AR052148A1 - Amidas de acidos pirazindicarboxilico y su uso - Google Patents
Amidas de acidos pirazindicarboxilico y su usoInfo
- Publication number
- AR052148A1 AR052148A1 ARP050105118A ARP050105118A AR052148A1 AR 052148 A1 AR052148 A1 AR 052148A1 AR P050105118 A ARP050105118 A AR P050105118A AR P050105118 A ARP050105118 A AR P050105118A AR 052148 A1 AR052148 A1 AR 052148A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- alkyl
- alkoxy
- hydroxy
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se refiere a procedimientos para su preparacion, a su uso para el tratamiento y/o la profilaxis de enfermedades, así como a su uso para la preparacion de fármacos para el tratamiento y/o la profilaxis de enfermedades, especialmente de enfermedades tromboembolicas. Reivindicacion 1: Compuesto de formula (1), en la que: A representa un grupo de formulas (2) a (9), en las que: R4 significa hidrogeno, alquilo C1-6, hidroxi, alcoxi C1-6, amino, mono- o dialquilC1-6-amino, cicloalquilC3-7-amino, alcanoilC1-6-amino o alcoxiC1-6- carbonilamino, en los que: alquilo C1-6, alcoxi C1-6, mono- y dialquilC1-6-amino pueden estar sustituidos respectivamente a su vez con hidroxi, alcoxi C1-4, mono- o dialquilC1-4-amino, cicloalquilC3-7-amino o un heterociclo de 4 a 7 miembros insaturado unido por un átomo de N, que puede contener un miembro de anillo del grupo de N-R5 u O, en el que: R5 significa hidrogeno o alquilo C1-4; y * significa el punto de union con el anillo fenilo; Z representa fenilo, piridilo, pirimidinilo, pirazinilo o tienilo, que pueden estar sustituidos respectivamente una o dos veces, de forma igual o distinta, con sustituyentes seleccionados del grupo de fluor, cloro, ciano, alquilo C1-4, que a su vez puede estar sustituido con amino, etinilo y amino; R1 y R2 son iguales o distintos y representan independientemente entre sí hidrogeno, fluor, cloro, ciano, alquilo C1-3, ciclopropilo, trifluorometilo, hidroxi, alcoxi C1-3, trifluorometoxi o amino, en los que: alquilo C1-3 y alcoxi C1-3 pueden estar sustituidos a su vez con hidroxi o amino; y R3 representa hidrogeno o alquilo C1-6, que puede estar sustituido con hidroxi, alcoxi C1-4, amino o mono- o dialquilC1-4-amino, así como sus sales, solvatos y solvatos de las sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004059219A DE102004059219A1 (de) | 2004-12-09 | 2004-12-09 | Pyrazindicarbonsäureamide und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052148A1 true AR052148A1 (es) | 2007-03-07 |
Family
ID=36088503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105118A AR052148A1 (es) | 2004-12-09 | 2005-12-07 | Amidas de acidos pirazindicarboxilico y su uso |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060287315A1 (es) |
| EP (1) | EP1824844B1 (es) |
| JP (1) | JP2008522992A (es) |
| AR (1) | AR052148A1 (es) |
| AT (1) | ATE413396T1 (es) |
| CA (1) | CA2594102A1 (es) |
| DE (2) | DE102004059219A1 (es) |
| DO (1) | DOP2005000250A (es) |
| ES (1) | ES2315932T3 (es) |
| TW (1) | TW200635920A (es) |
| WO (1) | WO2006061116A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2012DN00602A (es) * | 2009-06-25 | 2015-06-12 | Inst Univ De Ciencia I Technologia S A | |
| ES2354550B1 (es) * | 2009-06-26 | 2011-11-15 | Institut Univ. De Ciència I Tecnologia, S.A. | Biblioteca de n-(1-fenil-2-oxo-3-piperidil)sulfonamidas para el descubrimiento de fármacos. |
| ES2354551B1 (es) * | 2009-07-01 | 2011-11-15 | Institut Univ. De Ciencia I Tecnologia S.A. | Bibliotecas de n-(1-fenil-2-oxo-3-piperidil)sulfonamidas para la identificación de actividad biológica y farmacológica. |
| CN103804222A (zh) * | 2014-02-25 | 2014-05-21 | 湖北迅达药业股份有限公司 | 一种4-（4-氨基苯基）-3-吗啉酮的合成方法及其中间体 |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002000651A2 (en) * | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Factor xa inhibitors |
| DE60221505D1 (de) * | 2001-03-30 | 2007-09-13 | Millennium Pharm Inc | FAKTOR Xa BENZAMIDIN INHIBITOREN |
| ATE439360T1 (de) * | 2001-09-21 | 2009-08-15 | Bristol Myers Squibb Co | Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer |
| DE102004058062A1 (de) * | 2004-12-02 | 2006-06-08 | Bayer Healthcare Ag | Cyclische Iminocarbamate und ihre Verwendung |
-
2004
- 2004-12-09 DE DE102004059219A patent/DE102004059219A1/de not_active Withdrawn
-
2005
- 2005-11-28 ES ES05815232T patent/ES2315932T3/es active Active
- 2005-11-28 WO PCT/EP2005/012681 patent/WO2006061116A1/de active Application Filing
- 2005-11-28 CA CA002594102A patent/CA2594102A1/en not_active Abandoned
- 2005-11-28 JP JP2007544770A patent/JP2008522992A/ja active Pending
- 2005-11-28 EP EP05815232A patent/EP1824844B1/de not_active Not-in-force
- 2005-11-28 AT AT05815232T patent/ATE413396T1/de not_active IP Right Cessation
- 2005-11-28 DE DE502005005917T patent/DE502005005917D1/de not_active Expired - Fee Related
- 2005-12-07 AR ARP050105118A patent/AR052148A1/es not_active Application Discontinuation
- 2005-12-08 TW TW094143286A patent/TW200635920A/zh unknown
- 2005-12-08 US US11/299,342 patent/US20060287315A1/en not_active Abandoned
- 2005-12-08 DO DO2005000250A patent/DOP2005000250A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE102004059219A1 (de) | 2006-06-14 |
| US20060287315A1 (en) | 2006-12-21 |
| TW200635920A (en) | 2006-10-16 |
| DOP2005000250A (es) | 2006-06-15 |
| EP1824844A1 (de) | 2007-08-29 |
| CA2594102A1 (en) | 2006-06-15 |
| WO2006061116A1 (de) | 2006-06-15 |
| ES2315932T3 (es) | 2009-04-01 |
| ATE413396T1 (de) | 2008-11-15 |
| DE502005005917D1 (de) | 2008-12-18 |
| JP2008522992A (ja) | 2008-07-03 |
| EP1824844B1 (de) | 2008-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |