BR0114380A - Derivados-1-aminobutan-3-ol-substituìdos - Google Patents

Derivados-1-aminobutan-3-ol-substituìdos

Info

Publication number
BR0114380A
BR0114380A BR0114380-8A BR0114380A BR0114380A BR 0114380 A BR0114380 A BR 0114380A BR 0114380 A BR0114380 A BR 0114380A BR 0114380 A BR0114380 A BR 0114380A
Authority
BR
Brazil
Prior art keywords
aminobutan
substituted derivatives
derivatives
substituted
pharmaceutical compounds
Prior art date
Application number
BR0114380-8A
Other languages
English (en)
Inventor
Helmut Buschmann
Maul
Corinna
Sundermann Bernard
Jagusch Utz-Peter
Haurand Michael
Chizh Boris
Original Assignee
Gr Nenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7658871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0114380(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gr Nenthal Gmbh filed Critical Gr Nenthal Gmbh
Publication of BR0114380A publication Critical patent/BR0114380A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

"DERIVADOS-1 -AMINOBUTAN-3-OL-SUBSTITUìDOS". A invenção se relaciona com derivados 1-aminobutan-3-ol substituídos , métodos para a produção, compostos farmacêuticos contendo ditos compostos e o uso de derivados-1-aminobutan-3-ol-substituídos para a produção dos compostos farmacêuticos.
BR0114380-8A 2000-09-29 2001-09-28 Derivados-1-aminobutan-3-ol-substituìdos BR0114380A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10049483A DE10049483A1 (de) 2000-09-29 2000-09-29 Substituierte 1-Aminobutan-3-ol-Derivate
PCT/EP2001/011231 WO2002028817A1 (de) 2000-09-29 2001-09-28 Substituierte 1-aminobutan-3-ol-derivate

Publications (1)

Publication Number Publication Date
BR0114380A true BR0114380A (pt) 2003-12-30

Family

ID=7658871

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0114381-6A BR0114381A (pt) 2000-09-29 2001-09-28 Derivados de 6-metil-tramadol o-substituìdos
BR0114380-8A BR0114380A (pt) 2000-09-29 2001-09-28 Derivados-1-aminobutan-3-ol-substituìdos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0114381-6A BR0114381A (pt) 2000-09-29 2001-09-28 Derivados de 6-metil-tramadol o-substituìdos

Country Status (29)

Country Link
US (2) US7022739B2 (pt)
EP (2) EP1322592B2 (pt)
JP (2) JP2004509939A (pt)
KR (2) KR100864796B1 (pt)
CN (2) CN1478067A (pt)
AR (1) AR034158A1 (pt)
AT (2) ATE272046T1 (pt)
AU (4) AU2057802A (pt)
BR (2) BR0114381A (pt)
CA (2) CA2423860A1 (pt)
DE (3) DE10049483A1 (pt)
DK (2) DK1322592T4 (pt)
EC (2) ECSP034530A (pt)
ES (2) ES2225628T3 (pt)
HK (2) HK1052924B (pt)
HU (2) HUP0303361A3 (pt)
IL (2) IL155106A0 (pt)
MX (2) MXPA03002737A (pt)
NO (2) NO20031387L (pt)
NZ (2) NZ524976A (pt)
PE (1) PE20020413A1 (pt)
PL (2) PL361632A1 (pt)
PT (2) PT1322593E (pt)
RU (2) RU2288219C2 (pt)
SI (2) SI1322592T1 (pt)
SK (2) SK3382003A3 (pt)
TR (2) TR200402030T4 (pt)
WO (2) WO2002028817A1 (pt)
ZA (2) ZA200303214B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
CA2463518A1 (en) 2001-10-16 2003-04-24 Endo Pharmaceuticals Inc. Carbinols for the treatment of neuropathic dysfunction
MXPA04006709A (es) * 2002-01-11 2004-10-04 Sankyo Co Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen.
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
US8128957B1 (en) 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
EP3241550B1 (de) 2002-11-22 2020-07-22 Grünenthal GmbH (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol zur behandlung von entzündungsschmerz
US7910617B2 (en) 2004-02-24 2011-03-22 Sankyo Company, Limited Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound
CN103936605B (zh) * 2007-05-31 2017-09-01 赛诺维信制药公司 苯基取代的环烷胺作为一元胺再摄取抑制剂
WO2010065893A1 (en) * 2008-12-05 2010-06-10 Arqule, Inc. Raf inhibitors and their uses
ES2343050B1 (es) * 2008-12-16 2011-06-14 Chemo Iberica, S.A. Procedimiento para la preparacion de desvenlafaxina y sus sales de adicion de acido farmaceuticamente aceptables.
WO2012100423A1 (en) 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
JP2019502761A (ja) * 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
ZA732238B (en) * 1972-04-06 1974-01-30 American Home Prod Benzylamine analgesics
US4155935A (en) * 1973-03-26 1979-05-22 American Home Products Corporation Benzylamine analgesics
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
US6017963A (en) * 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
DE19547766A1 (de) * 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
DE19609847A1 (de) † 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
US5919826A (en) * 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
US6245804B1 (en) * 1997-05-30 2001-06-12 Schering Aktiengesellschaft Nonsteroidal gestagens
DE69809055T2 (de) * 1997-07-15 2003-06-05 Russinsky Ltd Verfahren zur herstellung von reinem cis-tramadol
JP2002516302A (ja) * 1998-05-22 2002-06-04 マリンクロッド・インコーポレイテッド （ｒ＊，ｒ＊）−２−［（ジメチルアミノ）メチル］−１−（３−メトキシフェニル）シクロヘキサノール塩酸塩の改良合成および精製
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
DE19915601A1 (de) * 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
WO2001013904A2 (en) * 1999-08-20 2001-03-01 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and an anticonvulsant drug
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
US6339105B1 (en) * 1999-10-12 2002-01-15 Ortho-Mcneil Pharmaceutical, Inc. Analgesic regimen
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10048714A1 (de) * 2000-09-30 2002-04-11 Gruenenthal Gmbh 5-Amino-1-penlen-3-ol-Derivate
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (en) * 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof

Also Published As

Publication number Publication date
CA2423903A1 (en) 2003-03-27
WO2002028817A1 (de) 2002-04-11
ECSP034530A (es) 2003-05-26
PT1322592E (pt) 2004-12-31
EP1322593A1 (de) 2003-07-02
IL155106A0 (en) 2003-10-31
CN100391933C (zh) 2008-06-04
AR034158A1 (es) 2004-02-04
DE50103035D1 (de) 2004-09-02
PL361632A1 (en) 2004-10-04
ZA200303214B (en) 2004-08-31
HUP0303361A3 (en) 2007-03-28
TR200402230T4 (tr) 2004-10-21
MXPA03002738A (es) 2004-01-26
SK3402003A3 (en) 2003-09-11
HUP0303195A3 (en) 2007-03-28
CN1466567A (zh) 2004-01-07
ES2225628T3 (es) 2005-03-16
WO2002026694A1 (de) 2002-04-04
US20030216393A1 (en) 2003-11-20
ATE272045T1 (de) 2004-08-15
ZA200303220B (en) 2004-08-19
KR20030059160A (ko) 2003-07-07
DK1322592T4 (da) 2009-10-12
US6828345B2 (en) 2004-12-07
BR0114381A (pt) 2003-12-30
NZ525171A (en) 2006-02-24
AU2002220578B2 (en) 2006-11-30
PL361382A1 (en) 2004-10-04
KR100864796B1 (ko) 2008-10-23
DK1322592T3 (da) 2004-11-22
PE20020413A1 (es) 2002-05-18
ECSP034532A (es) 2003-05-26
CN1478067A (zh) 2004-02-25
CA2423860A1 (en) 2003-03-27
NO20031382L (no) 2003-05-16
KR20030077531A (ko) 2003-10-01
AU2001289937B2 (en) 2007-01-18
HK1052925B (zh) 2005-04-01
AU2057802A (en) 2002-04-08
RU2286334C2 (ru) 2006-10-27
NO20031382D0 (no) 2003-03-26
KR100835549B1 (ko) 2008-06-09
RU2288219C2 (ru) 2006-11-27
EP1322592B1 (de) 2004-07-28
EP1322592A1 (de) 2003-07-02
DE10049483A1 (de) 2002-05-02
SI1322592T1 (en) 2005-02-28
HUP0303361A2 (hu) 2004-03-01
ES2225605T5 (es) 2009-11-18
HK1052924A1 (en) 2003-10-03
NO20031387D0 (no) 2003-03-26
JP2004510755A (ja) 2004-04-08
EP1322592B2 (de) 2009-06-17
HK1052924B (zh) 2005-03-24
PT1322593E (pt) 2004-12-31
MXPA03002737A (es) 2004-01-26
EP1322593B1 (de) 2004-07-28
JP2004509939A (ja) 2004-04-02
IL155105A0 (en) 2003-10-31
ATE272046T1 (de) 2004-08-15
NZ524976A (en) 2005-01-28
AU8993701A (en) 2002-04-15
HUP0303195A2 (hu) 2003-12-29
NO20031387L (no) 2003-05-21
ES2225605T3 (es) 2005-03-16
SK286727B6 (sk) 2009-04-06
SK3382003A3 (en) 2003-08-05
DE50103036D1 (de) 2004-09-02
US20030220389A1 (en) 2003-11-27
DK1322593T3 (da) 2004-10-11
SI1322593T1 (en) 2004-12-31
HK1052925A1 (en) 2003-10-03
US7022739B2 (en) 2006-04-04
TR200402030T4 (tr) 2004-09-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2125 DE 27/09/2011.