ATE403429T1 - Spiropyrazol-verbindungen - Google Patents

Spiropyrazol-verbindungen

Info

Publication number
ATE403429T1
ATE403429T1 AT02739163T AT02739163T ATE403429T1 AT E403429 T1 ATE403429 T1 AT E403429T1 AT 02739163 T AT02739163 T AT 02739163T AT 02739163 T AT02739163 T AT 02739163T AT E403429 T1 ATE403429 T1 AT E403429T1
Authority
AT
Austria
Prior art keywords
spiropyrazole
compounds
spiropyrazole compounds
whereinz
compound
Prior art date
Application number
AT02739163T
Other languages
English (en)
Inventor
R Goehring
Donald Kyle
Gary Lee
Parviz Gharagozloo
Sam Victory
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE403429T1 publication Critical patent/ATE403429T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT02739163T 2001-04-18 2002-04-18 Spiropyrazol-verbindungen ATE403429T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
ATE403429T1 true ATE403429T1 (de) 2008-08-15

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02739163T ATE403429T1 (de) 2001-04-18 2002-04-18 Spiropyrazol-verbindungen

Country Status (27)

Country Link
US (2) US6635653B2 (de)
EP (1) EP1385515B1 (de)
JP (1) JP4342181B2 (de)
KR (1) KR100628292B1 (de)
CN (1) CN1516584A (de)
AT (1) ATE403429T1 (de)
AU (1) AU2002311833B2 (de)
BR (1) BR0209127A (de)
CA (1) CA2444634C (de)
CY (1) CY1108454T1 (de)
CZ (1) CZ20032849A3 (de)
DE (1) DE60228071D1 (de)
DK (1) DK1385515T3 (de)
ES (1) ES2312584T3 (de)
HU (1) HUP0401333A3 (de)
IL (2) IL158485A0 (de)
MX (1) MXPA03009604A (de)
NO (1) NO20034660L (de)
NZ (1) NZ528978A (de)
PL (1) PL367263A1 (de)
PT (1) PT1385515E (de)
RU (1) RU2299883C2 (de)
SI (1) SI1385515T1 (de)
UA (1) UA74439C2 (de)
WO (1) WO2002085355A1 (de)
YU (1) YU82403A (de)
ZA (1) ZA200308103B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU82403A (sh) * 2001-04-18 2006-08-17 Euroceltique S.A. Jedinjenja spiropirazola
AU2003220886A1 (en) 2002-03-29 2003-10-13 Mitsubishi Pharma Corporation Remedy for sleep disturbance
MXPA05002622A (es) 2002-09-09 2005-09-08 Johnson & Johnson Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano.
MXPA05003881A (es) * 2002-10-17 2005-10-05 Euro Celtique Sa Preparacion de compuestos triazospiro.
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
WO2004103305A2 (en) * 2003-05-16 2004-12-02 Euroceltique S.A. Spiropyrazole compound
WO2005011665A1 (en) * 2003-07-22 2005-02-10 Arakis Ltd. The use of proglumide for the treatment of emesis
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20110008327A1 (en) * 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
EP1737472B1 (de) 2004-03-29 2014-08-13 University Of South Florida Wirksame Behandlung von Tumoren und Krebs mit Triciribin
ES2350647T3 (es) 2005-03-08 2011-01-25 Janssen Pharmaceutica Nv Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1).
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US8703948B2 (en) 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
WO2008089201A2 (en) 2007-01-16 2008-07-24 Purdue Pharma L.P. Heterocyclic-substituted piperidine as orl-1 ligands
JP5490677B2 (ja) 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
JP5554709B2 (ja) 2007-08-31 2014-07-23 パーデュー、ファーマ、リミテッド、パートナーシップ 置換キノキサリンタイプピペリジン化合物とその使用
RU2500678C2 (ru) * 2008-07-21 2013-12-10 Пэдью Фарма Л.П. Замещенные хиноксалинового типа мостиковые пиперидиновые соединения и их применение
UA107943C2 (xx) * 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1
ES2613631T3 (es) 2010-12-22 2017-05-25 Purdue Pharma L.P. Compuestos de piperidina de tipo quinoxalina sustituidos con fósforo y usos de los mismos
ES2583146T3 (es) 2011-12-01 2016-09-19 Purdue Pharma L.P. Compuestos de piperidina de tipo quinoxalina sustituidos con azetidina y usos de éstos
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102589A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Quinazolin-4(3h)-one-type piperidine compounds and uses thereof
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
WO2014102590A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
WO2014102594A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
RS66574B1 (sr) 2016-07-29 2025-03-31 Janssen Pharmaceutica Nv Niraparib za upotrebu u postupku lečenja raka prostate
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB157497A (de) *
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
US3325499A (en) 1964-11-02 1967-06-13 Mcneilab Inc 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone
US3923993A (en) * 1973-06-28 1975-12-02 American Home Prod Process for treating neuroendocrinopathic diseases employing fluspirilene
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
US4410528A (en) 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
JPS60120872A (ja) 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
WO1995028397A1 (en) 1994-04-14 1995-10-26 Merck & Co., Inc. Alpha1c adrenergic receptor antagonists
FR2722190B1 (fr) 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US5767118A (en) 1994-10-26 1998-06-16 Merck & Co., Inc. 4-Heterocyclic peperidines promote release of growth hormone
US5574044A (en) 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
EP0974583B1 (de) 1995-09-13 2002-05-29 Kyowa Hakko Kogyo Co., Ltd. Phenylpiperidin-derivate
AU2388697A (en) 1996-04-19 1997-11-12 Neurosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
US6063796A (en) 1997-04-04 2000-05-16 Merck & Co., Inc. Somatostatin agonists
CA2291094C (en) 1997-05-30 2008-02-26 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivative
JPH10330377A (ja) 1997-06-02 1998-12-15 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
EP0921125B1 (de) 1997-12-05 2002-01-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro[4,5]decan-4-on-derivate
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
IL137149A0 (en) 1998-01-19 2001-07-24 Pfizer 4-(2-keto-1-benzimidazolinyl) piperidine compounds as orl1-receptor agonists
HUP0101275A3 (en) 1998-03-26 2002-12-28 Japan Tobacco Inc Amide derivatives and pharmaceutical compositions containing them as nociceptin antagonists
AU3809999A (en) 1998-05-18 1999-12-06 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
HUP0302475A2 (hu) 2000-09-06 2003-11-28 Ortho-Mcneil Pharmaceutical, Inc. Eljárás allergia kezelésére szubsztituált pirazolok alkalmazásával
YU82403A (sh) * 2001-04-18 2006-08-17 Euroceltique S.A. Jedinjenja spiropirazola

Also Published As

Publication number Publication date
SI1385515T1 (sl) 2008-12-31
NO20034660D0 (no) 2003-10-17
IL158485A0 (en) 2004-05-12
MXPA03009604A (es) 2004-04-02
JP4342181B2 (ja) 2009-10-14
ES2312584T3 (es) 2009-03-01
NZ528978A (en) 2004-06-25
HUP0401333A3 (en) 2004-11-29
CA2444634A1 (en) 2002-10-31
CZ20032849A3 (en) 2004-03-17
CN1516584A (zh) 2004-07-28
US20040087641A1 (en) 2004-05-06
BR0209127A (pt) 2006-03-21
NO20034660L (no) 2003-12-17
JP2004531531A (ja) 2004-10-14
RU2003133455A (ru) 2005-05-10
HUP0401333A2 (hu) 2004-10-28
ZA200308103B (en) 2004-10-18
US6635653B2 (en) 2003-10-21
WO2002085355A1 (en) 2002-10-31
AU2002311833B2 (en) 2005-04-28
CA2444634C (en) 2011-06-07
UA74439C2 (uk) 2005-12-15
CY1108454T1 (el) 2014-04-09
US20030027834A1 (en) 2003-02-06
HK1062885A1 (en) 2004-12-03
KR20040008159A (ko) 2004-01-28
DK1385515T3 (da) 2008-10-27
RU2299883C2 (ru) 2007-05-27
IL158485A (en) 2009-09-01
PT1385515E (pt) 2008-09-15
EP1385515B1 (de) 2008-08-06
EP1385515A1 (de) 2004-02-04
DE60228071D1 (de) 2008-09-18
PL367263A1 (en) 2005-02-21
YU82403A (sh) 2006-08-17
KR100628292B1 (ko) 2006-09-27
EP1385515A4 (de) 2004-06-30

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