GB0918922D0 - Aminopyridine derivatives - Google Patents

Aminopyridine derivatives

Info

Publication number
GB0918922D0
GB0918922D0 GBGB0918922.6A GB0918922A GB0918922D0 GB 0918922 D0 GB0918922 D0 GB 0918922D0 GB 0918922 A GB0918922 A GB 0918922A GB 0918922 D0 GB0918922 D0 GB 0918922D0
Authority
GB
United Kingdom
Prior art keywords
aminopyridine derivatives
aminopyridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0918922.6A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vantia Ltd
Original Assignee
Vantia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vantia Ltd filed Critical Vantia Ltd
Priority to GBGB0918922.6A priority Critical patent/GB0918922D0/en
Publication of GB0918922D0 publication Critical patent/GB0918922D0/en
Priority to PCT/GB2010/001996 priority patent/WO2011051671A1/en
Priority to UY0001032975A priority patent/UY32975A/en
Priority to TW099136776A priority patent/TW201119654A/en
Priority to ARP100103978A priority patent/AR078817A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
GBGB0918922.6A 2009-10-28 2009-10-28 Aminopyridine derivatives Ceased GB0918922D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GBGB0918922.6A GB0918922D0 (en) 2009-10-28 2009-10-28 Aminopyridine derivatives
PCT/GB2010/001996 WO2011051671A1 (en) 2009-10-28 2010-10-27 Aminopyridine derivatives as kallikrein inhibitors
UY0001032975A UY32975A (en) 2009-10-28 2010-10-27 AMINOPIRIDINE DERIVATIVES
TW099136776A TW201119654A (en) 2009-10-28 2010-10-27 Aminopyridine derivatives
ARP100103978A AR078817A1 (en) 2009-10-28 2010-10-28 DERIVATIVES OF AMINOPIRIDINE SELECTIVE INHIBITORS OF HUMAN TISSULAR KLK1 CALICREIN, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN THE TREATMENT OF RESPIRATORY AND ALLERGIC DISEASES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0918922.6A GB0918922D0 (en) 2009-10-28 2009-10-28 Aminopyridine derivatives

Publications (1)

Publication Number Publication Date
GB0918922D0 true GB0918922D0 (en) 2009-12-16

Family

ID=41434814

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0918922.6A Ceased GB0918922D0 (en) 2009-10-28 2009-10-28 Aminopyridine derivatives

Country Status (5)

Country Link
AR (1) AR078817A1 (en)
GB (1) GB0918922D0 (en)
TW (1) TW201119654A (en)
UY (1) UY32975A (en)
WO (1) WO2011051671A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290485B2 (en) 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
US9409880B2 (en) 2011-01-20 2016-08-09 The Regents Of The University Of Colorado, A Body Corporate Modulators of TLR3/dsRNA complex and uses thereof
GB2510407A (en) 2013-02-04 2014-08-06 Kalvista Pharmaceuticals Ltd Aqueous suspensions of kallikrein inhibitors for parenteral administration
JP2016152772A (en) * 2013-06-27 2016-08-25 味の素株式会社 Novel umami-taste imparting agent
WO2020094008A1 (en) * 2018-11-06 2020-05-14 天津药物研究院有限公司 2-oxo-1,2-dihydroquinoline derivatives, preparation method therefor, and pharmaceutical applications thereof
CN114206852A (en) 2019-08-09 2022-03-18 卡尔维斯塔制药有限公司 Plasma kallikrein inhibitors

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147716A3 (en) 1983-12-24 1987-10-28 ANT Nachrichtentechnik GmbH Method and apparatus for the encipherable transmission of a series of binary information signals with authenticity check
JPS6235216A (en) 1985-08-09 1987-02-16 Noritoshi Nakabachi Method and device for measuring thickness of heterogeneous material layer nondestructively
US4873253A (en) * 1987-03-30 1989-10-10 Shosuke Okamoto Phenylalanine derivative and proteinase inhibitor
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
GB9019558D0 (en) 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
GR1001529B (en) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Process for the obtainment of a new pregna-1,4-diene-3,20-dione -16-17-acetal-21 esters
WO1993018007A1 (en) 1992-03-13 1993-09-16 Tokyo Tanabe Company Limited Novel carbostyril derivative
SE9301911D0 (en) 1993-06-03 1993-06-03 Ab Astra NEW PEPTIDE DERIVATIVES
US5464820A (en) 1993-06-22 1995-11-07 The University Hospital Specific inhibitors of tissue kallikrein
GB9318637D0 (en) 1993-09-08 1993-10-27 Ferring Res Ltd Enzyme inhibitors
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US6683115B2 (en) 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
OA11558A (en) 1999-12-08 2004-06-03 Advanced Medicine Inc Beta 2-adrenergic receptor agonists.
HUP0300832A2 (en) 2000-04-27 2003-08-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel, slow-acting betamimetics, a method for their production and their use as medicaments and pharmaceutical compositions containing them
GB0015876D0 (en) 2000-06-28 2000-08-23 Novartis Ag Organic compounds
GB0103630D0 (en) 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
WO2002070490A1 (en) 2001-03-08 2002-09-12 Glaxo Group Limited Agonists of beta-adrenoceptors
ES2296923T3 (en) 2001-03-22 2008-05-01 Glaxo Group Limited FORMANILID DERIVATIVES AS AGONISTS OF THE BETA2 ADRENORRECEPTOR.
CN101701006B (en) 2001-09-14 2014-03-05 葛兰素集团有限公司 Phenethanolamine derivatives for treatment of respiratory diseases
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
US6653323B2 (en) 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
WO2003053930A1 (en) 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
GB0204719D0 (en) 2002-02-28 2002-04-17 Glaxo Group Ltd Medicinal compounds
ATE381535T1 (en) 2002-04-25 2008-01-15 Glaxo Group Ltd PHENETHANOLAMINE DERIVATIVES
AU2003239880A1 (en) 2002-05-28 2003-12-12 Theravance, Inc. ALKOXY ARYL Beta2 ADRENERGIC RECEPTOR AGONISTS
AU2003231865A1 (en) 2002-05-31 2003-12-19 Genzyme Corporation Alpha acyloxyacetamides for kallikrein and urokinase inhibition
GB0217225D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
PE20050130A1 (en) 2002-08-09 2005-03-29 Novartis Ag ORGANIC COMPOUNDS
GB0219896D0 (en) 2002-08-27 2002-10-02 Bayer Ag Dihydropyridine derivatives
WO2004020410A2 (en) 2002-08-27 2004-03-11 Bayer Healthcare Ag Dihydropyridinone derivatives as hne inhibitors
GB0220730D0 (en) 2002-09-06 2002-10-16 Glaxo Group Ltd Medicinal compounds
US7566723B2 (en) 2002-09-10 2009-07-28 Bayer Healthcare Ag 1-phenyl1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use
US7687510B2 (en) 2002-09-10 2010-03-30 Bayer Healthcare Ag Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes
DE10246374A1 (en) 2002-10-04 2004-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg New 4-(2-alkylamino-1-hydroxyethyl)-3-alkoxy-benzene-1,2-diol derivatives, are beta-mimetics having a long duration of action, useful e.g. for treating asthma, chronic obstructive pulmonary disease or arrhythmia
EP1440966A1 (en) 2003-01-10 2004-07-28 Pfizer Limited Indole derivatives useful for the treatment of diseases
AU2003269316A1 (en) 2002-10-11 2004-05-04 Pfizer Inc. Indole derivatives as beta-2 agonists
US20060205790A1 (en) 2002-10-22 2006-09-14 Coe Diane M Medicinal arylethanolamine compounds
GB0225030D0 (en) 2002-10-28 2002-12-04 Glaxo Group Ltd Medicinal compounds
AR041724A1 (en) 2002-10-28 2005-05-26 Glaxo Group Ltd COMPOUNDS DERIVED FROM PHENETANOLAMINE AND ITS USE IN PHARMACEUTICAL COMPOSITIONS
GB0225540D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Medicinal compounds
GB0225535D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Medicinal compounds
JP2004161702A (en) 2002-11-14 2004-06-10 Hokko Chem Ind Co Ltd METHOD FOR PRODUCING gamma-JASMOLACTONE
DE10253220A1 (en) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg New 2-(N-phenylalkyl-amino)-1-phenyl-ethanol derivatives, are beta-adrenergic agents especially useful for treating inflammatory and obstructive respiratory diseases such as asthma or COPD
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10253282A1 (en) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Treatment of chronic obstructive pulmonary disease, using new or known N-substituted 2-amino-1-(benz-(1,4)-oxazin-3-on-8-yl)-ethanol derivative beta-mimetic agents, suitable for once-daily administration
DE10258695A1 (en) 2002-12-16 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg New 2-(2-hydroxy-2-(3-methylsulfonylamino-4-hydroxyphenyl)ethylamino-4-(pyrid-2-ylamino)-2-methylbutane used e.g. for treating asthma and chronic obstructive pulmonary disease
GB0303396D0 (en) 2003-02-14 2003-03-19 Glaxo Group Ltd Medicinal compounds
EP1460064A1 (en) 2003-03-14 2004-09-22 Pfizer Limited Indole-2-carboxamide derivatives useful as beta-2 agonists
EP1615881A2 (en) 2003-04-01 2006-01-18 Theravance, Inc. Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
US7745462B2 (en) 2003-04-04 2010-06-29 Novartis Ag Quinoline-2-one derivatives for the treatment of airways diseases
US7268147B2 (en) 2003-05-15 2007-09-11 Pfizer Inc Compounds useful for the treatment of diseases
EP1626970B1 (en) 2003-05-28 2009-07-08 Theravance, Inc. Azabicycloalkane compounds as muscarinic receptor antagonists
EP1633714B1 (en) 2003-06-04 2008-01-23 Pfizer Limited 2-amino-pyridine derivatives as beta-2 adrenoreceptor agonists
GB0312832D0 (en) 2003-06-04 2003-07-09 Pfizer Ltd 2-amino-pyridine derivatives useful for the treatment of diseases
SE0302323D0 (en) 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302324D0 (en) 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302487D0 (en) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
SE0302486D0 (en) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
WO2005033121A2 (en) 2003-10-03 2005-04-14 King Pharmaceuticals Research & Development, Inc. Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs
GB0323701D0 (en) 2003-10-09 2003-11-12 Glaxo Group Ltd Formulations
GB0324654D0 (en) 2003-10-22 2003-11-26 Glaxo Group Ltd Medicinal compounds
GB0324886D0 (en) 2003-10-24 2003-11-26 Glaxo Group Ltd Medicinal compounds
JP2007510723A (en) 2003-11-03 2007-04-26 ノートン　ヘルスケアー　リミテッド Soft steroid composition for use in dry powder inhalers
GB0328490D0 (en) 2003-12-09 2004-01-14 Glaxo Group Ltd Medicinal compounds
GB0329182D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Chemical compounds
US20050150818A1 (en) 2003-12-19 2005-07-14 Bhan Opinder K. Systems, methods, and catalysts for producing a crude product
DE102004001413A1 (en) 2004-01-09 2005-08-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-hydroxymethyl-4-hydroxy-phenyl derivatives for the treatment of chronic obstructive pulmonary disease
TW200531692A (en) 2004-01-12 2005-10-01 Theravance Inc Aryl aniline derivatives as β2 adrenergic receptor agonists
EP1708991B1 (en) 2004-01-22 2007-10-17 Pfizer Limited Sulfonamide derivatives for the treatment of diseases
SI1708992T1 (en) 2004-01-22 2007-12-31 Pfizer Sulfonamide derivatives for the treatment of diseases
DE102004003428A1 (en) 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New long-acting beta-2 agonists, and their use as pharmaceuticals
WO2005077361A1 (en) 2004-02-14 2005-08-25 Boehringer Ingelheim International Gmbh Novel, sustained-action beta-2-agonists and their use as medicaments
ES2367699T3 (en) 2004-02-19 2011-11-07 Bayer Pharma Aktiengesellschaft DERIVATIVES OF DIHYDROPIRIDINONE.
US8101615B2 (en) 2004-02-26 2012-01-24 Bayer Pharma Aktiengesellschaft 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors
EP1730121B1 (en) 2004-02-26 2013-08-07 Bayer Intellectual Property GmbH 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors
WO2005092861A1 (en) 2004-03-11 2005-10-06 Pfizer Limited Quinolinone derivatives pharmaceutical compositions containing them and their use
EP1577306A1 (en) 2004-03-17 2005-09-21 Boehringer Ingelheim Pharma GmbH & Co.KG novel benzoxazinone derivatives as slow-acting betamimetics and use thereof in treatment of respiratory tract diseases
EP1577292A1 (en) 2004-03-17 2005-09-21 Pfizer Limited Phenylaminoethanol derivatives as beta2 receptor agonists
HN2004000023A (en) 2004-03-22 2007-11-23 Mars Inc ANIMAL MASCADURE
WO2005092840A1 (en) 2004-03-23 2005-10-06 Pfizer Limited Formamide derivatives useful as adrenoceptor
WO2005092860A1 (en) 2004-03-23 2005-10-06 Pfizer Limited Compounds for the treatment of diseases
WO2005092841A1 (en) 2004-03-23 2005-10-06 Pfizer Limited Compounds having beta-agonist activity
ATE432278T1 (en) 2004-03-23 2009-06-15 Pfizer COMPOUNDS FOR TREATING DISEASES
JP4775259B2 (en) 2004-03-31 2011-09-21 味の素株式会社 Aniline derivative
EP1595873A1 (en) 2004-05-13 2005-11-16 Boehringer Ingelheim Pharma GmbH & Co.KG Substituted cycloalkyl derivatives for the treatment of respiratory diseases
JP2007537187A (en) 2004-05-13 2007-12-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Hydroxy-substituted benzofused heterocyclic compounds for use as beta agonists in the treatment of respiratory diseases
DE102004024454A1 (en) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
DE102004024451A1 (en) 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations for inhalation containing enantiomerically pure beta agonists
RU2006146042A (en) 2004-06-03 2008-07-20 Тереванс DIAMINE AGONISTS OF 2-ADRENERGIC RECEPTORS
WO2006014704A1 (en) 2004-07-21 2006-02-09 Theravance, Inc. DIARYL ETHER β2 ADRENERGIC RECEPTOR AGONISTS
CA2575791A1 (en) 2004-08-03 2006-02-16 Dyax Corp. Hk1-binding proteins
WO2006016245A1 (en) 2004-08-05 2006-02-16 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
JP2008512470A (en) 2004-09-10 2008-04-24 セラヴァンス， インコーポレーテッド Amidine-substituted arylaniline compounds
DE102004045648A1 (en) 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg New betamimetics for the treatment of respiratory diseases
WO2006051373A1 (en) 2004-11-12 2006-05-18 Pfizer Limited Compounds for the treatment of diseases
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
AU2007281220B2 (en) 2006-07-31 2013-08-15 Activesite Pharmaceuticals, Inc. Inhibitors of plasma kallikrein
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives

Also Published As

Publication number Publication date
AR078817A1 (en) 2011-12-07
WO2011051671A1 (en) 2011-05-05
UY32975A (en) 2011-05-31
TW201119654A (en) 2011-06-16

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Legal Events

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