DK1455779T3 - Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander - Google Patents

Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander

Info

Publication number
DK1455779T3
DK1455779T3 DK02805601T DK02805601T DK1455779T3 DK 1455779 T3 DK1455779 T3 DK 1455779T3 DK 02805601 T DK02805601 T DK 02805601T DK 02805601 T DK02805601 T DK 02805601T DK 1455779 T3 DK1455779 T3 DK 1455779T3
Authority
DK
Denmark
Prior art keywords
hydroxytryptamine
ligands
indolylalkylamine
derivatives
indolylalkylamine derivatives
Prior art date
Application number
DK02805601T
Other languages
English (en)
Inventor
Derek Cecil Cole
Joseph Raymond Stock
William Joseph Lennox
Ping Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1455779T3 publication Critical patent/DK1455779T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK02805601T 2001-12-20 2002-12-17 Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander DK1455779T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34290701P 2001-12-20 2001-12-20

Publications (1)

Publication Number Publication Date
DK1455779T3 true DK1455779T3 (da) 2006-10-30

Family

ID=23343804

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02805601T DK1455779T3 (da) 2001-12-20 2002-12-17 Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander

Country Status (30)

Country Link
US (2) US6770642B2 (da)
EP (1) EP1455779B1 (da)
JP (1) JP4335684B2 (da)
KR (1) KR100985140B1 (da)
CN (1) CN1309385C (da)
AR (1) AR037906A1 (da)
AT (1) ATE335477T1 (da)
AU (1) AU2002357270B2 (da)
BR (1) BR0215222A (da)
CA (1) CA2470863C (da)
CO (1) CO5590924A2 (da)
CY (1) CY1105705T1 (da)
DE (1) DE60213856T2 (da)
DK (1) DK1455779T3 (da)
EC (1) ECSP045156A (da)
ES (1) ES2269827T3 (da)
HK (1) HK1065949A1 (da)
HU (1) HUP0402640A3 (da)
IL (1) IL162243A0 (da)
MX (1) MXPA04005889A (da)
NO (1) NO330338B1 (da)
NZ (1) NZ533666A (da)
PL (1) PL210413B1 (da)
PT (1) PT1455779E (da)
RU (1) RU2309157C2 (da)
SI (1) SI1455779T1 (da)
TW (1) TWI254705B (da)
UA (1) UA78536C2 (da)
WO (1) WO2003053433A1 (da)
ZA (1) ZA200405731B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1340743A4 (en) * 2000-11-09 2007-04-25 Mitsui Chemicals Inc OPTICALLY ACTIVE AMINO DERIVATIVE AND METHOD OF SYNTHESIS
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
BRPI0412809A (pt) * 2003-07-23 2006-09-26 Wyeth Corp compostos de sulfonildihidrobenzimidazolona como ligantes a 5-hidróxitriptamina-6
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005012311A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
CA2534649A1 (en) * 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
BRPI0417895B8 (pt) 2004-01-02 2021-05-25 Suven Life Sciences Ltd composto, processo para a preparação de um composto e uso do composto
PE20060303A1 (es) * 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
AU2005316675A1 (en) * 2004-12-14 2006-06-22 Wyeth Use of a 5-HT6 agonist for the treatment and prevention of neurodegenerative disorders
JP2008526980A (ja) * 2005-01-14 2008-07-24 ジェネラブズ テクノロジーズ インコーポレーティッド ウイルス感染症を治療するためのインドール誘導体
EP1953153A1 (en) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
AU2008256859A1 (en) * 2007-05-24 2008-12-04 Memory Pharmaceuticals Corporation 4' substituted compounds having 5-HT6 receptor affinity
DE602007012683D1 (de) * 2007-07-19 2011-04-07 Esteve Labor Dr Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
EP2053052A1 (en) * 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
WO2009073118A1 (en) * 2007-12-04 2009-06-11 Merck & Co., Inc. Tryptamine sulfonamides as 5-ht6 antagonists
JP2011507835A (ja) 2007-12-21 2011-03-10 アンドレイ・アレクサンドロビッチ・イワシェンコ α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族複素環式化合物及び医薬におけるその応用
CN107105655A (zh) 2014-08-29 2017-08-29 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
US10479802B2 (en) 2014-08-29 2019-11-19 Chdi Foundation, Inc. Probes for imaging huntingtin protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
US6133287A (en) * 1998-03-24 2000-10-17 Allelix Biopharmaceuticals Inc. Piperidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
US6403808B1 (en) * 1999-12-10 2002-06-11 Virginia Commonwealth University Selective 5-HT6 receptor ligands
WO2001012629A1 (en) * 1999-08-12 2001-02-22 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
AU1542201A (en) * 1999-11-05 2001-05-14 Nps Allelix Corp. Compounds having 5-HT6 receptor antagonist activity
WO2001034146A1 (en) * 1999-11-08 2001-05-17 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
NO20043100L (no) 2004-08-26
CN1620290A (zh) 2005-05-25
NZ533666A (en) 2006-03-31
CY1105705T1 (el) 2010-12-22
KR20040075892A (ko) 2004-08-30
ECSP045156A (es) 2004-07-23
US20030171353A1 (en) 2003-09-11
AR037906A1 (es) 2004-12-22
DE60213856D1 (de) 2006-09-21
US20040209867A1 (en) 2004-10-21
JP4335684B2 (ja) 2009-09-30
BR0215222A (pt) 2005-05-24
MXPA04005889A (es) 2004-11-01
ATE335477T1 (de) 2006-09-15
PT1455779E (pt) 2006-11-30
WO2003053433A1 (en) 2003-07-03
AU2002357270B2 (en) 2007-06-14
EP1455779A1 (en) 2004-09-15
NO330338B1 (no) 2011-03-28
US6770642B2 (en) 2004-08-03
ES2269827T3 (es) 2007-04-01
RU2004122129A (ru) 2005-05-10
EP1455779B1 (en) 2006-08-09
US7022701B2 (en) 2006-04-04
HUP0402640A3 (en) 2012-09-28
IL162243A0 (en) 2005-11-20
PL210413B1 (pl) 2012-01-31
UA78536C2 (en) 2007-04-10
CA2470863C (en) 2012-05-15
JP2005517661A (ja) 2005-06-16
SI1455779T1 (sl) 2006-12-31
CN1309385C (zh) 2007-04-11
TW200301252A (en) 2003-07-01
DE60213856T2 (de) 2007-09-13
HUP0402640A2 (hu) 2005-04-28
TWI254705B (en) 2006-05-11
CO5590924A2 (es) 2005-12-30
HK1065949A1 (en) 2005-03-11
AU2002357270A1 (en) 2003-07-09
ZA200405731B (en) 2007-02-28
PL370711A1 (en) 2005-05-30
CA2470863A1 (en) 2003-07-03
KR100985140B1 (ko) 2010-10-05
RU2309157C2 (ru) 2007-10-27

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