MX2012007367A - Compuestos substituidos de imidazopiridinilo-aminopiridina. - Google Patents

Compuestos substituidos de imidazopiridinilo-aminopiridina.

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Publication number
MX2012007367A
MX2012007367A MX2012007367A MX2012007367A MX2012007367A MX 2012007367 A MX2012007367 A MX 2012007367A MX 2012007367 A MX2012007367 A MX 2012007367A MX 2012007367 A MX2012007367 A MX 2012007367A MX 2012007367 A MX2012007367 A MX 2012007367A
Authority
MX
Mexico
Prior art keywords
compounds
substituted imidazopyridinyl
aminopyridine compounds
aminopyridine
methods
Prior art date
Application number
MX2012007367A
Other languages
English (en)
Inventor
Shin Iimura
Yanbin Liu
Jason Hill
Rocio Palma
Jean-Marc Lapierre
Manish Tandon
David Vensel
Nivedita Namdev
Mark A Ashwell
Chris Brassard
Anton Filikov
Steffi Koerner
Robert Nicewonger
Akihisa Matsuda
Yuko Yamamoto
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of MX2012007367A publication Critical patent/MX2012007367A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

La presente invención se relaciona con compuestos sustituidos de imidazopiridinilo-aminopiridina y métodos para sintetizar estos compuestos. La presente invención también se relaciona con composiciones farmacéuticas que contienen compuestos sustituidos de imidazopiridinilo-aminopiridina y métodos para el tratamiento de trastornos celulares proliferativos, tales como cáncer, mediante la administración de estos compuestos y composiciones farmacéuticas a sujetos en necesidad de los mismos.
MX2012007367A 2009-12-30 2010-12-29 Compuestos substituidos de imidazopiridinilo-aminopiridina. MX2012007367A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29092309P 2009-12-30 2009-12-30
PCT/US2010/062440 WO2011082270A2 (en) 2009-12-30 2010-12-29 Substituted imidazopyridinyl-aminopyridine compounds

Publications (1)

Publication Number Publication Date
MX2012007367A true MX2012007367A (es) 2013-04-03

Family

ID=44227150

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007367A MX2012007367A (es) 2009-12-30 2010-12-29 Compuestos substituidos de imidazopiridinilo-aminopiridina.

Country Status (19)

Country Link
US (1) US8501770B2 (es)
EP (1) EP2519522B1 (es)
JP (1) JP5774602B2 (es)
KR (1) KR101689421B1 (es)
CN (1) CN102781940B (es)
AU (1) AU2010339533B2 (es)
CA (1) CA2785536C (es)
CO (1) CO6511271A2 (es)
DK (1) DK2519522T3 (es)
ES (1) ES2531109T3 (es)
HK (1) HK1177458A1 (es)
IL (1) IL220571A (es)
MX (1) MX2012007367A (es)
MY (1) MY157124A (es)
NZ (1) NZ600801A (es)
RU (1) RU2619463C2 (es)
SG (1) SG181947A1 (es)
TW (1) TWI585086B (es)
WO (1) WO2011082270A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8815854B2 (en) * 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
EP2723741B8 (en) * 2011-06-24 2016-09-21 ArQule, Inc. Substituted imidazopyridinyl-aminopyridine compounds
WO2013078254A1 (en) * 2011-11-22 2013-05-30 Array Biopharma Inc. Bicyclic heteroaryl derivatives as kinase inhibitors
US20140004044A1 (en) * 2012-05-17 2014-01-02 The University Of Chicago Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging
US9617215B2 (en) 2012-05-17 2017-04-11 The University Of Chicago Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging
AU2014312756B2 (en) * 2013-08-29 2018-11-22 Kyoto Pharmaceutical Industries, Ltd. Novel aromatic compound and use thereof
GB201321741D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
US9464083B2 (en) * 2014-03-24 2016-10-11 Arqule Inc. Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-yl)pyridin-2-amine
BR112016024521A2 (pt) * 2014-04-22 2017-08-15 Arqule Inc sais e polimorfos de um composto imidazopiridinil-aminopiridina
US9949981B2 (en) * 2014-09-05 2018-04-24 Arqule, Inc. Compositions and methods for treating proliferation disorders
CN105315161B (zh) * 2015-06-05 2017-08-04 厦门医学院 一类PKB/Akt抑制剂的关键中间体的制备方法
US11352328B2 (en) 2016-07-12 2022-06-07 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus
US11208478B2 (en) 2016-08-07 2021-12-28 The Wistar Institute Of Anatomy And Biology Methods of detecting and treating a tumor expressing pT346 PDK1
WO2019099314A1 (en) 2017-11-14 2019-05-23 Merck Sharp & Dohme Corp. Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
WO2019099294A1 (en) 2017-11-14 2019-05-23 Merck Sharp & Dohme Corp. Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
EP4364798A2 (en) 2018-10-05 2024-05-08 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity
AU2020319160A1 (en) * 2019-07-25 2022-01-27 Curadev Pharma Pvt. Ltd. Small molecule inhibitors of acetyl coenzyme A synthetase short chain 2 (ACSS2)
EP4143194A1 (en) * 2020-05-01 2023-03-08 Gilead Sciences, Inc. Cd73 inhibiting 2,4-dioxopyrimidine compounds
CN114262322A (zh) * 2020-09-16 2022-04-01 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
US20230357242A1 (en) * 2020-09-30 2023-11-09 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Compound as akt kinase inhibitor
CN114315839A (zh) * 2020-09-30 2022-04-12 武汉人福创新药物研发中心有限公司 嘧啶二酮类化合物及其用途
CN117769554A (zh) 2021-05-28 2024-03-26 大鹏药品工业株式会社 Kras突变蛋白的小分子抑制剂
AU2022376954A1 (en) 2021-10-29 2024-05-02 Gilead Sciences, Inc. Cd73 compounds
WO2023168291A1 (en) * 2022-03-02 2023-09-07 Terremoto Biosciences, Inc. Covalent modifiers of akt1 and uses thereof
WO2024064026A1 (en) * 2022-09-19 2024-03-28 Alterome Therapeutics, Inc. Akt1 modulators
WO2024073371A1 (en) * 2022-09-26 2024-04-04 Alterome Therapeutics, Inc. Akt1 modulators

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
DE3722992A1 (de) 1987-07-11 1989-01-19 Thomae Gmbh Dr K Neue imidazo-pyridine und purine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2002859C (en) 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
DE4129603A1 (de) 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0800391A1 (en) 1994-12-28 1997-10-15 Janssen Pharmaceutica N.V. Benzimidazoles as inhibitors of calcitriol metabolism
AU3538899A (en) 1998-04-30 1999-11-23 Nippon Chemiphar Co. Ltd. Condensed imidazole derivative and therapeutic agent for liver disease
JP2000344780A (ja) 1998-09-24 2000-12-12 Fuji Photo Film Co Ltd 新規ベンゾピラン化合物、発光素子材料及びそれを使用した発光素子
ES2244613T3 (es) * 2000-04-27 2005-12-16 Astellas Pharma Inc. Derivados de imidazopiridina.
US6403588B1 (en) 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
GB0206860D0 (en) 2002-03-22 2002-05-01 Glaxo Group Ltd Compounds
GB0206861D0 (en) 2002-03-22 2002-05-01 Glaxo Group Ltd Medicaments
PL373889A1 (en) 2002-04-18 2005-09-19 Schering Corporation (1-4-piperidinyl)benzimidazole derivatives useful as histamine h3 antagonists
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
TW200523262A (en) * 2003-07-29 2005-07-16 Smithkline Beecham Corp Inhibitors of AKT activity
AU2004268950A1 (en) * 2003-08-21 2005-03-10 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine-derivatives as c-kit inhibitors
US7442709B2 (en) 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
EP2298770A1 (en) 2005-11-03 2011-03-23 ChemBridge Corporation Heterocyclic compounds as TrkA modulators
PE20071162A1 (es) 2005-12-21 2007-11-30 Schering Corp Combinacion de un antagonista/agonista inverso de h3 y un supresor del apetito
DE602007004092D1 (de) * 2006-03-22 2010-02-11 Vertex Pharma C-met-proteinkinasehemmer zur behandlung proliferativer erkrankungen
CN100398540C (zh) 2006-04-03 2008-07-02 大连理工大学 芳杂环基咪唑并萘酰亚胺类化合物及其应用
NZ574697A (en) 2006-07-11 2011-12-22 Dae Woong Pharma Novel biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same
KR20090127902A (ko) 2007-03-02 2009-12-14 쉐링 코포레이션 벤즈이미다졸 유도체 및 이의 사용방법
WO2009000413A1 (en) 2007-06-26 2008-12-31 Sanofi-Aventis A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
WO2009051454A2 (en) 2007-10-17 2009-04-23 Cheil Industries Inc. Novel compound for organic photoelectric device and organic photoelectric device including the same
KR20090007347U (ko) 2008-01-16 2009-07-21 춘-치 왕 가속 페달 포지션 센서를 구비한 자동차용 연료 공급 기구

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HK1177458A1 (en) 2013-08-23
MY157124A (en) 2016-05-13
EP2519522A2 (en) 2012-11-07
ES2531109T3 (es) 2015-03-10
TWI585086B (zh) 2017-06-01
AU2010339533A1 (en) 2012-07-12
AU2010339533B2 (en) 2015-05-07
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CN102781940B (zh) 2016-09-07
IL220571A (en) 2015-03-31
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US20110172203A1 (en) 2011-07-14
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