CO5670358A2 - Derivados de 2-piridona como inhibidores de la elastasa neutrofila y su uso - Google Patents

Derivados de 2-piridona como inhibidores de la elastasa neutrofila y su uso

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Publication number
CO5670358A2
CO5670358A2 CO06026216A CO06026216A CO5670358A2 CO 5670358 A2 CO5670358 A2 CO 5670358A2 CO 06026216 A CO06026216 A CO 06026216A CO 06026216 A CO06026216 A CO 06026216A CO 5670358 A2 CO5670358 A2 CO 5670358A2
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CO
Colombia
Prior art keywords
alkyl
alkoxy
substituted
independently selected
optionally
Prior art date
Application number
CO06026216A
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English (en)
Inventor
Marjana Andersson
Peter Hansen
Antonios Nikitidis
Petter Sjolin
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Astrazeneca Ab
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29212488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5670358(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5670358A2 publication Critical patent/CO5670358A2/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

1.- Un compuesto de formula (I) en donde:Y representa CR3o N;R1 representa H o alquilo C1 a 6;R2 representa fenilo o un anillo heteroaromático de cinco o seis miembros que contiene 1 a 4 heteroátomos seleccionados independientemente de O, S y N; estando dicho anillo heteroaromático opcionalmente sustituido por 1 a 3 sustituyentes seleccionados independientemente de OH, halógeno, alquilo C1 a 6, alcoxi C1 a 6, NR58COR50, COOR51, COR52, CONR53R54 y NR47R48; estando dicho alquilo opcionalmente sustituido además por OH, alcoxi C1 a 6, CN o CO2R49;R47 y R48 representan independientemente H, alquilo C1 a 6 o alcanoilo C2 a 6;R3 representa H o F;G1 representa fenilo o un anillo heteroaromático de cinco o seis miembros que contiene 1 a 3 heteroátomos seleccionados independientemente de O, S y N;R5 representa H, halógeno, alquilo C1 a 6, CN, alcoxi C1 a 6, NO2, NR14R15, alquilo C1 a 3 sustituido por uno o más átomos de F o alcoxi C1 a 3 sustituido por uno o más átomos de F;R14 y R15 representan independientemente H o alquilo C1 a 3; estando dicho alquilo opcionalmente sustituido además por uno o más átomos de F;n representa un entero 1, 2 o 3 y cuando n representa 2 o 3, cada grupo R5 se selecciona independientemente;R4 representa H o alquilo C1 a 6; estando dicho alquilo opcionalmente sustituido además por OH o alcoxi C1 a 6;o R4 y L están unidos juntos de forma que el grupo-NR4L representa un anillo azacíclico de 5 a 7 miembros que incorpora opcionalmente un heteroátomo adicional seleccionado de O, S y NR16;L representa un enlace, O, S(O)p, NR29 o alquilo C1 a 6; dicho alquilo incorpora opcionalmente un heteroátomo seleccionado de O, S y NR16; y estando dicho alquilo opcionalmente sustituido además por OH o OMe; ...
CO06026216A 2003-09-18 2006-03-15 Derivados de 2-piridona como inhibidores de la elastasa neutrofila y su uso CO5670358A2 (es)

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SE0302486A SE0302486D0 (sv) 2003-09-18 2003-09-18 Novel compounds

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US (2) US8063073B2 (es)
EP (1) EP1663973B3 (es)
JP (1) JP4515455B2 (es)
KR (1) KR101141464B1 (es)
CN (1) CN1882542B (es)
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