KR960702830A - 방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents) - Google Patents
방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents)Info
- Publication number
- KR960702830A KR960702830A KR1019950705352A KR19950705352A KR960702830A KR 960702830 A KR960702830 A KR 960702830A KR 1019950705352 A KR1019950705352 A KR 1019950705352A KR 19950705352 A KR19950705352 A KR 19950705352A KR 960702830 A KR960702830 A KR 960702830A
- Authority
- KR
- South Korea
- Prior art keywords
- polyaine
- alkylthio
- derivatives
- radioprotective agents
- radioprotective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6930293A | 1993-05-26 | 1993-05-26 | |
PCT/US1994/004662 WO1994027961A1 (en) | 1993-05-26 | 1994-04-28 | N-alkylthio polyamine derivatives as radioprotective agents |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960702830A true KR960702830A (ko) | 1996-05-23 |
Family
ID=22088062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950705352A KR960702830A (ko) | 1993-05-26 | 1995-11-25 | 방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents) |
Country Status (19)
Country | Link |
---|---|
US (1) | US5434145A (ko) |
EP (1) | EP0700380B1 (ko) |
KR (1) | KR960702830A (ko) |
CN (1) | CN1124483A (ko) |
AT (1) | ATE167670T1 (ko) |
AU (1) | AU679236B2 (ko) |
CA (1) | CA2161869C (ko) |
DE (1) | DE69411271T2 (ko) |
DK (1) | DK0700380T3 (ko) |
ES (1) | ES2119203T3 (ko) |
FI (1) | FI955643A0 (ko) |
GR (1) | GR3027657T3 (ko) |
HU (1) | HUT73421A (ko) |
IL (1) | IL109720A (ko) |
MX (1) | MX9403915A (ko) |
NO (1) | NO306020B1 (ko) |
NZ (1) | NZ267211A (ko) |
WO (1) | WO1994027961A1 (ko) |
ZA (1) | ZA943520B (ko) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
US5677351A (en) * | 1986-12-02 | 1997-10-14 | University Of Florida Research Foundation, Inc. | Sterically hindered tetraamines and method for their production |
US5393757A (en) * | 1986-12-02 | 1995-02-28 | University Of Florida | Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment |
US5869338A (en) * | 1992-03-13 | 1999-02-09 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
US5567686A (en) * | 1992-03-13 | 1996-10-22 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
US5994409A (en) * | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
WO2000036667A2 (en) * | 1998-12-15 | 2000-06-22 | Duracell Inc. | Electrochemical cell closure |
EP1698629A3 (en) * | 1999-04-30 | 2006-11-29 | Cellgate, Inc. | Polyamines and their use in therapy |
US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
IL146126A0 (en) * | 1999-04-30 | 2002-07-25 | Slil Biomedical Corp | Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
US7312244B2 (en) * | 1999-04-30 | 2007-12-25 | Cellgate, Inc. | Polyamine analog-amino acid conjugates useful as anticancer agents |
US6482943B1 (en) * | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
US6489312B1 (en) * | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
US6160022A (en) * | 1999-07-19 | 2000-12-12 | University Of Florida | Chemical resection of pancreas |
US7053072B2 (en) | 2001-05-11 | 2006-05-30 | Medimmune Oncology, Inc. | Methods for the administration of amifostine and related compounds |
US7045550B2 (en) * | 2001-08-07 | 2006-05-16 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
CA2469354A1 (en) * | 2001-12-07 | 2003-06-19 | Slil Biomedical Corporation | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
JP2005517004A (ja) | 2002-02-07 | 2005-06-09 | ウィスコンシン アルムニ リサーチ ファンデーション | 癌治療に関連した使用に対するポリアミン化合物及び組成 |
WO2005014524A2 (en) * | 2003-08-07 | 2005-02-17 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
WO2007149484A2 (en) * | 2006-06-20 | 2007-12-27 | Dana-Farber Cancer Institute | Inhibitors of usp1 deubiquitinating enzyme complex |
US20100049284A1 (en) * | 2008-05-15 | 2010-02-25 | The Catholic University Of America | Use of heat to treat biological systems exposed to damaging radiation |
US9518032B2 (en) | 2010-04-30 | 2016-12-13 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of USP1 deubiquitinating enzyme activity |
US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2653977A (en) * | 1953-09-29 | Chxnx | ||
US2951092A (en) * | 1956-12-13 | 1960-08-30 | Olin Mathieson | Triamine derivatives |
US3892824A (en) * | 1968-12-16 | 1975-07-01 | Southern Res Inst | S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates |
US5091576A (en) * | 1986-12-02 | 1992-02-25 | University Of Florida | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
US5109024A (en) * | 1987-02-03 | 1992-04-28 | Merrell Dow Pharmaceuticals Inc. | Polyamine derivatives as antineoplastic agents |
US5217964A (en) * | 1991-01-23 | 1993-06-08 | Merrell Dow Pharmaceuticals Inc. | Polyamine thiols as radioprotective agents |
US5488042A (en) * | 1992-03-13 | 1996-01-30 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
-
1994
- 1994-04-28 AU AU69428/94A patent/AU679236B2/en not_active Ceased
- 1994-04-28 WO PCT/US1994/004662 patent/WO1994027961A1/en active IP Right Grant
- 1994-04-28 DK DK94917900T patent/DK0700380T3/da active
- 1994-04-28 HU HU9503370A patent/HUT73421A/hu unknown
- 1994-04-28 CN CN94192245A patent/CN1124483A/zh active Pending
- 1994-04-28 EP EP94917900A patent/EP0700380B1/en not_active Expired - Lifetime
- 1994-04-28 NZ NZ267211A patent/NZ267211A/en unknown
- 1994-04-28 CA CA002161869A patent/CA2161869C/en not_active Expired - Fee Related
- 1994-04-28 AT AT94917900T patent/ATE167670T1/de not_active IP Right Cessation
- 1994-04-28 DE DE69411271T patent/DE69411271T2/de not_active Expired - Fee Related
- 1994-04-28 ES ES94917900T patent/ES2119203T3/es not_active Expired - Lifetime
- 1994-05-20 ZA ZA943520A patent/ZA943520B/xx unknown
- 1994-05-22 IL IL10972094A patent/IL109720A/xx not_active IP Right Cessation
- 1994-05-25 MX MX9403915A patent/MX9403915A/es not_active IP Right Cessation
- 1994-10-14 US US08/323,472 patent/US5434145A/en not_active Expired - Fee Related
-
1995
- 1995-11-23 FI FI955643A patent/FI955643A0/fi unknown
- 1995-11-24 NO NO954768A patent/NO306020B1/no unknown
- 1995-11-25 KR KR1019950705352A patent/KR960702830A/ko not_active Application Discontinuation
-
1998
- 1998-08-14 GR GR980401833T patent/GR3027657T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO954768L (no) | 1996-01-23 |
IL109720A0 (en) | 1994-08-26 |
US5434145A (en) | 1995-07-18 |
ZA943520B (en) | 1995-01-23 |
GR3027657T3 (en) | 1998-11-30 |
AU679236B2 (en) | 1997-06-26 |
FI955643A (fi) | 1995-11-23 |
MX9403915A (es) | 1995-01-31 |
CN1124483A (zh) | 1996-06-12 |
DE69411271T2 (de) | 1998-11-05 |
IL109720A (en) | 1999-09-22 |
AU6942894A (en) | 1994-12-20 |
NO306020B1 (no) | 1999-09-06 |
CA2161869C (en) | 2001-11-13 |
FI955643A0 (fi) | 1995-11-23 |
NZ267211A (en) | 1997-11-24 |
ES2119203T3 (es) | 1998-10-01 |
HUT73421A (en) | 1996-07-29 |
DE69411271D1 (de) | 1998-07-30 |
EP0700380B1 (en) | 1998-06-24 |
HU9503370D0 (en) | 1996-01-29 |
CA2161869A1 (en) | 1994-12-08 |
WO1994027961A1 (en) | 1994-12-08 |
DK0700380T3 (da) | 1998-11-09 |
NO954768D0 (no) | 1995-11-24 |
ATE167670T1 (de) | 1998-07-15 |
EP0700380A1 (en) | 1996-03-13 |
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Legal Events
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |