TR200000808T2 - Triscyklik triyazolobenzazepin türevler, bunları üretme süreci ve anti alerjik. - Google Patents
Triscyklik triyazolobenzazepin türevler, bunları üretme süreci ve anti alerjik.Info
- Publication number
- TR200000808T2 TR200000808T2 TR2000/00808T TR200000808T TR200000808T2 TR 200000808 T2 TR200000808 T2 TR 200000808T2 TR 2000/00808 T TR2000/00808 T TR 2000/00808T TR 200000808 T TR200000808 T TR 200000808T TR 200000808 T2 TR200000808 T2 TR 200000808T2
- Authority
- TR
- Turkey
- Prior art keywords
- triyazolobenzazepine
- derivatives
- triscyklik
- producing
- anti allergic
- Prior art date
Links
- 230000003266 anti-allergic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Bir ön ilaç biçiminde , trisiklik triyazolobenzazepin türevleri saglanmistir. Bu bulusa uygun bilesikler, asagidaki formül (I) ile temsil edilen bilesikler ve bunlarin, farmakolojik bakimdan uygun tuzlari ve solvatlaridir. Bu bulusun bilesikleri, antialerjik etkenler olarak yaralidir ve mükemmel biyolojik yararlilik göstermektedir. Formül (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26461197 | 1997-09-29 | ||
| JP5206398 | 1998-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000808T2 true TR200000808T2 (tr) | 2000-08-21 |
Family
ID=26392670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00808T TR200000808T2 (tr) | 1997-09-29 | 1998-09-29 | Triscyklik triyazolobenzazepin türevler, bunları üretme süreci ve anti alerjik. |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6372735B1 (tr) |
| EP (1) | EP1026167B1 (tr) |
| JP (1) | JP3188482B2 (tr) |
| KR (1) | KR100389140B1 (tr) |
| CN (2) | CN1155599C (tr) |
| AT (1) | ATE233764T1 (tr) |
| AU (1) | AU744636B2 (tr) |
| BR (1) | BR9814055B1 (tr) |
| CA (1) | CA2305307C (tr) |
| DE (1) | DE69811930T2 (tr) |
| DK (1) | DK1026167T3 (tr) |
| ES (1) | ES2191963T3 (tr) |
| HK (1) | HK1032782A1 (tr) |
| HU (1) | HUP0004020A3 (tr) |
| ID (1) | ID24101A (tr) |
| IL (1) | IL135303A0 (tr) |
| NO (2) | NO319542B1 (tr) |
| NZ (1) | NZ503601A (tr) |
| PL (1) | PL339544A1 (tr) |
| PT (1) | PT1026167E (tr) |
| RU (1) | RU2198885C2 (tr) |
| SK (1) | SK283869B6 (tr) |
| TR (1) | TR200000808T2 (tr) |
| TW (1) | TW510902B (tr) |
| WO (1) | WO1999016770A1 (tr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2312650T3 (es) | 2001-12-26 | 2009-03-01 | Meiji Seika Kaisha Ltd. | Nuevo derivado de triazolobenzazepina triciclica cristalina. |
| US7238719B2 (en) * | 2002-02-01 | 2007-07-03 | Meiji Seika Kaisha, Ltd. | Process for producing 1,2,3-Triazole compounds |
| KR101120337B1 (ko) | 2002-07-09 | 2012-02-29 | 브리스톨-마이어스 스큅 컴퍼니 | 항당뇨제 및 항비만제로서 유용한 치환된 헤테로시클릭유도체 및 방법 |
| PL374860A1 (en) | 2002-07-09 | 2005-11-14 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| EP1642900A1 (en) * | 2003-06-19 | 2006-04-05 | Meiji Seika Kaisha Ltd. | Tricyclic triazolobenzazepine derivative produced as novel crystalline substance |
| EP1650266A1 (en) * | 2003-06-20 | 2006-04-26 | Meiji Seika Kaisha Ltd. | Product of coprecipitation of sparingly soluble substance and water-soluble polymer and process for producing the same |
| ATE381566T1 (de) | 2004-05-14 | 2008-01-15 | Millennium Pharm Inc | Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase |
| WO2007100079A1 (ja) | 2006-03-02 | 2007-09-07 | Meiji Seika Kaisha, Ltd. | 三環性トリアゾロベンゾアゼピン誘導体を含有する、アレルギー性眼疾患またはアレルギー性鼻疾患の予防または治療剤 |
| US8242105B2 (en) * | 2006-09-25 | 2012-08-14 | Forschungsverbund Berlin E.V. | Structural mimetics of proline-rich peptides and the pharmaceutical use thereof |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| ES2360461T3 (es) * | 2007-12-18 | 2011-06-06 | Meiji Seika Kaisha Ltd. | Agente preventivo o terapéutico para enfermedad inflamatoria del intestino. |
| CN102264368B (zh) | 2008-12-22 | 2014-09-10 | 米伦纽姆医药公司 | 极光激酶抑制剂与抗cd20抗体的组合 |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
| JP6106437B2 (ja) | 2010-01-07 | 2017-03-29 | アルカーメス ファーマ アイルランド リミテッド | 複素芳香族化合物のプロドラッグ |
| JP2013520424A (ja) | 2010-02-19 | 2013-06-06 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | ナトリウム４−｛［９−クロロ−７−（２−フルオロ−６−メトキシフェニル）−５Ｈ−ピリミド［５，４−ｄ］［２］ベンゾアゼピン−２−イル］アミノ｝−２−メトキシベンゾエートの結晶形 |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| JP6360881B2 (ja) | 2013-03-22 | 2018-07-18 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 触媒的ｍｔｏｒｃ１／２阻害薬及びオーロラａキナーゼの選択的阻害薬の組合せ |
| EP3324976A4 (en) | 2015-07-21 | 2019-03-27 | Millennium Pharmaceuticals, Inc. | ADMINISTRATION OF KINASE AURORA INHIBITOR AND CHEMOTHERAPEUTIC AGENTS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686442A (en) | 1993-12-28 | 1997-11-11 | Meiji Seika Kabushiki Kaisha | Tricyclic benzazepine and benzothiazepine derivatives |
| WO1997000258A1 (fr) * | 1995-06-15 | 1997-01-03 | Meiji Seika Kabushiki Kaisha | Composes de benzazepine tricyclique |
| IL126095A0 (en) * | 1996-03-08 | 1999-05-09 | Zeneca Ltd | Azolobenzazepine derivatives as neurogically active agents |
| US20070059533A1 (en) * | 2005-09-12 | 2007-03-15 | Burdette Steven R | Thermal reflow of glass and fused silica body |
-
1998
- 1998-09-29 IL IL13530398A patent/IL135303A0/xx unknown
- 1998-09-29 JP JP51996999A patent/JP3188482B2/ja not_active Expired - Fee Related
- 1998-09-29 TW TW087116198A patent/TW510902B/zh not_active IP Right Cessation
- 1998-09-29 ID IDW20000808A patent/ID24101A/id unknown
- 1998-09-29 DE DE69811930T patent/DE69811930T2/de not_active Expired - Lifetime
- 1998-09-29 RU RU2000111517/04A patent/RU2198885C2/ru not_active IP Right Cessation
- 1998-09-29 NZ NZ503601A patent/NZ503601A/en unknown
- 1998-09-29 US US09/509,494 patent/US6372735B1/en not_active Expired - Lifetime
- 1998-09-29 SK SK425-2000A patent/SK283869B6/sk unknown
- 1998-09-29 CN CNB98810735XA patent/CN1155599C/zh not_active Expired - Fee Related
- 1998-09-29 PL PL98339544A patent/PL339544A1/xx unknown
- 1998-09-29 EP EP98944289A patent/EP1026167B1/en not_active Expired - Lifetime
- 1998-09-29 DK DK98944289T patent/DK1026167T3/da active
- 1998-09-29 WO PCT/JP1998/004363 patent/WO1999016770A1/ja not_active Application Discontinuation
- 1998-09-29 PT PT98944289T patent/PT1026167E/pt unknown
- 1998-09-29 ES ES98944289T patent/ES2191963T3/es not_active Expired - Lifetime
- 1998-09-29 AU AU91869/98A patent/AU744636B2/en not_active Ceased
- 1998-09-29 HU HU0004020A patent/HUP0004020A3/hu unknown
- 1998-09-29 KR KR10-2000-7003362A patent/KR100389140B1/ko not_active IP Right Cessation
- 1998-09-29 AT AT98944289T patent/ATE233764T1/de active
- 1998-09-29 CA CA002305307A patent/CA2305307C/en not_active Expired - Fee Related
- 1998-09-29 CN CNB2003101047539A patent/CN1312135C/zh not_active Expired - Fee Related
- 1998-09-29 BR BRPI9814055-8A patent/BR9814055B1/pt not_active IP Right Cessation
- 1998-09-29 TR TR2000/00808T patent/TR200000808T2/tr unknown
-
2000
- 2000-03-23 NO NO20001500A patent/NO319542B1/no unknown
-
2001
- 2001-05-22 HK HK01103502A patent/HK1032782A1/xx not_active IP Right Cessation
-
2002
- 2002-02-13 US US10/073,326 patent/US7022860B2/en not_active Expired - Fee Related
-
2004
- 2004-09-08 NO NO20043765A patent/NO20043765L/no not_active Application Discontinuation
-
2005
- 2005-11-09 US US11/269,828 patent/US7238812B2/en not_active Expired - Fee Related
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