ATE403431T1 - Benzimidazolon-verbindungen - Google Patents
Benzimidazolon-verbindungenInfo
- Publication number
- ATE403431T1 ATE403431T1 AT02764243T AT02764243T ATE403431T1 AT E403431 T1 ATE403431 T1 AT E403431T1 AT 02764243 T AT02764243 T AT 02764243T AT 02764243 T AT02764243 T AT 02764243T AT E403431 T1 ATE403431 T1 AT E403431T1
- Authority
- AT
- Austria
- Prior art keywords
- benzimidazolone compounds
- compounds
- benzimidazolone
- analgetics
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28466501P | 2001-04-18 | 2001-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE403431T1 true ATE403431T1 (de) | 2008-08-15 |
Family
ID=23091051
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08011371T ATE456564T1 (de) | 2001-04-18 | 2002-04-18 | Octahydrobenzimidazolon-verbindungen als analgetika |
AT02764243T ATE403431T1 (de) | 2001-04-18 | 2002-04-18 | Benzimidazolon-verbindungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08011371T ATE456564T1 (de) | 2001-04-18 | 2002-04-18 | Octahydrobenzimidazolon-verbindungen als analgetika |
Country Status (13)
Country | Link |
---|---|
US (2) | US6872733B2 (de) |
EP (3) | EP2172468A1 (de) |
JP (1) | JP4401076B2 (de) |
AT (2) | ATE456564T1 (de) |
AU (1) | AU2002338424B2 (de) |
CA (1) | CA2444489C (de) |
CY (2) | CY1108456T1 (de) |
DE (2) | DE60235274D1 (de) |
DK (2) | DK1975164T3 (de) |
ES (2) | ES2340441T3 (de) |
PT (2) | PT1385518E (de) |
SI (2) | SI1975164T1 (de) |
WO (1) | WO2002085361A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7566728B2 (en) | 2002-03-29 | 2009-07-28 | Mitsubishi Tanabe Pharma Corporation | Remedy for sleep disturbance |
US8435959B2 (en) | 2004-03-29 | 2013-05-07 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
UA101299C2 (uk) * | 2005-09-30 | 2013-03-25 | Глаксо Груп Лімітед | Сполуки, що мають активність стосовно рецепторів м1, та їх застосування в медицині |
US8288412B2 (en) * | 2005-09-30 | 2012-10-16 | Glaxo Group Limited | Compounds which have activity at M1 receptor and their uses in medicine |
US8288413B2 (en) * | 2005-09-30 | 2012-10-16 | Glaxo Group Limited | Benzimidazolones which have activity at M1 receptor |
CN1870631B (zh) * | 2005-11-11 | 2010-04-14 | 华为技术有限公司 | 媒体网关的门控方法 |
TW200813018A (en) * | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
EP2280008B1 (de) * | 2007-01-16 | 2013-05-29 | Purdue Pharma L.P. | Heterozyklische substituierte piperidine als orl-1-liganden |
GB0706188D0 (en) * | 2007-03-29 | 2007-05-09 | Glaxo Group Ltd | Compounds |
RU2488585C2 (ru) * | 2007-08-31 | 2013-07-27 | Пэдью Фарма Л.П. | Замещенные пиперидиновые соединения хиноксалинового типа и их применение |
US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
GB0718415D0 (en) * | 2007-09-20 | 2007-10-31 | Glaxo Group Ltd | Compounds |
MX2011000872A (es) | 2008-07-21 | 2011-07-29 | Purdue Pharma Lp | Compuestos de piperidina puenteada tipo quinoxalina sustituida y los usos de los mismos. |
US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
US10118927B2 (en) | 2012-12-27 | 2018-11-06 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3161645A (en) | 1962-12-18 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds |
US3318900A (en) | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
US3325499A (en) | 1964-11-02 | 1967-06-13 | Mcneilab Inc | 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone |
DE2609645A1 (de) | 1976-03-09 | 1977-09-15 | Boehringer Sohn Ingelheim | Aminoalkylheterocyclen |
US4329353A (en) | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
US4410528A (en) | 1980-05-16 | 1983-10-18 | Kyowa Hakko Kogyo Co., Ltd. | Hypotensive piperidine derivatives |
JPS58180481A (ja) | 1982-04-15 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
JPS60120872A (ja) | 1983-12-01 | 1985-06-28 | Kyowa Hakko Kogyo Co Ltd | 新規なヘテロ環状化合物及び強心剤 |
US5760054A (en) | 1994-04-14 | 1998-06-02 | Merck & Co., Inc. | Alpha IC adrenergic receptor antagonists |
FR2722190B1 (fr) | 1994-07-05 | 1996-10-04 | Sanofi Sa | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant |
US5767118A (en) | 1994-10-26 | 1998-06-16 | Merck & Co., Inc. | 4-Heterocyclic peperidines promote release of growth hormone |
US5574044A (en) | 1994-10-27 | 1996-11-12 | Merck & Co., Inc. | Muscarine antagonists |
ATE301457T1 (de) | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
US6150355A (en) | 1995-09-13 | 2000-11-21 | Kyowa Hakko Kogyo Co., Ltd. | Phenylpiperidine derivative |
AU2388697A (en) | 1996-04-19 | 1997-11-12 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
US6063796A (en) | 1997-04-04 | 2000-05-16 | Merck & Co., Inc. | Somatostatin agonists |
JP4366532B2 (ja) | 1997-05-30 | 2009-11-18 | 萬有製薬株式会社 | 2−オキソイミダゾール誘導体 |
JPH10330377A (ja) | 1997-06-02 | 1998-12-15 | Kyowa Hakko Kogyo Co Ltd | ピペリジン誘導体 |
US6166037A (en) | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
EP0921125B1 (de) | 1997-12-05 | 2002-01-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro[4,5]decan-4-on-derivate |
US6166209A (en) | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
US6423725B1 (en) * | 1998-01-19 | 2002-07-23 | Pfizer Inc | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as ORL1-receptor agonists |
CA2325638A1 (en) | 1998-03-26 | 1999-09-30 | Hideki Yamada | Amide derivatives and nociceptin antagonists |
JP2002515503A (ja) | 1998-05-18 | 2002-05-28 | ノボ ノルディスク アクティーゼルスカブ | オピオイド受容体のサブタイプへの高い親和性を有する新規1,3,8−トリアザスピロ〔4,5〕デカノン |
US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
ID29137A (id) | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
MA26659A1 (fr) * | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
CA2421493A1 (en) | 2000-09-06 | 2002-03-14 | Ortho-Mcneil Pharmaceutical, Inc. | A method for treating allergies using substituted pyrazoles |
-
2002
- 2002-04-18 PT PT02764243T patent/PT1385518E/pt unknown
- 2002-04-18 PT PT08011371T patent/PT1975164E/pt unknown
- 2002-04-18 DK DK08011371.5T patent/DK1975164T3/da active
- 2002-04-18 JP JP2002582934A patent/JP4401076B2/ja not_active Expired - Fee Related
- 2002-04-18 SI SI200230894T patent/SI1975164T1/sl unknown
- 2002-04-18 AU AU2002338424A patent/AU2002338424B2/en not_active Ceased
- 2002-04-18 EP EP10000601A patent/EP2172468A1/de not_active Withdrawn
- 2002-04-18 AT AT08011371T patent/ATE456564T1/de not_active IP Right Cessation
- 2002-04-18 DK DK02764243T patent/DK1385518T3/da active
- 2002-04-18 EP EP02764243A patent/EP1385518B1/de not_active Expired - Lifetime
- 2002-04-18 US US10/126,437 patent/US6872733B2/en not_active Expired - Lifetime
- 2002-04-18 CA CA2444489A patent/CA2444489C/en not_active Expired - Fee Related
- 2002-04-18 DE DE60235274T patent/DE60235274D1/de not_active Expired - Lifetime
- 2002-04-18 WO PCT/US2002/012375 patent/WO2002085361A1/en active IP Right Grant
- 2002-04-18 ES ES08011371T patent/ES2340441T3/es not_active Expired - Lifetime
- 2002-04-18 ES ES02764243T patent/ES2312616T3/es not_active Expired - Lifetime
- 2002-04-18 AT AT02764243T patent/ATE403431T1/de not_active IP Right Cessation
- 2002-04-18 DE DE60228072T patent/DE60228072D1/de not_active Expired - Lifetime
- 2002-04-18 SI SI200230749T patent/SI1385518T1/sl unknown
- 2002-04-18 EP EP08011371A patent/EP1975164B1/de not_active Expired - Lifetime
-
2005
- 2005-03-28 US US11/091,229 patent/US20050192307A1/en not_active Abandoned
-
2008
- 2008-10-27 CY CY20081101210T patent/CY1108456T1/el unknown
-
2010
- 2010-04-14 CY CY20101100336T patent/CY1110000T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE60228072D1 (de) | 2008-09-18 |
US6872733B2 (en) | 2005-03-29 |
EP1975164A2 (de) | 2008-10-01 |
SI1975164T1 (sl) | 2010-05-31 |
US20050192307A1 (en) | 2005-09-01 |
EP1385518B1 (de) | 2008-08-06 |
US20030008886A1 (en) | 2003-01-09 |
JP2004531532A (ja) | 2004-10-14 |
CA2444489A1 (en) | 2002-10-31 |
CY1110000T1 (el) | 2012-05-23 |
WO2002085361A1 (en) | 2002-10-31 |
CY1108456T1 (el) | 2012-05-23 |
ATE456564T1 (de) | 2010-02-15 |
EP1385518A4 (de) | 2005-10-05 |
SI1385518T1 (sl) | 2009-02-28 |
DE60235274D1 (de) | 2010-03-18 |
CA2444489C (en) | 2010-06-22 |
PT1385518E (pt) | 2008-10-07 |
DK1975164T3 (da) | 2010-05-25 |
ES2340441T3 (es) | 2010-06-02 |
ES2312616T3 (es) | 2009-03-01 |
PT1975164E (pt) | 2010-04-20 |
EP1385518A1 (de) | 2004-02-04 |
JP4401076B2 (ja) | 2010-01-20 |
DK1385518T3 (da) | 2008-10-27 |
EP1975164A3 (de) | 2008-10-08 |
EP2172468A1 (de) | 2010-04-07 |
AU2002338424B2 (en) | 2005-04-21 |
EP1975164B1 (de) | 2010-01-27 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
Ref document number: 1385518 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |