ECSP034754A - Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad - Google Patents

Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad

Info

Publication number
ECSP034754A
ECSP034754A EC2003004754A ECSP034754A ECSP034754A EC SP034754 A ECSP034754 A EC SP034754A EC 2003004754 A EC2003004754 A EC 2003004754A EC SP034754 A ECSP034754 A EC SP034754A EC SP034754 A ECSP034754 A EC SP034754A
Authority
EC
Ecuador
Prior art keywords
carbolina
anxiety
beta
derivatives
pharmaceutical use
Prior art date
Application number
EC2003004754A
Other languages
English (en)
Inventor
Konstanze Hurth
Thomas J Troxler
Daniel Hoyer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP034754A publication Critical patent/ECSP034754A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona compuestos de la fórmula I: en donde R1 a R5 son como se definen en la descripción, y su preparación. Los compuestos de la fórmula I son útiles como productos farmacéuticos
EC2003004754A 2001-04-03 2003-08-27 Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad ECSP034754A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0108337.7A GB0108337D0 (en) 2001-04-03 2001-04-03 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP034754A true ECSP034754A (es) 2003-10-28

Family

ID=9912165

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004754A ECSP034754A (es) 2001-04-03 2003-08-27 Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad

Country Status (27)

Country Link
US (1) US6861430B2 (es)
EP (1) EP1377578B1 (es)
JP (1) JP4405732B2 (es)
KR (1) KR100564840B1 (es)
CN (1) CN1309721C (es)
AR (1) AR035451A1 (es)
AT (1) ATE517104T1 (es)
AU (1) AU2002316828B2 (es)
BR (1) BR0208566B1 (es)
CA (1) CA2440014C (es)
CZ (1) CZ295992B6 (es)
EC (1) ECSP034754A (es)
ES (1) ES2368389T3 (es)
GB (1) GB0108337D0 (es)
HU (1) HUP0400317A3 (es)
IL (1) IL157545A0 (es)
MX (1) MXPA03009057A (es)
MY (1) MY134026A (es)
NO (1) NO20034413L (es)
NZ (1) NZ528370A (es)
PE (1) PE20021018A1 (es)
PL (1) PL210861B1 (es)
PT (1) PT1377578E (es)
RU (1) RU2003130644A (es)
SK (1) SK12222003A3 (es)
WO (1) WO2002081471A1 (es)
ZA (1) ZA200306108B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
JP4671123B2 (ja) * 2003-06-23 2011-04-13 小野薬品工業株式会社 新規三環性複素環化合物
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
DK1829874T3 (da) * 2004-12-22 2014-05-12 Ono Pharmaceutical Co Tricyklisk forbindelse og anvendelse deraf
US7879859B2 (en) 2005-11-21 2011-02-01 Merck Sharp & Dohme Corp. Diagnosis and treatment of type 2 diabetes and other disorders
US20070149557A1 (en) * 2005-11-21 2007-06-28 Amgen Inc. CXCR3 antagonists
AU2008276568A1 (en) * 2007-07-19 2009-01-22 Merck & Co., Inc. Beta carboline derivatives as antidiabetic compounds
WO2009016329A1 (en) * 2007-07-31 2009-02-05 Cambridge Enterprise Limited Use of gabaa receptor antagonists to treat cognitive impairment in patients with psychiatric conditions
EP2300466B1 (en) 2008-06-20 2014-08-06 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
ES2541528T3 (es) 2008-11-19 2015-07-21 Forum Pharmaceuticals Inc. Tratamiento de trastornos cognitivos con (R)-7-cloro-N-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y sales farmacéuticamente aceptables de la misma
TW201028414A (en) * 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
CN102695414A (zh) 2010-01-15 2012-09-26 默沙东公司 作为抗糖尿病化合物的噁二唑β-咔啉衍生物
JP5749797B2 (ja) 2010-05-17 2015-07-15 フォルム ファーマシューティカルズ、インコーポレイテッド （ｒ）−７−クロロ−ｎ−（キヌクリジン−３−イル）ベンゾ［ｂ］チオフェン−２−カルボキサミド塩酸塩一水和物の結晶形
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
CN111349096B (zh) * 2020-04-14 2021-03-09 石河子大学 一种吲哚类化合物及其制备方法、应用
KR102467844B1 (ko) 2021-04-21 2022-11-16 삼성전자주식회사 솔리드 스테이트 드라이브 장치 및 이를 포함하는 데이터 저장 장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4118741A1 (de) * 1991-06-05 1992-12-10 Schering Ag Neue hetaryloxy-(beta)-carboline, deren herstellung und verwendung in arzneimitteln
US6057340A (en) * 1998-02-03 2000-05-02 American Home Products Corporation Oxazole derivatives as serotonin-1A receptor agonists
NZ508765A (en) * 1998-06-12 2003-10-31 Sod Conseils Rech Applic Beta-carboline derivatives and pharmaceuticals thereof that selectively bind somatostatin receptor subtypes

Also Published As

Publication number Publication date
CZ295992B6 (cs) 2005-12-14
AU2002316828B2 (en) 2006-05-11
ATE517104T1 (de) 2011-08-15
CZ20032655A3 (cs) 2003-12-17
PL362571A1 (en) 2004-11-02
JP4405732B2 (ja) 2010-01-27
SK12222003A3 (sk) 2004-06-08
HUP0400317A2 (hu) 2004-09-28
HUP0400317A3 (en) 2007-10-29
JP2004525178A (ja) 2004-08-19
NZ528370A (en) 2005-10-28
ES2368389T3 (es) 2011-11-16
IL157545A0 (en) 2004-03-28
WO2002081471A1 (en) 2002-10-17
EP1377578B1 (en) 2011-07-20
US20040132735A1 (en) 2004-07-08
MXPA03009057A (es) 2004-02-12
MY134026A (en) 2007-11-30
NO20034413D0 (no) 2003-10-02
EP1377578A1 (en) 2004-01-07
CN1309721C (zh) 2007-04-11
CA2440014C (en) 2010-11-23
NO20034413L (no) 2003-10-02
RU2003130644A (ru) 2005-04-10
BR0208566B1 (pt) 2013-12-24
PT1377578E (pt) 2011-09-23
CN1500090A (zh) 2004-05-26
PE20021018A1 (es) 2003-01-13
GB0108337D0 (en) 2001-05-23
BR0208566A (pt) 2004-03-30
AR035451A1 (es) 2004-05-26
PL210861B1 (pl) 2012-03-30
ZA200306108B (en) 2004-07-05
CA2440014A1 (en) 2002-10-17
US6861430B2 (en) 2005-03-01
KR100564840B1 (ko) 2006-03-28
KR20040008150A (ko) 2004-01-28

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