha, Ltd.
Publication of HUP0004020A2 publication Critical patent/HUP0004020A2/hu
Publication of HUP0004020A3 publication Critical patent/HUP0004020A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgya triciklusos triazolo-benzazepin-származékok egyprodrug formájában. A találmány szerinti vegyületek, farmakoló-giailag elfogadható sói és szolvátjai az (I) általános képletteljellemezhetők. A vegyületek hasznos antiallergiás szerek és kiválóbiohozzáférhetőséggel rendelkeznek. Az (I) általános képletben aszubsztituensek főbb jelentései: R1 jelentése hidrogénatom, hidroxil-,alkil- vagy fenil-alkilcsoport; R2, R3, R4 és R5 hidrogén- vagyhalogénatom, adott esetben védett hidroxil-, formil-, adott esetbenszubsztituált alkil-, alkenil- alkoxicsoport és R31, R32 jelentésehidrogénatom, adott esetben halogénatommal helyettesítettalkilcsoport, Q jelentése (i) - (iv) általános képletű csoport,halogénatom vagy alkoxicsoport. Ó
HU0004020A 1997-09-29 1998-09-29 Tricyclic triazolobenzazepine derivatives, process for producing the same, and their use as antiallergic agent HUP0004020A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26461197 1997-09-29
JP5206398 1998-03-04
PCT/JP1998/004363 WO1999016770A1 (fr) 1997-09-29 1998-09-29 Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique

Publications (2)

Publication Number Publication Date
HUP0004020A2 true HUP0004020A2 (hu) 2001-09-28
HUP0004020A3 HUP0004020A3 (en) 2002-12-28

Family

ID=26392670

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004020A HUP0004020A3 (en) 1997-09-29 1998-09-29 Tricyclic triazolobenzazepine derivatives, process for producing the same, and their use as antiallergic agent

Country Status (25)

Country Link
US (3) US6372735B1 (hu)
EP (1) EP1026167B1 (hu)
JP (1) JP3188482B2 (hu)
KR (1) KR100389140B1 (hu)
CN (2) CN1155599C (hu)
AT (1) ATE233764T1 (hu)
AU (1) AU744636B2 (hu)
BR (1) BR9814055B1 (hu)
CA (1) CA2305307C (hu)
DE (1) DE69811930T2 (hu)
DK (1) DK1026167T3 (hu)
ES (1) ES2191963T3 (hu)
HK (1) HK1032782A1 (hu)
HU (1) HUP0004020A3 (hu)
ID (1) ID24101A (hu)
IL (1) IL135303A0 (hu)
NO (2) NO319542B1 (hu)
NZ (1) NZ503601A (hu)
PL (1) PL339544A1 (hu)
PT (1) PT1026167E (hu)
RU (1) RU2198885C2 (hu)
SK (1) SK283869B6 (hu)
TR (1) TR200000808T2 (hu)
TW (1) TW510902B (hu)
WO (1) WO1999016770A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1275968C (zh) * 2001-12-26 2006-09-20 明治制果株式会社 三环型三唑并苯并氮杂䓬衍生物的非晶态物质
ES2283781T3 (es) 2002-02-01 2007-11-01 Meiji Seika Kaisha, Ltd. Procedimiento para producir un compuesto de 1,2,3-triazol.
WO2004004665A2 (en) 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
AU2003248861B2 (en) 2002-07-09 2009-01-22 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004113343A1 (ja) * 2003-06-19 2004-12-29 Meiji Seika Kaisha, Ltd. 三環性トリアゾロベンゾアゼピン誘導体の新規結晶性物質
WO2004113451A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難溶性物質と水溶性高分子との共沈物およびその製造方法
JP4467616B2 (ja) 2004-05-14 2010-05-26 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法
WO2007100079A1 (ja) 2006-03-02 2007-09-07 Meiji Seika Kaisha, Ltd. 三環性トリアゾロベンゾアゼピン誘導体を含有する、アレルギー性眼疾患またはアレルギー性鼻疾患の予防または治療剤
EP2094711B8 (de) * 2006-09-25 2018-03-28 Forschungsverbund Berlin e.V. Strukturmimetika prolinreicher peptide und ihre pharmazeutische verwendung
CL2007003244A1 (es) * 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
JP4343268B2 (ja) * 2007-12-18 2009-10-14 明治製菓株式会社 炎症性腸疾患の予防または治療剤
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
AU2010339691B2 (en) * 2010-01-07 2015-04-02 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
JP2013520424A (ja) 2010-02-19 2013-06-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド ナトリウム４−｛［９−クロロ−７−（２−フルオロ−６−メトキシフェニル）−５Ｈ−ピリミド［５，４−ｄ］［２］ベンゾアゼピン−２−イル］アミノ｝−２−メトキシベンゾエートの結晶形
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN105209042B (zh) 2013-03-22 2019-03-08 米伦纽姆医药公司 催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018130A1 (fr) * 1993-12-28 1995-07-06 Meiji Seika Kabushiki Kaisha Derives tricycliques de benzazepine et benzothiazepine
JP3537446B2 (ja) * 1995-06-15 2004-06-14 明治製菓株式会社 三環性ベンゾアゼピン化合物
CN1084747C (zh) * 1996-03-08 2002-05-15 曾尼卡有限公司 作为神经活性剂的吡咯并苯并氮杂䓬衍生物
US20070059533A1 (en) * 2005-09-12 2007-03-15 Burdette Steven R Thermal reflow of glass and fused silica body

Also Published As

Publication number Publication date
RU2198885C2 (ru) 2003-02-20
AU9186998A (en) 1999-04-23
US20060074074A1 (en) 2006-04-06
JP3188482B2 (ja) 2001-07-16
NO20043765L (no) 2000-05-18
AU744636B2 (en) 2002-02-28
NO319542B1 (no) 2005-08-29
CN1312135C (zh) 2007-04-25
US6372735B1 (en) 2002-04-16
ES2191963T3 (es) 2003-09-16
EP1026167B1 (en) 2003-03-05
BR9814055A (pt) 2000-09-26
DE69811930D1 (de) 2003-04-10
EP1026167A1 (en) 2000-08-09
US7022860B2 (en) 2006-04-04
NO20001500D0 (no) 2000-03-23
HUP0004020A3 (en) 2002-12-28
DE69811930T2 (de) 2003-12-18
ATE233764T1 (de) 2003-03-15
NO20001500L (no) 2000-05-18
TW510902B (en) 2002-11-21
CN1278262A (zh) 2000-12-27
ID24101A (id) 2000-07-06
KR20010030784A (ko) 2001-04-16
CN1523019A (zh) 2004-08-25
TR200000808T2 (tr) 2000-08-21
NZ503601A (en) 2002-02-01
CN1155599C (zh) 2004-06-30
SK4252000A3 (en) 2000-10-09
CA2305307C (en) 2004-11-30
US20020137739A1 (en) 2002-09-26
EP1026167A4 (en) 2001-07-11
KR100389140B1 (ko) 2003-06-25
HK1032782A1 (en) 2002-08-30
BR9814055B1 (pt) 2009-05-05
PT1026167E (pt) 2003-07-31
PL339544A1 (en) 2000-12-18
SK283869B6 (sk) 2004-03-02
DK1026167T3 (da) 2003-05-26
US7238812B2 (en) 2007-07-03
CA2305307A1 (en) 1999-04-08
IL135303A0 (en) 2001-05-20
WO1999016770A1 (fr) 1999-04-08

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