ATE167670T1 - N-alkylthiopolyaminderivate als radioprotektive mittel - Google Patents

N-alkylthiopolyaminderivate als radioprotektive mittel

Info

Publication number
ATE167670T1
ATE167670T1 AT94917900T AT94917900T ATE167670T1 AT E167670 T1 ATE167670 T1 AT E167670T1 AT 94917900 T AT94917900 T AT 94917900T AT 94917900 T AT94917900 T AT 94917900T AT E167670 T1 ATE167670 T1 AT E167670T1
Authority
AT
Austria
Prior art keywords
alkylthiopolyamine
derivatives
radioprotective agents
radioprotective
agents
Prior art date
Application number
AT94917900T
Other languages
English (en)
Inventor
Michael L Edwards
Ronald D Snyder
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE167670T1 publication Critical patent/ATE167670T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Polyamides (AREA)
AT94917900T 1993-05-26 1994-04-28 N-alkylthiopolyaminderivate als radioprotektive mittel ATE167670T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6930293A 1993-05-26 1993-05-26

Publications (1)

Publication Number Publication Date
ATE167670T1 true ATE167670T1 (de) 1998-07-15

Family

ID=22088062

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94917900T ATE167670T1 (de) 1993-05-26 1994-04-28 N-alkylthiopolyaminderivate als radioprotektive mittel

Country Status (19)

Country Link
US (1) US5434145A (de)
EP (1) EP0700380B1 (de)
KR (1) KR960702830A (de)
CN (1) CN1124483A (de)
AT (1) ATE167670T1 (de)
AU (1) AU679236B2 (de)
CA (1) CA2161869C (de)
DE (1) DE69411271T2 (de)
DK (1) DK0700380T3 (de)
ES (1) ES2119203T3 (de)
FI (1) FI955643A7 (de)
GR (1) GR3027657T3 (de)
HU (1) HUT73421A (de)
IL (1) IL109720A (de)
MX (1) MX9403915A (de)
NO (1) NO306020B1 (de)
NZ (1) NZ267211A (de)
WO (1) WO1994027961A1 (de)
ZA (1) ZA943520B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5393757A (en) * 1986-12-02 1995-02-28 University Of Florida Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5677351A (en) * 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5567686A (en) * 1992-03-13 1996-10-22 Arch Development Corporation Method for protection against genotoxic mutagenesis
US5869338A (en) * 1992-03-13 1999-02-09 Arch Development Corporation Method for protection against genotoxic mutagenesis
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
DE69919401T2 (de) * 1998-12-15 2005-07-14 The Gillette Co. (N.D.Ges.D. Staates Delaware), Boston Verschluss einer elektrochemischen zelle
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
HK1040993B (en) 1999-04-30 2006-11-10 Cellgate, Inc. Polyamines and their use in therapy
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
BR0010700A (pt) * 1999-04-30 2002-02-13 Slil Biomedical Corp Conjugados análogos de poliamina e conjugados de quinona como terapias para cânceres e doenças na próstata
US6489312B1 (en) * 1999-06-15 2002-12-03 Medimmune Oncology, Inc. Pharmaceutical formulations comprising aminoalkyl phosphorothioates
US6160022A (en) * 1999-07-19 2000-12-12 University Of Florida Chemical resection of pancreas
AU2002235126A1 (en) * 2000-11-08 2002-05-21 Slil Biomedical Corporation Novel polyamine analog-amino acid conjugates useful as anticancer agents
US7053072B2 (en) 2001-05-11 2006-05-30 Medimmune Oncology, Inc. Methods for the administration of amifostine and related compounds
US7045550B2 (en) * 2001-08-07 2006-05-16 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
JP2005511734A (ja) * 2001-12-07 2005-04-28 スリル バイオメディカル コーポレイション 癌治療用のシクロアルキル置換ポリアミンおよびそれらの合成方法
KR20040091014A (ko) * 2002-02-07 2004-10-27 위스콘신 얼럼나이 리서어치 화운데이션 항암 요법과 병행해서 사용하기 위한 폴리아민 화합물 및조성물
WO2005014524A2 (en) * 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
WO2007149484A2 (en) * 2006-06-20 2007-12-27 Dana-Farber Cancer Institute Inhibitors of usp1 deubiquitinating enzyme complex
US20100049284A1 (en) * 2008-05-15 2010-02-25 The Catholic University Of America Use of heat to treat biological systems exposed to damaging radiation
WO2011137320A2 (en) 2010-04-30 2011-11-03 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653977A (en) * 1953-09-29 Chxnx
US2951092A (en) * 1956-12-13 1960-08-30 Olin Mathieson Triamine derivatives
US3892824A (en) * 1968-12-16 1975-07-01 Southern Res Inst S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5109024A (en) * 1987-02-03 1992-04-28 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US5217964A (en) * 1991-01-23 1993-06-08 Merrell Dow Pharmaceuticals Inc. Polyamine thiols as radioprotective agents
US5488042A (en) * 1992-03-13 1996-01-30 Arch Development Corporation Method for protection against genotoxic mutagenesis

Also Published As

Publication number Publication date
HU9503370D0 (en) 1996-01-29
EP0700380A1 (de) 1996-03-13
KR960702830A (ko) 1996-05-23
AU679236B2 (en) 1997-06-26
FI955643A0 (fi) 1995-11-23
EP0700380B1 (de) 1998-06-24
WO1994027961A1 (en) 1994-12-08
MX9403915A (es) 1995-01-31
NO306020B1 (no) 1999-09-06
CA2161869A1 (en) 1994-12-08
HUT73421A (en) 1996-07-29
GR3027657T3 (en) 1998-11-30
FI955643L (fi) 1995-11-23
DE69411271T2 (de) 1998-11-05
AU6942894A (en) 1994-12-20
ZA943520B (en) 1995-01-23
NZ267211A (en) 1997-11-24
DK0700380T3 (da) 1998-11-09
IL109720A (en) 1999-09-22
CA2161869C (en) 2001-11-13
NO954768D0 (no) 1995-11-24
US5434145A (en) 1995-07-18
FI955643A7 (fi) 1995-11-23
IL109720A0 (en) 1994-08-26
ES2119203T3 (es) 1998-10-01
NO954768L (no) 1996-01-23
CN1124483A (zh) 1996-06-12
DE69411271D1 (de) 1998-07-30

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee