SE9301911D0 - NEW PEPTIDE DERIVATIVES - Google Patents

NEW PEPTIDE DERIVATIVES

Info

Publication number
SE9301911D0
SE9301911D0 SE19939301911A SE9301911A SE9301911D0 SE 9301911 D0 SE9301911 D0 SE 9301911D0 SE 19939301911 A SE19939301911 A SE 19939301911A SE 9301911 A SE9301911 A SE 9301911A SE 9301911 D0 SE9301911 D0 SE 9301911D0
Authority
SE
Sweden
Prior art keywords
peptide derivatives
new peptide
structural fragment
iie
iid
Prior art date
Application number
SE19939301911A
Other languages
Swedish (sv)
Inventor
Thomas *Antonsson Karl
Elvy *Bylund Ruth
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Astra filed Critical Ab Astra
Priority to SE19939301911A priority Critical patent/SE9301911D0/en
Publication of SE9301911D0 publication Critical patent/SE9301911D0/en
Priority to JP7501664A priority patent/JPH08511017A/en
Priority to PCT/SE1994/000534 priority patent/WO1994029335A1/en
Priority to EP94917871A priority patent/EP0701567A1/en
Priority to AU69408/94A priority patent/AU685465B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A compound of the general formula (I): A<1> - A<2> -NH-(CH2)n - NH-C(NH)-NH2, wherein n is an integer 2, 3, 4, 5, or 6; preferably 3 or 4; A<1> represents a structural fragment of formulae (IIa), (IIb), (IIc), (IId) or (IIe); A<2> represents a structural fragment (a), as well as processes for the preparation thereof, the use and the pharmaceutical formulations.
SE19939301911A 1993-06-03 1993-06-03 NEW PEPTIDE DERIVATIVES SE9301911D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SE19939301911A SE9301911D0 (en) 1993-06-03 1993-06-03 NEW PEPTIDE DERIVATIVES
JP7501664A JPH08511017A (en) 1993-06-03 1994-06-02 New peptide derivatives
PCT/SE1994/000534 WO1994029335A1 (en) 1993-06-03 1994-06-02 New peptides derivatives
EP94917871A EP0701567A1 (en) 1993-06-03 1994-06-02 New peptides derivatives
AU69408/94A AU685465B2 (en) 1993-06-03 1994-06-02 New peptides derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19939301911A SE9301911D0 (en) 1993-06-03 1993-06-03 NEW PEPTIDE DERIVATIVES

Publications (1)

Publication Number Publication Date
SE9301911D0 true SE9301911D0 (en) 1993-06-03

Family

ID=20390161

Family Applications (1)

Application Number Title Priority Date Filing Date
SE19939301911A SE9301911D0 (en) 1993-06-03 1993-06-03 NEW PEPTIDE DERIVATIVES

Country Status (5)

Country Link
EP (1) EP0701567A1 (en)
JP (1) JPH08511017A (en)
AU (1) AU685465B2 (en)
SE (1) SE9301911D0 (en)
WO (1) WO1994029335A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5614198A (en) * 1995-07-25 1997-03-25 The Trustees Of The University Of Pennsylvania Bowman-Birk Inhibitor compositions for treatment of inflammatory disease
US5965532A (en) * 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
KR100458403B1 (en) 1997-09-29 2004-11-26 포인트 써러퓨틱스, 인크. Stimulation of Hematopoietic Cells in vitro
WO1999056753A1 (en) 1998-05-04 1999-11-11 Point Therapeutics, Inc. Hematopoietic stimulation
IL139885A (en) 1998-06-05 2004-05-12 Point Therapeutics Inc Cyclic boroproline compounds
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
GB0205527D0 (en) * 2002-03-08 2002-04-24 Ferring Bv Inhibitors
EP1736465A4 (en) 2004-03-31 2009-06-17 Ajinomoto Kk Aniline derivatives
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
GB2494851A (en) 2011-07-07 2013-03-27 Kalvista Pharmaceuticals Ltd Plasma kallikrein inhibitors
GB201212081D0 (en) 2012-07-06 2012-08-22 Kalvista Pharmaceuticals Ltd New polymorph
GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
PH12015501492A1 (en) 2013-01-08 2015-09-28 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
GB2510407A (en) 2013-02-04 2014-08-06 Kalvista Pharmaceuticals Ltd Aqueous suspensions of kallikrein inhibitors for parenteral administration
RU2712621C2 (en) 2013-05-23 2020-01-30 Калвиста Фармасьютикалз Лимитед Nitrogen-containing heterocyclic derivatives useful as plasma kallikrein inhibitor
TWI636047B (en) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 Heterocyclic derivatives
GB2517908A (en) 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
RU2674028C2 (en) 2013-08-14 2018-12-04 Калвиста Фармасьютикалз Лимитед Enzyme inhibitors
GB201421088D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
WO2017207983A1 (en) 2016-05-31 2017-12-07 Kalvista Pharmaceuticals Limited Pyrazole derivatives as plasma kallikrein inhibitors
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
PL3716952T3 (en) 2017-11-29 2022-05-02 Kalvista Pharmaceuticals Limited Dosage forms comprising a plasma kallikrein inhibitor
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
US11584714B2 (en) 2018-05-29 2023-02-21 Omeros Corporation MASP-2 inhibitors and methods of use
GB201910125D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of angioedema
GB201910116D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of hereditary angioedema
WO2021028645A1 (en) 2019-08-09 2021-02-18 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
IL293550A (en) 2019-12-04 2022-08-01 Omeros Corp Masp-2 inhibitor compounds, compositions comprising same and uses thereof
GB2591730A (en) 2019-12-09 2021-08-11 Kalvista Pharmaceuticals Ltd New polymorphs
GB201918994D0 (en) 2019-12-20 2020-02-05 Kalvista Pharmaceuticals Ltd Treatments of diabetic macular edema and impaired visual acuity
WO2022079446A1 (en) 2020-10-15 2022-04-21 Kalvista Pharmaceuticals Limited Treatments of angioedema
WO2022084693A1 (en) 2020-10-23 2022-04-28 Kalvista Pharmaceuticals Limited Treatments of angioedema
EP4291186A1 (en) 2021-02-09 2023-12-20 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
WO2023002219A1 (en) 2021-07-23 2023-01-26 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
EP4288036A1 (en) 2022-04-27 2023-12-13 Kalvista Pharmaceuticals Limited Formulations of a plasma kallikrein inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
GB9019558D0 (en) * 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors

Also Published As

Publication number Publication date
AU685465B2 (en) 1998-01-22
EP0701567A1 (en) 1996-03-20
JPH08511017A (en) 1996-11-19
AU6940894A (en) 1995-01-03
WO1994029335A1 (en) 1994-12-22

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