ATE218126T1 - Phenylpiperidin-derivate - Google Patents
Phenylpiperidin-derivateInfo
- Publication number
- ATE218126T1 ATE218126T1 AT96930358T AT96930358T ATE218126T1 AT E218126 T1 ATE218126 T1 AT E218126T1 AT 96930358 T AT96930358 T AT 96930358T AT 96930358 T AT96930358 T AT 96930358T AT E218126 T1 ATE218126 T1 AT E218126T1
- Authority
- AT
- Austria
- Prior art keywords
- represents hydrogen
- halogen
- phenylpiperidine
- lower alkyl
- alkyl
- Prior art date
Links
- LLSKXGRDUPMXLC-UHFFFAOYSA-N 1-phenylpiperidine Chemical class C1CCCCN1C1=CC=CC=C1 LLSKXGRDUPMXLC-UHFFFAOYSA-N 0.000 title abstract 3
- 229940051803 opioid analgesics phenylpiperidine derivative Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23502295 | 1995-09-13 | ||
| PCT/JP1996/002589 WO1997010213A1 (en) | 1995-09-13 | 1996-09-11 | Phenylpiperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218126T1 true ATE218126T1 (de) | 2002-06-15 |
Family
ID=16979926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96930358T ATE218126T1 (de) | 1995-09-13 | 1996-09-11 | Phenylpiperidin-derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6150355A (de) |
| EP (1) | EP0974583B1 (de) |
| AT (1) | ATE218126T1 (de) |
| AU (1) | AU6943996A (de) |
| CA (1) | CA2231773A1 (de) |
| DE (1) | DE69621469T2 (de) |
| WO (1) | WO1997010213A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| CA2318088A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| ES2251176T3 (es) | 1998-01-21 | 2006-04-16 | Millennium Pharmaceuticals, Inc. | Antagonistas del receptor de quimioquina y procedimientos de uso de los mismos. |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| EP1244437A4 (de) | 1999-12-06 | 2005-02-09 | Euro Celtique Sa | Tertiäre aminoverbindungen mit opioid-rezeptor affinität |
| ATE302770T1 (de) | 1999-12-06 | 2005-09-15 | Euro Celtique Sa | Benzimidazolverbindungen die nociceptinrezeptoraffinität haben |
| JP3989247B2 (ja) | 1999-12-06 | 2007-10-10 | ユーロ−セルティーク エス．エイ． | ノシセプチン受容体親和性を有するトリアゾスピロ化合物 |
| EP2033644A1 (de) | 2001-04-18 | 2009-03-11 | Euro-Celtique S.A. | Spiroinden- und Spiroindan-Verbindungen |
| ATE424385T1 (de) | 2001-04-18 | 2009-03-15 | Euro Celtique Sa | 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz |
| DE60228072D1 (de) | 2001-04-18 | 2008-09-18 | Euro Celtique Sa | Benzimidazolon-verbindungen |
| RU2299883C2 (ru) | 2001-04-18 | 2007-05-27 | Эро-Селтик, С.А. | Соединения спиропиразола, содержащая их фармацевтическая композиция, способ модуляции опиоидного рецептора и способ лечения с применением таких соединений |
| JP4380992B2 (ja) | 2001-04-18 | 2009-12-09 | ユーロ−セルティーク エス．エイ． | ノシセプチン類似体 |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| EP1987009A1 (de) * | 2006-01-30 | 2008-11-05 | Euro-Celtique S.A. | Cycloharnstoffverbindung als calciumkanalblocker |
| WO2008128166A1 (en) * | 2007-04-13 | 2008-10-23 | Concert Pharmaceuticals Inc. | Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61225167A (ja) * | 1985-03-28 | 1986-10-06 | Yoshitomi Pharmaceut Ind Ltd | ベンゾ〔ｇ〕キノリン誘導体 |
| US4882351A (en) * | 1987-10-14 | 1989-11-21 | Roussel Uclaf | Tricyclic compounds |
| JPH02250A (ja) * | 1987-10-14 | 1990-01-05 | Kyowa Hakko Kogyo Co Ltd | 三環式化合物 |
| US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
-
1996
- 1996-09-11 AT AT96930358T patent/ATE218126T1/de not_active IP Right Cessation
- 1996-09-11 EP EP96930358A patent/EP0974583B1/de not_active Expired - Lifetime
- 1996-09-11 CA CA002231773A patent/CA2231773A1/en not_active Abandoned
- 1996-09-11 WO PCT/JP1996/002589 patent/WO1997010213A1/ja not_active Ceased
- 1996-09-11 US US09/043,154 patent/US6150355A/en not_active Expired - Fee Related
- 1996-09-11 AU AU69439/96A patent/AU6943996A/en not_active Abandoned
- 1996-09-11 DE DE69621469T patent/DE69621469T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69621469D1 (de) | 2002-07-04 |
| EP0974583A4 (de) | 2000-03-08 |
| AU6943996A (en) | 1997-04-01 |
| US6150355A (en) | 2000-11-21 |
| CA2231773A1 (en) | 1997-03-20 |
| EP0974583B1 (de) | 2002-05-29 |
| WO1997010213A1 (en) | 1997-03-20 |
| DE69621469T2 (de) | 2002-12-12 |
| EP0974583A1 (de) | 2000-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |