BRPI0113162B8 - compostos ariloxialquilaminas nao-imidazólicos e composição farmacêutica compreendendo os referidos compostos - Google Patents

compostos ariloxialquilaminas nao-imidazólicos e composição farmacêutica compreendendo os referidos compostos

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Publication number
BRPI0113162B8
BRPI0113162B8 BRPI0113162A BR0113162A BRPI0113162B8 BR PI0113162 B8 BRPI0113162 B8 BR PI0113162B8 BR PI0113162 A BRPI0113162 A BR PI0113162A BR 0113162 A BR0113162 A BR 0113162A BR PI0113162 B8 BRPI0113162 B8 BR PI0113162B8
Authority
BR
Brazil
Prior art keywords
compounds
imidazole
aryloxyalkylamine
pharmaceutical composition
aryloxyalkylamines
Prior art date
Application number
BRPI0113162A
Other languages
English (en)
Other versions
BRPI0113162B1 (pt
BR0113162A (pt
Inventor
R Shah Chandravadan
A Dvorak Curt
A Rudolph Dale
I Carruthers Nicholas
Apodaca Richard
Xiao Wei
Original Assignee
Johnson & Johnson
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson, Ortho Mcneil Pharm Inc filed Critical Johnson & Johnson
Publication of BR0113162A publication Critical patent/BR0113162A/pt
Publication of BRPI0113162B1 publication Critical patent/BRPI0113162B1/pt
Publication of BRPI0113162B8 publication Critical patent/BRPI0113162B8/pt

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/40—Oxygen atoms
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Abstract

"ariloxialquilaminas não-imidazol". a presente invenção refere-se a ariloxialquilaminas substituídas da fórmula (i), composições contendo-as e métodos de fabricação e uso delas para tratar condições mediadas por histamina.
BRPI0113162A 2000-08-08 2001-08-06 compostos ariloxialquilaminas nao-imidazólicos e composição farmacêutica compreendendo os referidos compostos BRPI0113162B8 (pt)

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US09/922,631 US7186732B2 (en) 2000-08-08 2001-08-06 Non-imidazole aryloxyalkylamines
PCT/US2001/024655 WO2002012214A2 (en) 2000-08-08 2001-08-06 Non-imidazole aryloxyalkylamines as h3 receptor ligands

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PL360886A1 (en) 2004-09-20
US20100004241A1 (en) 2010-01-07
KR20030038692A (ko) 2003-05-16
EP1313721B1 (en) 2006-03-08
JP2004505960A (ja) 2004-02-26
US20020065278A1 (en) 2002-05-30
HK1053110A1 (zh) 2003-10-10
ES2260276T3 (es) 2006-11-01
BRPI0113162B1 (pt) 2016-06-28
HUP0302959A2 (hu) 2003-12-29
AU8473301A (en) 2002-02-18
WO2002012214A2 (en) 2002-02-14
BR0113162A (pt) 2004-04-06
ATE319696T1 (de) 2006-03-15
WO2002012214A3 (en) 2002-06-20
US7429586B2 (en) 2008-09-30
EP1313721A2 (en) 2003-05-28
CA2418369A1 (en) 2002-02-14
KR100819381B1 (ko) 2008-04-04
HUP0302959A3 (en) 2006-04-28
DE60117814T2 (de) 2006-11-02
JP5279161B2 (ja) 2013-09-04
HU230055B1 (hu) 2015-06-29
US20060235049A1 (en) 2006-10-19
CN1468227A (zh) 2004-01-14
CZ2003685A3 (cs) 2003-08-13
US7186732B2 (en) 2007-03-06
DE60117814D1 (de) 2006-05-04
MXPA03001267A (es) 2004-07-30
US20080306085A1 (en) 2008-12-11
AU2001284733B2 (en) 2006-11-02
PT1313721E (pt) 2006-06-30
DK1313721T3 (da) 2006-06-26

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