BRPI0414548A - derivados de 2-piridona inibidores de elastase de neutrófilo e seu uso - Google Patents

derivados de 2-piridona inibidores de elastase de neutrófilo e seu uso

Info

Publication number
BRPI0414548A
BRPI0414548A BRPI0414548-8A BRPI0414548A BRPI0414548A BR PI0414548 A BRPI0414548 A BR PI0414548A BR PI0414548 A BRPI0414548 A BR PI0414548A BR PI0414548 A BRPI0414548 A BR PI0414548A
Authority
BR
Brazil
Prior art keywords
neutrophil elastase
pyridone derivatives
elastase inhibitor
elastase inhibitors
compounds
Prior art date
Application number
BRPI0414548-8A
Other languages
English (en)
Inventor
Marjana Andersson
Peter Hansen
Hans Loenn
Antonios Nikitidis
Petter Sjoelin
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29212488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0414548(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0414548A publication Critical patent/BRPI0414548A/pt
Publication of BRPI0414548A8 publication Critical patent/BRPI0414548A8/pt
Publication of BRPI0414548B1 publication Critical patent/BRPI0414548B1/pt
Publication of BRPI0414548B8 publication Critical patent/BRPI0414548B8/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

"DERIVADOS DE 2-PIRIDONA INIBIDORES DE ELASTASE DE NEUTRóFILO E SEU USO". A invenção provê novos compostos de fórmula (I) onde R¬ 1¬, R¬ 2¬, R¬ 4¬, R¬ 5¬, G¬ 1¬, G¬ 2¬, L, Y e n são como definidos no relatório descritivo, e isómeros áticos, racematos e tautómeros destes, e sais farmaceuticamente aceitáveis destes; juntamente com processos para sua preparação, composições os contendo e seu uso em terapia. Os compostos são inibidores da elastase de neutrófilo.
BRPI0414548A 2003-09-18 2004-09-15 derivados de 2-piridona como inibidores de elastase de neutrófilo e seu uso BRPI0414548B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0302486A SE0302486D0 (sv) 2003-09-18 2003-09-18 Novel compounds
PCT/SE2004/001335 WO2005026123A1 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as neutrophil elastase inhibitors and their use

Publications (4)

Publication Number Publication Date
BRPI0414548A true BRPI0414548A (pt) 2006-11-07
BRPI0414548A8 BRPI0414548A8 (pt) 2018-12-26
BRPI0414548B1 BRPI0414548B1 (pt) 2019-02-05
BRPI0414548B8 BRPI0414548B8 (pt) 2021-05-25

Family

ID=29212488

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414548A BRPI0414548B8 (pt) 2003-09-18 2004-09-15 derivados de 2-piridona como inibidores de elastase de neutrófilo e seu uso

Country Status (25)

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US (2) US8063073B2 (pt)
EP (1) EP1663973B3 (pt)
JP (1) JP4515455B2 (pt)
KR (1) KR101141464B1 (pt)
CN (1) CN1882542B (pt)
AR (1) AR045761A1 (pt)
AU (1) AU2004272484C1 (pt)
BR (1) BRPI0414548B8 (pt)
CA (1) CA2538405C (pt)
CO (1) CO5670358A2 (pt)
ES (1) ES2448465T7 (pt)
HK (1) HK1089166A1 (pt)
IL (1) IL173990A (pt)
IS (1) IS8381A (pt)
MX (1) MXPA06002724A (pt)
MY (1) MY143400A (pt)
NO (1) NO20061660L (pt)
NZ (1) NZ545963A (pt)
RU (1) RU2353616C2 (pt)
SA (1) SA04250299B1 (pt)
SE (1) SE0302486D0 (pt)
TW (1) TWI354665B (pt)
UY (1) UY28514A1 (pt)
WO (1) WO2005026123A1 (pt)
ZA (1) ZA200602261B (pt)

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TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
SE0302487D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
NZ566068A (en) 2005-08-08 2011-03-31 Argenta Discovery Ltd Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses
GB0605469D0 (en) * 2006-03-17 2006-04-26 Argenta Discovery Ltd Multimers of heterocyclic compounds and their use
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
TW200808763A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
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