CN105315161B - 一类PKB/Akt抑制剂的关键中间体的制备方法 - Google Patents
一类PKB/Akt抑制剂的关键中间体的制备方法 Download PDFInfo
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- CN105315161B CN105315161B CN201510304809.8A CN201510304809A CN105315161B CN 105315161 B CN105315161 B CN 105315161B CN 201510304809 A CN201510304809 A CN 201510304809A CN 105315161 B CN105315161 B CN 105315161B
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- 0 *c1ccc(C2(CCC2)C#*)cc1 Chemical compound *c1ccc(C2(CCC2)C#*)cc1 0.000 description 5
- JHOHTGSVQASAEI-UHFFFAOYSA-N N#CC1(CCC1)c(cc1)ccc1[N+]([O-])=O Chemical compound N#CC1(CCC1)c(cc1)ccc1[N+]([O-])=O JHOHTGSVQASAEI-UHFFFAOYSA-N 0.000 description 1
- IOAUYDAXZBMLJU-UHFFFAOYSA-N NC(C1(CCC1)c(cc1)ccc1[N+]([O-])=O)=O Chemical compound NC(C1(CCC1)c(cc1)ccc1[N+]([O-])=O)=O IOAUYDAXZBMLJU-UHFFFAOYSA-N 0.000 description 1
- ZJRQRRUUGNADQN-UHFFFAOYSA-N NC1(CCC1)c(cc1)ccc1[N+]([O-])=O Chemical compound NC1(CCC1)c(cc1)ccc1[N+]([O-])=O ZJRQRRUUGNADQN-UHFFFAOYSA-N 0.000 description 1
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CN106631843A (zh) * | 2016-11-23 | 2017-05-10 | 山东友帮生化科技有限公司 | 一种3‑氧代环丁基氨的制备方法 |
CN111848423B (zh) * | 2019-04-30 | 2022-10-14 | 尚科生物医药(上海)有限公司 | 3-氧代环丁基氨基甲酸叔丁酯的制备方法 |
Citations (2)
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CN102781940A (zh) * | 2009-12-30 | 2012-11-14 | 艾科尔公司 | 取代的咪唑并吡啶基-氨基吡啶化合物 |
CN103748093A (zh) * | 2011-06-24 | 2014-04-23 | 艾科尔公司 | 被取代的咪唑并吡啶基-氨基吡啶化合物 |
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CN102781940A (zh) * | 2009-12-30 | 2012-11-14 | 艾科尔公司 | 取代的咪唑并吡啶基-氨基吡啶化合物 |
CN103748093A (zh) * | 2011-06-24 | 2014-04-23 | 艾科尔公司 | 被取代的咪唑并吡啶基-氨基吡啶化合物 |
Non-Patent Citations (2)
Title |
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Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT;Jason G. Kettle et al.;《J. Med. Chem.》;20120116;第55卷;第1261−1273页 * |
REG;AMERICAN CHEMICAL SOCIETY;《STN ON THE WEB》;20140311;第1-7页 * |
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