CY1106247T1 - Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες - Google Patents

Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες

Info

Publication number
CY1106247T1
CY1106247T1 CY20061101669T CY061101669T CY1106247T1 CY 1106247 T1 CY1106247 T1 CY 1106247T1 CY 20061101669 T CY20061101669 T CY 20061101669T CY 061101669 T CY061101669 T CY 061101669T CY 1106247 T1 CY1106247 T1 CY 1106247T1
Authority
CY
Cyprus
Prior art keywords
thiazolesulfonamides
thiophen
antineoplastic agents
antineoplastic
agents
Prior art date
Application number
CY20061101669T
Other languages
English (en)
Inventor
Alfonso Lilly S.A. DE DIOS
Cora Sue Grossman
Philip Arthur Hipskind
Ho-Shen Lin
Karen Lynn Lobb
Beatriz Lilly S. A. LOPEZ DE URALDE-GARMENDIA
Jose Eduardo Lopez
Mary Margaret Mader
Michael Enrico Richett
Chaun Shih
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1106247T1 publication Critical patent/CY1106247T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Abstract

Η παρούσα εφεύρεση παρέχει αντί-νεοπλαστικές ενώσεις του τύπου (Ι).
CY20061101669T 2001-10-25 2006-11-16 Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες CY1106247T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35201201P 2001-10-25 2001-10-25
PCT/US2002/031568 WO2003035629A1 (en) 2001-10-25 2002-10-15 Thiopene- amd thiazolesulfonamides as antineoplastic agents

Publications (1)

Publication Number Publication Date
CY1106247T1 true CY1106247T1 (el) 2011-06-08

Family

ID=23383421

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101669T CY1106247T1 (el) 2001-10-25 2006-11-16 Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες

Country Status (34)

Country Link
US (2) US7084170B2 (el)
EP (1) EP1442030B1 (el)
JP (1) JP4464681B2 (el)
KR (1) KR100913471B1 (el)
CN (1) CN1298709C (el)
AR (1) AR037248A1 (el)
AT (1) ATE338033T1 (el)
AU (1) AU2002334817B2 (el)
BR (1) BR0212386A (el)
CA (1) CA2463300C (el)
CY (1) CY1106247T1 (el)
DE (1) DE60214413T2 (el)
DK (1) DK1442030T3 (el)
EA (1) EA006081B1 (el)
EC (1) ECSP045078A (el)
EG (1) EG26021A (el)
ES (1) ES2269816T3 (el)
HK (1) HK1068337A1 (el)
HR (1) HRP20040371B1 (el)
HU (1) HUP0401638A3 (el)
IL (2) IL160851A0 (el)
MX (1) MXPA04003886A (el)
MY (1) MY130718A (el)
NO (1) NO20041316L (el)
NZ (1) NZ531136A (el)
PE (1) PE20030574A1 (el)
PL (1) PL208083B1 (el)
PT (1) PT1442030E (el)
SI (1) SI1442030T1 (el)
SV (1) SV2004001367A (el)
TW (1) TWI281916B (el)
UA (1) UA75716C2 (el)
WO (1) WO2003035629A1 (el)
ZA (1) ZA200403089B (el)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
SK288015B6 (sk) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
SE0102616D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
EP1532133A4 (en) * 2002-06-06 2006-11-15 Smithkline Beecham Corp NF-: B INHIBITORS
PT1569929E (pt) * 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
SE0300091D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300092D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
EP2364699A1 (en) * 2004-09-13 2011-09-14 Eisai R&D Management Co., Ltd. Joint use of sulfonamide based compound with angiogenesis inhibitor
JP5134247B2 (ja) * 2004-09-13 2013-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有化合物の血管新生阻害物質との併用
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006090921A1 (ja) * 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. スルホンアミド化合物のリンパ球活性化抑制作用
WO2006090928A1 (ja) * 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. スルホンアミド化合物の血管新生阻害物質との新規併用
EP1859793B1 (en) * 2005-02-28 2011-04-20 Eisai R&D Management Co., Ltd. Novel combinational use of a sulfonamide compound in the treatment of cancer
NZ563909A (en) * 2005-05-13 2011-10-28 Virochem Pharma Inc Thiophene derivatives and their use for the treatment or prevention of flavivirus infections
US7208506B2 (en) 2005-07-07 2007-04-24 Hoffmann-La Roche Inc. Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
US7625896B2 (en) 2005-11-25 2009-12-01 Hoffman-La Roche Inc. Pyridylsulfonamide derivatives
WO2007123274A1 (ja) 2006-04-20 2007-11-01 Eisai R & D Management Co., Ltd. スルホンアミド化合物の新規感受性マーカー
US7939532B2 (en) * 2006-10-26 2011-05-10 Hoffmann-La Roche Inc. Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CA2670260A1 (en) 2006-11-15 2008-05-22 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of flavivirus infections
US7879884B2 (en) 2007-05-16 2011-02-01 Hoffmann-La Roche Inc. Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CN101899008B (zh) * 2010-05-20 2012-10-17 中国人民解放军第二军医大学 N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途
CN103450149B (zh) * 2012-06-01 2015-10-14 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物及其制备方法和用途
JP6364967B2 (ja) * 2014-05-30 2018-08-01 東ソー株式会社 ジチエノベンゾジチオフェンの製造方法
CN106588868A (zh) * 2016-11-16 2017-04-26 武汉理工大学 一种2‑溴‑3‑噻吩甲酸中间体的合成方法
CN108558822B (zh) * 2018-06-01 2020-12-18 盐城锦明药业有限公司 N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法
CN110835345A (zh) * 2018-08-17 2020-02-25 中国科学院上海药物研究所 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途
CN109265437A (zh) * 2018-10-19 2019-01-25 凯莱英医药集团（天津）股份有限公司 一种3-羟基噻吩-2-羧酸酯类化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA813332B (en) * 1980-06-21 1982-05-26 Pfizer Larvicides and isecticides
IL98784A0 (en) * 1990-07-17 1992-07-15 Lilly Co Eli Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them
US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5169860A (en) * 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
DE69734734D1 (de) * 1996-07-05 2005-12-29 Us Gov Health & Human Serv Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen
EP0929540A4 (en) 1996-10-04 2001-12-12 Lilly Co Eli ANTI-TUMOR COMPOSITIONS AND THERAPEUTIC METHODS
JP4316787B2 (ja) 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、

Also Published As

Publication number Publication date
HK1068337A1 (en) 2005-04-29
EA200400582A1 (ru) 2004-08-26
BR0212386A (pt) 2004-07-27
ECSP045078A (es) 2004-06-28
EP1442030B1 (en) 2006-08-30
PL368234A1 (en) 2005-03-21
EP1442030A1 (en) 2004-08-04
HUP0401638A3 (en) 2012-09-28
CN1298709C (zh) 2007-02-07
HRP20040371B1 (en) 2012-07-31
US7084170B2 (en) 2006-08-01
UA75716C2 (en) 2006-05-15
US20060223871A1 (en) 2006-10-05
AU2002334817B2 (en) 2008-02-21
CA2463300C (en) 2011-07-19
US20040198784A1 (en) 2004-10-07
NZ531136A (en) 2006-08-31
IL160851A (en) 2009-11-18
AR037248A1 (es) 2004-11-03
MY130718A (en) 2007-07-31
IL160851A0 (en) 2004-08-31
KR100913471B1 (ko) 2009-08-25
DK1442030T3 (da) 2006-12-27
JP2005511547A (ja) 2005-04-28
HRP20040371A2 (en) 2004-08-31
NO20041316L (no) 2004-03-30
SV2004001367A (es) 2004-02-24
TWI281916B (en) 2007-06-01
DE60214413T2 (de) 2007-03-08
WO2003035629A1 (en) 2003-05-01
KR20040062583A (ko) 2004-07-07
ZA200403089B (en) 2005-04-22
CN1575286A (zh) 2005-02-02
PL208083B1 (pl) 2011-03-31
SI1442030T1 (sl) 2006-12-31
ATE338033T1 (de) 2006-09-15
PE20030574A1 (es) 2003-07-03
MXPA04003886A (es) 2004-07-08
ES2269816T3 (es) 2007-04-01
EG26021A (en) 2012-12-10
JP4464681B2 (ja) 2010-05-19
CA2463300A1 (en) 2003-05-01
HUP0401638A2 (hu) 2004-11-29
PT1442030E (pt) 2006-12-29
DE60214413D1 (de) 2006-10-12
EA006081B1 (ru) 2005-08-25
US7250430B2 (en) 2007-07-31

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