EA200700758A1 - Новые производные бис-азаиндолов, их получение и фармацевтическое применение в качестве ингибиторов киназ - Google Patents

Новые производные бис-азаиндолов, их получение и фармацевтическое применение в качестве ингибиторов киназ

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Publication number
EA200700758A1
EA200700758A1 EA200700758A EA200700758A EA200700758A1 EA 200700758 A1 EA200700758 A1 EA 200700758A1 EA 200700758 A EA200700758 A EA 200700758A EA 200700758 A EA200700758 A EA 200700758A EA 200700758 A1 EA200700758 A1 EA 200700758A1
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EA
Eurasian Patent Office
Prior art keywords
getting
pharmaceutical application
new bis
alkoxy
kinaz
Prior art date
Application number
EA200700758A
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English (en)
Inventor
Консепсьон Немесек
Уилльям А. Метц
Сильви Венслер
Доминик Лесюисс
Юссеф Эль-Амад
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200700758A1 publication Critical patent/EA200700758A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение относится к новым соединениям формулы (I), в которой R1 представляет собой водород и необязательно замещенные алкил и алкенил; R2 представляет собой алкокси, a R3 представляет собой алкил или алкокси; R4 представляет собой водород; галоген; диоксолан; -СН=O; -CH=N-OH; -СН=N-фенил, причем фенил, необязательно, может быть замещенным; циано, необязательно замещенные алкил и алкокси; R5 представляет собой водород или галоген; причем все упомянутые радикалы, необязательно, могут быть замещенными; при этом упомянутые соединения в качестве лекарственных средств представляют собой все изомерные формы и соли.
EA200700758A 2004-10-01 2005-09-29 Новые производные бис-азаиндолов, их получение и фармацевтическое применение в качестве ингибиторов киназ EA200700758A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0410386A FR2876103B1 (fr) 2004-10-01 2004-10-01 Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
PCT/FR2005/002410 WO2006037875A1 (fr) 2004-10-01 2005-09-29 Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases

Publications (1)

Publication Number Publication Date
EA200700758A1 true EA200700758A1 (ru) 2007-10-26

Family

ID=34952807

Family Applications (1)

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EA200700758A EA200700758A1 (ru) 2004-10-01 2005-09-29 Новые производные бис-азаиндолов, их получение и фармацевтическое применение в качестве ингибиторов киназ

Country Status (20)

Country Link
US (2) US7786114B2 (ru)
EP (1) EP1799691B1 (ru)
JP (1) JP2008514683A (ru)
KR (1) KR20070067116A (ru)
CN (1) CN101052642A (ru)
AR (1) AR050963A1 (ru)
AT (1) ATE538125T1 (ru)
AU (1) AU2005291137A1 (ru)
BR (1) BRPI0516841A (ru)
CA (1) CA2580831A1 (ru)
EA (1) EA200700758A1 (ru)
FR (1) FR2876103B1 (ru)
IL (1) IL182054A0 (ru)
MA (1) MA28941B1 (ru)
MX (1) MX2007003872A (ru)
NO (1) NO20072053L (ru)
SG (1) SG155946A1 (ru)
TW (1) TW200626605A (ru)
WO (1) WO2006037875A1 (ru)
ZA (1) ZA200702596B (ru)

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EP2483407A2 (en) 2009-09-30 2012-08-08 President and Fellows of Harvard College Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
AU2011263546B2 (en) * 2010-06-10 2015-01-22 Midatech Limited Peptide-carrying nanoparticles
EP2601192B1 (en) 2010-08-04 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
EP2675275B1 (en) 2011-02-14 2017-12-20 The Regents Of The University Of Michigan Compositions and methods for the treatment of obesity and related disorders
KR101964479B1 (ko) 2011-03-31 2019-04-01 카나 바이오사이언스, 인코포레이션 신규 푸라논 유도체
US9365581B2 (en) 2013-05-02 2016-06-14 The Regents Of The University Of Michigan Deuterated amlexanox
EP3851437A3 (en) * 2013-11-13 2021-11-03 Vertex Pharmaceuticals Incorporated Methods of preparing 1h-pyrrolo[2,3-b]pyridine derivates
EP3100742B1 (en) 2014-01-31 2020-05-20 Carna Biosciences Inc. Anticancer agent composition comprising a cdc7 inhibitor and a wee1 inhibitor
ES2763527T3 (es) 2014-04-04 2020-05-29 Univ Michigan Regents Inhibidores de molécula pequeña de mcl-1 y usos de los mismos
EP3453710B1 (en) 2014-09-17 2022-09-21 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
CN107001330A (zh) * 2014-09-17 2017-08-01 赛尔基因昆蒂赛尔研究公司 组蛋白脱甲基酶抑制剂
US10030017B2 (en) 2014-09-17 2018-07-24 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
EP3407974A4 (en) 2016-01-29 2019-08-28 The Regents Of The University Of Michigan ANALOGUES OF AMLEXANOX

Family Cites Families (6)

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EP1263759B1 (en) 1999-12-24 2010-09-08 Aventis Pharma Limited Azaindoles
US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
GB0115393D0 (en) * 2001-06-23 2001-08-15 Aventis Pharma Ltd Chemical compounds
WO2003024969A1 (en) * 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
US7361671B2 (en) * 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids

Also Published As

Publication number Publication date
SG155946A1 (en) 2009-10-29
US20100256141A1 (en) 2010-10-07
TW200626605A (en) 2006-08-01
MA28941B1 (fr) 2007-10-01
ZA200702596B (en) 2009-09-30
JP2008514683A (ja) 2008-05-08
WO2006037875A1 (fr) 2006-04-13
BRPI0516841A (pt) 2008-09-23
US7786114B2 (en) 2010-08-31
AU2005291137A1 (en) 2006-04-13
IL182054A0 (en) 2007-07-24
US20080045561A1 (en) 2008-02-21
FR2876103B1 (fr) 2008-02-22
CA2580831A1 (fr) 2006-04-13
CN101052642A (zh) 2007-10-10
NO20072053L (no) 2007-04-20
MX2007003872A (es) 2007-06-07
KR20070067116A (ko) 2007-06-27
EP1799691B1 (fr) 2011-12-21
EP1799691A1 (fr) 2007-06-27
FR2876103A1 (fr) 2006-04-07
ATE538125T1 (de) 2012-01-15
AR050963A1 (es) 2006-12-06

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