AR028743A1 - DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA - Google Patents

DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA

Info

Publication number
AR028743A1
AR028743A1 ARP010102959A ARP010102959A AR028743A1 AR 028743 A1 AR028743 A1 AR 028743A1 AR P010102959 A ARP010102959 A AR P010102959A AR P010102959 A ARP010102959 A AR P010102959A AR 028743 A1 AR028743 A1 AR 028743A1
Authority
AR
Argentina
Prior art keywords
derivatives
triazolilmetil
piperazina
antagonist action
neuroquinine
Prior art date
Application number
ARP010102959A
Other languages
English (en)
Inventor
Daniel Jasserand
Uwe Schoen
Reinhard Brueckner
Christian Eeckhout
Holger Sann
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of AR028743A1 publication Critical patent/AR028743A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de N-triazolilmetil-piperazina con accion antagonista de receptores de neuroquinina de la formula general 1 en donde R1, R2 y R3 poseen los significados indicados en la memoria descriptiva, así como medicamentos que contienen a estos compuestos. Además, se describen procedimientos para la preparacion de los nuevos compuestos y productos intermedios de este procedimiento.
ARP010102959A 2000-07-28 2001-06-21 DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA AR028743A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10036818A DE10036818A1 (de) 2000-07-28 2000-07-28 Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (1)

Publication Number Publication Date
AR028743A1 true AR028743A1 (es) 2003-05-21

Family

ID=7650544

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102959A AR028743A1 (es) 2000-07-28 2001-06-21 DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA

Country Status (28)

Country Link
US (1) US6407106B1 (es)
EP (1) EP1176144B1 (es)
JP (1) JP2002053577A (es)
KR (1) KR100924405B1 (es)
CN (1) CN1167698C (es)
AR (1) AR028743A1 (es)
AT (1) ATE244716T1 (es)
AU (1) AU779318B2 (es)
BR (1) BR0103048A (es)
CA (1) CA2354213C (es)
CZ (1) CZ301695B6 (es)
DE (2) DE10036818A1 (es)
DK (1) DK1176144T3 (es)
DZ (1) DZ3119A1 (es)
ES (1) ES2201007T3 (es)
HK (1) HK1042699A1 (es)
HU (1) HU226687B1 (es)
IL (1) IL144299A (es)
IN (1) IN191021B (es)
NO (1) NO323233B1 (es)
NZ (1) NZ513041A (es)
PL (1) PL210436B1 (es)
PT (1) PT1176144E (es)
RU (1) RU2288918C2 (es)
SK (1) SK284802B6 (es)
TW (1) TWI304403B (es)
UA (1) UA73728C2 (es)
ZA (1) ZA200105737B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77515C2 (en) * 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
WO2003091227A1 (en) * 2002-04-26 2003-11-06 Eli Lilly And Company Tachykinin receptor antagonists
BRPI0309534B8 (pt) * 2002-04-26 2021-05-25 Lilly Co Eli derivados de triazol como antagonistas do receptor de taquicinina, seu uso, e composição farmacêutica
US20060160794A1 (en) * 2003-06-12 2006-07-20 Amegadzie Albert K Tachykinin receptor antagonists
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
AU2006274051B2 (en) * 2005-07-25 2012-03-22 F. Hoffmann-La Roche Ag Substituted triazole derivatives and their use as neurokinin 3 receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
US20100105688A1 (en) 2007-01-24 2010-04-29 Glaxo Group Limited Pharmaceutical compositions comprising 3,5-diamino-6-(2,3-dichlophenyl)-1,2,4-triazine or r(-)-2,4-diamino-5-(2,3-dichlorophenyl)-6-fluoromethyl pyrimidine and an nk1
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
EP3758688B1 (en) 2018-02-26 2024-03-27 Ospedale San Raffaele S.r.l. Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency
CN115184498B (zh) * 2022-07-15 2023-02-21 山东京卫制药有限公司 N-Boc-哌嗪中有关物质哌嗪的检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111730A (en) 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
US5883098A (en) 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
JP3071829B2 (ja) * 1995-05-25 2000-07-31 藤沢薬品工業株式会社 ニューロキニン受容体拮抗剤としての１−ベンゾイル−２−（インドリル−３−アルキル）−ピペラジン誘導体
GB9513118D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
HUP9901037A3 (en) * 1995-12-18 2001-11-28 Fujisawa Pharmaceutical Co Piperazine derivatives,preparation and use thereof, pharmaceutical compositions containing these compounds
KR100458346B1 (ko) * 1996-03-29 2005-06-21 듀파 인터내셔날 리서치 베 파우 피페라진및피페리딘화합물
AUPO735997A0 (en) * 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
DE59814233D1 (de) * 1997-08-27 2008-07-03 Solvay Pharm Gmbh Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Also Published As

Publication number Publication date
PL210436B1 (pl) 2012-01-31
HUP0102931A3 (en) 2003-07-28
AU779318B2 (en) 2005-01-13
PT1176144E (pt) 2003-11-28
CN1335316A (zh) 2002-02-13
HU0102931D0 (en) 2001-09-28
US20020065276A1 (en) 2002-05-30
IL144299A0 (en) 2002-05-23
DE50100358D1 (de) 2003-08-14
KR20020010482A (ko) 2002-02-04
NZ513041A (en) 2002-12-20
HUP0102931A2 (hu) 2002-11-28
NO20013709D0 (no) 2001-07-27
ZA200105737B (en) 2002-01-22
IL144299A (en) 2004-08-31
EP1176144B1 (de) 2003-07-09
UA73728C2 (en) 2005-09-15
IN191021B (es) 2003-09-13
DZ3119A1 (fr) 2004-09-19
CZ301695B6 (cs) 2010-05-26
CN1167698C (zh) 2004-09-22
DK1176144T3 (da) 2003-10-27
SK284802B6 (sk) 2005-11-03
JP2002053577A (ja) 2002-02-19
PL348946A1 (en) 2002-02-11
DE10036818A1 (de) 2002-02-07
ATE244716T1 (de) 2003-07-15
CZ20011813A3 (cs) 2002-03-13
CA2354213C (en) 2010-04-27
NO323233B1 (no) 2007-02-05
ES2201007T3 (es) 2004-03-16
AU5767501A (en) 2002-01-31
TWI304403B (en) 2008-12-21
NO20013709L (no) 2002-01-29
BR0103048A (pt) 2002-04-02
CA2354213A1 (en) 2002-01-28
US6407106B1 (en) 2002-06-18
KR100924405B1 (ko) 2009-10-29
HK1042699A1 (en) 2002-08-23
RU2288918C2 (ru) 2006-12-10
EP1176144A1 (de) 2002-01-30
SK7572001A3 (en) 2002-02-05
HU226687B1 (en) 2009-06-29

Similar Documents

Publication Publication Date Title
UY28946A1 (es) Compuestos de aril-y heteroaril-alquilanina que contienen pirazol, composiciones farmacéuticas que contienen los compuestos y nuevos productos químicos intermedios
UY28572A1 (es) Compuestos novedosos
UY27381A1 (es) 2-tio-3,5-diciano-4-fenil-6-aminopiridinas sustituidas y su uso
EA200300595A1 (ru) Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора
ECSP055671A (es) Nuevas quinazolinonas espirocondensadas y su uso como inhibidores de la fosfodiesteresa
ECSP066773A (es) Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la síntesis de los mismos
ECSP067077A (es) Derivados de pirrolopiridina y su uso como antagonistas de crth2
ES2195785B1 (es) Nuevos derivados de piridazin-3(2h)-ona.
HN1999000149A (es) Derivados de 4,4-biarilpiperidina
ECSP099394A (es) Derivados de quinuclidinol como antogonistas de receptores muscarínicos
UY27851A1 (es) Difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso.
AR028743A1 (es) DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA
ECSP034531A (es) Derivados sustituidos de c-ciclohexilmetilamina
AR021843A1 (es) Derivados de propanolamina sustituidos con heterociclos, procedimiento para su preparacion, y su utilizacion.
AR035570A1 (es) Derivados de isotiazol
UY27980A1 (es) Indoles 2,7-sustituidos
ECSP034754A (es) Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad
MXPA04006113A (es) Derivados de triazoloquinolina utiles como ligandos receptores de adenosina.
AR028947A1 (es) Compuestos novedosos
ECSP034532A (es) Derivados del 1-aminobutan-3-ol sustituido
UY26988A1 (es) Nuevas indolinonas sustituidas, su preparación y su utilización como medicamentos.
UY27770A1 (es) Imidazolinilmetil aralquilsulfonamidas
AR035247A1 (es) Derivados de piperidinacarboxamida, un procedimiento para su preparacion y las composiciones farmaceuticas que los contienen
TR200402546T4 (tr) Taksan türevleri hazırlamak için işlem.
HN2001000021A (es) Nuevos derivados de amidas heterociclicas

Legal Events

Date Code Title Description
FG Grant, registration