BRPI0512060A - compostos orgánicos - Google Patents

compostos orgánicos

Info

Publication number
BRPI0512060A
BRPI0512060A BRPI0512060-8A BRPI0512060A BRPI0512060A BR PI0512060 A BRPI0512060 A BR PI0512060A BR PI0512060 A BRPI0512060 A BR PI0512060A BR PI0512060 A BRPI0512060 A BR PI0512060A
Authority
BR
Brazil
Prior art keywords
organic compounds
compounds
nep
pharmaceuticals
processes
Prior art date
Application number
BRPI0512060-8A
Other languages
English (en)
Inventor
Kamlesh Bala
Catherine Leblanc
David Andrew Sandham
Katharine Louise Turner
Simon James Watson
Lyndon Nigel Brown
Brian Cox
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0413619A external-priority patent/GB0413619D0/en
Priority claimed from GB0507693A external-priority patent/GB0507693D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0512060A publication Critical patent/BRPI0512060A/pt
Publication of BRPI0512060B1 publication Critical patent/BRPI0512060B1/pt
Publication of BRPI0512060B8 publication Critical patent/BRPI0512060B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS ORGáNICOS. A presente invenção refere-se a compostos de fórmula (l), em forma livre ou de sal, em que R¬ ¹¬,R¬ ²¬, R¬ ³¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, Q, W, X, m, n e p são tais como descritos no relatório descritivo, processos para a preparação deles, e o seu uso como produtos farmacêuticos.
BRPI0512060A 2004-06-17 2005-06-16 compostos orgânicos, composições farmacêuticas compreendendo os mesmos, bem como uso e processo de preparação dos referidos compostos BRPI0512060B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0413619.8 2004-06-17
GB0413619A GB0413619D0 (en) 2004-06-17 2004-06-17 Organic compounds
GB0507693A GB0507693D0 (en) 2005-04-15 2005-04-15 Organic compounds
GB0507693.0 2005-04-15
PCT/EP2005/006493 WO2005123731A2 (en) 2004-06-17 2005-06-16 Pyrrolopyridine derivatives and their use as crth2 antagonists

Publications (3)

Publication Number Publication Date
BRPI0512060A true BRPI0512060A (pt) 2008-02-06
BRPI0512060B1 BRPI0512060B1 (pt) 2018-08-07
BRPI0512060B8 BRPI0512060B8 (pt) 2021-05-25

Family

ID=35510318

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512060A BRPI0512060B8 (pt) 2004-06-17 2005-06-16 compostos orgânicos, composições farmacêuticas compreendendo os mesmos, bem como uso e processo de preparação dos referidos compostos

Country Status (29)

Country Link
US (5) US7666878B2 (pt)
EP (1) EP1761529B3 (pt)
JP (1) JP4886680B2 (pt)
KR (1) KR101183330B1 (pt)
AR (1) AR049443A1 (pt)
AT (1) ATE378338T1 (pt)
AU (1) AU2005254681B2 (pt)
BR (1) BRPI0512060B8 (pt)
CA (1) CA2569125C (pt)
CY (1) CY1107851T1 (pt)
DE (1) DE602005003365T3 (pt)
DK (1) DK1761529T3 (pt)
EC (1) ECSP067077A (pt)
ES (1) ES2294717T7 (pt)
HK (1) HK1103730A1 (pt)
HR (1) HRP20080022T4 (pt)
IL (1) IL179604A (pt)
MA (1) MA28666B1 (pt)
MX (1) MXPA06014694A (pt)
MY (1) MY144903A (pt)
NO (1) NO338319B1 (pt)
NZ (1) NZ551439A (pt)
PE (1) PE20060301A1 (pt)
PL (1) PL1761529T6 (pt)
PT (1) PT1761529E (pt)
RS (1) RS50552B (pt)
RU (1) RU2379309C2 (pt)
TW (1) TWI352702B (pt)
WO (1) WO2005123731A2 (pt)

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GB0525144D0 (en) * 2005-12-09 2006-01-18 Novartis Ag Organic compounds
GB0525337D0 (en) * 2005-12-13 2006-01-18 Novartis Ag Organic compounds
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CN115244028A (zh) 2019-12-20 2022-10-25 凯瑞康宁生物工程有限公司 4-缬氨酰氧基丁酸的合成方法
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US11780843B2 (en) 2020-03-31 2023-10-10 Nuevolution A/S Compounds active towards nuclear receptors
EP4126875A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors
CN115803017A (zh) 2020-06-18 2023-03-14 凯瑞康宁生物工程有限公司 水溶性活性药物成分的药物造粒物
KR20230011359A (ko) 2020-06-18 2023-01-20 엑스더블유파마 리미티드 수용성 활성 약제 성분의 제어 방출 과립화물
CN116261451A (zh) 2020-07-24 2023-06-13 凯瑞康宁生物工程有限公司 γ-羟基丁酸衍生物的药物组合物和药物动力学
JP2023544420A (ja) 2020-10-05 2023-10-23 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の調節放出組成物
JP2024511991A (ja) 2021-03-19 2024-03-18 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の組み合わされた放出製剤の薬物動態

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Also Published As

Publication number Publication date
US7666878B2 (en) 2010-02-23
AR049443A1 (es) 2006-08-02
EP1761529B1 (en) 2007-11-14
US20080114022A1 (en) 2008-05-15
US20140309254A1 (en) 2014-10-16
US20100210610A1 (en) 2010-08-19
TW200617009A (en) 2006-06-01
WO2005123731A3 (en) 2006-05-04
US20100204225A1 (en) 2010-08-12
ECSP067077A (es) 2007-01-26
CA2569125A1 (en) 2005-12-29
US9169251B2 (en) 2015-10-27
DK1761529T3 (da) 2008-03-25
BRPI0512060B1 (pt) 2018-08-07
ES2294717T7 (es) 2012-06-14
TWI352702B (en) 2011-11-21
PL1761529T3 (pl) 2008-04-30
RU2007101277A (ru) 2008-07-27
EP1761529A2 (en) 2007-03-14
DE602005003365D1 (de) 2011-01-05
AU2005254681B2 (en) 2009-01-29
EP1761529B3 (en) 2011-06-15
HRP20080022T4 (hr) 2011-10-31
CA2569125C (en) 2013-01-08
NZ551439A (en) 2009-09-25
US8455645B2 (en) 2013-06-04
JP2008502638A (ja) 2008-01-31
DE602005003365T2 (de) 2008-09-11
ATE378338T1 (de) 2007-11-15
BRPI0512060B8 (pt) 2021-05-25
MY144903A (en) 2011-11-30
PL1761529T6 (pl) 2011-11-30
RS50552B (sr) 2010-05-07
MA28666B1 (fr) 2007-06-01
PE20060301A1 (es) 2006-05-18
KR101183330B1 (ko) 2012-09-17
US8470848B2 (en) 2013-06-25
NO338319B1 (no) 2016-08-08
ES2294717T3 (es) 2008-04-01
PT1761529E (pt) 2008-02-11
AU2005254681A1 (en) 2005-12-29
IL179604A (en) 2014-04-30
HK1103730A1 (en) 2007-12-28
IL179604A0 (en) 2007-05-15
US20130267518A1 (en) 2013-10-10
CY1107851T1 (el) 2013-06-19
KR20070032694A (ko) 2007-03-22
WO2005123731A2 (en) 2005-12-29
MXPA06014694A (es) 2007-02-12
HRP20080022T3 (en) 2008-02-29
NO20070323L (no) 2007-03-12
JP4886680B2 (ja) 2012-02-29
RU2379309C2 (ru) 2010-01-20
DE602005003365T3 (de) 2012-08-30
US8791256B2 (en) 2014-07-29

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