CO5670358A2 - Derivados de 2-piridona como inhibidores de la elastasa neutrofila y su uso - Google Patents
Derivados de 2-piridona como inhibidores de la elastasa neutrofila y su usoInfo
- Publication number
- CO5670358A2 CO5670358A2 CO06026216A CO06026216A CO5670358A2 CO 5670358 A2 CO5670358 A2 CO 5670358A2 CO 06026216 A CO06026216 A CO 06026216A CO 06026216 A CO06026216 A CO 06026216A CO 5670358 A2 CO5670358 A2 CO 5670358A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- alkoxy
- substituted
- independently selected
- optionally
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/82—Amides; Imides in position 3
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- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
1.- Un compuesto de formula (I) en donde:Y representa CR3o N;R1 representa H o alquilo C1 a 6;R2 representa fenilo o un anillo heteroaromático de cinco o seis miembros que contiene 1 a 4 heteroátomos seleccionados independientemente de O, S y N; estando dicho anillo heteroaromático opcionalmente sustituido por 1 a 3 sustituyentes seleccionados independientemente de OH, halógeno, alquilo C1 a 6, alcoxi C1 a 6, NR58COR50, COOR51, COR52, CONR53R54 y NR47R48; estando dicho alquilo opcionalmente sustituido además por OH, alcoxi C1 a 6, CN o CO2R49;R47 y R48 representan independientemente H, alquilo C1 a 6 o alcanoilo C2 a 6;R3 representa H o F;G1 representa fenilo o un anillo heteroaromático de cinco o seis miembros que contiene 1 a 3 heteroátomos seleccionados independientemente de O, S y N;R5 representa H, halógeno, alquilo C1 a 6, CN, alcoxi C1 a 6, NO2, NR14R15, alquilo C1 a 3 sustituido por uno o más átomos de F o alcoxi C1 a 3 sustituido por uno o más átomos de F;R14 y R15 representan independientemente H o alquilo C1 a 3; estando dicho alquilo opcionalmente sustituido además por uno o más átomos de F;n representa un entero 1, 2 o 3 y cuando n representa 2 o 3, cada grupo R5 se selecciona independientemente;R4 representa H o alquilo C1 a 6; estando dicho alquilo opcionalmente sustituido además por OH o alcoxi C1 a 6;o R4 y L están unidos juntos de forma que el grupo-NR4L representa un anillo azacíclico de 5 a 7 miembros que incorpora opcionalmente un heteroátomo adicional seleccionado de O, S y NR16;L representa un enlace, O, S(O)p, NR29 o alquilo C1 a 6; dicho alquilo incorpora opcionalmente un heteroátomo seleccionado de O, S y NR16; y estando dicho alquilo opcionalmente sustituido además por OH o OMe; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0302486A SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
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CO5670358A2 true CO5670358A2 (es) | 2006-08-31 |
Family
ID=29212488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CO06026216A CO5670358A2 (es) | 2003-09-18 | 2006-03-15 | Derivados de 2-piridona como inhibidores de la elastasa neutrofila y su uso |
Country Status (25)
Country | Link |
---|---|
US (2) | US8063073B2 (es) |
EP (1) | EP1663973B3 (es) |
JP (1) | JP4515455B2 (es) |
KR (1) | KR101141464B1 (es) |
CN (1) | CN1882542B (es) |
AR (1) | AR045761A1 (es) |
AU (1) | AU2004272484C1 (es) |
BR (1) | BRPI0414548B8 (es) |
CA (1) | CA2538405C (es) |
CO (1) | CO5670358A2 (es) |
ES (1) | ES2448465T7 (es) |
HK (1) | HK1089166A1 (es) |
IL (1) | IL173990A (es) |
IS (1) | IS8381A (es) |
MX (1) | MXPA06002724A (es) |
MY (1) | MY143400A (es) |
NO (1) | NO20061660L (es) |
NZ (1) | NZ545963A (es) |
RU (1) | RU2353616C2 (es) |
SA (1) | SA04250299B1 (es) |
SE (1) | SE0302486D0 (es) |
TW (1) | TWI354665B (es) |
UY (1) | UY28514A1 (es) |
WO (1) | WO2005026123A1 (es) |
ZA (1) | ZA200602261B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200700392A (en) * | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
NZ566068A (en) | 2005-08-08 | 2011-03-31 | Argenta Discovery Ltd | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses |
GB0605469D0 (en) * | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
TW200808763A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
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