DE60226469D1 - Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren - Google Patents

Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren

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Publication number
DE60226469D1
DE60226469D1 DE60226469T DE60226469T DE60226469D1 DE 60226469 D1 DE60226469 D1 DE 60226469D1 DE 60226469 T DE60226469 T DE 60226469T DE 60226469 T DE60226469 T DE 60226469T DE 60226469 D1 DE60226469 D1 DE 60226469D1
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DE
Germany
Prior art keywords
kinase inhibitors
carboxyl acid
acid amid
amid derivatives
biphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60226469T
Other languages
English (en)
Inventor
Richard Martyn Angell
Nicola Mary Aston
Paul Bamborough
Mark James Bamford
George Stuart Cockerill
Stephen Sean Flack
Dramane Ibrahim Laine
Ann Louise Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE60226469D1 publication Critical patent/DE60226469D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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DE60226469T 2001-10-17 2002-10-16 Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren Expired - Fee Related DE60226469D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0124933.3A GB0124933D0 (en) 2001-10-17 2001-10-17 Chemical compounds
PCT/EP2002/011572 WO2003033483A1 (en) 2001-10-17 2002-10-16 Biphenylcarboxylic amide derivatives as p38 kinase inhibitors

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DE60226469D1 true DE60226469D1 (de) 2008-06-19

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DE60226469T Expired - Fee Related DE60226469D1 (de) 2001-10-17 2002-10-16 Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren

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US (2) US7151118B2 (de)
EP (1) EP1436272B1 (de)
JP (1) JP2005508967A (de)
AT (1) ATE394383T1 (de)
DE (1) DE60226469D1 (de)
ES (1) ES2305317T3 (de)
GB (1) GB0124933D0 (de)
WO (1) WO2003033483A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0124932D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124931D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
ATE485275T1 (de) 2002-02-12 2010-11-15 Glaxosmithkline Llc Nicotinamide und deren verwendung als p38 inhibitoren
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US20070105860A1 (en) 2007-05-10
ATE394383T1 (de) 2008-05-15
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