PE20141598A1 - Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina - Google Patents

Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina

Info

Publication number
PE20141598A1
PE20141598A1 PE2014001003A PE2014001003A PE20141598A1 PE 20141598 A1 PE20141598 A1 PE 20141598A1 PE 2014001003 A PE2014001003 A PE 2014001003A PE 2014001003 A PE2014001003 A PE 2014001003A PE 20141598 A1 PE20141598 A1 PE 20141598A1
Authority
PE
Peru
Prior art keywords
oxazine
dihydro
pyrid
benzo
derivatives
Prior art date
Application number
PE2014001003A
Other languages
English (en)
Inventor
Giorgio Caravatti
Sylvie Chamoin
Pascal Furet
Klemens Hogenauer
Konstanze Hurth
Christoph Kalis
Karen Kammertoens
Ian Lewis
Henrik Moebitz
Alexander Baxter Smith
Nicolas Soldermann
Romain Wolf
Frederic Zecri
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20141598A1 publication Critical patent/PE20141598A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Q1/6844—Nucleic acid amplification reactions
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: Y ES O O NH; V ES CR5 O N; W ES CH2 U O; U ES N O CH; Q ES N O CR6; DONDE U Y Q NO SON AMBOS N; R1 ES FENILO, PIRIDILO, PIRIMIDINILO, PIRAZINILO, ENTRE OTROS; R7 ES H, HALOGENO, CIANO, NITRO, ENTRE OTROS; R5 ES H, ALQUILO C1-C2, ENTRE OTROS; R6 ES H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; R30 ES H, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UNA COMBINACION. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ALERGICAS, ASMA, CANCER, ENFERMEDAD OBSTRUCTIVA CRONICA (COPD)
PE2014001003A 2011-12-22 2012-12-20 Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina PE20141598A1 (es)

Applications Claiming Priority (1)

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US201161579231P 2011-12-22 2011-12-22

Publications (1)

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PE20141598A1 true PE20141598A1 (es) 2014-11-14

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PE2014001003A PE20141598A1 (es) 2011-12-22 2012-12-20 Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina

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US (2) US9539260B2 (es)
EP (1) EP2794600B1 (es)
JP (1) JP5903499B2 (es)
KR (1) KR101656592B1 (es)
CN (1) CN104011045B (es)
AP (1) AP4055A (es)
AR (1) AR089424A1 (es)
AU (1) AU2012356083B2 (es)
BR (1) BR112014015103B1 (es)
CA (1) CA2859764C (es)
CL (1) CL2014001452A1 (es)
CO (1) CO6990717A2 (es)
CR (2) CR20200286A (es)
CU (1) CU20140072A7 (es)
CY (1) CY1119939T1 (es)
DK (1) DK2794600T3 (es)
EA (1) EA025322B1 (es)
EC (1) ECSP14009999A (es)
ES (1) ES2661864T3 (es)
GT (1) GT201400131A (es)
HR (1) HRP20180384T1 (es)
HU (1) HUE036953T2 (es)
IL (1) IL233117A (es)
IN (1) IN2014CN04174A (es)
JO (1) JO3398B1 (es)
LT (1) LT2794600T (es)
MA (1) MA37142B1 (es)
MX (1) MX353342B (es)
MY (1) MY170922A (es)
NO (1) NO2809782T3 (es)
PE (1) PE20141598A1 (es)
PH (1) PH12014501417A1 (es)
PL (1) PL2794600T3 (es)
PT (1) PT2794600T (es)
RS (1) RS56891B1 (es)
SG (1) SG11201402237WA (es)
SI (1) SI2794600T1 (es)
TN (1) TN2014000210A1 (es)
TW (1) TWI577674B (es)
UA (1) UA112558C2 (es)
UY (1) UY34541A (es)
WO (1) WO2013093849A1 (es)

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