DK1442030T3 - Thiopen- og thiazolsulfonamider som antineoplastiske midler - Google Patents

Thiopen- og thiazolsulfonamider som antineoplastiske midler

Info

Publication number
DK1442030T3
DK1442030T3 DK02802117T DK02802117T DK1442030T3 DK 1442030 T3 DK1442030 T3 DK 1442030T3 DK 02802117 T DK02802117 T DK 02802117T DK 02802117 T DK02802117 T DK 02802117T DK 1442030 T3 DK1442030 T3 DK 1442030T3
Authority
DK
Denmark
Prior art keywords
thiopen
antineoplastic agents
thiazole sulfonamides
sulfonamides
thiazole
Prior art date
Application number
DK02802117T
Other languages
English (en)
Inventor
Dios Alfonso De
Cora Sue Grossman
De Uralde Lopez
Jose Eduardo Lopez
Mary Margaret Mader
Chaun Shih
Philip Arthur Hipskind
Ho-Shen Lin
Karen Lynn Lobb
Michael Enrico Richett
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1442030T3 publication Critical patent/DK1442030T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
DK02802117T 2001-10-25 2002-10-15 Thiopen- og thiazolsulfonamider som antineoplastiske midler DK1442030T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35201201P 2001-10-25 2001-10-25

Publications (1)

Publication Number Publication Date
DK1442030T3 true DK1442030T3 (da) 2006-12-27

Family

ID=23383421

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02802117T DK1442030T3 (da) 2001-10-25 2002-10-15 Thiopen- og thiazolsulfonamider som antineoplastiske midler

Country Status (34)

Country Link
US (2) US7084170B2 (da)
EP (1) EP1442030B1 (da)
JP (1) JP4464681B2 (da)
KR (1) KR100913471B1 (da)
CN (1) CN1298709C (da)
AR (1) AR037248A1 (da)
AT (1) ATE338033T1 (da)
AU (1) AU2002334817B2 (da)
BR (1) BR0212386A (da)
CA (1) CA2463300C (da)
CY (1) CY1106247T1 (da)
DE (1) DE60214413T2 (da)
DK (1) DK1442030T3 (da)
EA (1) EA006081B1 (da)
EC (1) ECSP045078A (da)
EG (1) EG26021A (da)
ES (1) ES2269816T3 (da)
HK (1) HK1068337A1 (da)
HR (1) HRP20040371B1 (da)
HU (1) HUP0401638A3 (da)
IL (2) IL160851A0 (da)
MX (1) MXPA04003886A (da)
MY (1) MY130718A (da)
NO (1) NO20041316L (da)
NZ (1) NZ531136A (da)
PE (1) PE20030574A1 (da)
PL (1) PL208083B1 (da)
PT (1) PT1442030E (da)
SI (1) SI1442030T1 (da)
SV (1) SV2004001367A (da)
TW (1) TWI281916B (da)
UA (1) UA75716C2 (da)
WO (1) WO2003035629A1 (da)
ZA (1) ZA200403089B (da)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
SK288015B6 (sk) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
SE0102616D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
EP1532133A4 (en) * 2002-06-06 2006-11-15 Smithkline Beecham Corp NF-: B INHIBITORS
KR101058696B1 (ko) 2002-12-10 2011-08-22 바이로켐 파마 인코포레이티드 후라비바이러스 감염의 치료 또는 예방을 위한 화합물과방법
SE0300092D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300091D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
WO2006030947A1 (ja) * 2004-09-13 2006-03-23 Eisai R & D Management Co., Ltd. スルホンアミド含有化合物の血管新生阻害物質との併用
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
JP5134247B2 (ja) * 2004-09-13 2013-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有化合物の血管新生阻害物質との併用
WO2006090921A1 (ja) * 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. スルホンアミド化合物のリンパ球活性化抑制作用
JPWO2006090928A1 (ja) * 2005-02-28 2008-07-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の血管新生阻害物質との新規併用
SI1859793T1 (sl) * 2005-02-28 2011-08-31 Eisai R&D Man Co Ltd Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka
NZ563909A (en) * 2005-05-13 2011-10-28 Virochem Pharma Inc Thiophene derivatives and their use for the treatment or prevention of flavivirus infections
US7208506B2 (en) 2005-07-07 2007-04-24 Hoffmann-La Roche Inc. Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
US7625896B2 (en) * 2005-11-25 2009-12-01 Hoffman-La Roche Inc. Pyridylsulfonamide derivatives
EP2015070A4 (en) 2006-04-20 2010-04-21 Eisai R&D Man Co Ltd NEW MARKER AGAINST SENSITIVITY TO A SULFONAMIDE COMPOUND
US7939532B2 (en) * 2006-10-26 2011-05-10 Hoffmann-La Roche Inc. Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CN102250074A (zh) * 2006-11-15 2011-11-23 沃泰克斯药物(加拿大)股份有限公司 用于治疗或预防黄病毒属感染的噻吩类似物
EP2148861A1 (en) 2007-05-16 2010-02-03 F. Hoffmann-Roche AG Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CN101899008B (zh) * 2010-05-20 2012-10-17 中国人民解放军第二军医大学 N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途
CN103450149B (zh) * 2012-06-01 2015-10-14 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物及其制备方法和用途
JP6364967B2 (ja) * 2014-05-30 2018-08-01 東ソー株式会社 ジチエノベンゾジチオフェンの製造方法
CN106588868A (zh) * 2016-11-16 2017-04-26 武汉理工大学 一种2‑溴‑3‑噻吩甲酸中间体的合成方法
CN108558822B (zh) * 2018-06-01 2020-12-18 盐城锦明药业有限公司 N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法
CN110835345A (zh) * 2018-08-17 2020-02-25 中国科学院上海药物研究所 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途
CN109265437A (zh) * 2018-10-19 2019-01-25 凯莱英医药集团（天津）股份有限公司 一种3-羟基噻吩-2-羧酸酯类化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA813332B (en) * 1980-06-21 1982-05-26 Pfizer Larvicides and isecticides
NZ238911A (en) * 1990-07-17 1993-10-26 Lilly Co Eli Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor
US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5169860A (en) * 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
ATE310738T1 (de) * 1996-07-05 2005-12-15 Us Gov Health & Human Serv Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen
CA2267998A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment
JP4316787B2 (ja) 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、

Also Published As

Publication number Publication date
HRP20040371B1 (en) 2012-07-31
HRP20040371A2 (en) 2004-08-31
EA006081B1 (ru) 2005-08-25
DE60214413T2 (de) 2007-03-08
HUP0401638A3 (en) 2012-09-28
PE20030574A1 (es) 2003-07-03
US7084170B2 (en) 2006-08-01
PL368234A1 (en) 2005-03-21
PT1442030E (pt) 2006-12-29
CY1106247T1 (el) 2011-06-08
PL208083B1 (pl) 2011-03-31
SI1442030T1 (sl) 2006-12-31
NZ531136A (en) 2006-08-31
ES2269816T3 (es) 2007-04-01
US7250430B2 (en) 2007-07-31
MY130718A (en) 2007-07-31
MXPA04003886A (es) 2004-07-08
JP4464681B2 (ja) 2010-05-19
TWI281916B (en) 2007-06-01
NO20041316L (no) 2004-03-30
JP2005511547A (ja) 2005-04-28
SV2004001367A (es) 2004-02-24
BR0212386A (pt) 2004-07-27
CN1575286A (zh) 2005-02-02
IL160851A (en) 2009-11-18
DE60214413D1 (de) 2006-10-12
ECSP045078A (es) 2004-06-28
ATE338033T1 (de) 2006-09-15
HUP0401638A2 (hu) 2004-11-29
US20040198784A1 (en) 2004-10-07
EP1442030B1 (en) 2006-08-30
EP1442030A1 (en) 2004-08-04
UA75716C2 (en) 2006-05-15
CA2463300C (en) 2011-07-19
EG26021A (en) 2012-12-10
EA200400582A1 (ru) 2004-08-26
AU2002334817B2 (en) 2008-02-21
KR20040062583A (ko) 2004-07-07
CN1298709C (zh) 2007-02-07
IL160851A0 (en) 2004-08-31
US20060223871A1 (en) 2006-10-05
AR037248A1 (es) 2004-11-03
ZA200403089B (en) 2005-04-22
CA2463300A1 (en) 2003-05-01
KR100913471B1 (ko) 2009-08-25
WO2003035629A1 (en) 2003-05-01
HK1068337A1 (en) 2005-04-29

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