CO5590924A2 - Derivados de indolilalquilamina como ligandos de 5- hidroxitriptamina-6 - Google Patents

Derivados de indolilalquilamina como ligandos de 5- hidroxitriptamina-6

Info

Publication number
CO5590924A2
CO5590924A2 CO04055771A CO04055771A CO5590924A2 CO 5590924 A2 CO5590924 A2 CO 5590924A2 CO 04055771 A CO04055771 A CO 04055771A CO 04055771 A CO04055771 A CO 04055771A CO 5590924 A2 CO5590924 A2 CO 5590924A2
Authority
CO
Colombia
Prior art keywords
optionally substituted
independently
alkyl
optionally
aryl
Prior art date
Application number
CO04055771A
Other languages
English (en)
Inventor
Derek Cecil Cole
Joseph Raymond Stock
William Joseph Lennox
Ping Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5590924A2 publication Critical patent/CO5590924A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

1.- Un compuesto de formula I en donde Q es SO2, CO, CONR9 o CSNR10;n es un entero 2 o 3;R1 y R2 son cada uno independientemente H, halógeno, CN, OCO2R12, CO2R13, CONR14R15, CNR16NR17R18, SOmR19, NR20R21, OR22, COR23, o un grupo alquiloC1-C6, alqueniloC2-C6, alquiniloC2-C6, cicloalquiloC3-C6, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido;R3 y R4 son cada uno independientemente H o un grupo alquiloC1-C6 opcionalmente sustituido;R5 y R6 son cada uno independientemente H o un grupo alquiloC1-C6, alqueniloC2-C6, alquiniloC2-C6, cicloalquiloC3-C6, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido, o R5 y R6 pueden ser tomados juntos con el átomo al cual están unidos para formar un anillo de 5- a 7- miembros opcionalmente sustituido, que contiene opcionalmente un heteroátomo adicional seleccionado de O, N o S;R7 es H, halógeno o un grupo alquiloC1-C6, alcoxiC1-C6, arilo o heteroarilo cada uno opcionalmente sustituido;R8 es un sistema de anillo bicíclico o tricíclico de 8- a 13- miembros opcionalmente sustituido, que tiene un átomo de N en el puente de la molécula, y opcionalmente contiene 1, 2 o 3 heteroátomos adicionales seleccionados de N, O o S;m es 0 o un entero 1 o 2;R9 y R10 son cada uno independientemente H o un grupo alquiloC1-C6, arilo o heteroarilo cada uno opcionalmente sustituido;R12, R13, R19 y R23 son cada uno independientemente H o un grupo alquiloC1-C6, alqueniloC2-C6, alquiniloC2-C6, cicloalquiloC3-C6, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido;R14, R15 y R22 son cada uno independientemente H o un grupo alquiloC1-C6 opcionalmente sustituido; yR16, R17, R18, R20 y R21 son cada uno independientemente H o un grupo alquiloC1-C4 opcionalmente sustituido; o R20 y R21 pueden ser tomados juntos con el átomo al cual están unidos para formar un anillo de 5- a 7- miembros que contiene opcionalmente otro heteroátomo seleccionado de O, N o S; o los esteroisómeros de estos o las sales farmacéuticamente aceptables de estos.
CO04055771A 2001-12-20 2004-06-15 Derivados de indolilalquilamina como ligandos de 5- hidroxitriptamina-6 CO5590924A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34290701P 2001-12-20 2001-12-20

Publications (1)

Publication Number Publication Date
CO5590924A2 true CO5590924A2 (es) 2005-12-30

Family

ID=23343804

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04055771A CO5590924A2 (es) 2001-12-20 2004-06-15 Derivados de indolilalquilamina como ligandos de 5- hidroxitriptamina-6

Country Status (30)

Country Link
US (2) US6770642B2 (es)
EP (1) EP1455779B1 (es)
JP (1) JP4335684B2 (es)
KR (1) KR100985140B1 (es)
CN (1) CN1309385C (es)
AR (1) AR037906A1 (es)
AT (1) ATE335477T1 (es)
AU (1) AU2002357270B2 (es)
BR (1) BR0215222A (es)
CA (1) CA2470863C (es)
CO (1) CO5590924A2 (es)
CY (1) CY1105705T1 (es)
DE (1) DE60213856T2 (es)
DK (1) DK1455779T3 (es)
EC (1) ECSP045156A (es)
ES (1) ES2269827T3 (es)
HK (1) HK1065949A1 (es)
HU (1) HUP0402640A3 (es)
IL (1) IL162243A0 (es)
MX (1) MXPA04005889A (es)
NO (1) NO330338B1 (es)
NZ (1) NZ533666A (es)
PL (1) PL210413B1 (es)
PT (1) PT1455779E (es)
RU (1) RU2309157C2 (es)
SI (1) SI1455779T1 (es)
TW (1) TWI254705B (es)
UA (1) UA78536C2 (es)
WO (1) WO2003053433A1 (es)
ZA (1) ZA200405731B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0115262A (pt) * 2000-11-09 2003-08-12 Mitsui Chemicals Inc Derivados de amina opticamente ativos e processo de preparação destes
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
WO2005009996A1 (en) * 2003-07-23 2005-02-03 Wyeth Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
ES2290740T3 (es) * 2003-07-31 2008-02-16 Wyeth Compuestos de n-sulfonilheterociclopirrolilalquilamina como ligandos de 5-hidroxitriptamina-6.
CN1829709A (zh) * 2003-08-01 2006-09-06 健亚生物科技公司 对抗黄病毒的双环咪唑衍生物
BRPI0417895B8 (pt) 2004-01-02 2021-05-25 Suven Life Sciences Ltd composto, processo para a preparação de um composto e uso do composto
PE20060303A1 (es) * 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
AU2005316675A1 (en) * 2004-12-14 2006-06-22 Wyeth Use of a 5-HT6 agonist for the treatment and prevention of neurodegenerative disorders
WO2006076529A1 (en) * 2005-01-14 2006-07-20 Genelabs Technologies, Inc. Indole derivatives for treating viral infections
EP1953153A1 (en) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
JP2010528037A (ja) * 2007-05-24 2010-08-19 メモリー・ファーマシューティカルズ・コーポレイション ５−ｈｔ６受容体親和性を有する４’置換化合物
DE602007012683D1 (de) * 2007-07-19 2011-04-07 Esteve Labor Dr Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
EP2053052A1 (en) 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
EP2231160B1 (en) * 2007-12-04 2013-08-14 Merck Sharp & Dohme Corp. Tryptamine sulfonamides as 5-ht6 antagonists
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
EP3083588B1 (en) 2013-12-20 2020-12-09 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
ES2818107T3 (es) * 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina

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US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
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Also Published As

Publication number Publication date
NO20043100L (no) 2004-08-26
DE60213856T2 (de) 2007-09-13
AR037906A1 (es) 2004-12-22
SI1455779T1 (sl) 2006-12-31
CA2470863A1 (en) 2003-07-03
HK1065949A1 (en) 2005-03-11
ATE335477T1 (de) 2006-09-15
EP1455779B1 (en) 2006-08-09
US20040209867A1 (en) 2004-10-21
NO330338B1 (no) 2011-03-28
BR0215222A (pt) 2005-05-24
CY1105705T1 (el) 2010-12-22
US7022701B2 (en) 2006-04-04
MXPA04005889A (es) 2004-11-01
US20030171353A1 (en) 2003-09-11
PL370711A1 (en) 2005-05-30
PL210413B1 (pl) 2012-01-31
RU2309157C2 (ru) 2007-10-27
CA2470863C (en) 2012-05-15
JP2005517661A (ja) 2005-06-16
NZ533666A (en) 2006-03-31
ZA200405731B (en) 2007-02-28
ECSP045156A (es) 2004-07-23
AU2002357270A1 (en) 2003-07-09
PT1455779E (pt) 2006-11-30
TWI254705B (en) 2006-05-11
DE60213856D1 (de) 2006-09-21
TW200301252A (en) 2003-07-01
KR100985140B1 (ko) 2010-10-05
RU2004122129A (ru) 2005-05-10
ES2269827T3 (es) 2007-04-01
WO2003053433A1 (en) 2003-07-03
UA78536C2 (en) 2007-04-10
HUP0402640A2 (hu) 2005-04-28
EP1455779A1 (en) 2004-09-15
IL162243A0 (en) 2005-11-20
CN1620290A (zh) 2005-05-25
US6770642B2 (en) 2004-08-03
KR20040075892A (ko) 2004-08-30
AU2002357270B2 (en) 2007-06-14
DK1455779T3 (da) 2006-10-30
JP4335684B2 (ja) 2009-09-30
CN1309385C (zh) 2007-04-11
HUP0402640A3 (en) 2012-09-28

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