ATE236148T1 - Synthese der terfenadin und deren derivate - Google Patents

Synthese der terfenadin und deren derivate

Info

Publication number
ATE236148T1
ATE236148T1 AT98901831T AT98901831T ATE236148T1 AT E236148 T1 ATE236148 T1 AT E236148T1 AT 98901831 T AT98901831 T AT 98901831T AT 98901831 T AT98901831 T AT 98901831T AT E236148 T1 ATE236148 T1 AT E236148T1
Authority
AT
Austria
Prior art keywords
terfenadine
synthesis
derivatives
processes
general formula
Prior art date
Application number
AT98901831T
Other languages
English (en)
Inventor
Chris Hugh Senanayake
Qun Kevin Fang
Scott Harold Wilkinson
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ATE236148T1 publication Critical patent/ATE236148T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT98901831T 1997-02-04 1998-01-20 Synthese der terfenadin und deren derivate ATE236148T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/803,895 US5925761A (en) 1997-02-04 1997-02-04 Synthesis of terfenadine and derivatives
PCT/US1998/000898 WO1998033789A1 (en) 1997-02-04 1998-01-20 Synthesis of terfenadine and derivatives

Publications (1)

Publication Number Publication Date
ATE236148T1 true ATE236148T1 (de) 2003-04-15

Family

ID=25187720

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98901831T ATE236148T1 (de) 1997-02-04 1998-01-20 Synthese der terfenadin und deren derivate

Country Status (11)

Country Link
US (2) US5925761A (de)
EP (1) EP0956286B1 (de)
JP (1) JP4330179B2 (de)
AT (1) ATE236148T1 (de)
AU (1) AU724665B2 (de)
CA (1) CA2279960C (de)
DE (1) DE69812895T2 (de)
DK (1) DK0956286T3 (de)
ES (1) ES2196531T3 (de)
PT (1) PT956286E (de)
WO (1) WO1998033789A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
IN191492B (de) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
CA2444456A1 (en) * 2001-04-09 2002-10-17 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
WO2003104197A1 (en) * 2002-06-10 2003-12-18 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
SK285548B6 (sk) * 2002-11-13 2007-03-01 Zentiva, A. S. Spôsob prípravy terfenadinu a jeho derivátov
MXPA06012281A (es) * 2004-04-26 2007-07-18 Teva Pharma Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion.
EP1685106A2 (de) * 2004-09-28 2006-08-02 Teva Pharmaceutical Industries, Inc. Fexofendadin-kristallform und verfahren zu deren herstellung
WO2007135693A2 (en) * 2006-05-18 2007-11-29 Ind-Swift Laboratories Limited Intermediates useful for the preparation of antihistaminic piperidine derivative
MEP8009A (en) 2006-09-15 2011-12-20 Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors
US7868200B2 (en) * 2008-12-30 2011-01-11 Lyondellbasell Flavors & Fragrances, Llc Process for preparing alicyclic carboxylic acid compounds
KR102233327B1 (ko) * 2013-12-26 2021-03-26 스미또모 가가꾸 가부시끼가이샤 할로겐 치환 프탈리드의 제조 방법
CN104876853B (zh) * 2015-06-17 2017-06-16 苏州卫生职业技术学院 盐酸非索非那定的合成方法
US10092087B2 (en) 2016-06-03 2018-10-09 Israel Harry Zimmerman Self-righting toothbrush
US10485330B2 (en) 2017-02-20 2019-11-26 Israel Harry Zimmerman Self-righting toothbrush
US10517386B2 (en) 2017-03-30 2019-12-31 Israel Harry Zimmerman Self-righting toothbrush
USD874832S1 (en) 2018-03-23 2020-02-11 Israel Harry Zimmerman Toothbrush handle
USD876097S1 (en) 2018-03-23 2020-02-25 Israel Harry Zimmerman Toothbrush handle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141024A (en) * 1964-07-14 S-trimethoxy benzoyl amino
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
EP0479601B1 (de) * 1990-10-05 1999-12-15 Ajinomoto Co., Inc. Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe
RO116043B1 (ro) * 1992-08-03 2000-10-30 Sepracor Inc Compozitie farmaceutica
WO1995000482A1 (en) * 1993-06-24 1995-01-05 Albany Molecular Research, Inc. Piperidine derivatives and process for their production
CN1159277C (zh) * 1993-06-25 2004-07-28 默里尔药物公司 用于制备抗组胺哌啶衍生物的新中间体
CA2189000C (en) * 1994-05-16 2002-08-13 Mitsuo Nakamura Process and diastereomeric salts useful for the optical resolution of racemic .alpha.-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol and derivative compounds

Also Published As

Publication number Publication date
DE69812895D1 (de) 2003-05-08
EP0956286A1 (de) 1999-11-17
DK0956286T3 (da) 2003-07-14
PT956286E (pt) 2003-08-29
AU724665B2 (en) 2000-09-28
EP0956286B1 (de) 2003-04-02
AU5826298A (en) 1998-08-25
US5925761A (en) 1999-07-20
WO1998033789A1 (en) 1998-08-06
CA2279960C (en) 2007-07-17
US6147217A (en) 2000-11-14
JP4330179B2 (ja) 2009-09-16
CA2279960A1 (en) 1998-08-06
JP2001511144A (ja) 2001-08-07
DE69812895T2 (de) 2004-04-22
ES2196531T3 (es) 2003-12-16

Similar Documents

Publication Publication Date Title
DE69812895D1 (de) Synthese der terfenadin und deren derivate
NO995846L (no) Oksazolidinon-antibakterielle midler med en tiokarbonylfunksjonalitet
AU1676200A (en) Polyhydroxylated heterocyclic derivatives as anti-coagulants
MY129613A (en) Cannabinoid receptor binding compounds
ATE270817T1 (de) Fungizide
ES2172864T3 (es) 2-metoxibenzofenonas fungicidas.
DE60042762D1 (de) Zwischenprodukte für die Herstellung von Harnstoffderivaten mit Muskarinrezeptor-antagonistischer Aktivität
DE69817802D1 (de) Substituierte phenylderivate, ihre herstellung und verwendung
SE9702773D0 (sv) Novel compounds
NO20025186D0 (no) FremgangsmÕte for syntese av en ecteinascidinforbindelse
DE69916582D1 (de) Synthese von zsm-48
ATE416185T1 (de) Sapogenin derivate, deren synthese und verwendung
MY122453A (en) Derivatives of benzoxadiazoles, benzothiadiazoles, benzotriazoles and quinoxalines
DE69912206D1 (de) Verbesserte Synthese von Haloformiminverbindungen
BR0209901A (pt) Processos para a sìntese de derivados de 2,3-dihidro-1,4-dioxino-[2,3-f] quinolina
MY136297A (en) Piperazine derivatives having sst1 antagonistic activity
BR0114380A (pt) Derivados-1-aminobutan-3-ol-substituìdos
ATE217308T1 (de) Chemische synthese von morpholinderivaten
TR200100286T2 (tr) (1H)-Benzo[C]kuinolizin-3-on türevlerinin sentezi için proses.
ATE196292T1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
TR200200017T2 (tr) Benzofuran türevleri
EE200000024A (et) Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine
ATE213236T1 (de) Substituierte benzyloxyimino-verbindungen
TR200001122T2 (tr) Farmasötikler olarak bifenil türevleri.
BG105247A (en) N-substituted azabicycloheptane derivatives, production and use thereof

Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
UEP Publication of translation of european patent specification

Ref document number: 0956286

Country of ref document: EP