US20140044802A1 - Compounds useful as inhibitors of atr kinase and combination therapies thereof - Google Patents

Compounds useful as inhibitors of atr kinase and combination therapies thereof Download PDF

Info

Publication number
US20140044802A1
US20140044802A1 US13/857,658 US201313857658A US2014044802A1 US 20140044802 A1 US20140044802 A1 US 20140044802A1 US 201313857658 A US201313857658 A US 201313857658A US 2014044802 A1 US2014044802 A1 US 2014044802A1
Authority
US
United States
Prior art keywords
aliphatic
compound
cancer
compounds
nh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/857,658
Inventor
John Robert Pollard
Philip Michael Reaper
Mohammed Asmal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261620717P priority Critical
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Priority to US13/857,658 priority patent/US20140044802A1/en
Assigned to VERTEX PHARMACEUTICALS INCORPORATED reassignment VERTEX PHARMACEUTICALS INCORPORATED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ASMAL, Mohammed
Assigned to VERTEX PHARMACEUTICALS (EUROPE) LIMITED reassignment VERTEX PHARMACEUTICALS (EUROPE) LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: POLLARD, JOHN ROBERT, REAPER, MICHAEL
Assigned to VERTEX PHARMACEUTICALS INCORPORATED reassignment VERTEX PHARMACEUTICALS INCORPORATED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: VERTEX PHARMACEUTICALS (EUROPE) LIMITED
Publication of US20140044802A1 publication Critical patent/US20140044802A1/en
Assigned to MACQUARIE US TRADING LLC reassignment MACQUARIE US TRADING LLC SECURITY INTEREST Assignors: VERTEX PHARMACEUTICALS (SAN DIEGO) LLC, VERTEX PHARMACEUTICALS INCORPORATED
Assigned to VERTEX PHARMACEUTICALS INCORPORATED, VERTEX PHARMACEUTICALS (SAN DIEGO) LLC reassignment VERTEX PHARMACEUTICALS INCORPORATED RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: MACQUARIE US TRADING LLC
Application status is Abandoned legal-status Critical

Links