EA201170595A1 - ПРОИЗВОДНОЕ ФЕНАНТРОИНДОЛИЗИДИНА И ИНГИБИТОР NFkB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА - Google Patents
ПРОИЗВОДНОЕ ФЕНАНТРОИНДОЛИЗИДИНА И ИНГИБИТОР NFkB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТАInfo
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- EA201170595A1 EA201170595A1 EA201170595A EA201170595A EA201170595A1 EA 201170595 A1 EA201170595 A1 EA 201170595A1 EA 201170595 A EA201170595 A EA 201170595A EA 201170595 A EA201170595 A EA 201170595A EA 201170595 A1 EA201170595 A1 EA 201170595A1
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- Eurasian Patent Office
- Prior art keywords
- group
- hydrogen atom
- formed together
- lower alkyl
- phenantroindolizidine
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
Abstract
Обеспечивают новое соединение, обладающее превосходным NFkB ингибирующим эффектом. В частности, раскрытое представляет собой соединение, представленное следующей формулой (1), или его соль, в которой Rпредставляет собой атом водорода, низшую алкильную группу или подобное; Rпредставляет собой атом водорода, низшую алкильную группу, атом галогена или подобное; Rпредставляет собой атом водорода, низшую алкильную группу, гидроксильную группу или атом галогена; Rпредставляет собой атом водорода или низшую алкилоксигруппу; Rпредставляет собой атом водорода, низшую алкилоксигруппу, атом галогена, гидроксильную группу, или метилендиоксигруппу, образованную вместе с R, или изопропилидендиоксигруппу, образованную вместе с R; Rпредставляет собой атом водорода, низшую алкилоксигруппу, или метилендиоксигруппу, образованную вместе с R, или изопропилидендиоксигруппу, образованную вместе с R; Rпредставляет собой атом водорода или низшую алкильную группу и Rпредставляет собой атом водорода, гидроксильную группу, аминогруппу, низшую алкилкарбонилоксигруппу или атом галогена.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008273556 | 2008-10-23 | ||
PCT/JP2009/005593 WO2010047126A1 (ja) | 2008-10-23 | 2009-10-23 | フェナンスロインドリジジン誘導体及びこれを有効成分とするNFκB阻害剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201170595A1 true EA201170595A1 (ru) | 2011-12-30 |
EA023622B1 EA023622B1 (ru) | 2016-06-30 |
Family
ID=42119178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170595A EA023622B1 (ru) | 2008-10-23 | 2009-10-23 | ПРОИЗВОДНОЕ ФЕНАНТРОИНДОЛИЗИДИНА И ИНГИБИТОР NFκB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА |
Country Status (10)
Country | Link |
---|---|
US (1) | US8569327B2 (ru) |
EP (1) | EP2351753B1 (ru) |
JP (1) | JP5583589B2 (ru) |
KR (1) | KR101708512B1 (ru) |
CN (1) | CN102186850B (ru) |
AU (1) | AU2009307580B2 (ru) |
CA (1) | CA2740807C (ru) |
EA (1) | EA023622B1 (ru) |
NZ (1) | NZ592429A (ru) |
WO (1) | WO2010047126A1 (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103446211B (zh) * | 2013-09-24 | 2016-02-10 | 兰州理工大学 | 一种牛心朴子总生物碱及其制备方法和应用 |
CN104557909B (zh) * | 2013-10-09 | 2019-01-01 | 中国医学科学院药物研究所 | 3-酰氧基取代右旋去氧娃儿藤宁衍生物、其制法和药物组合物与用途 |
KR101693035B1 (ko) | 2015-01-14 | 2017-01-06 | 충북대학교 산학협력단 | 1,2,3,4-테트라하이드로퀴놀린-2-카르복실산 n-(치환)페닐아미드 유도체 및 이의 용도 |
CN105924380B (zh) * | 2015-02-27 | 2019-03-05 | 顺天乡大学校产学协力团 | 菲类化合物或其衍生物、以及含有该菲类化合物或其衍生物的治疗结核病用药物组合物 |
WO2016161538A1 (zh) * | 2015-04-09 | 2016-10-13 | 中国医学科学院药物研究所 | 3-酰氧基取代右旋去氧娃儿藤宁衍生物、其制法和药物组合物与用途 |
JP6363765B1 (ja) * | 2017-05-02 | 2018-07-25 | スンチョンヒャン ユニバーシティ インダストリー アカデミー コーポレーション ファウンデーション | 新規な化合物及びそれを含む結核の治療用薬学組成物 |
CN110294752B (zh) * | 2018-03-21 | 2022-01-11 | 中国医学科学院药物研究所 | 光学纯(s)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的制备 |
CN110283170B (zh) * | 2019-07-17 | 2020-11-06 | 清华大学 | 一种化合物制备及其在抑制多种肿瘤细胞生长中的应用 |
TWI811724B (zh) | 2020-07-08 | 2023-08-11 | 財團法人國家衛生研究院 | 正股核糖核酸病毒之抑制劑 |
KR102249543B1 (ko) | 2020-08-26 | 2021-05-11 | 한국화학연구원 | 페난트로인돌리지딘 및 페난트로퀴놀리지딘 알칼로이드 유도체, 이의 광학이성질체, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 코로나바이러스감염증-19 치료용 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08319238A (ja) * | 1995-05-24 | 1996-12-03 | Asahi Chem Ind Co Ltd | リン酸化酵素阻害剤 |
JPH11322602A (ja) * | 1998-05-13 | 1999-11-24 | Kazuo Umezawa | 転写因子NFκB活性化阻害剤 |
WO2001023384A1 (fr) | 1999-09-27 | 2001-04-05 | Japan As Represented By Director General Of Agency Of National Cancer Center | Agents antitumoraux |
DE19951360A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
AU2003217373B2 (en) | 2002-02-15 | 2009-04-30 | University Of Tennessee Research Foundation | Novel tyloindicines and related processes, pharmaceutical compositions and methods |
EP1604990A1 (en) | 2004-06-11 | 2005-12-14 | National Health Research Institutes | Phenanthroindolizidine alkaloids |
CN101189968B (zh) | 2006-11-23 | 2011-06-01 | 南开大学 | 菲并吲哚里西啶和菲并喹喏里西啶衍生物及其盐在农药上的应用 |
-
2009
- 2009-10-23 EP EP09821826.6A patent/EP2351753B1/en not_active Not-in-force
- 2009-10-23 CN CN200980141120.0A patent/CN102186850B/zh not_active Expired - Fee Related
- 2009-10-23 WO PCT/JP2009/005593 patent/WO2010047126A1/ja active Application Filing
- 2009-10-23 US US13/124,554 patent/US8569327B2/en active Active
- 2009-10-23 NZ NZ592429A patent/NZ592429A/xx not_active IP Right Cessation
- 2009-10-23 KR KR1020117009005A patent/KR101708512B1/ko active IP Right Grant
- 2009-10-23 CA CA2740807A patent/CA2740807C/en not_active Expired - Fee Related
- 2009-10-23 EA EA201170595A patent/EA023622B1/ru not_active IP Right Cessation
- 2009-10-23 JP JP2010534719A patent/JP5583589B2/ja not_active Expired - Fee Related
- 2009-10-23 AU AU2009307580A patent/AU2009307580B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
KR20110079661A (ko) | 2011-07-07 |
WO2010047126A1 (ja) | 2010-04-29 |
CN102186850A (zh) | 2011-09-14 |
EA023622B1 (ru) | 2016-06-30 |
EP2351753B1 (en) | 2015-02-11 |
US8569327B2 (en) | 2013-10-29 |
US20110201637A1 (en) | 2011-08-18 |
JP5583589B2 (ja) | 2014-09-03 |
CA2740807A1 (en) | 2010-04-29 |
AU2009307580B2 (en) | 2015-04-23 |
NZ592429A (en) | 2012-10-26 |
EP2351753A1 (en) | 2011-08-03 |
AU2009307580A1 (en) | 2010-04-29 |
CN102186850B (zh) | 2014-10-29 |
CA2740807C (en) | 2016-12-20 |
EP2351753A4 (en) | 2012-05-30 |
KR101708512B1 (ko) | 2017-02-20 |
JPWO2010047126A1 (ja) | 2012-03-22 |
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