BR0209127A - compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos - Google Patents

compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos

Info

Publication number
BR0209127A
BR0209127A BRPI0209127-5A BR0209127A BR0209127A BR 0209127 A BR0209127 A BR 0209127A BR 0209127 A BR0209127 A BR 0209127A BR 0209127 A BR0209127 A BR 0209127A
Authority
BR
Brazil
Prior art keywords
compounds
methods
modulating
pharmaceutical compositions
pharmacological response
Prior art date
Application number
BRPI0209127-5A
Other languages
English (en)
Inventor
R Richard Goehring
Donald Kyle
Gary Lee
Parviz Gharagozloo
Sam Victory
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of BR0209127A publication Critical patent/BR0209127A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

"COMPOSTOS, COMPOSIçõES FARMACêUTICAS, MéTODOS PARA O TRATAMENTO DE DORES, MéTODOS PARA A MODULAçãO DE UMA RESPOSTA FARMACOLóGICA E USOS DE COMPOSTOS". Composto de fórmula (I) em que Z, W, A, B, C, R~ 1~, R~ 2~, Q e n são conforme descritos na presente invenção.
BRPI0209127-5A 2001-04-18 2002-04-18 compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos BR0209127A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18
PCT/US2002/012376 WO2002085355A1 (en) 2001-04-18 2002-04-18 Spiropyrazole compounds

Publications (1)

Publication Number Publication Date
BR0209127A true BR0209127A (pt) 2006-03-21

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0209127-5A BR0209127A (pt) 2001-04-18 2002-04-18 compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos

Country Status (28)

Country Link
US (2) US6635653B2 (pt)
EP (1) EP1385515B1 (pt)
JP (1) JP4342181B2 (pt)
KR (1) KR100628292B1 (pt)
CN (1) CN1516584A (pt)
AT (1) ATE403429T1 (pt)
AU (1) AU2002311833B2 (pt)
BR (1) BR0209127A (pt)
CA (1) CA2444634C (pt)
CY (1) CY1108454T1 (pt)
CZ (1) CZ20032849A3 (pt)
DE (1) DE60228071D1 (pt)
DK (1) DK1385515T3 (pt)
ES (1) ES2312584T3 (pt)
HK (1) HK1062885A1 (pt)
HU (1) HUP0401333A3 (pt)
IL (2) IL158485A0 (pt)
MX (1) MXPA03009604A (pt)
NO (1) NO20034660L (pt)
NZ (1) NZ528978A (pt)
PL (1) PL367263A1 (pt)
PT (1) PT1385515E (pt)
RU (1) RU2299883C2 (pt)
SI (1) SI1385515T1 (pt)
UA (1) UA74439C2 (pt)
WO (1) WO2002085355A1 (pt)
YU (1) YU82403A (pt)
ZA (1) ZA200308103B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU82403A (sh) * 2001-04-18 2006-08-17 Euroceltique S.A. Jedinjenja spiropirazola
WO2003082333A1 (fr) 2002-03-29 2003-10-09 Mitsubishi Pharma Corporation Remede contre les troubles du sommeil
RS20050208A (en) 2002-09-09 2007-08-03 Janssen Pharmaceutica N.V., Hydroxy alkyl substituted 1,3,8- triazaspiro/4,5/decan-4- one derivatives useful for the treatment of orl-1 receptor mediated disorders
JP2006503093A (ja) * 2002-10-17 2006-01-26 ユーロ−セルティーク エス．エイ． トリアゾスピロ化合物の調製
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
WO2004103305A2 (en) * 2003-05-16 2004-12-02 Euroceltique S.A. Spiropyrazole compound
WO2005011665A1 (en) * 2003-07-22 2005-02-10 Arakis Ltd. The use of proglumide for the treatment of emesis
US20100173864A1 (en) * 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20110008327A1 (en) * 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
DK2574341T3 (en) 2004-03-29 2017-06-26 Univ South Florida Effective treatment of tumors and cancer with triciribin phosphate
US8604200B2 (en) 2005-03-08 2013-12-10 Janssen Pharmaceutica N.V. Diaza-spiro-{4,4}-nonane derivatives as neurokinin (NK1) antagonists
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
EP2102206B1 (en) 2006-11-28 2015-04-08 Janssen Pharmaceutica NV Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
CN101595100B (zh) 2007-01-16 2014-06-11 普渡制药公司 作为orl-1配体的杂环取代的哌啶
EP2150552B1 (en) 2007-04-09 2013-01-02 Janssen Pharmaceutica NV 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
EP2433937B1 (en) 2007-08-31 2016-06-29 Purdue Pharma LP Substituted-quinoxaline-type-piperidine compounds and the uses thereof
PT2324013E (pt) 2008-07-21 2012-12-24 Purdue Pharma Lp Compostos de piperidina ligados por pontes do tipo de quinoxalina substituída e as respectivas utilizações
UA107943C2 (en) * 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors
JP5872585B2 (ja) 2010-12-22 2016-03-01 パーデュー、ファーマ、リミテッド、パートナーシップ リン置換キノキサリンタイプピペリジン化合物とその使用
EP2797912B1 (en) 2011-12-01 2016-05-25 Purdue Pharma L.P. Azetidine-substituted quinoxaline-type piperidine compounds and uses thereof
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9040533B2 (en) 2012-12-27 2015-05-26 Purdue Pharma L.P. Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
WO2014102594A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102589A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Quinazolin-4(3h)-one-type piperidine compounds and uses thereof
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
WO2014102590A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB157497A (pt) *
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
US3325499A (en) 1964-11-02 1967-06-13 Mcneilab Inc 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone
US3923993A (en) * 1973-06-28 1975-12-02 American Home Prod Process for treating neuroendocrinopathic diseases employing fluspirilene
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
US4410528A (en) 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
JPS60120872A (ja) 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
EP0755392A4 (en) 1994-04-14 1997-05-02 Merck & Co Inc ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS
FR2722190B1 (fr) 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
US5767118A (en) 1994-10-26 1998-06-16 Merck & Co., Inc. 4-Heterocyclic peperidines promote release of growth hormone
US5574044A (en) 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
WO1997010213A1 (fr) 1995-09-13 1997-03-20 Kyowa Hakko Kogyo Co., Ltd. Derives de phenylpiperidine
ATE341542T1 (de) 1996-04-19 2006-10-15 Neurosearch As 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität
US6063796A (en) 1997-04-04 2000-05-16 Merck & Co., Inc. Somatostatin agonists
CA2291094C (en) 1997-05-30 2008-02-26 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivative
JPH10330377A (ja) 1997-06-02 1998-12-15 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
SI0921125T1 (en) 1997-12-05 2002-04-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
ES2175925T3 (es) 1998-01-19 2002-11-16 Pfizer Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orl1.
US6410561B1 (en) 1998-03-26 2002-06-25 Japan Tobacco Inc. Amide derivatives and nociceptin antagonists
EP1080091A1 (en) 1998-05-18 2001-03-07 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
CN1212839C (zh) 2000-09-06 2005-08-03 奥索-麦克尼尔药品公司 取代的吡唑在制备用于治疗变态反应的药物方面的用途
YU82403A (sh) * 2001-04-18 2006-08-17 Euroceltique S.A. Jedinjenja spiropirazola

Also Published As

Publication number Publication date
NZ528978A (en) 2004-06-25
JP4342181B2 (ja) 2009-10-14
NO20034660D0 (no) 2003-10-17
US20040087641A1 (en) 2004-05-06
KR20040008159A (ko) 2004-01-28
US20030027834A1 (en) 2003-02-06
NO20034660L (no) 2003-12-17
ES2312584T3 (es) 2009-03-01
JP2004531531A (ja) 2004-10-14
ATE403429T1 (de) 2008-08-15
RU2003133455A (ru) 2005-05-10
HK1062885A1 (en) 2004-12-03
KR100628292B1 (ko) 2006-09-27
IL158485A (en) 2009-09-01
CA2444634A1 (en) 2002-10-31
MXPA03009604A (es) 2004-04-02
IL158485A0 (en) 2004-05-12
CN1516584A (zh) 2004-07-28
RU2299883C2 (ru) 2007-05-27
DE60228071D1 (de) 2008-09-18
EP1385515B1 (en) 2008-08-06
CA2444634C (en) 2011-06-07
PL367263A1 (en) 2005-02-21
YU82403A (sh) 2006-08-17
WO2002085355A1 (en) 2002-10-31
UA74439C2 (uk) 2005-12-15
ZA200308103B (en) 2004-10-18
DK1385515T3 (da) 2008-10-27
AU2002311833B2 (en) 2005-04-28
EP1385515A1 (en) 2004-02-04
CY1108454T1 (el) 2014-04-09
HUP0401333A3 (en) 2004-11-29
EP1385515A4 (en) 2004-06-30
PT1385515E (pt) 2008-09-15
CZ20032849A3 (en) 2004-03-17
HUP0401333A2 (hu) 2004-10-28
SI1385515T1 (sl) 2008-12-31
US6635653B2 (en) 2003-10-21

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA:INT.CI.A61K 31/438, A61P 25/04, C07D 471/10

Ipc: A61K 31/438 (2011.01), C07D 471/10 (2011.01), A61P

B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]