DK0859766T3 - Chirale methylphenyloxazolidinoner - Google Patents

Chirale methylphenyloxazolidinoner

Info

Publication number
DK0859766T3
DK0859766T3 DK96902871T DK96902871T DK0859766T3 DK 0859766 T3 DK0859766 T3 DK 0859766T3 DK 96902871 T DK96902871 T DK 96902871T DK 96902871 T DK96902871 T DK 96902871T DK 0859766 T3 DK0859766 T3 DK 0859766T3
Authority
DK
Denmark
Prior art keywords
methylphenyloxazolidinones
chiral
production
relates
pharmaceutical agents
Prior art date
Application number
DK96902871T
Other languages
English (en)
Inventor
Henry Laurent
Eckhard Ottow
Gerald Kirsch
Helmut Wachtel
Herbert Schneider
Daryl Faulds
Harald Dinter
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0859766T3 publication Critical patent/DK0859766T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DK96902871T 1995-10-20 1996-02-09 Chirale methylphenyloxazolidinoner DK0859766T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19540475A DE19540475A1 (de) 1995-10-20 1995-10-20 Chirale Methylphenyloxazolidinone
PCT/DE1996/000259 WO1997015561A1 (de) 1995-10-20 1996-02-09 Chirale methylphenyloxazolidinone

Publications (1)

Publication Number Publication Date
DK0859766T3 true DK0859766T3 (da) 2001-08-13

Family

ID=7776217

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96902871T DK0859766T3 (da) 1995-10-20 1996-02-09 Chirale methylphenyloxazolidinoner

Country Status (25)

Country Link
US (1) US6025376A (da)
EP (1) EP0859766B1 (da)
JP (1) JPH11513693A (da)
KR (1) KR100417359B1 (da)
CN (1) CN1077103C (da)
AT (1) ATE201203T1 (da)
AU (1) AU715344B2 (da)
CZ (1) CZ292167B6 (da)
DE (2) DE19540475A1 (da)
DK (1) DK0859766T3 (da)
ES (1) ES2158284T3 (da)
FI (1) FI980862A (da)
GR (1) GR3036305T3 (da)
HK (1) HK1015788A1 (da)
HU (1) HUP9802630A3 (da)
IL (1) IL117091A (da)
NO (1) NO310772B1 (da)
NZ (1) NZ301645A (da)
PL (1) PL185526B1 (da)
PT (1) PT859766E (da)
RU (1) RU2156243C2 (da)
SK (1) SK282653B6 (da)
TR (1) TR199800679T2 (da)
WO (1) WO1997015561A1 (da)
ZA (1) ZA961074B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2300813A1 (en) * 1997-08-21 1999-03-04 Hiroyuki Odaka Anti-inflammatory agent
DE19928312A1 (de) * 1999-06-16 2000-12-21 Schering Ag Arzneimittelzubereitung mit verzögerter Wirkstoffabgabe
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
EP1216700A1 (de) * 2000-12-21 2002-06-26 Schering Aktiengesellschaft Transdermalsysteme (TDS) enthaltend (R)-(-)-Methylphenyloxazolidinon-Derivate, Inhibitoren der Phosphodiesterase IV
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
YU103003A (sh) 2001-06-26 2006-05-25 Abgenix Inc. Antitela za opgl
EP1414517A4 (en) * 2001-06-26 2008-02-06 Photomed Technologies Inc MULTIPLE WAVELENGTH ILLUMINATOR
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
AU2003208525B9 (en) * 2002-02-04 2009-08-27 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Amend the invention title to read Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
JP2006517191A (ja) * 2002-12-30 2006-07-20 アムジエン・インコーポレーテツド 共刺激因子を用いた併用療法
WO2004098592A1 (ja) * 2003-05-06 2004-11-18 Senju Pharmaceutical Co. Ltd. オキサゾリジノン誘導体含有組成物
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
ES2320954B1 (es) * 2007-03-02 2010-03-16 Laboratorio Almirall S.A. Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
EP2699242B1 (en) 2011-04-19 2017-11-01 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
US11141410B2 (en) 2015-12-16 2021-10-12 Merck Sharp & Dohme Corp Oxazolidinones as taro inhibitors
US10736905B1 (en) 2016-09-09 2020-08-11 Shahin Fatholahi Nefopam dosage forms and methods of treatment
US10736874B1 (en) 2017-09-08 2020-08-11 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
US11446311B2 (en) 2017-09-08 2022-09-20 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
CA3135420A1 (en) * 2018-04-05 2019-10-10 Universiteit Hasselt Selective pde4d inhibitors against demyelinating diseases

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
DE2541855A1 (de) * 1975-09-18 1977-03-31 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone ii
FR2358155A1 (fr) * 1976-07-15 1978-02-10 Lapinet Eugene Composition pour le traitement et la prevention de l'irritation et de l'inflammation de la peau, de l'oeil et des muqueuses
DE2655369A1 (de) * 1976-12-03 1978-06-08 Schering Ag 5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung
DE3438839A1 (de) * 1984-10-19 1986-04-24 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische praeparate
US5783591A (en) * 1984-10-19 1998-07-21 Schering Aktiengesellschaft Administration of oxazolidinone and pyrolidinone compounds for the treatment of inflammation
DE3639225A1 (de) * 1986-11-14 1988-05-19 Schering Ag Verwendung von 5-(subst. phenyl)-oxazolidinonderiaten als psychopharmaka
AU6355190A (en) * 1989-06-13 1991-01-17 Smithkline Beecham Corporation Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
DK0542795T5 (da) * 1990-08-03 1998-09-07 Smithkline Beecham Corp TNF-inhibitorer
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
US5227369A (en) * 1991-07-11 1993-07-13 The Regents Of The University Of California Compositions and methods for inhibiting leukocyte adhesion to cns myelin
WO1993017096A1 (en) * 1992-02-24 1993-09-02 Q. P. Corporation Ice nucleus producing bacterium, culture of said bacterium, ice nucleus producing substance containing said bacterium, and use of said substance
GB9204808D0 (en) * 1992-03-04 1992-04-15 Rhone Poulenc Rorer Ltd Novel compositions of matter
US5264437A (en) * 1992-03-20 1993-11-23 Syntex (U.S.A.) Inc. Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
US5672622A (en) * 1994-04-21 1997-09-30 Berlex Laboratories, Inc. Treatment of multiple sclerosis

Also Published As

Publication number Publication date
HK1015788A1 (en) 1999-10-22
HUP9802630A2 (hu) 1999-04-28
NO310772B1 (no) 2001-08-27
ZA961074B (en) 1997-02-26
KR19990064339A (ko) 1999-07-26
GR3036305T3 (en) 2001-10-31
KR100417359B1 (ko) 2004-03-19
TR199800679T2 (xx) 1998-07-21
DE19540475A1 (de) 1997-04-24
SK282653B6 (sk) 2002-11-06
PL185526B1 (pl) 2003-05-30
CN1200115A (zh) 1998-11-25
CN1077103C (zh) 2002-01-02
NO981688D0 (no) 1998-04-15
IL117091A (en) 2000-07-26
NO981688L (no) 1998-04-15
EP0859766A1 (de) 1998-08-26
FI980862A0 (fi) 1998-04-17
NZ301645A (en) 1999-11-29
HUP9802630A3 (en) 2000-01-28
PL326322A1 (en) 1998-09-14
RU2156243C2 (ru) 2000-09-20
AU715344B2 (en) 2000-01-20
DE59606920D1 (de) 2001-06-21
JPH11513693A (ja) 1999-11-24
CZ292167B6 (cs) 2003-08-13
ES2158284T3 (es) 2001-09-01
CZ120198A3 (cs) 1998-07-15
AU4712396A (en) 1997-05-15
SK49598A3 (en) 1998-09-09
ATE201203T1 (de) 2001-06-15
FI980862A (fi) 1998-04-17
WO1997015561A1 (de) 1997-05-01
US6025376A (en) 2000-02-15
EP0859766B1 (de) 2001-05-16
IL117091A0 (en) 1996-06-18
PT859766E (pt) 2001-10-30

Similar Documents

Publication Publication Date Title
DK0859766T3 (da) Chirale methylphenyloxazolidinoner
SE9704545D0 (sv) Novel compounds
SE9704544D0 (sv) Novel compounds
NO20000935L (no) Fremgangsmåte for inhibering av komplementaktivering via den alternative reaksjonsvei
ZA965752B (en) Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents.
KR960702830A (ko) 방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents)
MX9705726A (es) Amidas del acido alcoximinoacetico.
BR0007643A (pt) Processo para obter ésteres de (nitroximetil) fenila de derivados de aspirina, e, (hidroximetil) feniléter de derivados de aspirina
YU63696A (sh) Novi fenilamidin-derivati, postupci za njihovo pripremanje i njihova primena kao lekova
AU2895397A (en) Novel substance library and supramolecular complexes prepared therewith
YU12000A (sh) Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
MX9706744A (es) Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol.
PT1246790E (pt) Bases de mannich de 1- e 2-naftol substituido
ATE196292T1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
ATE242763T1 (de) Methoximinophenylessigsäureamide
MY127328A (en) 5-amino-1-pentene-3-ol substituted derivatives
PT796256E (pt) Novos processos de preparacao da ranitidina
SE9704834D0 (sv) New process
MX9603450A (es) Procedimiento para la obtencion de aminotriazolinas substituidas.
HK1038017A1 (en) Novel 2,3,3a,4,9,9a hexahydro-8-hydroxy-1h-benzÄfÜindoles, a method for the production thereof, and their use as medicaments.
MY113450A (en) Anellated b-carbolines
SE9503757D0 (sv) Process for the production of ranitidine
MX9606264A (es) Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol como sustancias farmacologicas activas.
MX9710530A (es) Derivados de benzo (a) quinolina.
KR970028045U (ko) 목업 제작용 둥근톱기계