AU2003254650B2
(en)
|
2002-07-24 |
2010-09-09 |
Qlt, Inc. |
Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
|
US7459454B2
(en)
*
|
2003-03-21 |
2008-12-02 |
Smithkline Beecham Corporation |
Aminopyrazine derivatives and compositions
|
AR045134A1
(es)
*
|
2003-07-29 |
2005-10-19 |
Smithkline Beecham Plc |
Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic
|
JP4692281B2
(ja)
*
|
2003-08-05 |
2011-06-01 |
味の素株式会社 |
新規アゾール化合物
|
EP1670466A4
(de)
*
|
2003-10-06 |
2007-04-25 |
Glaxo Group Ltd |
Zubereitung von 1,6,7-trisubstituierten azabenzimidazolen als kinasehemmer
|
US7547779B2
(en)
|
2003-10-06 |
2009-06-16 |
Glaxo Group Limited |
Preparation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
|
JP2007507547A
(ja)
*
|
2003-10-06 |
2007-03-29 |
グラクソ グループ リミテッド |
キナーゼ阻害剤としての1,7−二置換アザベンゾイミダゾールの調製
|
TW200538453A
(en)
*
|
2004-04-26 |
2005-12-01 |
Bristol Myers Squibb Co |
Bicyclic heterocycles as kinase inhibitors
|
US7709518B2
(en)
*
|
2004-09-21 |
2010-05-04 |
Synta Pharmaceuticals Corp. |
Compounds for inflammation and immune-related uses
|
EP1809628B1
(de)
*
|
2004-10-13 |
2011-06-08 |
Merck Patent GmbH |
Phenylharnstoffderivate als hemmstoffe von tyrosinkinasen zur behandlung von tumorerkrankungen
|
JP2008520745A
(ja)
*
|
2004-11-22 |
2008-06-19 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Rhoキナーゼの二環式阻害剤
|
MX2007008843A
(es)
*
|
2005-01-21 |
2007-08-22 |
Schering Corp |
Derivados de imidazol y bencimidazol utiles como antagonistas de histamina h3.
|
CR9465A
(es)
*
|
2005-03-25 |
2008-06-19 |
Surface Logix Inc |
Compuestos mejorados farmacocineticamente
|
PE20061378A1
(es)
*
|
2005-04-20 |
2006-12-03 |
Smithkline Beecham Corp |
INHIBIDORES DE LA ACTIVIDAD DE Akt
|
GB0512844D0
(en)
*
|
2005-06-23 |
2005-08-03 |
Novartis Ag |
Organic compounds
|
US20090215857A1
(en)
*
|
2005-09-13 |
2009-08-27 |
Pfizer Products Inc. |
Therapeutic Pyrrolidines
|
US7625890B2
(en)
|
2005-11-10 |
2009-12-01 |
Smithkline Beecham Corp. |
Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors
|
JP4738419B2
(ja)
*
|
2005-11-30 |
2011-08-03 |
富士フイルムRiファーマ株式会社 |
アミロイドの凝集及び/又は沈着に起因する疾患の診断薬及び治療薬
|
KR20080077652A
(ko)
*
|
2005-12-22 |
2008-08-25 |
알콘 리서치, 리미티드 |
로 키나제-매개 질환 및 증상 치료용 (인다졸-5-일)피라진및 (1,3-디하이드로인돌-2-온)피라진
|
US8227603B2
(en)
*
|
2006-08-01 |
2012-07-24 |
Cytokinetics, Inc. |
Modulating skeletal muscle
|
US8299248B2
(en)
|
2006-08-02 |
2012-10-30 |
Cytokinetics, Incorporated |
Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
|
ES2439590T3
(es)
*
|
2006-08-02 |
2014-01-23 |
Cytokinetics, Inc. |
Ciertas entidades químicas, composiciones y métodos
|
FR2910473B1
(fr)
|
2006-12-26 |
2009-02-13 |
Sanofi Aventis Sa |
Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
WO2008121333A1
(en)
*
|
2007-03-30 |
2008-10-09 |
Cytokinetics, Incorporated |
Certain chemical entities, compositions and methods
|
ATE523508T1
(de)
|
2007-10-25 |
2011-09-15 |
Astrazeneca Ab |
Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate
|
US7989469B2
(en)
*
|
2008-02-04 |
2011-08-02 |
Cytokinetics, Incorporated |
Certain chemical entities, compositions, and methods
|
CA2723852A1
(en)
*
|
2008-05-16 |
2009-11-19 |
Cellzome Ag |
Methods for the identification of parp interacting molecules and for the purification of parp proteins
|
MX2011004953A
(es)
|
2008-11-10 |
2011-12-14 |
Vertex Pharma |
Compuestos utiles como inhibidores de cinasa atr.
|
KR101745331B1
(ko)
|
2008-12-19 |
2017-06-09 |
버텍스 파마슈티칼스 인코포레이티드 |
Atr 키나제의 억제제로서 유용한 피라진 유도체
|
EP2387315B1
(de)
|
2009-01-16 |
2015-07-15 |
Merck Sharp & Dohme Corp. |
Imidazo-[1,2-a-]pyridine und imidazo-[1,2-b-]pyridazine als mark-hemmer
|
AR075153A1
(es)
*
|
2009-01-30 |
2011-03-16 |
Glaxosmithkline Llc |
Compuesto hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil]etil)-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2- tiofenocarboxamida en forma cristalina, composicion farmaceitica que lo comprende, procedimiento para prepararla, su uso para preparar un medicamento util para tratar o disminuir la
|
EP2398897B1
(de)
|
2009-02-20 |
2017-06-28 |
Cellular Dynamics International, Inc. |
Verfahren und zusammensetzungen zur differenzierung von stammzellen
|
WO2010099539A1
(en)
|
2009-02-27 |
2010-09-02 |
Cellular Dynamics International, Inc. |
Differentiation of pluripotent cells
|
WO2011034741A1
(en)
*
|
2009-09-15 |
2011-03-24 |
Merck Sharp & Dohme Corp. |
Imidazopyridin-2-one derivatives
|
DK2519522T3
(en)
*
|
2009-12-30 |
2014-12-08 |
Arqule Inc |
SUBSTITUTED IDAZOPYRIDINYL AMINOPYRIDINE COMPOUNDS
|
AU2011253025A1
(en)
|
2010-05-12 |
2012-11-29 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2011143423A2
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
JP2013526538A
(ja)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
MX2012013082A
(es)
|
2010-05-12 |
2013-05-09 |
Vertex Pharma |
Derivados de 2-aminopiridina utiles como iinhibidores de cinasa atr.
|
EP2569289A1
(de)
|
2010-05-12 |
2013-03-20 |
Vertex Pharmaceuticals Incorporated |
Pyrazine als hemmer der atr-kinase
|
EP2569287B1
(de)
|
2010-05-12 |
2014-07-09 |
Vertex Pharmaceuticals Inc. |
Verbindungen als hemmer der atr-kinase
|
MX2013000103A
(es)
|
2010-06-23 |
2013-06-13 |
Vertex Pharma |
Derivados de pirrolo-pirazina utiles como inhibidores de cinasa art.
|
DK2638149T3
(da)
|
2010-11-12 |
2019-08-12 |
Univ Georgetown |
Immortalisering af epitelceller og fremgangsmåder til anvendelse
|
EP2694498B1
(de)
|
2011-04-05 |
2016-03-30 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazinverbindungen als tra kinase-hemmer
|
WO2012178124A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
EP2723746A1
(de)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Als art-kinasehemmer nützliche verbindungen
|
JP2014520161A
(ja)
|
2011-06-22 |
2014-08-21 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
AU2012272937B2
(en)
|
2011-06-24 |
2016-09-29 |
Arqule, Inc |
Substituted imidazopyridinyl-aminopyridine compounds
|
US8815854B2
(en)
|
2011-06-24 |
2014-08-26 |
Arqule, Inc. |
Substituted imidazopyridinyl compounds
|
CN102295594B
(zh)
*
|
2011-07-12 |
2016-01-20 |
上海医药工业研究院 |
4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
|
CA2849213A1
(en)
|
2011-07-13 |
2013-01-17 |
Cytokinetics, Inc. |
Combination of riluzole and ck-2017357 for treating als
|
BR112014007690B1
(pt)
|
2011-09-30 |
2022-10-04 |
Vertex Pharmaceuticals Incorporated |
Usos de inibidores de atr no tratamento de câncer pancreático e câncer de pulmão de células não pequenas
|
KR102184246B1
(ko)
|
2011-09-30 |
2020-12-01 |
버텍스 파마슈티칼스 인코포레이티드 |
Atr 키나제의 억제제로서 유용한 화합물의 제조 방법
|
CA2850564A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
US8853217B2
(en)
|
2011-09-30 |
2014-10-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
EP2751088B1
(de)
|
2011-09-30 |
2016-04-13 |
Vertex Pharmaceuticals Incorporated |
Als atr-kinasehemmer nützliche verbindungen
|
US8841449B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2013071094A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2013071090A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2013071093A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
US8846917B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
RS56673B1
(sr)
|
2012-04-05 |
2018-03-30 |
Vertex Pharma |
Jedinjenja korisna kao inhibitori atr kinaze i kombinovane terapije koje ih koriste
|
EP2841563B1
(de)
|
2012-04-24 |
2019-06-12 |
Dan S. Kaufman |
Verfahren zur entwicklung natürlicher killerzellen aus stammzellen
|
EP2900223B1
(de)
|
2012-09-28 |
2017-10-25 |
Merck Sharp & Dohme Corp. |
Neuartige verbindungen als erk-hemmer
|
US9233979B2
(en)
|
2012-09-28 |
2016-01-12 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
US8999632B2
(en)
|
2012-10-04 |
2015-04-07 |
Vertex Pharmaceuticals Incorporated |
Method for measuring ATR inhibition mediated increases in DNA damage
|
US8912198B2
(en)
|
2012-10-16 |
2014-12-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
CN107501275B
(zh)
|
2012-12-07 |
2019-11-22 |
沃泰克斯药物股份有限公司 |
可用作atr激酶抑制剂的化合物
|
GB201304526D0
(en)
*
|
2013-03-13 |
2013-04-24 |
Proximagen Ltd |
New compounds
|
AU2014236150B2
(en)
|
2013-03-14 |
2019-10-31 |
The Regents Of The University Of California |
In vitro production of medial ganglionic eminence precursor cells
|
BR112015022993B1
(pt)
|
2013-03-14 |
2021-12-14 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Inibidores de jak2 e alk2, composição farmacêutica compreendendo os referidos inibidores e uso destes
|
EP2970286A1
(de)
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Inc. |
Kondensierte pyrazolopyrimidinderivate als inhibitoren der atr-kinase
|
ES2563902T3
(es)
|
2013-05-14 |
2016-03-16 |
Active Biotech Ab |
Derivados de N-(heteroaril)-sulfonamida útiles como inhibidores de S100
|
WO2015041533A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
Rock in combination with mapk-pathway
|
RU2720408C2
(ru)
|
2013-12-06 |
2020-04-29 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способ получения ингибиторов atr киназы (варианты)
|
AU2015249809B2
(en)
*
|
2014-04-22 |
2019-05-02 |
Arqule, Inc. |
Salts and polymorphs of a substituted imidazopyridinyl-aminopyridine compound
|
AU2015271030B2
(en)
|
2014-06-05 |
2019-05-16 |
Vertex Pharmaceuticals Incorporated |
Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof
|
ES2733847T3
(es)
|
2014-06-17 |
2019-12-03 |
Vertex Pharma |
Método para tratar cáncer usando una combinación de inhibidores de CHK1 y ATR
|
KR20170020527A
(ko)
|
2014-06-27 |
2017-02-22 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
배양된 포유동물 윤부 줄기세포, 이를 생성하는 방법, 및 이의 용도
|
CA2968655C
(en)
|
2014-11-25 |
2021-11-16 |
President And Fellows Of Harvard College |
Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
|
EP3277799B1
(de)
|
2015-04-03 |
2020-09-23 |
Propagenix Inc. |
Ex-vivo-proliferation von epithelzellen
|
US10100285B2
(en)
|
2015-04-03 |
2018-10-16 |
Propagenix Inc. |
Ex vivo proliferation of epithelial cells
|
EP3347450B1
(de)
|
2015-09-11 |
2021-03-17 |
Propagenix Inc. |
Ex-vivo-proliferation von epithelzellen
|
WO2017059357A1
(en)
|
2015-09-30 |
2017-04-06 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of dna damaging agents and atr inhibitors
|
CA3001857A1
(en)
*
|
2015-10-14 |
2017-04-20 |
Aquinnah Pharmaceuticals, Inc. |
Compounds, compositions and methods of use against stress granules
|
WO2017151409A1
(en)
|
2016-02-29 |
2017-09-08 |
University Of Florida Research Foundation, Incorporated |
Chemotherapeutic methods
|
WO2019126567A1
(en)
*
|
2017-12-22 |
2019-06-27 |
Southern Research Institute |
Substituted heterocyclic-pyridinones as hiv-1 nef-hck inhibitors
|
EP3826684A4
(de)
|
2018-07-26 |
2022-04-06 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Verfahren zur behandlung von mit abnormaler acvr1 -expression verbundenen krankheiten und acvr1 -inhibitoren zur verwendung in demselben
|
EP3841195A1
(de)
|
2018-08-20 |
2021-06-30 |
Propagenix Inc. |
Epithelzellsphäroide
|
US20210292766A1
(en)
|
2018-08-29 |
2021-09-23 |
University Of Massachusetts |
Inhibition of Protein Kinases to Treat Friedreich Ataxia
|
BR112021006488A2
(pt)
|
2018-10-05 |
2021-07-06 |
Annapurna Bio Inc |
compostos e composições para o tratamento de condições associadas com atividade do receptor apj
|
UY38427A
(es)
|
2018-10-26 |
2020-05-29 |
Novartis Ag |
Métodos y composiciones para terapia con células oculares
|
CN111732584B
(zh)
*
|
2019-03-25 |
2024-02-27 |
复旦大学 |
二芳基取代稠杂环类化合物及其制备方法和在制药中的用途
|
EP4142879A1
(de)
|
2020-04-27 |
2023-03-08 |
Novartis AG |
Verfahren und zusammensetzungen zur augenzelltherapie
|
CA3235384A1
(en)
|
2021-10-18 |
2023-04-27 |
Takahiro Ochiya |
Compositions and methods of use thereof for treating liver fibrosis
|
AU2022369459A1
(en)
|
2021-10-22 |
2024-05-30 |
Evia Life Sciences Inc. |
Methods for making extracellular vesicles, and compositions and methods of use thereof
|
WO2024083237A1
(en)
*
|
2022-10-20 |
2024-04-25 |
Impact Therapeutics (Shanghai) , Inc |
Substituted heteroaryl bicyclic compounds as usp1 inhibitors and the use thereof
|