FR2708609B1 - Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant. - Google Patents

Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant.

Info

Publication number
FR2708609B1
FR2708609B1 FR9309362A FR9309362A FR2708609B1 FR 2708609 B1 FR2708609 B1 FR 2708609B1 FR 9309362 A FR9309362 A FR 9309362A FR 9309362 A FR9309362 A FR 9309362A FR 2708609 B1 FR2708609 B1 FR 2708609B1
Authority
FR
France
Prior art keywords
processes
preparation
compositions containing
methylguanidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9309362A
Other languages
English (en)
Other versions
FR2708609A1 (fr
Inventor
Lucchetti Jean
Rinaldi Murielle
Pialot Francoise
Merschaert Alain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elf Sanofi SA
Original Assignee
Elf Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9309362A priority Critical patent/FR2708609B1/fr
Application filed by Elf Sanofi SA filed Critical Elf Sanofi SA
Priority to JP7505627A priority patent/JPH09500895A/ja
Priority to EP94923764A priority patent/EP0711290A1/fr
Priority to PCT/FR1994/000962 priority patent/WO1995004052A1/fr
Priority to ZA945597A priority patent/ZA945597B/xx
Priority to AU73870/94A priority patent/AU7387094A/en
Priority to IL11048094A priority patent/IL110480A0/xx
Priority to HU9600179A priority patent/HUT75118A/hu
Publication of FR2708609A1 publication Critical patent/FR2708609A1/fr
Application granted granted Critical
Publication of FR2708609B1 publication Critical patent/FR2708609B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
FR9309362A 1993-07-29 1993-07-29 Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant. Expired - Fee Related FR2708609B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR9309362A FR2708609B1 (fr) 1993-07-29 1993-07-29 Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant.
EP94923764A EP0711290A1 (fr) 1993-07-29 1994-07-28 Derives de methylguanidine, leurs procedes de preparation ainsi que les compositions en contenant
PCT/FR1994/000962 WO1995004052A1 (fr) 1993-07-29 1994-07-28 Derives de methylguanidine, leurs procedes de preparation ainsi que les compositions en contenant
ZA945597A ZA945597B (en) 1993-07-29 1994-07-28 Methyiguanidine derivatives process for their preparation and the compositions containing them
JP7505627A JPH09500895A (ja) 1993-07-29 1994-07-28 メチルグアニジン誘導体、その製造方法およびそれを含有する組成物
AU73870/94A AU7387094A (en) 1993-07-29 1994-07-28 Methylguanidine derivatives, methods for preparing same and compositions containing said derivatives
IL11048094A IL110480A0 (en) 1993-07-29 1994-07-28 Methylguanidine derivatives, their preparation and pharmaceutical compositions containing them
HU9600179A HUT75118A (en) 1993-07-29 1994-07-28 Methylguanidine derivatives, methods for preparing same and compositions containing said derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9309362A FR2708609B1 (fr) 1993-07-29 1993-07-29 Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant.

Publications (2)

Publication Number Publication Date
FR2708609A1 FR2708609A1 (fr) 1995-02-10
FR2708609B1 true FR2708609B1 (fr) 1995-10-20

Family

ID=9449769

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9309362A Expired - Fee Related FR2708609B1 (fr) 1993-07-29 1993-07-29 Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant.

Country Status (8)

Country Link
EP (1) EP0711290A1 (fr)
JP (1) JPH09500895A (fr)
AU (1) AU7387094A (fr)
FR (1) FR2708609B1 (fr)
HU (1) HUT75118A (fr)
IL (1) IL110480A0 (fr)
WO (1) WO1995004052A1 (fr)
ZA (1) ZA945597B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19547263C2 (de) * 1995-12-07 1999-04-29 Cardiotec Inc Amidinohydrazone vom Benzo[b]furan abgeleiteter Ketone, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
WO2002012224A2 (fr) * 2000-08-08 2002-02-14 Ortho Mcneil Pharmaceutical, Inc. Composes bicycliques
PT1311482E (pt) 2000-08-08 2007-04-30 Ortho Mcneil Pharm Inc Ariloxipiperidinas não imidazólicas como ligandos do receptor h3
WO2002012214A2 (fr) 2000-08-08 2002-02-14 Ortho Mcneil Pharmaceutical Inc. Aryloxyalkylamines exemptes de fraction imidazole
US6969730B2 (en) 2001-03-16 2005-11-29 Abbott Laboratories Amines as histamine-3 receptor ligands and their therapeutic applications
FR2846882A1 (fr) * 2002-09-05 2004-05-14 Oreal Utilisation d'une amine phenylee secondaire ou tertiaire pour lisser les rides et ridules
WO2005035534A1 (fr) * 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. Composes a anneau bicyclique heterocyclique et a anneau tricyclique heterocyclique et medicaments les contenant
TW200806290A (en) 2006-01-25 2008-02-01 Synta Pharmaceuticals Corp Substituted biaryl compounds for inflammation and immune-related uses
JP5376451B2 (ja) 2006-05-17 2013-12-25 エッペンドルフ アレイ テクノロジーズ エス．アー． 複数の（微）生物又はそれらの成分の同定及び定量
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
US9475806B2 (en) 2013-03-14 2016-10-25 Novartis Ag Complement factor B inhibitors and uses there of
EP3089963A1 (fr) 2013-10-30 2016-11-09 Novartis AG Inhibiteurs du facteur b du complément à base de 2-benzyl-benzimidazole et leurs utilisations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1148214A (en) * 1965-11-26 1969-04-10 Ward Blenkinsop & Co Ltd Heterocyclic guanidine derivatives
US3855242A (en) * 1967-12-15 1974-12-17 Aspro Nicholas Ltd Benzo{8 b{9 thienyl-alkyl-guanidines
US3700697A (en) * 1968-04-22 1972-10-24 Sterling Drug Inc (2,3-dihydro-2-benzofuranylmethyl) guanidines and their preparation
IT1154888B (it) * 1980-11-12 1987-01-21 Menarini Sas Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione

Also Published As

Publication number Publication date
FR2708609A1 (fr) 1995-02-10
HUT75118A (en) 1997-04-28
IL110480A0 (en) 1994-10-21
ZA945597B (en) 1996-01-29
JPH09500895A (ja) 1997-01-28
WO1995004052A1 (fr) 1995-02-09
AU7387094A (en) 1995-02-28
EP0711290A1 (fr) 1996-05-15

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