ATE402174T1 - Imidazopyridinderivate als kinaseinhibitoren - Google Patents

Imidazopyridinderivate als kinaseinhibitoren

Info

Publication number
ATE402174T1
ATE402174T1 AT03744904T AT03744904T ATE402174T1 AT E402174 T1 ATE402174 T1 AT E402174T1 AT 03744904 T AT03744904 T AT 03744904T AT 03744904 T AT03744904 T AT 03744904T AT E402174 T1 ATE402174 T1 AT E402174T1
Authority
AT
Austria
Prior art keywords
sub
group selected
kinase inhibitors
imidazopyridine derivatives
group
Prior art date
Application number
AT03744904T
Other languages
English (en)
Inventor
Nicholas Bailey
Mark James Bamford
Stephen Garland
Krista B Goodman
Cui Haifeng
Mark A Hilfiker
Dennis Lee
Terence Aaron Panchal
Robert A Stavenger
David Matthew Wilson
Jason Witherington
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE402174T1 publication Critical patent/ATE402174T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03744904T 2002-03-22 2003-03-21 Imidazopyridinderivate als kinaseinhibitoren ATE402174T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0206860.9A GB0206860D0 (en) 2002-03-22 2002-03-22 Compounds

Publications (1)

Publication Number Publication Date
ATE402174T1 true ATE402174T1 (de) 2008-08-15

Family

ID=9933560

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03744904T ATE402174T1 (de) 2002-03-22 2003-03-21 Imidazopyridinderivate als kinaseinhibitoren

Country Status (9)

Country Link
US (1) US7348339B2 (de)
EP (1) EP1490367B1 (de)
JP (1) JP2005526802A (de)
AT (1) ATE402174T1 (de)
AU (1) AU2003215753A1 (de)
DE (1) DE60322359D1 (de)
ES (1) ES2309330T3 (de)
GB (1) GB0206860D0 (de)
WO (1) WO2003080610A1 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7847101B2 (en) 2002-07-24 2010-12-07 Valocor Therapeutics, Inc. Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
JP2006520794A (ja) * 2003-03-21 2006-09-14 スミスクライン ビーチャム コーポレーション 化合物
TW200523262A (en) * 2003-07-29 2005-07-16 Smithkline Beecham Corp Inhibitors of AKT activity
WO2005012269A1 (ja) * 2003-08-05 2005-02-10 Ajinomoto Co., Inc. 新規アゾール化合物
JP2007507549A (ja) * 2003-10-06 2007-03-29 グラクソ グループ リミテッド キナーゼ阻害剤としての1,6,7−三置換アザベンゾイミダゾールの調製
JP2007507547A (ja) * 2003-10-06 2007-03-29 グラクソ グループ リミテッド キナーゼ阻害剤としての1,7−二置換アザベンゾイミダゾールの調製
WO2005037197A2 (en) * 2003-10-06 2005-04-28 Glaxo Group Limited Preperation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
MX2007003342A (es) 2004-09-21 2007-06-05 Synta Pharmaceutical Corp Compuestos para inflamacion y usos relacionados con trastornos inmunitarios.
WO2006042599A1 (de) * 2004-10-13 2006-04-27 Merck Patent Gmbh Phenylharnstoffderivate als hemmstoffe von tyrosinkinasen zur behandlung von tumorerkrankungen
EP1814883A1 (de) * 2004-11-22 2007-08-08 Vertex Pharmaceuticals Incorporated Bicyclische rho-kinase-hemmer
EP1848696A1 (de) 2005-01-21 2007-10-31 Schering Corporation Als histamin-h3-antagonisten geeignete imidazol- und benzimidazolderivate
CR9465A (es) * 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
PE20061378A1 (es) * 2005-04-20 2006-12-03 Smithkline Beecham Corp INHIBIDORES DE LA ACTIVIDAD DE Akt
GB0512844D0 (en) * 2005-06-23 2005-08-03 Novartis Ag Organic compounds
US20090215857A1 (en) * 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
US7625890B2 (en) 2005-11-10 2009-12-01 Smithkline Beecham Corp. Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors
WO2007063946A1 (ja) * 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び/又は沈着に起因する疾患の診断薬及び治療薬
BRPI0620463A2 (pt) * 2005-12-22 2011-11-16 Alcon Res Ltd composição farmacêutica oftálmica, compostos, e seus usos
US8227603B2 (en) * 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) * 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
EP2666777A1 (de) * 2006-08-02 2013-11-27 Cytokinetics, Inc. Bestimmte chemische Stoffe mit eine imidazo<4,5-b>pyrazin-2(3H)-one Kernstruktur, Zusammensetzungen und Verfahren
FR2910473B1 (fr) 2006-12-26 2009-02-13 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
UY30892A1 (es) * 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
EP2139478A4 (de) 2007-03-30 2010-05-05 Cytokinetics Inc Bestimmte chemische entitäten, zusammensetzungen und verfahren
AU2008315746A1 (en) 2007-10-25 2009-04-30 Astrazeneca Ab Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders
MX2010008518A (es) * 2008-02-04 2010-11-10 Cytokinetics Inc Ciertas entidades quimicas, composiciones y metodos.
JP2011521214A (ja) * 2008-05-16 2011-07-21 セルゾーム アーゲー Parp相互作用分子の同定およびparpタンパク質の精製のための方法
MX2011004953A (es) 2008-11-10 2011-12-14 Vertex Pharma Compuestos utiles como inhibidores de cinasa atr.
ES2921576T3 (es) 2008-12-19 2022-08-29 Vertex Pharma Compuestos útiles como inhibidores de la quinasa ATR
EP2387315B1 (de) 2009-01-16 2015-07-15 Merck Sharp & Dohme Corp. Imidazo-[1,2-a-]pyridine und imidazo-[1,2-b-]pyridazine als mark-hemmer
MY161598A (en) * 2009-01-30 2017-04-28 Glaxosmithkline Llc Crystalline n-{ (1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl} -5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
JP6189581B2 (ja) 2009-02-20 2017-08-30 セルラー ダイナミクス インターナショナル, インコーポレイテッド 幹細胞の分化のための方法および組成物
US8372642B2 (en) * 2009-02-27 2013-02-12 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
WO2011034741A1 (en) * 2009-09-15 2011-03-24 Merck Sharp & Dohme Corp. Imidazopyridin-2-one derivatives
MX2012007367A (es) 2009-12-30 2013-04-03 Arqule Inc Compuestos substituidos de imidazopiridinilo-aminopiridina.
WO2011143419A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Pyrazines useful as inhibitors of atr kinase
EP2569313A1 (de) 2010-05-12 2013-03-20 Vertex Pharmaceuticals Incorporated Als art-kinasehemmer nützliche verbindungen
NZ603478A (en) 2010-05-12 2014-09-26 Vertex Pharma 2 -aminopyridine derivatives useful as inhibitors of atr kinase
US8969356B2 (en) 2010-05-12 2015-03-03 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US9334244B2 (en) 2010-05-12 2016-05-10 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
EP2569286B1 (de) 2010-05-12 2014-08-20 Vertex Pharmaceuticals Inc. Verbindungen als hemmer der atr-kinase
EP2585468A1 (de) 2010-06-23 2013-05-01 Vertex Pharmaceuticals Incorporated Pyrrolo-pyrazinderivate als atr-kinaseinhibitoren
WO2012065067A2 (en) 2010-11-12 2012-05-18 Georgetown University Immortalization of epithelial cells and methods of use
AU2012240030A1 (en) 2011-04-05 2013-10-24 Vertex Pharmaceuticals Incorporated Aminopyrazine compounds useful as inhibitors of TRA kinase
EP2723747A1 (de) 2011-06-22 2014-04-30 Vertex Pharmaceuticals Inc. Als art-kinasehemmer nützliche verbindungen
WO2012178123A1 (en) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US9309250B2 (en) 2011-06-22 2016-04-12 Vertex Pharmaceuticals Incorporated Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
KR101974673B1 (ko) 2011-06-24 2019-05-02 아르퀼 인코포레이티드 치환된 이미다조피리디닐-아미노피리딘 화합물
WO2012177852A1 (en) 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
WO2013010015A2 (en) 2011-07-13 2013-01-17 Cytokinetics, Inc. Combination als therapy
CA2850564A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US8765751B2 (en) 2011-09-30 2014-07-01 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
RU2018108589A (ru) 2011-09-30 2019-02-25 Вертекс Фармасьютикалз Инкорпорейтед Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr
WO2013049720A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP3878851A1 (de) 2011-09-30 2021-09-15 Vertex Pharmaceuticals Incorporated Verfahren zur herstellung von verbindungen welche als hemmer der atr-kinase nützlich sind
JP2015502925A (ja) 2011-11-09 2015-01-29 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Atrキナーゼの阻害剤として有用なピラジン化合物
EP2776420A1 (de) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Pyrazinverbindungen als atr-kinaseinhibitoren
EP2776429A1 (de) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Als atr-kinaseinhibitoren nützliche verbindungen
US8846917B2 (en) 2011-11-09 2014-09-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
WO2013071090A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
PT2833973T (pt) 2012-04-05 2017-12-21 Vertex Pharma Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos
EP2841563B1 (de) 2012-04-24 2019-06-12 Dan S. Kaufman Verfahren zur entwicklung natürlicher killerzellen aus stammzellen
US9226922B2 (en) 2012-09-28 2016-01-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
CN105050598B (zh) * 2012-09-28 2018-04-27 默沙东公司 作为erk抑制剂的新型化合物
WO2014055756A1 (en) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
EP2909202A1 (de) 2012-10-16 2015-08-26 Vertex Pharmaceuticals Incorporated Als atr-kinaseinhibitoren nützliche verbindungen
WO2014089379A1 (en) 2012-12-07 2014-06-12 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
GB201304526D0 (en) * 2013-03-13 2013-04-24 Proximagen Ltd New compounds
RU2693480C2 (ru) 2013-03-14 2019-07-03 Толеро Фармасьютикалз, Инк. Ингибиторы jak2 и alk2 и способы их использования
CA3143449C (en) 2013-03-14 2026-01-06 The Regents Of The University Of California In vitro production of medial ganglionic eminence precursor cells
US9663519B2 (en) 2013-03-15 2017-05-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
CN105377837B (zh) 2013-05-14 2017-08-04 活跃生物技术有限公司 用作s100‑抑制剂的n‑(杂芳基)磺酰胺衍生物
WO2015041533A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut Rock in combination with mapk-pathway
WO2015085132A1 (en) 2013-12-06 2015-06-11 Vertex Pharmaceuticals Incorporated 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
CA2945778A1 (en) * 2014-04-22 2015-10-29 Arqule, Inc. Salts and polymorphs of a substituted imidazopyridinyl-aminopyridine compound
HRP20200186T1 (hr) 2014-06-05 2020-05-29 Vertex Pharmaceuticals Inc. Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici
JP6936007B2 (ja) 2014-06-17 2021-09-15 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Chk1阻害剤とatr阻害剤との組み合わせを使用してがんを処置する方法
CA2953524A1 (en) 2014-06-27 2015-12-30 The Regents Of The University Of California Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof
WO2016085765A1 (en) 2014-11-25 2016-06-02 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
US10100285B2 (en) 2015-04-03 2018-10-16 Propagenix Inc. Ex vivo proliferation of epithelial cells
AU2016243750B2 (en) 2015-04-03 2022-02-03 Propagenix Inc. Ex vivo proliferation of epithelial cells
EP3347450B1 (de) 2015-09-11 2021-03-17 Propagenix Inc. Ex-vivo-proliferation von epithelzellen
EP3355926B1 (de) 2015-09-30 2025-12-24 Vertex Pharmaceuticals Inc. Kombination von dna-schädigenden mitteln und atr-inhibitoren zur verwendung in einem verfahren zur behandlung von krebs
CA3001857A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
WO2019126567A1 (en) * 2017-12-22 2019-06-27 Southern Research Institute Substituted heterocyclic-pyridinones as hiv-1 nef-hck inhibitors
CA3103995A1 (en) 2018-07-26 2020-01-30 Sumitomo Dainippon Pharma Oncology, Inc. Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
CA3107502A1 (en) 2018-08-20 2020-02-27 Chengkang ZHANG Epithelial cell spheroids
US12281308B2 (en) 2018-08-29 2025-04-22 University Of Massachusetts Inhibition of protein kinases to treat Friedreich ataxia
HUE066335T2 (hu) 2018-10-05 2024-07-28 Annapurna Bio Inc Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére
UY38427A (es) 2018-10-26 2020-05-29 Novartis Ag Métodos y composiciones para terapia con células oculares
CN111732584B (zh) * 2019-03-25 2024-02-27 复旦大学 二芳基取代稠杂环类化合物及其制备方法和在制药中的用途
EP4142879A1 (de) 2020-04-27 2023-03-08 Novartis AG Verfahren und zusammensetzungen zur augenzelltherapie
US20240425816A1 (en) 2021-10-18 2024-12-26 Evia Life Sciences Inc. Compositions and methods of use thereof for treating liver fibrosis
JP2024539220A (ja) 2021-10-22 2024-10-28 エヴィア ライフ サイエンシズ インコーポレイテッド 細胞外小胞を作製するための方法、組成物、およびその使用方法
WO2024083237A1 (en) * 2022-10-20 2024-04-25 Impact Therapeutics (Shanghai) , Inc Substituted heteroaryl bicyclic compounds as usp1 inhibitors and the use thereof
TW202539660A (zh) * 2024-01-17 2025-10-16 南韓商Lg化學股份有限公司 作為CBP/p300抑制劑之新穎化合物和含有彼作為活性成分以預防或治療癌症、發炎病症或自體免疫疾病之醫藥組成物
CN119235877B (zh) * 2024-11-08 2025-11-11 中山大学 一种钌(iii)酸盐的组合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722992A1 (de) * 1987-07-11 1989-01-19 Thomae Gmbh Dr K Neue imidazo-pyridine und purine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE359822T1 (de) * 1996-08-12 2007-05-15 Mitsubishi Pharma Corp Medikamente enthaltend rho-kinase inhibitoren
CA2307285C (en) * 1998-08-17 2009-03-31 Senju Pharmaceutical Co., Ltd. Agent for prophylaxis and treatment of glaucoma
JP2000063274A (ja) * 1998-08-20 2000-02-29 Yoshitomi Pharmaceut Ind Ltd 喘息抑制用吸入剤
KR20010110793A (ko) * 1999-04-22 2001-12-13 가마쿠라 아키오 혈관협착증 예방 및 치료제
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
WO2001057018A1 (en) * 2000-02-02 2001-08-09 Abbott Laboratories Azaazulene inhibitors of p38 map kinase and tnf-alpha
HK1049837B (en) * 2000-03-16 2007-01-19 Mitsubishi Pharma Corporation Amide compounds and uses
KR20040084896A (ko) * 2002-02-06 2004-10-06 버텍스 파마슈티칼스 인코포레이티드 Gsk-3의 억제제로서 유용한 헤테로아릴 화합물
JP2007507549A (ja) * 2003-10-06 2007-03-29 グラクソ グループ リミテッド キナーゼ阻害剤としての1,6,7−三置換アザベンゾイミダゾールの調製

Also Published As

Publication number Publication date
US20050197328A1 (en) 2005-09-08
EP1490367A1 (de) 2004-12-29
AU2003215753A1 (en) 2003-10-08
WO2003080610A1 (en) 2003-10-02
ES2309330T3 (es) 2008-12-16
DE60322359D1 (de) 2008-09-04
JP2005526802A (ja) 2005-09-08
EP1490367B1 (de) 2008-07-23
US7348339B2 (en) 2008-03-25
GB0206860D0 (en) 2002-05-01

Similar Documents

Publication Publication Date Title
ATE402174T1 (de) Imidazopyridinderivate als kinaseinhibitoren
SE0202463D0 (sv) Novel compounds
NO20075059L (no) Nye forbindelser II 2-pyridinderivater som inhibitorer av neutrofil elastase
UA84878C2 (ru) Производные 2-пиридона как ингибиторы нейтрофилов эластазы, фармацевтическая композиция на их основе, способ их получения
WO2003013484A3 (en) N-monoacylated derivatives of o-phenylenediamines, their six membered heterocyclic analogues and their use as pharmaceutical agents
DK0889877T3 (da) Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
NO20070432L (no) Pyrimidinureaderivater som kinaseinhibitorer
NO20091893L (no) Nye 1,4-benzotiepin-1,1-dioksidderivater som er substituert med benzylgrupper, fremgangsmater for fremstilling av medisiner inneholdende forbindelsene og anvendelse derav.
ATE253545T1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
MX2009011964A (es) Derivados heterociclicos pirrolo-nitrogenosos, su preparacion y uso farmaceutico.
NO20085087L (no) Nye heterocykliske forbindelser
DK0734383T3 (da) Cykliske amidderivater som neurokinin-A-antagonister
DE602004012758D1 (de) Chinoxalinderivate als inhibitoren der neutrophilelastase und deren verwendung
NO20051695L (no) Nye spirokondenserte kinazolinoner og deres anvendelse som fosfodiestereaseinbibitorer
NO20072515L (no) 2-amido-4-fenyltnazolderivater, fremstilling og terapeutsik anvendelse derav
NO20052683L (no) Nye pyridopyrimidinonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
ATE359791T1 (de) Pyrimidin-2,4-dion-derivate als matrix- metalloproteinase-hemmer
GB0308201D0 (en) Novel compounds
SE0300908D0 (sv) Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
MY140630A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0301701D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ATE476431T1 (de) Piperidin- und azetidinderivate als glyt1- inhibitoren
SE0301699D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
DE69916066D1 (de) Neue benzoxazole mit pde-hemmender wirkung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties