BR0200782A - Compostos para o tratamento da isquemia - Google Patents
Compostos para o tratamento da isquemiaInfo
- Publication number
- BR0200782A BR0200782A BR0200782-7A BR0200782A BR0200782A BR 0200782 A BR0200782 A BR 0200782A BR 0200782 A BR0200782 A BR 0200782A BR 0200782 A BR0200782 A BR 0200782A
- Authority
- BR
- Brazil
- Prior art keywords
- ischemia
- agonists
- compounds
- treatment
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
"COMPOSTOS PARA O TRATAMENTO DA ISQUEMIA". Estão descritos os agonistas de A~ 3~ de Fórmula I, bem como os métodos de utilização de tais agonistas de A~ 3~ e as composições farmacêuticas contendo tais agonistas de A~ 3~. Fórmula I Os agonistas de A~ 3~ são úteis para a redução do dano ao tecido resultante da isquemia ou hipoxia do tecido.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27641101P | 2001-03-16 | 2001-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0200782A true BR0200782A (pt) | 2003-01-07 |
Family
ID=23056556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0200782-7A BR0200782A (pt) | 2001-03-16 | 2002-03-13 | Compostos para o tratamento da isquemia |
Country Status (6)
Country | Link |
---|---|
US (2) | US20030055021A1 (pt) |
EP (1) | EP1241176A1 (pt) |
JP (1) | JP2002322193A (pt) |
BR (1) | BR0200782A (pt) |
CA (1) | CA2376738A1 (pt) |
MX (1) | MXPA02002971A (pt) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2474337A1 (en) * | 2002-01-25 | 2003-07-31 | Muscagen Limited | Compounds useful as a3 adenosine receptor agonists |
US7414036B2 (en) | 2002-01-25 | 2008-08-19 | Muscagen Limited | Compounds useful as A3 adenosine receptor agonists |
KR20040036417A (ko) * | 2002-10-25 | 2004-04-30 | 정낙신 | 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물 |
JP2006517807A (ja) * | 2002-12-30 | 2006-08-03 | パーデュー・リサーチ・ファウンデーション | 中枢神経系の損傷の治療方法 |
CA2515368A1 (en) * | 2003-02-13 | 2004-08-26 | Luciano Rossetti | Regulation of food intake and glucose production by modulation of long-chain fatty acyl-coa levels in the hypothalamus |
AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
GB0317951D0 (en) * | 2003-07-31 | 2003-09-03 | Trigen Ltd | Compounds |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
KR101267202B1 (ko) * | 2004-05-26 | 2013-05-24 | 이노텍 파마슈티컬스 코포레이션 | 아데노신 a1 수용체 아고니스트로서의 퓨린 유도체 및 이것의 사용 방법 |
WO2006031505A1 (en) * | 2004-09-09 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as a3 and a1 adenosine receptor agonists |
JP5011112B2 (ja) * | 2004-09-20 | 2012-08-29 | イノテック ファーマシューティカルズ コーポレイション | プリン誘導体を含有する炎症性疾患の治療用医薬 |
WO2006041922A2 (en) * | 2004-10-08 | 2006-04-20 | Dara Biosciences, Inc. | Agents and methods for administration to the central nervous system |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
US20070026079A1 (en) * | 2005-02-14 | 2007-02-01 | Louis Herlands | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
EP2281813A1 (en) | 2005-08-08 | 2011-02-09 | Pulmagen Therapeutics (Synergy) Limited | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses |
JP5006330B2 (ja) | 2005-10-21 | 2012-08-22 | ノバルティス アーゲー | Il13に対するヒト抗体および治療的使用 |
JP5203214B2 (ja) * | 2005-11-30 | 2013-06-05 | イノテック ファーマシューティカルズ コーポレイション | プリン化合物およびその使用方法 |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
US20090286779A1 (en) | 2006-09-29 | 2009-11-19 | Novartis Ag | Pyrazolopyrimidines as lipid kinase inhibitors |
RU2009120389A (ru) | 2006-10-30 | 2010-12-10 | Новартис АГ (CH) | Гетероциклические соединения в качестве противовоспалительных агентов |
EA017573B1 (ru) | 2007-12-14 | 2013-01-30 | Пульмаджен Терапьютикс (Эсме) Лимитед | Производные индол-1-илуксусной кислоты и их терапевтическое применение |
US8431578B2 (en) | 2008-01-11 | 2013-04-30 | Novartis Ag | Organic compounds |
WO2010011824A1 (en) * | 2008-07-25 | 2010-01-28 | Concert Pharmaceuticals, Inc. | Novel xanthine compounds |
PL2391366T3 (pl) | 2009-01-29 | 2013-04-30 | Novartis Ag | Podstawione benzimidazole do leczenia gwiaździaków |
MA33128B1 (fr) | 2009-02-17 | 2012-03-01 | Chiesi Farma Spa | Derives de triazolopyridine utilises comme inhibiteurs de la p38 map kinase |
GB0902648D0 (en) | 2009-02-17 | 2009-04-01 | Argenta Discovery Ltd | Pharmaceutical compounds and compositions |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
EP2464649A1 (en) | 2009-08-12 | 2012-06-20 | Novartis AG | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
EA026693B1 (ru) | 2009-08-17 | 2017-05-31 | Интелликайн ЭлЭлСи | Производные бензоксазола и бензотиазола в качестве ингибиторов pi3-киназы |
IN2012DN01453A (pt) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
KR20120115344A (ko) | 2010-01-11 | 2012-10-17 | 이노텍 파마슈티컬스 코포레이션 | 안압을 감소시키는 혼합물, 키트 및 방법 |
BR112012023749A2 (pt) | 2010-03-26 | 2016-08-23 | Inotek Pharmaceuticals Corp | método para reduzir a pressão intraocular em humanos utilizando n6-ciclopentiladenosina (cpa), derivados de cpa ou pró-fármacos desses |
GB201009731D0 (en) | 2010-06-10 | 2010-07-21 | Pulmagen Therapeutics Inflamma | Kinase inhibitors |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
AU2012310168B2 (en) | 2011-09-15 | 2015-07-16 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン, エルエルシー | Mtor阻害剤を使用する強化された治療レジメン |
PL2788349T3 (pl) | 2011-12-09 | 2017-04-28 | Chiesi Farmaceutici S.P.A. | Inhibitory kinaz |
EP2788345B1 (en) | 2011-12-09 | 2020-06-10 | Chiesi Farmaceutici S.p.A. | Derivatives of 4-hydroxy-1,2,3,4-tetrahydronaphtalen-1-yl urea and their use in the treatment of, inter alia, diseases of the respiratory tract |
EP2788348B1 (en) | 2011-12-09 | 2016-10-19 | Chiesi Farmaceutici S.p.A. | Kinase inhibitors |
MX2014009086A (es) | 2012-01-26 | 2015-06-05 | Inotek Pharmaceuticals Corp | Polimorfos anhidros de nitrato de [ (2r,3s,4r,5r) -5- (6- (ciclopentilamino) -9h-purin-9-il) -3,4-dihidroxitetra-hidrofuran- 2-il) ] metilo y procesos para su preparación. |
WO2013149581A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
WO2014152723A1 (en) | 2013-03-15 | 2014-09-25 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
WO2014195402A1 (en) | 2013-06-06 | 2014-12-11 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
SG11201601707PA (en) | 2013-09-05 | 2016-04-28 | Hoffmann La Roche | Triazolopyridine compounds, compositions and methods of use thereof |
TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Mdm2抑制劑與BRAF抑制劑之組合及其用途 |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
WO2016016822A1 (en) | 2014-07-31 | 2016-02-04 | Novartis Ag | Combination therapy |
WO2016139212A1 (en) | 2015-03-04 | 2016-09-09 | F. Hoffmann-La Roche Ag | Triazolopyridine compounds and methods of use thereof |
TW201720828A (zh) | 2015-11-23 | 2017-06-16 | 赫孚孟拉羅股份公司 | 治療性化合物及組合物以及其使用方法 |
WO2017108737A1 (en) | 2015-12-23 | 2017-06-29 | Chiesi Farmaceutici S.P.A. | 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors |
AR107164A1 (es) | 2015-12-23 | 2018-03-28 | Chiesi Farm Spa | INHIBIDORES DE QUINASA p38 |
AR107163A1 (es) | 2015-12-23 | 2018-03-28 | Chiesi Farm Spa | Inhibidores de quinasa |
JP7034942B2 (ja) | 2016-05-05 | 2022-03-14 | エフ.ホフマン-ラ ロシュ アーゲー | ピラゾール誘導体、その組成物及び治療的使用 |
AU2017324281A1 (en) | 2016-09-06 | 2019-03-21 | F. Hoffmann-La Roche Ag | 8-(azetidin-1-yl)-[1,2,4]triazolo[1,5-A]pyridinyl compounds, compositions and methods of use thereof |
WO2018122212A1 (en) | 2016-12-29 | 2018-07-05 | F. Hoffmann-La Roche Ag | Pyrazolopyrimidine compounds and methods of use thereof |
WO2018166993A2 (en) | 2017-03-14 | 2018-09-20 | F. Hoffmann-La Roche Ag | Pyrazolochlorophenyl compounds, compositions and methods of use thereof |
WO2018215390A1 (en) | 2017-05-22 | 2018-11-29 | F. Hoffmann-La Roche Ag | Therapeutic compounds and compositions, and methods of use thereof |
BR112019024322A2 (pt) | 2017-05-22 | 2020-06-16 | F. Hoffmann-La Roche Ag | Compostos e composições terapêuticos e métodos de uso dos mesmos |
US10364245B2 (en) | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
CN111587250A (zh) | 2018-01-15 | 2020-08-25 | 豪夫迈·罗氏有限公司 | 作为jak抑制剂的吡唑并嘧啶化合物 |
CN114026096A (zh) | 2019-06-18 | 2022-02-08 | 豪夫迈·罗氏有限公司 | 四唑取代的吡唑并嘧啶类jak激酶抑制剂及其用途 |
MA56518A (fr) | 2019-06-18 | 2022-04-27 | Hoffmann La Roche | Inhibiteurs de sulfone pyrazolopyrimidine de jak kinases et leurs utilisations |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2852505A (en) * | 1955-10-31 | 1958-09-16 | American Cyanamid Co | Aminodeoxyglycosidopurines |
US2852506A (en) * | 1955-10-31 | 1958-09-16 | American Cyanamid Co | Method of preparing aminodeoxyglycosidopurines |
US5817760A (en) * | 1992-03-13 | 1998-10-06 | Merck & Co., Inc. | Human A3 adenosine receptors |
US5688774A (en) * | 1993-07-13 | 1997-11-18 | The United States Of America As Represented By The Department Of Health And Human Services | A3 adenosine receptor agonists |
ATE206432T1 (de) * | 1993-07-13 | 2001-10-15 | Nasa | A3 -adenosin -rezeptor agonisten |
EP0704215A3 (en) * | 1994-06-02 | 1998-04-01 | Takeda Chemical Industries, Ltd. | Inhibitor of vascular permeability enhancer |
US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
CO5180581A1 (es) * | 1999-09-30 | 2002-07-30 | Pfizer Prod Inc | Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia |
-
2002
- 2002-02-20 EP EP02251174A patent/EP1241176A1/en not_active Withdrawn
- 2002-03-08 JP JP2002062987A patent/JP2002322193A/ja active Pending
- 2002-03-13 BR BR0200782-7A patent/BR0200782A/pt not_active IP Right Cessation
- 2002-03-14 CA CA002376738A patent/CA2376738A1/en not_active Abandoned
- 2002-03-15 MX MXPA02002971A patent/MXPA02002971A/es unknown
- 2002-03-15 US US10/099,620 patent/US20030055021A1/en not_active Abandoned
-
2005
- 2005-03-29 US US11/093,089 patent/US20050171049A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030055021A1 (en) | 2003-03-20 |
US20050171049A1 (en) | 2005-08-04 |
MXPA02002971A (es) | 2003-07-14 |
JP2002322193A (ja) | 2002-11-08 |
CA2376738A1 (en) | 2002-09-16 |
EP1241176A1 (en) | 2002-09-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1980 DE 16/12/2008. |