ECSP067077A - Derivados de pirrolopiridina y su uso como antagonistas de crth2 - Google Patents
Derivados de pirrolopiridina y su uso como antagonistas de crth2Info
- Publication number
- ECSP067077A ECSP067077A EC2006007077A ECSP067077A ECSP067077A EC SP067077 A ECSP067077 A EC SP067077A EC 2006007077 A EC2006007077 A EC 2006007077A EC SP067077 A ECSP067077 A EC SP067077A EC SP067077 A ECSP067077 A EC SP067077A
- Authority
- EC
- Ecuador
- Prior art keywords
- pirrolopiridine
- derivatives
- crth2 antagonists
- crth2
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Abstract
De acuerdo con la invención, se proporcionan compuestos de Fórmula (I):en forma libre o de sal, donde R1, R2, R3, R4, R5, R6, Q, W, X, m, n y p son como se describen en la especificación, un proceso para su preparación, y su uso como productos farmacéuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0413619A GB0413619D0 (en) | 2004-06-17 | 2004-06-17 | Organic compounds |
GB0507693A GB0507693D0 (en) | 2005-04-15 | 2005-04-15 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP067077A true ECSP067077A (es) | 2007-01-26 |
Family
ID=35510318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006007077A ECSP067077A (es) | 2004-06-17 | 2006-12-12 | Derivados de pirrolopiridina y su uso como antagonistas de crth2 |
Country Status (29)
Country | Link |
---|---|
US (5) | US7666878B2 (es) |
EP (1) | EP1761529B3 (es) |
JP (1) | JP4886680B2 (es) |
KR (1) | KR101183330B1 (es) |
AR (1) | AR049443A1 (es) |
AT (1) | ATE378338T1 (es) |
AU (1) | AU2005254681B2 (es) |
BR (1) | BRPI0512060B8 (es) |
CA (1) | CA2569125C (es) |
CY (1) | CY1107851T1 (es) |
DE (1) | DE602005003365T3 (es) |
DK (1) | DK1761529T3 (es) |
EC (1) | ECSP067077A (es) |
ES (1) | ES2294717T7 (es) |
HK (1) | HK1103730A1 (es) |
HR (1) | HRP20080022T4 (es) |
IL (1) | IL179604A (es) |
MA (1) | MA28666B1 (es) |
MX (1) | MXPA06014694A (es) |
MY (1) | MY144903A (es) |
NO (1) | NO338319B1 (es) |
NZ (1) | NZ551439A (es) |
PE (1) | PE20060301A1 (es) |
PL (1) | PL1761529T6 (es) |
PT (1) | PT1761529E (es) |
RS (1) | RS50552B (es) |
RU (1) | RU2379309C2 (es) |
TW (1) | TWI352702B (es) |
WO (1) | WO2005123731A2 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY144903A (en) | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
GB0525144D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525143D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525337D0 (en) * | 2005-12-13 | 2006-01-18 | Novartis Ag | Organic compounds |
SI1986633T1 (sl) | 2006-02-10 | 2015-03-31 | Summit Corporation Plc | Zdravljenje Duchennove mišične distrofije |
GB0611695D0 (en) * | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
KR101411820B1 (ko) | 2006-08-07 | 2014-06-24 | 액테리온 파마슈티칼 리미티드 | (3-아미노-1,2,3,4-테트라하이드로-9h-카르바졸-9-일)-아세트산 유도체 |
JP2010535708A (ja) * | 2007-08-03 | 2010-11-25 | ビオマリン アイジーエー リミテッド | デュシェンヌ型筋ジストロフィーの治療のための薬物併用 |
GB0715937D0 (en) * | 2007-08-15 | 2007-09-26 | Vastox Plc | Method of treatment og duchenne muscular dystrophy |
WO2009102462A1 (en) * | 2008-02-15 | 2009-08-20 | Abbott Laboratories | Thienopyrroles and pyrrolothiazoles as new therapeutic agents |
JP5688366B2 (ja) | 2008-08-15 | 2015-03-25 | エヌサーティー・ファーマシューティカルズ・インコーポレーテッド | 治療薬剤としての、s−ニトロソグルタチオンレダクターゼの新規ピロール阻害剤 |
DK2315590T3 (da) | 2008-08-15 | 2012-11-19 | N30 Pharmaceuticals Inc | Pyrrolinhibitorer af S-nitrosoglutathionreduktase |
HUE031580T2 (en) | 2008-08-15 | 2017-07-28 | Nivalis Therapeutics Inc | New pyrrole inhibitors of S-nitrosoglutathion reductase as therapeutic agents |
BR112012024114B1 (pt) | 2010-03-22 | 2021-02-09 | Idorsia Pharmaceuticals Ltd | Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
MX2013007295A (es) * | 2010-12-23 | 2013-08-26 | Merck Sharp & Dohme | Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. |
WO2012087872A1 (en) | 2010-12-23 | 2012-06-28 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as crth2 receptor modulators |
AU2012241442B2 (en) | 2011-04-14 | 2017-01-12 | Idorsia Pharmaceuticals Ltd | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido(1,2-a)indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators |
EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
WO2013061977A1 (ja) | 2011-10-25 | 2013-05-02 | 塩野義製薬株式会社 | Pgd2受容体アンタゴニスト活性を有するへテロ環誘導体 |
MX2014007239A (es) | 2011-12-16 | 2014-08-08 | Atopix Therapeutics Ltd | Combinacion de un antagonista crth2 y un inhibidor de bomba de proton para el tratamiento de esofagitis eosinofilica. |
LT3119779T (lt) | 2014-03-17 | 2018-09-10 | Idorsia Pharmaceuticals Ltd | Azaindolo acto rūgšties dariniai ir jų panaudojimas kaip prostaglandino d2 receptoriaus moduliatorių |
TW201620909A (zh) | 2014-03-18 | 2016-06-16 | 艾克泰聯製藥有限公司 | 氮雜吲哚乙酸衍生物及彼等作為前列腺素d2受體調節劑之用途 |
WO2016020288A1 (en) | 2014-08-04 | 2016-02-11 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
US11091806B2 (en) | 2015-07-23 | 2021-08-17 | Merck Sharp & Dohme Corp. | Genetic markers associated with response to CRTH2 receptor antagonists |
MX2018003202A (es) | 2015-09-15 | 2018-06-08 | Idorsia Pharmaceuticals Ltd | Formas cristalinas. |
AU2016328150B2 (en) | 2015-09-23 | 2020-10-01 | Xw Laboratories Inc. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
ES2805307T3 (es) * | 2015-09-29 | 2021-02-11 | Novartis Ag | Procedimiento para preparar ácido 1-(4-metanosulfonil-2-trifluorometil-bencil)-2-metil-1H-pirrolo[2,3-b]piridin-3-il-acético |
WO2017210261A1 (en) * | 2016-05-31 | 2017-12-07 | Concert Pharmaceuticals, Inc. | Deuterated fevipiprant |
PL3730487T3 (pl) | 2016-06-13 | 2022-08-16 | Gilead Sciences, Inc. | Pochodne azetydyny jako modulatory fxr (nr1h4) |
CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
CN106188040B (zh) * | 2016-06-28 | 2018-03-23 | 浙江宏鑫染化材料有限公司 | 一种Fevipiprant及其中间体的制备方法 |
EP3489235A4 (en) | 2016-07-21 | 2020-01-08 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | TRICYCLIC COMPOUND AS A CRTH2 INHIBITOR |
JP6906626B2 (ja) | 2017-03-28 | 2021-07-21 | ギリアード サイエンシーズ, インコーポレイテッド | 肝疾患を処置するための治療的組み合わせ |
KR102378845B1 (ko) | 2017-03-30 | 2022-03-24 | 엑스더블유파마 리미티드 | 이환형 헤테로아릴 유도체 및 이의 제조 및 용도 |
JOP20190223A1 (ar) * | 2017-04-01 | 2019-09-26 | Novartis Ag | عملية لتحضير حمض 1-(4- ميثان سلفونيل -2- تراي فلورو ميثيل - بنزيل)-2- ميثيل -1h- بيرولو [2، 3-b] بيريدين -3- يل- أسيتيك |
EP3644989A4 (en) | 2017-06-30 | 2021-07-14 | The Regents of the University of California | HAIR GROWTH MODULATION COMPOSITIONS AND METHODS |
WO2019011336A1 (zh) * | 2017-07-14 | 2019-01-17 | 苏州科睿思制药有限公司 | Qaw-039的晶型及其制备方法和用途 |
WO2019130166A1 (en) * | 2017-12-26 | 2019-07-04 | Mankind Pharma Ltd. | Preparation of 2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoro methyl)phenyl]methyl] pyrrolo[2,3-b]pyridin-3-yl]acetic acid |
CA3088917A1 (en) | 2018-01-19 | 2019-07-25 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystal form of indole derivative and preparation method and use thereof |
CN110467612B (zh) * | 2018-05-09 | 2020-09-25 | 新发药业有限公司 | 一种前列腺素d2受体抑制剂化合物的简便制备方法 |
EP3856719B1 (en) | 2018-09-30 | 2023-06-07 | XWPharma Ltd. | Compounds as neuronal histamine receptor-3 antagonists and uses thereof |
AU2020209564B2 (en) | 2019-01-15 | 2022-12-01 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
JP2022519906A (ja) | 2019-02-19 | 2022-03-25 | ギリアード サイエンシーズ, インコーポレイテッド | Fxrアゴニストの固体形態 |
TW202136194A (zh) | 2019-12-20 | 2021-10-01 | 香港商凱瑞康寧有限公司 | 4-纈胺醯氧基丁酸的合成方法 |
EP4076657A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
MX2022012260A (es) | 2020-03-31 | 2022-11-30 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
CA3174176A1 (en) | 2020-03-31 | 2021-10-07 | Sanne Schroder Glad | Compounds active towards nuclear receptors |
US11357734B2 (en) | 2020-06-18 | 2022-06-14 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
CA3182394A1 (en) | 2020-06-18 | 2021-12-23 | Sami Karaborni | Controlled release granulations of water-soluble active pharmaceutical ingredients |
CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
KR20230058151A (ko) | 2020-10-05 | 2023-05-02 | 엑스더블유파마 리미티드 | 감마-하이드록시부티르산 유도체의 변형된 방출 조성물 |
AU2022238423A1 (en) | 2021-03-19 | 2023-10-19 | XWPharma Ltd. | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3320268A (en) * | 1964-08-14 | 1967-05-16 | Merck & Co Inc | 1-aroyl or heteroaroyl-7-azaindole-3-carboxylates and derivatives |
US5212195A (en) | 1992-05-13 | 1993-05-18 | Syntex (U.S.A.) Inc. | Substituted indole antagonists derivatives which are angiotensin II |
GB9319297D0 (en) | 1993-09-17 | 1993-11-03 | Wellcome Found | Indole derivatives |
EP0763035A4 (en) | 1994-06-09 | 1997-10-01 | Smithkline Beecham Corp | ENDOTHELIN RECEPTOR ANTAGONISTS |
PL181895B1 (pl) | 1994-06-16 | 2001-10-31 | Pfizer | Nowe pirazolo-i pirolopirydyny _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ PL PL PL PL |
TWI262920B (en) | 2000-10-27 | 2006-10-01 | Elbion Ag | New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them |
US7153852B2 (en) * | 2001-09-07 | 2006-12-26 | Ono Pharmaceutical Co., Ltd. | Indole compounds, process for producing the same and drugs containing the same as the active ingredient |
SE0200356D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
WO2003097598A1 (fr) * | 2002-05-16 | 2003-11-27 | Shionogi & Co., Ltd. | Composé comprenant un antagonisme du récepteur de pdg2 |
SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
WO2005040112A1 (en) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds with pgd2 antagonist activity |
GB0412914D0 (en) * | 2004-06-10 | 2004-07-14 | Oxagen Ltd | Compounds |
MY144903A (en) * | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
GB0525144D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525143D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525337D0 (en) * | 2005-12-13 | 2006-01-18 | Novartis Ag | Organic compounds |
-
2005
- 2005-06-14 MY MYPI20052685A patent/MY144903A/en unknown
- 2005-06-15 PE PE2005000686A patent/PE20060301A1/es active IP Right Grant
- 2005-06-15 AR ARP050102448A patent/AR049443A1/es active IP Right Grant
- 2005-06-16 DE DE602005003365T patent/DE602005003365T3/de active Active
- 2005-06-16 AU AU2005254681A patent/AU2005254681B2/en not_active Ceased
- 2005-06-16 TW TW094119931A patent/TWI352702B/zh not_active IP Right Cessation
- 2005-06-16 KR KR1020067026449A patent/KR101183330B1/ko active IP Right Grant
- 2005-06-16 EP EP05751627A patent/EP1761529B3/en active Active
- 2005-06-16 JP JP2007515886A patent/JP4886680B2/ja not_active Expired - Fee Related
- 2005-06-16 US US11/597,781 patent/US7666878B2/en active Active
- 2005-06-16 BR BRPI0512060A patent/BRPI0512060B8/pt not_active IP Right Cessation
- 2005-06-16 PT PT05751627T patent/PT1761529E/pt unknown
- 2005-06-16 RS RSP-2007/0507A patent/RS50552B/sr unknown
- 2005-06-16 ES ES05751627T patent/ES2294717T7/es active Active
- 2005-06-16 PL PL05751627T patent/PL1761529T6/pl unknown
- 2005-06-16 WO PCT/EP2005/006493 patent/WO2005123731A2/en active Application Filing
- 2005-06-16 RU RU2007101277/04A patent/RU2379309C2/ru active
- 2005-06-16 MX MXPA06014694A patent/MXPA06014694A/es active IP Right Grant
- 2005-06-16 NZ NZ551439A patent/NZ551439A/en not_active IP Right Cessation
- 2005-06-16 CA CA2569125A patent/CA2569125C/en active Active
- 2005-06-16 DK DK05751627T patent/DK1761529T3/da active
- 2005-06-16 AT AT05751627T patent/ATE378338T1/de active
-
2006
- 2006-11-27 IL IL179604A patent/IL179604A/en active IP Right Grant
- 2006-12-12 EC EC2006007077A patent/ECSP067077A/es unknown
- 2006-12-15 MA MA29535A patent/MA28666B1/fr unknown
-
2007
- 2007-01-17 NO NO20070323A patent/NO338319B1/no not_active IP Right Cessation
- 2007-07-24 HK HK07108031A patent/HK1103730A1/xx not_active IP Right Cessation
-
2008
- 2008-01-10 CY CY20081100039T patent/CY1107851T1/el unknown
- 2008-01-16 HR HR20080022T patent/HRP20080022T4/hr unknown
-
2010
- 2010-02-03 US US12/699,723 patent/US8455645B2/en active Active
- 2010-02-03 US US12/699,686 patent/US8470848B2/en active Active
-
2013
- 2013-06-05 US US13/910,769 patent/US8791256B2/en active Active
-
2014
- 2014-06-26 US US14/316,503 patent/US9169251B2/en active Active
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