DE60228071D1 - Spiropyrazol-verbindungen - Google Patents

Spiropyrazol-verbindungen

Info

Publication number
DE60228071D1
DE60228071D1 DE60228071T DE60228071T DE60228071D1 DE 60228071 D1 DE60228071 D1 DE 60228071D1 DE 60228071 T DE60228071 T DE 60228071T DE 60228071 T DE60228071 T DE 60228071T DE 60228071 D1 DE60228071 D1 DE 60228071D1
Authority
DE
Germany
Prior art keywords
spiropyrazol
connections
whereinz
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228071T
Other languages
German (de)
English (en)
Inventor
R Richard Goehring
Donald Kyle
Gary Lee
Parviz Gharagozloo
Sam Victory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Application granted granted Critical
Publication of DE60228071D1 publication Critical patent/DE60228071D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DE60228071T 2001-04-18 2002-04-18 Spiropyrazol-verbindungen Expired - Lifetime DE60228071D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18
PCT/US2002/012376 WO2002085355A1 (en) 2001-04-18 2002-04-18 Spiropyrazole compounds

Publications (1)

Publication Number Publication Date
DE60228071D1 true DE60228071D1 (de) 2008-09-18

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228071T Expired - Lifetime DE60228071D1 (de) 2001-04-18 2002-04-18 Spiropyrazol-verbindungen

Country Status (28)

Country Link
US (2) US6635653B2 (pt)
EP (1) EP1385515B1 (pt)
JP (1) JP4342181B2 (pt)
KR (1) KR100628292B1 (pt)
CN (1) CN1516584A (pt)
AT (1) ATE403429T1 (pt)
AU (1) AU2002311833B2 (pt)
BR (1) BR0209127A (pt)
CA (1) CA2444634C (pt)
CY (1) CY1108454T1 (pt)
CZ (1) CZ20032849A3 (pt)
DE (1) DE60228071D1 (pt)
DK (1) DK1385515T3 (pt)
ES (1) ES2312584T3 (pt)
HK (1) HK1062885A1 (pt)
HU (1) HUP0401333A3 (pt)
IL (2) IL158485A0 (pt)
MX (1) MXPA03009604A (pt)
NO (1) NO20034660L (pt)
NZ (1) NZ528978A (pt)
PL (1) PL367263A1 (pt)
PT (1) PT1385515E (pt)
RU (1) RU2299883C2 (pt)
SI (1) SI1385515T1 (pt)
UA (1) UA74439C2 (pt)
WO (1) WO2002085355A1 (pt)
YU (1) YU82403A (pt)
ZA (1) ZA200308103B (pt)

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US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100028339A1 (en) * 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
MXPA06011219A (es) 2004-03-29 2007-05-08 Univ South Florida Tratamiento efectivo de tumores y cancer con triciribina y compuestos relacionados.
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
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CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
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CN101595100B (zh) 2007-01-16 2014-06-11 普渡制药公司 作为orl-1配体的杂环取代的哌啶
US8741916B2 (en) 2007-04-09 2014-06-03 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor
EP3564240B1 (en) * 2007-08-31 2022-04-06 Purdue Pharma L.P. Piperidine intermediates
AU2009275218C1 (en) 2008-07-21 2015-02-05 Purdue Pharma L.P. Substituted-Quinoxaline-Type Bridged-Piperidine Compounds and the uses thereof
UA107943C2 (en) * 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors
AU2011346749A1 (en) 2010-12-22 2013-05-02 Purdue Pharma L.P. Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
ES2583146T3 (es) 2011-12-01 2016-09-19 Purdue Pharma L.P. Compuestos de piperidina de tipo quinoxalina sustituidos con azetidina y usos de éstos
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102589A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Quinazolin-4(3h)-one-type piperidine compounds and uses thereof
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

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US4410528A (en) 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
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JPS60120872A (ja) 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
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ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
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MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
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HUP0401333A3 (en) * 2001-04-18 2004-11-29 Euro Celtique Sa Spiropyrazole compounds and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO2002085355A1 (en) 2002-10-31
NZ528978A (en) 2004-06-25
UA74439C2 (uk) 2005-12-15
DK1385515T3 (da) 2008-10-27
HUP0401333A3 (en) 2004-11-29
CA2444634C (en) 2011-06-07
CA2444634A1 (en) 2002-10-31
PT1385515E (pt) 2008-09-15
CZ20032849A3 (en) 2004-03-17
NO20034660D0 (no) 2003-10-17
ES2312584T3 (es) 2009-03-01
AU2002311833B2 (en) 2005-04-28
MXPA03009604A (es) 2004-04-02
HUP0401333A2 (hu) 2004-10-28
RU2003133455A (ru) 2005-05-10
IL158485A0 (en) 2004-05-12
PL367263A1 (en) 2005-02-21
US20030027834A1 (en) 2003-02-06
KR20040008159A (ko) 2004-01-28
CY1108454T1 (el) 2014-04-09
IL158485A (en) 2009-09-01
EP1385515B1 (en) 2008-08-06
EP1385515A1 (en) 2004-02-04
US20040087641A1 (en) 2004-05-06
HK1062885A1 (en) 2004-12-03
RU2299883C2 (ru) 2007-05-27
NO20034660L (no) 2003-12-17
JP2004531531A (ja) 2004-10-14
CN1516584A (zh) 2004-07-28
ATE403429T1 (de) 2008-08-15
KR100628292B1 (ko) 2006-09-27
BR0209127A (pt) 2006-03-21
YU82403A (sh) 2006-08-17
JP4342181B2 (ja) 2009-10-14
US6635653B2 (en) 2003-10-21
SI1385515T1 (sl) 2008-12-31
ZA200308103B (en) 2004-10-18
EP1385515A4 (en) 2004-06-30

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Legal Events

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